Vitamin K4_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0388122
NUP58 nucleoporin 58 0.0247853
ATP13A3 ATPase type 13A3 0.0238681
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0197385
DSCAM Down syndrome cell adhesion molecule 0.0196652
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0193828
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0182282
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0181635
OGA O-GlcNAcase 0.0180451
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0177757
CAPRIN2 caprin family member 2 0.0174721
TM9SF3 transmembrane 9 superfamily member 3 0.0171538
USP9X ubiquitin specific peptidase 9, X-linked 0.0167824
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0167385
CCNL1 cyclin L1 0.0166249
STK4 serine/threonine kinase 4 0.0163626
ETNK1 ethanolamine kinase 1 0.0150657
GARS1 glycyl-tRNA synthetase 1 0.0147117
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0146471
VMP1 vacuole membrane protein 1 0.0143426
KMT2C lysine (K)-specific methyltransferase 2C 0.0142915
RPL3 ribosomal protein L3 0.0142385
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0139718
RAB8B RAB8B, member RAS oncogene family 0.0138972
WDR26 WD repeat domain 26 0.0134989
ATP11B ATPase, class VI, type 11B 0.0131869
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0127371
MYH9 myosin, heavy chain 9, non-muscle 0.0124977
CARD16 caspase recruitment domain family, member 16 0.0122991
SPRED2 sprouty-related, EVH1 domain containing 2 0.0122595
TAOK1 TAO kinase 1 0.0119797
KDM6A lysine (K)-specific demethylase 6A 0.0119549
GLS2 glutaminase 2 (liver, mitochondrial) 0.0118562
GATAD2B GATA zinc finger domain containing 2B 0.011699
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0116484
KDM2A lysine (K)-specific demethylase 2A 0.0116339
TM4SF19 transmembrane 4 L six family member 19 0.0116319
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0115773
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0115185
SNX13 sorting nexin 13 0.0114712
USP34 ubiquitin specific peptidase 34 0.0114385
TPX2 TPX2, microtubule-associated 0.0114123
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0112345
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0112319
YME1L1 YME1-like 1 ATPase 0.0112296
EIF4B eukaryotic translation initiation factor 4B 0.0112224
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0111792
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0111154
CKAP5 cytoskeleton associated protein 5 0.0110964
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0110766
SPRED1 sprouty-related, EVH1 domain containing 1 0.0110088
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0109617
ECPAS Ecm29 proteasome adaptor and scaffold 0.0108915
ADAM17 ADAM metallopeptidase domain 17 0.010881
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0107728
NCKAP1 NCK-associated protein 1 0.0107483
WDFY3 WD repeat and FYVE domain containing 3 0.0106717
MCL1 myeloid cell leukemia 1 0.0106666
NEK7 NIMA-related kinase 7 0.0106635
FAR1 fatty acyl CoA reductase 1 0.0105621
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0104077
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0103859
ZNF148 zinc finger protein 148 0.0103219
FZD6 frizzled class receptor 6 0.0103025
RB1CC1 RB1-inducible coiled-coil 1 0.0102536
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0102439
FAM91A1 family with sequence similarity 91, member A1 0.0102034
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0101906
UBXN7 UBX domain protein 7 0.010182
GSK3B glycogen synthase kinase 3 beta 0.0101346
TPM3 tropomyosin 3 0.0101144
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0100565
EPS15 epidermal growth factor receptor pathway substrate 15 0.00996767
SFPQ splicing factor proline/glutamine-rich 0.00990016
YTHDC1 YTH domain containing 1 0.00979548
APLP2 amyloid beta (A4) precursor-like protein 2 0.00975712
LNPEP leucyl/cystinyl aminopeptidase 0.00974042
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00973183
FOXO3 forkhead box O3 0.00968871
NUP54 nucleoporin 54kDa 0.00966815
BIRC6 baculoviral IAP repeat containing 6 0.00964595
TUT7 terminal uridylyl transferase 7 0.00964576
PCNX1 pecanex 1 0.009626
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.00960416
CTTNBP2NL CTTNBP2 N-terminal like 0.00948365
RNF24 ring finger protein 24 0.00944243
ATAD2B ATPase family, AAA domain containing 2B 0.0094244
ZNF654 zinc finger protein 654 0.00939765
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.00936395
TRAM1 translocation associated membrane protein 1 0.00936059
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.00928701
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.00926206
LRRC8C leucine rich repeat containing 8 family, member C 0.00926192
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.00925237
SERINC3 serine incorporator 3 0.00921555
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.00915652
NBAS neuroblastoma amplified sequence 0.00906384
JUN jun proto-oncogene 0.00903817
CDK17 cyclin-dependent kinase 17 0.00902663
AFTPH aftiphilin 0.00901393

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.222773
RPS6 ribosomal protein S6 -0.135869
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115677
TPT1 tumor protein, translationally-controlled 1 -0.105836
RPS8 ribosomal protein S8 -0.105814
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100536
RPL35A ribosomal protein L35a -0.0995264
ZNF438 zinc finger protein 438 -0.0962605
FRMD4A FERM domain containing 4A -0.0921716
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0842578
PTMA prothymosin, alpha -0.0822772
RPL12 ribosomal protein L12 -0.081496
RPL37A ribosomal protein L37a -0.0793426
RPLP1 ribosomal protein, large, P1 -0.0789918
NAV3 neuron navigator 3 -0.0769745
ARHGAP22 Rho GTPase activating protein 22 -0.0764284
FLNB filamin B, beta -0.0754349
FRMD6 FERM domain containing 6 -0.0745347
IFI16 interferon, gamma-inducible protein 16 -0.0716117
RPL8 ribosomal protein L8 -0.0709732
FTL ferritin, light polypeptide -0.0707569
RPL7A ribosomal protein L7a -0.0704408
RPL9 ribosomal protein L9 -0.0688387
RPLP2 ribosomal protein, large, P2 -0.06457
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0644909
RPS12 ribosomal protein S12 -0.0634199
RPL11 ribosomal protein L11 -0.063013
DLC1 DLC1 Rho GTPase activating protein -0.0628858
TMSB10 thymosin beta 10 -0.0622957
ACTG1 actin gamma 1 -0.0599315
RPS19 ribosomal protein S19 -0.0580123
RPS29 ribosomal protein S29 -0.0574284
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0563468
RPL7 ribosomal protein L7 -0.0558979
NAP1L1 nucleosome assembly protein 1-like 1 -0.0552789
RPS24 ribosomal protein S24 -0.0552775
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0548496
RPL30 ribosomal protein L30 -0.0547001
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0544133
RPL23 ribosomal protein L23 -0.0542935
RPL34 ribosomal protein L34 -0.0531913
RPS27A ribosomal protein S27a -0.0512672
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0490313
RPL26 ribosomal protein L26 -0.048663
RPS25 ribosomal protein S25 -0.0480895
RPL35 ribosomal protein L35 -0.0479413
RPS3 ribosomal protein S3 -0.0477938
RPS13 ribosomal protein S13 -0.0469973
RPS21 ribosomal protein S21 -0.0461667
RPL31 ribosomal protein L31 -0.045882
RPL19 ribosomal protein L19 -0.0457257
RPLP0 ribosomal protein, large, P0 -0.0453622
BNC2 basonuclin 2 -0.0452212
STC1 stanniocalcin 1 -0.0443409
RPS20 ribosomal protein S20 -0.0434084
RAD51B RAD51 paralog B -0.0426175
RPL13A ribosomal protein L13a -0.0425436
TM4SF1 transmembrane 4 L six family member 1 -0.0424077
HDAC9 histone deacetylase 9 -0.0417203
RPL5 ribosomal protein L5 -0.0413008
RRBP1 ribosome binding protein 1 -0.0410645
NABP1 nucleic acid binding protein 1 -0.0407727
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0402514
KPNB1 karyopherin (importin) beta 1 -0.0397852
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0395466
ASPH aspartate beta-hydroxylase -0.0394586
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0393626
RPS10 ribosomal protein S10 -0.0391777
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0389903
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0384866
RPS15 ribosomal protein S15 -0.0368708
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0368492
ENO1 enolase 1, (alpha) -0.0366993
NAV2 neuron navigator 2 -0.0360291
RPS23 ribosomal protein S23 -0.0360095
RPL38 ribosomal protein L38 -0.0358528
TPM4 tropomyosin 4 -0.0357834
LPP LIM domain containing preferred translocation partner in lipoma -0.035745
RPL32 ribosomal protein L32 -0.0347237
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0346441
SLC38A2 solute carrier family 38, member 2 -0.0337859
RPS17 ribosomal protein S17 -0.0336305
RAB7A RAB7A, member RAS oncogene family -0.0333437
RPL10A ribosomal protein L10a -0.0329137
RPL37 ribosomal protein L37 -0.0327381
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0324541
HMGA1 high mobility group AT-hook 1 -0.0323387
HMGA2 high mobility group AT-hook 2 -0.0322659
RPL28 ribosomal protein L28 -0.0321777
RPS16 ribosomal protein S16 -0.031969
RACK1 receptor for activated C kinase 1 -0.0319557
SP100 SP100 nuclear antigen -0.0316743
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0314354
RPS2 ribosomal protein S2 -0.0312847
IFI6 interferon, alpha-inducible protein 6 -0.0310483
GNAS GNAS complex locus -0.0310156
RPL36 ribosomal protein L36 -0.0308937
EFNB2 ephrin-B2 -0.0305087
RPS14 ribosomal protein S14 -0.0301874
PDIA3 protein disulfide isomerase family A, member 3 -0.0300389