Vitamin K4_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.163356
FMN1 formin 1 0.104314
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0966682
LINGO2 leucine rich repeat and Ig domain containing 2 0.0740527
AKAP12 A kinase (PRKA) anchor protein 12 0.0633344
LSAMP limbic system-associated membrane protein 0.0612073
NRG3 neuregulin 3 0.045163
DST dystonin 0.0443919
SLC39A11 solute carrier family 39, member 11 0.0442992
MSI2 musashi RNA-binding protein 2 0.035808
HDAC9 histone deacetylase 9 0.0352362
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0350079
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0347606
NLGN1 neuroligin 1 0.0324698
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0319364
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0319228
FHIT fragile histidine triad 0.0315406
SOX6 SRY (sex determining region Y)-box 6 0.0309519
RAD51B RAD51 paralog B 0.0309431
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0304022
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0296389
SMYD3 SET and MYND domain containing 3 0.0293678
EHBP1 EH domain binding protein 1 0.0292498
TAS2R14 taste receptor, type 2, member 14 0.0288782
FRMD5 FERM domain containing 5 0.0273328
CA8 carbonic anhydrase VIII 0.0269321
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0265465
FBXL17 F-box and leucine-rich repeat protein 17 0.0265462
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0260837
FRMD4A FERM domain containing 4A 0.0258143
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0253514
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0246602
DENND1A DENN/MADD domain containing 1A 0.024505
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0242504
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0241631
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0232715
COMMD10 COMM domain containing 10 0.0227837
CDK13 cyclin-dependent kinase 13 0.0224539
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0221859
PRELID2 PRELI domain containing 2 0.0220753
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0220728
CADM1 cell adhesion molecule 1 0.0220597
RASAL2 RAS protein activator like 2 0.0219481
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0210665
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0204891
FNIP1 folliculin interacting protein 1 0.0204633
NBEA neurobeachin 0.0203749
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0203039
ARB2A ARB2 cotranscriptional regulator A 0.0202859
FNDC3B fibronectin type III domain containing 3B 0.0202249
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.020157
TBC1D22A TBC1 domain family, member 22A 0.019967
MARCHF1 membrane associated ring-CH-type finger 1 0.0195917
AFF3 AF4/FMR2 family, member 3 0.0194787
DNAH14 dynein, axonemal, heavy chain 14 0.0193131
FAF1 Fas (TNFRSF6) associated factor 1 0.0191718
LRMDA leucine rich melanocyte differentiation associated 0.0190821
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0187566
CFAP20DC CFAP20 domain containing 0.018345
ZCCHC7 zinc finger, CCHC domain containing 7 0.018055
PCBP3 poly(rC) binding protein 3 0.0180521
UBASH3B ubiquitin associated and SH3 domain containing B 0.017963
FER fer (fps/fes related) tyrosine kinase 0.0179475
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0176855
KDM4C lysine (K)-specific demethylase 4C 0.0176518
FGF13 fibroblast growth factor 13 0.0174822
SND1 staphylococcal nuclease and tudor domain containing 1 0.0174535
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0173362
MACROD2 MACRO domain containing 2 0.0171081
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0171061
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0168339
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0165928
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.0163454
TULP4 tubby like protein 4 0.0163219
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0162495
ZNF26 zinc finger protein 26 0.0162188
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0161967
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0160848
RUNX1 runt-related transcription factor 1 0.0160486
CSNK1A1 casein kinase 1, alpha 1 0.0160332
PMM2 phosphomannomutase 2 0.0159437
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0158558
EXOC4 exocyst complex component 4 0.0158473
GPHN gephyrin 0.0158047
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0158008
ZNF644 zinc finger protein 644 0.0156476
AATF apoptosis antagonizing transcription factor 0.015632
C10ORF90 chromosome 10 open reading frame 90 0.0155619
GLS2 glutaminase 2 (liver, mitochondrial) 0.015537
EIF4B eukaryotic translation initiation factor 4B 0.0154785
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0154307
SCFD1 sec1 family domain containing 1 0.0153571
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.015261
CYTH3 cytohesin 3 0.015217
TIAM2 T-cell lymphoma invasion and metastasis 2 0.015175
GPATCH8 G patch domain containing 8 0.0151222
CCDC91 coiled-coil domain containing 91 0.0150646
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0150562
CALD1 caldesmon 1 0.0149939
DNHD1 dynein heavy chain domain 1 0.0147828

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.278747
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.244791
MT2A metallothionein 2A -0.18529
TMSB10 thymosin beta 10 -0.10901
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.106003
FTL ferritin, light polypeptide -0.0962747
ENO1 enolase 1, (alpha) -0.0771319
PKM pyruvate kinase, muscle -0.0761834
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0735248
NDRG1 N-myc downstream regulated 1 -0.0701037
ICAM1 intercellular adhesion molecule 1 -0.0699803
RPLP1 ribosomal protein, large, P1 -0.0676578
PTMA prothymosin, alpha -0.0666959
PGK1 phosphoglycerate kinase 1 -0.0623771
RPS6 ribosomal protein S6 -0.0619718
POTEF POTE ankyrin domain family, member F -0.0577853
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0573361
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0564391
RPS3 ribosomal protein S3 -0.0519569
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0489622
EEF2 eukaryotic translation elongation factor 2 -0.0486338
LOC112694756 uncharaterized LOC112694756 -0.0483984
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0475828
RPL23 ribosomal protein L23 -0.0472491
CCND1 cyclin D1 -0.0460601
MT1X metallothionein 1X -0.0454008
TM4SF1 transmembrane 4 L six family member 1 -0.0439729
CD44 CD44 molecule (Indian blood group) -0.0439409
VDAC1 voltage-dependent anion channel 1 -0.043529
RPL35A ribosomal protein L35a -0.0429315
B2M beta-2-microglobulin -0.042794
EIF1 eukaryotic translation initiation factor 1 -0.042531
CENPF centromere protein F, 350/400kDa -0.0422834
NAP1L1 nucleosome assembly protein 1-like 1 -0.0422769
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0420993
S100A9 S100 calcium binding protein A9 -0.0404351
RPL19 ribosomal protein L19 -0.0400057
RPS13 ribosomal protein S13 -0.0395205
RACK1 receptor for activated C kinase 1 -0.0393055
SEPTIN7 septin 7 -0.038861
ACTG1 actin gamma 1 -0.0384942
SPAG9 sperm associated antigen 9 -0.0381777
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0373878
KMT2E lysine (K)-specific methyltransferase 2E -0.0364075
RPS8 ribosomal protein S8 -0.0362791
LMNA lamin A/C -0.0356546
ANGPTL4 angiopoietin-like 4 -0.0355472
RPS14 ribosomal protein S14 -0.0353179
RPL36 ribosomal protein L36 -0.0348173
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0344751
PDIA3 protein disulfide isomerase family A, member 3 -0.0338518
TPI1 triosephosphate isomerase 1 -0.0323567
TPT1 tumor protein, translationally-controlled 1 -0.0323452
RPL37A ribosomal protein L37a -0.0321409
RPL11 ribosomal protein L11 -0.0320395
RPL12 ribosomal protein L12 -0.0318209
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0316021
SQSTM1 sequestosome 1 -0.031537
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0314436
IFI6 interferon, alpha-inducible protein 6 -0.0312405
HMGA1 high mobility group AT-hook 1 -0.0307651
KTN1 kinectin 1 (kinesin receptor) -0.0301428
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0301071
WDR45B WD repeat domain 45B -0.030025
RPL34 ribosomal protein L34 -0.0299734
RPLP2 ribosomal protein, large, P2 -0.0298527
RPS29 ribosomal protein S29 -0.0293648
TFPI2 tissue factor pathway inhibitor 2 -0.0292282
RPS19 ribosomal protein S19 -0.0287196
NAV2 neuron navigator 2 -0.028192
RPS16 ribosomal protein S16 -0.0281276
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0279562
S100A10 S100 calcium binding protein A10 -0.027615
APOD apolipoprotein D -0.0274019
RPS12 ribosomal protein S12 -0.0272117
RPS4X ribosomal protein S4, X-linked -0.0266583
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0266378
RPL32 ribosomal protein L32 -0.0265199
RPS23 ribosomal protein S23 -0.0262193
FN1 fibronectin 1 -0.0257565
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0256759
TFG TRK-fused gene -0.0256488
WSB1 WD repeat and SOCS box containing 1 -0.025624
HLA-B major histocompatibility complex, class I, B -0.0253219
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0252076
RPL28 ribosomal protein L28 -0.0251124
RPL31 ribosomal protein L31 -0.0249101
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0246925
RPL5 ribosomal protein L5 -0.024637
RPS27 ribosomal protein S27 -0.0246041
TPM4 tropomyosin 4 -0.0244557
RPL8 ribosomal protein L8 -0.0244488
RPLP0 ribosomal protein, large, P0 -0.0241862
RPS5 ribosomal protein S5 -0.0241222
LDHA lactate dehydrogenase A -0.0238434
EGR1 early growth response 1 -0.023822
GARS1 glycyl-tRNA synthetase 1 -0.0235486
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0234833
IFITM3 interferon induced transmembrane protein 3 -0.0233298
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0232577