Vitamin K4_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0928673
RPL35A ribosomal protein L35a 0.06409
EIF1 eukaryotic translation initiation factor 1 0.062628
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0568786
VIM vimentin 0.0568716
CLASP2 cytoplasmic linker associated protein 2 0.0532582
DGKD diacylglycerol kinase, delta 130kDa 0.053101
TMSB10 thymosin beta 10 0.052342
DSCAM Down syndrome cell adhesion molecule 0.0515849
GIGYF2 GRB10 interacting GYF protein 2 0.0481765
LDHA lactate dehydrogenase A 0.0476769
FTL ferritin, light polypeptide 0.0466942
TPT1 tumor protein, translationally-controlled 1 0.0457519
AKAP12 A kinase (PRKA) anchor protein 12 0.0450859
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0434385
RPL37 ribosomal protein L37 0.0429302
EEF2 eukaryotic translation elongation factor 2 0.0418496
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0413898
CANX calnexin 0.0409051
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0405318
CAPRIN2 caprin family member 2 0.039839
COG5 component of oligomeric golgi complex 5 0.0386331
UBXN7 UBX domain protein 7 0.0384959
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0382914
S100A9 S100 calcium binding protein A9 0.0380053
NAMPT nicotinamide phosphoribosyltransferase 0.0375644
GOLGA2 golgin A2 0.0375014
ANXA2 annexin A2 0.0373689
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0361355
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0360956
RPL23 ribosomal protein L23 0.0360816
ZNF148 zinc finger protein 148 0.0360378
RPL28 ribosomal protein L28 0.0348302
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0343351
YME1L1 YME1-like 1 ATPase 0.0342035
EEF1G eukaryotic translation elongation factor 1 gamma 0.034203
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0339055
RPLP1 ribosomal protein, large, P1 0.0332385
TMEM41B transmembrane protein 41B 0.0329082
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0328327
LPP LIM domain containing preferred translocation partner in lipoma 0.0325096
PKM pyruvate kinase, muscle 0.0324521
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0321208
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0320846
RPS3 ribosomal protein S3 0.031937
KIAA1958 KIAA1958 0.0318705
RPL4 ribosomal protein L4 0.0316179
FAF1 Fas (TNFRSF6) associated factor 1 0.0314654
RORA RAR-related orphan receptor A 0.0314192
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0311041
RPS8 ribosomal protein S8 0.0309456
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0302979
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0301301
CEP295 centrosomal protein 295kDa 0.0298155
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0293342
RPL32 ribosomal protein L32 0.0290021
TLK1 tousled-like kinase 1 0.0289837
TRIO trio Rho guanine nucleotide exchange factor 0.0286439
CCDC47 coiled-coil domain containing 47 0.0276865
RPS19 ribosomal protein S19 0.0273724
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0272326
CAMKMT calmodulin-lysine N-methyltransferase 0.0270615
CALU calumenin 0.0269454
AKAP8L A kinase (PRKA) anchor protein 8-like 0.0268418
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0266356
IFITM3 interferon induced transmembrane protein 3 0.026524
BICD1 bicaudal D homolog 1 (Drosophila) 0.0264198
ITPRID2 ITPR interacting domain containing 2 0.0262237
ANKRD11 ankyrin repeat domain 11 0.025816
RACK1 receptor for activated C kinase 1 0.0256878
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0256696
FBL fibrillarin 0.0255654
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0255364
INTS6 integrator complex subunit 6 0.0255235
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.0254287
RPS14 ribosomal protein S14 0.0253598
DERA deoxyribose-phosphate aldolase (putative) 0.0252906
RFC3 replication factor C (activator 1) 3, 38kDa 0.0252477
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0252461
RPS27A ribosomal protein S27a 0.0252103
RNF213 ring finger protein 213 0.0252098
PARD3 par-3 family cell polarity regulator 0.0251867
PNN pinin, desmosome associated protein 0.0251003
CCNL1 cyclin L1 0.0250877
RPL35 ribosomal protein L35 0.0250752
EXOC6 exocyst complex component 6 0.0249951
RPL26 ribosomal protein L26 0.0249145
RPS21 ribosomal protein S21 0.0249053
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0248965
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.024876
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0248598
REST RE1-silencing transcription factor 0.0246226
NPTN neuroplastin 0.0246114
RNF216 ring finger protein 216 0.0244358
ZFR zinc finger RNA binding protein 0.0244296
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0241841
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0241522
SAFB2 scaffold attachment factor B2 0.0241018
HLTF helicase-like transcription factor 0.0240669
UBP1 upstream binding protein 1 (LBP-1a) 0.0240254

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.249632
CD44 CD44 molecule (Indian blood group) -0.112417
CENPF centromere protein F, 350/400kDa -0.090885
BIRC3 baculoviral IAP repeat containing 3 -0.082485
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0726101
TPX2 TPX2, microtubule-associated -0.0711212
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0683022
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0680517
ANKRD28 ankyrin repeat domain 28 -0.0663526
CHD1 chromodomain helicase DNA binding protein 1 -0.0653281
AKAP13 A kinase (PRKA) anchor protein 13 -0.0586394
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.057737
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0571177
NAV2 neuron navigator 2 -0.0557984
ATM ATM serine/threonine kinase -0.0546889
SMYD3 SET and MYND domain containing 3 -0.0534843
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0509701
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0496029
NUP58 nucleoporin 58 -0.0469146
ELL2 elongation factor, RNA polymerase II, 2 -0.0451466
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0445667
ASXL1 additional sex combs like transcriptional regulator 1 -0.0442079
DTNA dystrobrevin, alpha -0.04382
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0422647
ITCH itchy E3 ubiquitin protein ligase -0.0417841
UGCG UDP-glucose ceramide glucosyltransferase -0.0412795
NAP1L1 nucleosome assembly protein 1-like 1 -0.0396662
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0395561
YAP1 Yes-associated protein 1 -0.0388201
DST dystonin -0.0380026
FMNL2 formin-like 2 -0.0377655
SOD2 superoxide dismutase 2, mitochondrial -0.0375377
ANLN anillin, actin binding protein -0.0373365
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0371088
NCKAP1 NCK-associated protein 1 -0.0369935
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0365669
HELZ helicase with zinc finger -0.0363954
NGLY1 N-glycanase 1 -0.0359421
RIGI RNA sensor RIG-I -0.0355419
SNX14 sorting nexin 14 -0.0353512
RTN4 reticulon 4 -0.0351218
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0345653
PDE4D phosphodiesterase 4D, cAMP-specific -0.0344108
ANKRD12 ankyrin repeat domain 12 -0.0341953
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0340023
SCAF8 SR-related CTD-associated factor 8 -0.0322526
CSNK1A1 casein kinase 1, alpha 1 -0.0321293
LMO7 LIM domain 7 -0.0317763
TFRC transferrin receptor -0.0317512
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0316422
OSMR oncostatin M receptor -0.0316103
POTEF POTE ankyrin domain family, member F -0.0314947
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0314012
DOCK4 dedicator of cytokinesis 4 -0.031273
CPNE1 copine I -0.0312633
NCEH1 neutral cholesterol ester hydrolase 1 -0.0311416
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0311255
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0309956
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0309783
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0307145
SMIM44 small integral membrane protein 44 -0.030639
PANX1 pannexin 1 -0.0302447
DGKH diacylglycerol kinase, eta -0.029858
SLC38A2 solute carrier family 38, member 2 -0.0295326
AURKA aurora kinase A -0.0291614
PTMA prothymosin, alpha -0.0289708
ASXL2 additional sex combs like transcriptional regulator 2 -0.0286572
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0281718
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0281145
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0280703
OGA O-GlcNAcase -0.0279185
FBXL7 F-box and leucine-rich repeat protein 7 -0.0279147
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0278848
ZBTB1 zinc finger and BTB domain containing 1 -0.0276903
BIRC6 baculoviral IAP repeat containing 6 -0.0276058
AHCTF1 AT hook containing transcription factor 1 -0.0275134
CEP57 centrosomal protein 57kDa -0.0275109
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0274352
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0273405
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0272456
MARCHF4 membrane associated ring-CH-type finger 4 -0.0271265
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0269853
TM9SF2 transmembrane 9 superfamily member 2 -0.0269355
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0268876
CNKSR3 CNKSR family member 3 -0.0267843
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0267093
YBX3 Y box binding protein 3 -0.0265623
CCDC50 coiled-coil domain containing 50 -0.026498
EIF5B eukaryotic translation initiation factor 5B -0.0262676
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0259262
MBNL1 muscleblind-like splicing regulator 1 -0.0256669
PRKCA protein kinase C, alpha -0.025236
NUSAP1 nucleolar and spindle associated protein 1 -0.0251814
TTC14 tetratricopeptide repeat domain 14 -0.0251591
EML4 echinoderm microtubule associated protein like 4 -0.0251193
RCOR1 REST corepressor 1 -0.0249507
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.0247778
MYOF myoferlin -0.0246996
CERT1 ceramide transporter 1 -0.0244483
PHF20 PHD finger protein 20 -0.024446