Vitamin K4_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0792912
NRG1 neuregulin 1 0.0451577
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0271785
SOS1 son of sevenless homolog 1 (Drosophila) 0.0264574
AHRR aryl-hydrocarbon receptor repressor 0.0214005
GLIS3 GLIS family zinc finger 3 0.0193686
TMEM156 transmembrane protein 156 0.0190621
VEGFA vascular endothelial growth factor A 0.0183537
RUNX2 runt-related transcription factor 2 0.0155195
NTN4 netrin 4 0.0135343
HIPK2 homeodomain interacting protein kinase 2 0.0123807
EFNA5 ephrin-A5 0.0123731
CCNL1 cyclin L1 0.011722
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0111866
BICC1 BicC family RNA binding protein 1 0.0111104
SMOX spermine oxidase 0.0104678
LMCD1 LIM and cysteine-rich domains 1 0.0103143
TMEM178B transmembrane protein 178B 0.0092445
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.00910089
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00884258
RBPMS RNA binding protein with multiple splicing 0.00846958
AOPEP aminopeptidase O (putative) 0.00821412
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.00784269
STC2 stanniocalcin 2 0.00776327
FAM20C family with sequence similarity 20, member C 0.00770012
RDH10 retinol dehydrogenase 10 (all-trans) 0.00756384
SSH1 slingshot protein phosphatase 1 0.00735882
LRP5 low density lipoprotein receptor-related protein 5 0.00699995
MB21D2 Mab-21 domain containing 2 0.00685935
CARD16 caspase recruitment domain family, member 16 0.00667632
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.00642958
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.00623759
MTUS1 microtubule associated tumor suppressor 1 0.00623513
PCBP3 poly(rC) binding protein 3 0.00599584
OSMR oncostatin M receptor 0.00584951
IL1R1 interleukin 1 receptor, type I 0.00580385
CCNJL cyclin J-like 0.00571183
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.00570275
MCEE methylmalonyl CoA epimerase 0.00551804
PDE7B phosphodiesterase 7B 0.00546336
GLCCI1 glucocorticoid induced 1 0.00545206
NKD2 naked cuticle homolog 2 (Drosophila) 0.00538578
NPAS2 neuronal PAS domain protein 2 0.00526005
KSR1 kinase suppressor of ras 1 0.00524577
NBEA neurobeachin 0.00522212
YLPM1 YLP motif containing 1 0.00516454
SCFD2 sec1 family domain containing 2 0.00514298
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.00508727
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0050824
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00501406
TMED2 transmembrane emp24 domain trafficking protein 2 0.00501139
DNAH5 dynein, axonemal, heavy chain 5 0.00495962
PPARA peroxisome proliferator-activated receptor alpha 0.00490561
CAB39 calcium binding protein 39 0.00489839
FOSL2 FOS-like antigen 2 0.00485354
PNN pinin, desmosome associated protein 0.00484458
TTC3 tetratricopeptide repeat domain 3 0.00476291
ZNF26 zinc finger protein 26 0.00475199
CEP250 centrosomal protein 250kDa 0.00473138
FMN1 formin 1 0.00472274
ZNF721 zinc finger protein 721 0.00470877
JARID2 jumonji, AT rich interactive domain 2 0.00469453
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.00461912
PXK PX domain containing serine/threonine kinase 0.00458615
MEIS1 Meis homeobox 1 0.0045775
PBX1 pre-B-cell leukemia homeobox 1 0.00455622
ZNF655 zinc finger protein 655 0.0045516
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.00453907
ARFIP1 ADP-ribosylation factor interacting protein 1 0.00451132
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.00450355
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00450084
ZNF780B zinc finger protein 780B 0.00448171
PCNX1 pecanex 1 0.00447204
CRACR2A calcium release activated channel regulator 2A 0.00447189
CD99L2 CD99 molecule-like 2 0.00441381
ZDHHC5 zinc finger, DHHC-type containing 5 0.00439243
BBS9 Bardet-Biedl syndrome 9 0.00438119
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00432171
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 0.00429241
ADGRE2 adhesion G protein-coupled receptor E2 0.00428481
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.00428055
CD38 CD38 molecule 0.00427612
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.00425268
PTEN phosphatase and tensin homolog 0.00424224
THBD thrombomodulin 0.00423306
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.00421451
LRP6 low density lipoprotein receptor-related protein 6 0.00419379
DPYD dihydropyrimidine dehydrogenase 0.00412629
GOSR2 golgi SNAP receptor complex member 2 0.00411553
KIAA0232 KIAA0232 0.00410926
MNT MAX network transcriptional repressor 0.00410869
CEMIP2 cell migration inducing hyaluronidase 2 0.00408725
SLC38A6 solute carrier family 38, member 6 0.00408257
FAM120B family with sequence similarity 120B 0.00404631
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.00403909
DMTF1 cyclin D binding myb-like transcription factor 1 0.00403382
EXT1 exostosin glycosyltransferase 1 0.0040298
COG6 component of oligomeric golgi complex 6 0.00399732
FNBP4 formin binding protein 4 0.0039859
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.00397639

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.385216
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.11462
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.114531
PTMA prothymosin, alpha -0.11073
FN1 fibronectin 1 -0.096652
MT2A metallothionein 2A -0.092177
VIM vimentin -0.0752166
NAMPT nicotinamide phosphoribosyltransferase -0.0744121
UBC ubiquitin C -0.0740675
NDRG1 N-myc downstream regulated 1 -0.0738478
CANX calnexin -0.072838
TMSB10 thymosin beta 10 -0.0710082
ASPH aspartate beta-hydroxylase -0.0594338
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0573692
S100A6 S100 calcium binding protein A6 -0.0562917
RPS27A ribosomal protein S27a -0.0531994
ENO1 enolase 1, (alpha) -0.05299
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.052089
TXNIP thioredoxin interacting protein -0.0516467
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0484277
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0476131
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0471875
PKM pyruvate kinase, muscle -0.0467405
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0437215
LMNA lamin A/C -0.0406259
HLA-B major histocompatibility complex, class I, B -0.0403165
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.039582
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.039095
B2M beta-2-microglobulin -0.0381188
S100A10 S100 calcium binding protein A10 -0.0373874
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0370235
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0368579
NAP1L1 nucleosome assembly protein 1-like 1 -0.0366805
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0365039
RACK1 receptor for activated C kinase 1 -0.0347994
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0342674
ELL2 elongation factor, RNA polymerase II, 2 -0.0341296
CALU calumenin -0.0334144
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0315916
FNDC3B fibronectin type III domain containing 3B -0.0314911
RPS12 ribosomal protein S12 -0.0313946
AHR aryl hydrocarbon receptor -0.0312666
CALR calreticulin -0.0311042
RPL23 ribosomal protein L23 -0.0310709
TRIO trio Rho guanine nucleotide exchange factor -0.030879
RPL26 ribosomal protein L26 -0.0308702
RPL9 ribosomal protein L9 -0.0305181
IER3 immediate early response 3 -0.0300822
SPAG9 sperm associated antigen 9 -0.0298973
ZNF292 zinc finger protein 292 -0.0292027
LOC112694756 uncharaterized LOC112694756 -0.0290907
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0289008
SFTPA2 surfactant protein A2 -0.0288899
RPS3 ribosomal protein S3 -0.0287492
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0283327
HILPDA hypoxia inducible lipid droplet-associated -0.0281155
PGK1 phosphoglycerate kinase 1 -0.0279242
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0274598
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0273675
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0272379
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0265667
SMAD3 SMAD family member 3 -0.0263106
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0262883
MKI67 marker of proliferation Ki-67 -0.0260956
PCBP2 poly(rC) binding protein 2 -0.0260569
SQSTM1 sequestosome 1 -0.0260485
EMP1 epithelial membrane protein 1 -0.0260052
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0259925
RPL31 ribosomal protein L31 -0.0259699
EEF2 eukaryotic translation elongation factor 2 -0.0258947
RPLP1 ribosomal protein, large, P1 -0.0256694
TPT1 tumor protein, translationally-controlled 1 -0.0255357
CENPF centromere protein F, 350/400kDa -0.0255084
AHNAK AHNAK nucleoprotein -0.0251413
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0248484
RPS6 ribosomal protein S6 -0.0247356
RPL37A ribosomal protein L37a -0.0247132
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0244501
KMT2E lysine (K)-specific methyltransferase 2E -0.0244056
GNAS GNAS complex locus -0.0241666
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0240595
HMGA1 high mobility group AT-hook 1 -0.0236691
TFG TRK-fused gene -0.023649
TPI1 triosephosphate isomerase 1 -0.0235887
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0235503
ACTN4 actinin, alpha 4 -0.0234485
RPS5 ribosomal protein S5 -0.0232396
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0231974
TMSB4X thymosin beta 4, X-linked -0.0231579
RPL12 ribosomal protein L12 -0.0227838
SUCO SUN domain containing ossification factor -0.0227137
MYH9 myosin, heavy chain 9, non-muscle -0.0227014
PRRC2C proline-rich coiled-coil 2C -0.0226447
FTL ferritin, light polypeptide -0.022288
EZR ezrin -0.0222866
SEPTIN7 septin 7 -0.0221015
RPS19 ribosomal protein S19 -0.0220983
RPS29 ribosomal protein S29 -0.0220806
KDM3A lysine (K)-specific demethylase 3A -0.0220003
RHEB Ras homolog enriched in brain -0.0217806