Vitamin K4_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.129437
LMO7 LIM domain 7 0.104246
HDAC2 histone deacetylase 2 0.052108
ANXA1 annexin A1 0.0509155
PDLIM5 PDZ and LIM domain 5 0.0464349
SERINC5 serine incorporator 5 0.0439613
OSBPL3 oxysterol binding protein-like 3 0.0339389
MBNL1 muscleblind-like splicing regulator 1 0.0287734
DSPP dentin sialophosphoprotein 0.0282393
KLF3 Kruppel-like factor 3 (basic) 0.0276464
RAB10 RAB10, member RAS oncogene family 0.0269429
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0258903
RAD51B RAD51 paralog B 0.0246802
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0244294
OXR1 oxidation resistance 1 0.0237523
ZCCHC7 zinc finger, CCHC domain containing 7 0.0232038
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0227936
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0224365
NFIA nuclear factor I/A 0.0224012
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0223177
GPHN gephyrin 0.0217023
CD36 CD36 molecule (thrombospondin receptor) 0.0211024
UBE3C ubiquitin protein ligase E3C 0.0200113
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0194716
VCL vinculin 0.0194035
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0193313
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0192901
ITPRID2 ITPR interacting domain containing 2 0.0191004
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0189773
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0189765
FRAS1 Fraser extracellular matrix complex subunit 1 0.0183452
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.017477
WDR43 WD repeat domain 43 0.0173721
MPRIP myosin phosphatase Rho interacting protein 0.0172508
BCL2L1 BCL2-like 1 0.0171485
CLDND1 claudin domain containing 1 0.0168132
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0165851
DOCK5 dedicator of cytokinesis 5 0.0164244
GIGYF2 GRB10 interacting GYF protein 2 0.0161434
PTK2 protein tyrosine kinase 2 0.0158194
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.015813
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0158018
GDF15 growth differentiation factor 15 0.0157709
AKAP13 A kinase (PRKA) anchor protein 13 0.01569
UBAP2 ubiquitin associated protein 2 0.0155728
MTUS1 microtubule associated tumor suppressor 1 0.0155248
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.015306
IGFBP3 insulin-like growth factor binding protein 3 0.0152447
FAT1 FAT atypical cadherin 1 0.0150961
OSBPL10 oxysterol binding protein-like 10 0.014952
CD46 CD46 molecule, complement regulatory protein 0.014942
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0148666
TUT4 terminal uridylyl transferase 4 0.0148308
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0145338
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0142749
RNF145 ring finger protein 145 0.0141188
BIRC6 baculoviral IAP repeat containing 6 0.0140966
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0140917
TCERG1 transcription elongation regulator 1 0.014064
RUNX2 runt-related transcription factor 2 0.0140528
TTC17 tetratricopeptide repeat domain 17 0.0140297
EVA1C eva-1 homolog C (C. elegans) 0.0138923
RBM26 RNA binding motif protein 26 0.013878
AOPEP aminopeptidase O (putative) 0.0137596
TBC1D5 TBC1 domain family, member 5 0.0137461
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.013677
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0136667
ADGRA3 adhesion G protein-coupled receptor A3 0.0136148
TNRC6B trinucleotide repeat containing 6B 0.0135994
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0133814
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0133415
CEP152 centrosomal protein 152kDa 0.0133147
USP34 ubiquitin specific peptidase 34 0.0132958
SND1 staphylococcal nuclease and tudor domain containing 1 0.0131648
PUM3 pumilio RNA binding family member 3 0.0128911
LAMA4 laminin, alpha 4 0.0125627
ARHGAP42 Rho GTPase activating protein 42 0.0125329
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0125128
ZNF146 zinc finger protein 146 0.0124807
NF1 neurofibromin 1 0.0124722
CUX1 cut-like homeobox 1 0.0124569
FAM3C family with sequence similarity 3, member C 0.0124042
YLPM1 YLP motif containing 1 0.0123597
MAP4 microtubule-associated protein 4 0.0122722
TOP1 topoisomerase (DNA) I 0.0121497
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0121167
FAR1 fatty acyl CoA reductase 1 0.0121125
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0120429
ANXA3 annexin A3 0.0119614
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0119546
RBM25 RNA binding motif protein 25 0.011895
TNS3 tensin 3 0.0117597
THSD4 thrombospondin, type I, domain containing 4 0.0117117
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0116554
SHROOM3 shroom family member 3 0.011541
KIF16B kinesin family member 16B 0.0115307
PUM2 pumilio RNA-binding family member 2 0.0115089
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.011506
MDN1 MDN1, midasin homolog (yeast) 0.0114822
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0114344

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154744
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.145311
PTMA prothymosin, alpha -0.121004
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.10242
ACTG1 actin gamma 1 -0.0997267
IER3 immediate early response 3 -0.0996468
TMSB10 thymosin beta 10 -0.0975919
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0822995
AREG amphiregulin -0.0743151
UBC ubiquitin C -0.073625
EEF2 eukaryotic translation elongation factor 2 -0.0727782
RPS6 ribosomal protein S6 -0.0664603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0640625
AHNAK AHNAK nucleoprotein -0.0618076
RPS27A ribosomal protein S27a -0.0572374
TPT1 tumor protein, translationally-controlled 1 -0.0534044
RPS8 ribosomal protein S8 -0.0532528
ENO1 enolase 1, (alpha) -0.0507057
EZR ezrin -0.045587
HILPDA hypoxia inducible lipid droplet-associated -0.0453368
RPS24 ribosomal protein S24 -0.0430381
RPL34 ribosomal protein L34 -0.0428924
NDRG1 N-myc downstream regulated 1 -0.0428052
RPS3 ribosomal protein S3 -0.0412648
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0384143
RPL35A ribosomal protein L35a -0.0382005
RPLP1 ribosomal protein, large, P1 -0.0377818
RPL5 ribosomal protein L5 -0.0374693
RPL9 ribosomal protein L9 -0.0369786
RPS12 ribosomal protein S12 -0.0368139
RPL23 ribosomal protein L23 -0.0357165
RPL37A ribosomal protein L37a -0.03482
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0347067
ATXN1 ataxin 1 -0.034659
PDIA3 protein disulfide isomerase family A, member 3 -0.0308135
RPL36 ribosomal protein L36 -0.0308074
RPL12 ribosomal protein L12 -0.0304801
RPLP2 ribosomal protein, large, P2 -0.030021
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.029983
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0298649
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0297194
BIRC3 baculoviral IAP repeat containing 3 -0.0293505
RPL26 ribosomal protein L26 -0.0289645
LOC112694756 uncharaterized LOC112694756 -0.0288838
PKM pyruvate kinase, muscle -0.0287981
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0280952
S100A10 S100 calcium binding protein A10 -0.0280711
RPS19 ribosomal protein S19 -0.0279811
RPL19 ribosomal protein L19 -0.027664
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0276173
EIF1 eukaryotic translation initiation factor 1 -0.0275903
RPS5 ribosomal protein S5 -0.0271201
RPS29 ribosomal protein S29 -0.0271001
S100A6 S100 calcium binding protein A6 -0.0270894
CANX calnexin -0.025884
CALU calumenin -0.0257312
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0255889
RPS25 ribosomal protein S25 -0.0248797
RPL8 ribosomal protein L8 -0.0248323
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0246856
EGR1 early growth response 1 -0.024655
HSPA8 heat shock 70kDa protein 8 -0.0245256
RPS13 ribosomal protein S13 -0.0240636
PCBP2 poly(rC) binding protein 2 -0.0239647
KDM3A lysine (K)-specific demethylase 3A -0.0238268
SET SET nuclear proto-oncogene -0.0237645
MT2A metallothionein 2A -0.0235502
CALR calreticulin -0.0234708
RPS2 ribosomal protein S2 -0.0233818
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0232137
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0232113
RPL31 ribosomal protein L31 -0.0226271
FLNA filamin A, alpha -0.0225581
RPL11 ribosomal protein L11 -0.0219657
FTL ferritin, light polypeptide -0.0217856
POTEF POTE ankyrin domain family, member F -0.0216299
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0214474
RPS4X ribosomal protein S4, X-linked -0.0214397
DDIT4 DNA-damage-inducible transcript 4 -0.0213725
ITPKC inositol-trisphosphate 3-kinase C -0.0213551
RPS17 ribosomal protein S17 -0.0212377
CD44 CD44 molecule (Indian blood group) -0.0210925
HMGA1 high mobility group AT-hook 1 -0.0208962
RPL15 ribosomal protein L15 -0.0203342
ZNF292 zinc finger protein 292 -0.0199836
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0198608
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0194365
PDE4B phosphodiesterase 4B, cAMP-specific -0.0194088
ITGB4 integrin, beta 4 -0.0193399
RPL35 ribosomal protein L35 -0.0192007
RPLP0 ribosomal protein, large, P0 -0.0191273
MYO5B myosin VB -0.0191104
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0187881
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0187306
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0187293
SEPTIN7 septin 7 -0.018475
RPS11 ribosomal protein S11 -0.0184643
RPS15 ribosomal protein S15 -0.0183309
RPL7A ribosomal protein L7a -0.0182184
LDHA lactate dehydrogenase A -0.018196