Vitamin K4_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.053543
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0416698
NAV2 neuron navigator 2 0.039629
VCL vinculin 0.0366636
SDK1 sidekick cell adhesion molecule 1 0.0337092
ASPH aspartate beta-hydroxylase 0.0317112
WWOX WW domain containing oxidoreductase 0.0307947
RPL4 ribosomal protein L4 0.0290947
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0285041
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0246844
AHRR aryl-hydrocarbon receptor repressor 0.024369
YAP1 Yes-associated protein 1 0.023806
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0223621
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0222014
WDR43 WD repeat domain 43 0.0221559
RAD51B RAD51 paralog B 0.021763
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0210702
UBAP2 ubiquitin associated protein 2 0.0202785
CDH13 cadherin 13 0.0201683
SKAP1 src kinase associated phosphoprotein 1 0.019838
ANO1 anoctamin 1, calcium activated chloride channel 0.0194888
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0193102
SAMD4A sterile alpha motif domain containing 4A 0.0191012
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0190557
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0183062
SFPQ splicing factor proline/glutamine-rich 0.0182856
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0181399
NCEH1 neutral cholesterol ester hydrolase 1 0.0180069
CD44 CD44 molecule (Indian blood group) 0.0179849
SMC1A structural maintenance of chromosomes 1A 0.0179408
PDLIM5 PDZ and LIM domain 5 0.0176558
ADGRL2 adhesion G protein-coupled receptor L2 0.0172873
INTS6 integrator complex subunit 6 0.0171042
EGFR epidermal growth factor receptor 0.0164433
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.016058
RCOR1 REST corepressor 1 0.0159345
AXIN2 axin 2 0.0159288
NTSR1 neurotensin receptor 1 (high affinity) 0.0158373
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0158303
BCL2L1 BCL2-like 1 0.0156433
TNS3 tensin 3 0.0155699
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0154546
SMAD3 SMAD family member 3 0.0152616
SERBP1 SERPINE1 mRNA binding protein 1 0.0150731
CENPP centromere protein P 0.0150722
SIK3 SIK family kinase 3 0.0149171
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0148362
NOP56 NOP56 ribonucleoprotein 0.0146273
FRMD5 FERM domain containing 5 0.0145298
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0144847
GMDS GDP-mannose 4,6-dehydratase 0.0141756
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0139808
ZZZ3 zinc finger, ZZ-type containing 3 0.0138574
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0138492
UTP4 UTP4 small subunit processome component 0.0137982
SPATA13 spermatogenesis associated 13 0.0134956
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0134398
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0133536
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0129689
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.012947
EXOC4 exocyst complex component 4 0.0125922
SORBS1 sorbin and SH3 domain containing 1 0.0125833
LRMDA leucine rich melanocyte differentiation associated 0.012509
RPTOR regulatory associated protein of MTOR, complex 1 0.0124276
CHKA choline kinase alpha 0.0121962
ZNF146 zinc finger protein 146 0.0118888
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0118335
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0117896
ANKRD11 ankyrin repeat domain 11 0.0115958
PMM2 phosphomannomutase 2 0.0115691
MRTFA myocardin related transcription factor A 0.0115548
EHBP1 EH domain binding protein 1 0.0115526
MTAP methylthioadenosine phosphorylase 0.0114633
ZSWIM6 zinc finger, SWIM-type containing 6 0.0114593
LRP5 low density lipoprotein receptor-related protein 5 0.0114431
STK38L serine/threonine kinase 38 like 0.0113277
TRAF3 TNF receptor-associated factor 3 0.0113081
YLPM1 YLP motif containing 1 0.0112226
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0110984
SET SET nuclear proto-oncogene 0.0110616
EIF4B eukaryotic translation initiation factor 4B 0.0109104
MCU mitochondrial calcium uniporter 0.0108756
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.0108599
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0108466
RNPS1 RNA binding protein S1, serine-rich domain 0.0108397
SQSTM1 sequestosome 1 0.0108013
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0107046
MRPS6 mitochondrial ribosomal protein S6 0.0107046
CCDC138 coiled-coil domain containing 138 0.0106611
MYO19 myosin XIX 0.010659
SH3RF1 SH3 domain containing ring finger 1 0.0105585
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0105329
ARSG arylsulfatase G 0.0105326
BCAR3 breast cancer anti-estrogen resistance 3 0.0105103
FTH1 ferritin, heavy polypeptide 1 0.0104549
E2F3 E2F transcription factor 3 0.0103078
AATF apoptosis antagonizing transcription factor 0.0102508
CSMD3 CUB and Sushi multiple domains 3 0.0102336
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0102015
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0101533

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.253665
TMSB10 thymosin beta 10 -0.126684
TPT1 tumor protein, translationally-controlled 1 -0.107719
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.102437
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0963907
RPS6 ribosomal protein S6 -0.0917934
PGK1 phosphoglycerate kinase 1 -0.0856486
RPS3 ribosomal protein S3 -0.0840933
EZR ezrin -0.0827491
RPL35A ribosomal protein L35a -0.0809331
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0746303
EEF2 eukaryotic translation elongation factor 2 -0.068675
EIF1 eukaryotic translation initiation factor 1 -0.068632
ENO1 enolase 1, (alpha) -0.0685281
EGR1 early growth response 1 -0.0674235
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0668392
RPS19 ribosomal protein S19 -0.0635174
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0598589
RPLP1 ribosomal protein, large, P1 -0.0598123
RPS24 ribosomal protein S24 -0.0550824
RPS13 ribosomal protein S13 -0.0538401
RPLP2 ribosomal protein, large, P2 -0.053701
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0532021
CANX calnexin -0.052892
RPL19 ribosomal protein L19 -0.0527546
VIM vimentin -0.0519401
TXNIP thioredoxin interacting protein -0.0510125
RPL12 ribosomal protein L12 -0.0508796
RPL11 ribosomal protein L11 -0.0505736
ESYT2 extended synaptotagmin-like protein 2 -0.0505412
ANXA2 annexin A2 -0.0494589
NDRG1 N-myc downstream regulated 1 -0.0483561
RPLP0 ribosomal protein, large, P0 -0.0483477
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0482709
MT2A metallothionein 2A -0.0479602
RPL23 ribosomal protein L23 -0.0472058
RPL26 ribosomal protein L26 -0.0469075
RPL32 ribosomal protein L32 -0.0459003
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0448804
RPL31 ribosomal protein L31 -0.0447545
ATXN1 ataxin 1 -0.0439322
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0435284
PTMA prothymosin, alpha -0.0427002
PERP PERP, TP53 apoptosis effector -0.0423772
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0423656
GARS1 glycyl-tRNA synthetase 1 -0.040943
RPL36A ribosomal protein L36a -0.0404437
ZNF292 zinc finger protein 292 -0.0393483
RPS21 ribosomal protein S21 -0.0392071
KDM3A lysine (K)-specific demethylase 3A -0.0391462
KPNB1 karyopherin (importin) beta 1 -0.0389045
GLG1 golgi glycoprotein 1 -0.0388327
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0385575
RPL7A ribosomal protein L7a -0.0385018
OXR1 oxidation resistance 1 -0.0384796
ITGA6 integrin, alpha 6 -0.0380998
LDHA lactate dehydrogenase A -0.0380762
KMT2E lysine (K)-specific methyltransferase 2E -0.0377115
FTL ferritin, light polypeptide -0.0377006
RACK1 receptor for activated C kinase 1 -0.0375099
EIF4A1 eukaryotic translation initiation factor 4A1 -0.037061
TPI1 triosephosphate isomerase 1 -0.0369779
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0366971
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036266
PCLO piccolo presynaptic cytomatrix protein -0.0362332
RPL5 ribosomal protein L5 -0.0362235
RPL28 ribosomal protein L28 -0.0361392
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0359874
MORF4L2 mortality factor 4 like 2 -0.035396
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0342027
RPL36 ribosomal protein L36 -0.0340067
RPS23 ribosomal protein S23 -0.0335547
RPL8 ribosomal protein L8 -0.0335335
RPS5 ribosomal protein S5 -0.0333163
RPS27A ribosomal protein S27a -0.0328316
ZMYND8 zinc finger, MYND-type containing 8 -0.0326912
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0325086
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0324995
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.032497
RPS11 ribosomal protein S11 -0.0321478
NAP1L1 nucleosome assembly protein 1-like 1 -0.0320691
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0318962
MYL12B myosin, light chain 12B, regulatory -0.031874
ACTG1 actin gamma 1 -0.0318076
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0317919
RPL13A ribosomal protein L13a -0.0317042
H1-0 H1.0 linker histone -0.0316294
KRT19 keratin 19, type I -0.0315093
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0315051
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0314445
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0311104
WDFY2 WD repeat and FYVE domain containing 2 -0.0310517
RPS25 ribosomal protein S25 -0.0308536
JMJD1C jumonji domain containing 1C -0.0306622
ACTN4 actinin, alpha 4 -0.0306058
RPL9 ribosomal protein L9 -0.0304503
PIBF1 progesterone immunomodulatory binding factor 1 -0.0304338
H3-3B H3.3 histone B -0.0303969
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0301503
RPL27A ribosomal protein L27a -0.0300671