Vitiligo Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached. (Experimental Factor Ontology, EFO_0004208)
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Genes

236 genes associated with the disease Vitiligo in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 2.028
BTNL2 butyrophilin-like 2 2.028
GRM5 glutamate receptor, metabotropic 5 2.015
NOX4 NADPH oxidase 4 2.015
TYR tyrosinase 2.015
PMEL premelanosome protein 2.009
RAB5B RAB5B, member RAS oncogene family 2.009
RPS26 ribosomal protein S26 2.009
SUOX sulfite oxidase 2.009
DGKA diacylglycerol kinase, alpha 80kDa 2.009
CDK2 cyclin-dependent kinase 2 2.009
ERBB3 erb-b2 receptor tyrosine kinase 3 2.009
IKZF4 IKAROS family zinc finger 4 (Eos) 2.009
PA2G4 proliferation-associated 2G4, 38kDa 2.009
PYM1 PYM homolog 1, exon junction complex associated factor 2.009
SPIRE2 spire-type actin nucleation factor 2 1.998
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 1.997
LPP LIM domain containing preferred translocation partner in lipoma 1.992
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 1.988
TFF1 trefoil factor 1 1.988
TFF2 trefoil factor 2 1.988
UBASH3A ubiquitin associated and SH3 domain containing A 1.988
TMPRSS3 transmembrane protease, serine 3 1.988
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 1.988
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 1.986
HLA-A major histocompatibility complex, class I, A 1.986
ATXN2 ataxin 2 1.965
PHETA1 PH domain containing endocytic trafficking adaptor 1 1.965
SH2B3 SH2B adaptor protein 3 1.965
VWA7 von Willebrand factor A domain containing 7 1.952
NEU1 sialidase 1 (lysosomal sialidase) 1.952
NELFE negative elongation factor complex member E 1.952
HSPA1B heat shock 70kDa protein 1B 1.952
SLC44A4 solute carrier family 44, member 4 1.952
HSPA1L heat shock 70kDa protein 1-like 1.952
ZBTB12 zinc finger and BTB domain containing 12 1.952
C2 complement component 2 1.952
CFB complement factor B 1.952
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.952
HSPA1A heat shock 70kDa protein 1A 1.952
VARS1 valyl-tRNA synthetase 1 1.952
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.952
RNASET2 ribonuclease T2 1.93
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 1.93
CD44 CD44 molecule (Indian blood group) 1.919
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.919
SSTR3 somatostatin receptor 3 1.907
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 1.907
CYTH4 cytohesin 4 1.907
TMPRSS6 transmembrane protease, serine 6 1.907
C1QTNF6 C1q and tumor necrosis factor related protein 6 1.907
IL2RB interleukin 2 receptor, beta 1.907
RBM17 RNA binding motif protein 17 1.888
IL15RA interleukin 15 receptor, alpha 1.888
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.888
IL2RA interleukin 2 receptor, alpha 1.888
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 1.859
TCF25 transcription factor 25 (basic helix-loop-helix) 1.859
PRDM7 PR domain containing 7 1.859
DEF8 differentially expressed in FDCP 8 homolog (mouse) 1.859
GAS8 growth arrest-specific 8 1.859
TUBB3 tubulin, beta 3 class III 1.859
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 1.859
RERE arginine-glutamic acid dipeptide (RE) repeats 1.858
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.842
CPVL carboxypeptidase, vitellogenic-like 1.816
CHN2 chimerin 2 1.816
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1.809
OCA2 oculocutaneous albinism II 1.809
TG thyroglobulin 1.799
PHF20L1 PHD finger protein 20-like 1 1.799
TSBP1 testis expressed basic protein 1 1.797
CUX2 cut-like homeobox 2 1.791
TOB2 transducer of ERBB2, 2 1.765
PHF5A PHD finger protein 5A 1.765
TEF thyrotrophic embryonic factor 1.765
ACO2 aconitase 2, mitochondrial 1.765
RANGAP1 Ran GTPase activating protein 1 1.765
RALY RALY heterogeneous nuclear ribonucleoprotein 1.751
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 1.751
PNPT1 polyribonucleotide nucleotidyltransferase 1 1.742
CFAP36 cilia and flagella associated protein 36 1.742
PPP4R3B protein phosphatase 4 regulatory subunit 3B 1.742
FOXP1 forkhead box P1 1.735
CTSG cathepsin G 1.734
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.734
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 1.734
STXBP6 syntaxin binding protein 6 (amisyn) 1.734
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.733
HIPK1 homeodomain interacting protein kinase 1 1.733
RSBN1 round spermatid basic protein 1 1.733
DCLRE1B DNA cross-link repair 1B 1.733
BCL2L15 BCL2-like 15 1.733
PHTF1 putative homeodomain transcription factor 1 1.733
AP4B1 adaptor-related protein complex 4, beta 1 subunit 1.733
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.732
NRAP nebulin-related anchoring protein 1.732
PLEKHS1 pleckstrin homology domain containing, family S member 1 1.732
ZC3H10 zinc finger CCCH-type containing 10 1.663
RPL41 ribosomal protein L41 1.663
ESYT1 extended synaptotagmin-like protein 1 1.663
SPATA2L spermatogenesis associated 2-like 1.617
CDK10 cyclin-dependent kinase 10 1.617
SPATA33 spermatogenesis associated 33 1.617
ZNF276 zinc finger protein 276 1.617
FANCA Fanconi anemia, complementation group A 1.617
SLC45A1 solute carrier family 45, member 1 1.617
VPS9D1 VPS9 domain containing 1 1.617
CHMP1A charged multivesicular body protein 1A 1.617
GOLGA8F golgin A8 family, member F 1.545
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.456
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.456
RPGRIP1L RPGRIP1-like 1.449
AKTIP AKT interacting protein 1.449
FTO fat mass and obesity associated 1.449
HLA-C major histocompatibility complex, class I, C 1.34
HLA-B major histocompatibility complex, class I, B 1.34
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 1.256
RNF39 ring finger protein 39 1.256
IRF4 interferon regulatory factor 4 1.256
DUSP22 dual specificity phosphatase 22 1.256
EXOC2 exocyst complex component 2 1.256
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.256
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 1.203
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 1.203
C17ORF113 chromosome 17 open reading frame 113 1.203
HCRT hypocretin (orexin) neuropeptide precursor 1.203
ZNF385C zinc finger protein 385C 1.203
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 1.203
STAT5B signal transducer and activator of transcription 5B 1.203
RAB5C RAB5C, member RAS oncogene family 1.203
KAT2A K(lysine) acetyltransferase 2A 1.203
GHDC GH3 domain containing 1.203
HSPB9 heat shock protein, alpha-crystallin-related, B9 1.203
FAP fibroblast activation protein, alpha 1.183
IFIH1 interferon induced with helicase C domain 1 1.183
GCA grancalcin, EF-hand calcium binding protein 1.183
PTPRC protein tyrosine phosphatase, receptor type, C 1.182
NOSIP nitric oxide synthase interacting protein 1.156
SCAF1 SR-related CTD-associated factor 1 1.156
PRR12 proline rich 12 1.156
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 1.156
TSKS testis-specific serine kinase substrate 1.156
IRF3 interferon regulatory factor 3 1.156
CPT1C carnitine palmitoyltransferase 1C 1.156
BCL2L12 BCL2-like 12 (proline rich) 1.156
ADM5 adrenomedullin 5 (putative) 1.156
RRAS related RAS viral (r-ras) oncogene homolog 1.156
PRMT1 protein arginine methyltransferase 1 1.156
UNC5B unc-5 homolog B (C. elegans) 1.11
CDH23 cadherin-related 23 1.11
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 1.11
STK25 serine/threonine kinase 25 1.105
SEPTIN2 septin 2 1.105
BOK BCL2-related ovarian killer 1.105
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.105
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 1.105
FAM76B family with sequence similarity 76, member B 1.093
RTKN2 rhotekin 2 1.059
ARID5B AT rich interactive domain 5B (MRF1-like) 1.059
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.034
LHX2 LIM homeobox 2 1.034
NEK6 NIMA-related kinase 6 1.034
FASLG Fas ligand (TNF superfamily, member 6) 0.989
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.961
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.961
FEM1A fem-1 homolog a (C. elegans) 0.939
ARRDC5 arrestin domain containing 5 0.939
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.939
TICAM1 toll-like receptor adaptor molecule 1 0.939
PLIN3 perilipin 3 0.939
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.929
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 0.929
CCDC88B coiled-coil domain containing 88B 0.904
BAD BCL2-associated agonist of cell death 0.904
PRDX5 peroxiredoxin 5 0.904
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.904
TRPT1 tRNA phosphotransferase 1 0.904
NUDT22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 0.904
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 0.904
GPR137 G protein-coupled receptor 137 0.904
STIP1 stress-induced phosphoprotein 1 0.904
PABPN1L poly(A) binding protein, nuclear 1-like (cytoplasmic) 0.904
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.904
FERMT3 fermitin family member 3 0.904
FKBP2 FK506 binding protein 2, 13kDa 0.904
ESRRA estrogen-related receptor alpha 0.904
KCNK4 potassium channel, two pore domain subfamily K, member 4 0.904
CATSPERZ catsper channel auxiliary subunit zeta 0.904
VEGFB vascular endothelial growth factor B 0.904
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 0.904
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.904
ACSF3 acyl-CoA synthetase family member 3 0.904
MACROD1 MACRO domain containing 1 0.904
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.828
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae) 0.828
MTTP microsomal triglyceride transfer protein 0.828
C4ORF17 chromosome 4 open reading frame 17 0.828
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.656
ICOS inducible T-cell co-stimulator 0.656
RHOH ras homolog family member H 0.637
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 0.637
POPDC2 popeye domain containing 2 0.634
ADPRH ADP-ribosylarginine hydrolase 0.634
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.634
CD80 CD80 molecule 0.634
COX17 COX17 cytochrome c oxidase copper chaperone 0.634
POGLUT1 protein O-glucosyltransferase 1 0.634
PLA1A phospholipase A1 member A 0.634
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.617
BCL9L B-cell CLL/lymphoma 9-like 0.617
UPK2 uroplakin 2 0.617
CXCR5 chemokine (C-X-C motif) receptor 5 0.617
GAGE12D G antigen 12D 0.599
GAGE12C G antigen 12C 0.599
GAGE1 G antigen 1 0.599
GAGE12E G antigen 12E 0.599
GAGE12F G antigen 12F 0.599
PAGE1 P antigen family, member 1 (prostate associated) 0.599
GAGE12H G antigen 12H 0.599
GAGE2A G antigen 2A 0.599
GAGE12G G antigen 12G 0.599
RIPOR3 RIPOR family member 3 0.566
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.566
CLNK cytokine-dependent hematopoietic cell linker 0.562
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.562
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.539
NQO2 NAD(P)H dehydrogenase, quinone 2 0.539
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.539
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.539
CEP19 centrosomal protein 19kDa 0.525
SMCO1 single-pass membrane protein with coiled-coil domains 1 0.525
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 0.525
WDR53 WD repeat domain 53 0.525
FBXO45 F-box protein 45 0.525
NRROS negative regulator of reactive oxygen species 0.525