Vitiligo Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached. (Experimental Factor Ontology, EFO_0004208)
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Genes

763 genes co-occuring with the disease Vitiligo in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TYR tyrosinase 3.296
PMEL premelanosome protein 3.06
CD8A CD8a molecule 3.026
TYRP1 tyrosinase-related protein 1 3.001
DCT dopachrome tautomerase 2.943
MITF microphthalmia-associated transcription factor 2.918
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.908
CD4 CD4 molecule 2.827
IFNG interferon, gamma 2.823
AIRE autoimmune regulator 2.806
NLRP1 NLR family, pyrin domain containing 1 2.783
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.707
IL17A interleukin 17A 2.657
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.643
IL2 interleukin 2 2.631
TNF tumor necrosis factor 2.615
PDCD1 programmed cell death 1 2.614
CD274 CD274 molecule 2.576
POMC proopiomelanocortin 2.508
CXCR3 chemokine (C-X-C motif) receptor 3 2.496
CXCL10 chemokine (C-X-C motif) ligand 10 2.494
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 2.488
CXCL9 chemokine (C-X-C motif) ligand 9 2.464
FOXP3 forkhead box P3 2.446
IL6 interleukin 6 2.444
TG thyroglobulin 2.435
TPO thyroid peroxidase 2.431
IL1B interleukin 1, beta 2.429
JAK1 Janus kinase 1 2.405
IL10 interleukin 10 2.394
IFNA1 interferon, alpha 1 2.37
IL15 interleukin 15 2.353
IL4 interleukin 4 2.331
IL22 interleukin 22 2.32
KITLG KIT ligand 2.301
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.287
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.285
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.277
HLA-A major histocompatibility complex, class I, A 2.277
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 2.259
JAK3 Janus kinase 3 2.247
CD28 CD28 molecule 2.244
MLANA melan-A 2.243
CD80 CD80 molecule 2.223
CD69 CD69 molecule 2.204
TGFB1 transforming growth factor, beta 1 2.172
IL1A interleukin 1, alpha 2.166
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.159
ITGA1 integrin, alpha 1 2.154
CXCL8 chemokine (C-X-C motif) ligand 8 2.14
TYK2 tyrosine kinase 2 2.134
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.13
PRF1 perforin 1 (pore forming protein) 2.129
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.125
SOX10 SRY (sex determining region Y)-box 10 2.122
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.116
IKZF4 IKAROS family zinc finger 4 (Eos) 2.108
STAT1 signal transducer and activator of transcription 1, 91kDa 2.106
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.103
IL2RA interleukin 2 receptor, alpha 2.101
OCA2 oculocutaneous albinism II 2.1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.096
IL13 interleukin 13 2.089
IL18 interleukin 18 2.068
UBASH3A ubiquitin associated and SH3 domain containing A 2.054
INS insulin 2.048
CCR6 chemokine (C-C motif) receptor 6 2.023
JAK2 Janus kinase 2 2.023
PDCD1LG2 programmed cell death 1 ligand 2 2.021
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.021
CXCL16 chemokine (C-X-C motif) ligand 16 2.018
HLA-B major histocompatibility complex, class I, B 2.018
CD86 CD86 molecule 2.011
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.011
RNASET2 ribonuclease T2 2.008
IFIH1 interferon induced with helicase C domain 1 2.004
GPX8 glutathione peroxidase 8 (putative) 1.992
CCR7 chemokine (C-C motif) receptor 7 1.987
COL17A1 collagen, type XVII, alpha 1 1.984
IL7 interleukin 7 1.983
IL5 interleukin 5 1.982
GPX6 glutathione peroxidase 6 1.982
GPX5 glutathione peroxidase 5 1.982
FOXD3 forkhead box D3 1.979
GPX7 glutathione peroxidase 7 1.979
IFNA2 interferon, alpha 2 1.979
LAG3 lymphocyte-activation gene 3 1.973
GPX2 glutathione peroxidase 2 1.973
CCRL2 chemokine (C-C motif) receptor-like 2 1.97
IL17F interleukin 17F 1.965
GPX3 glutathione peroxidase 3 1.964
CXCL11 chemokine (C-X-C motif) ligand 11 1.959
FGF2 fibroblast growth factor 2 (basic) 1.956
IL2RB interleukin 2 receptor, beta 1.951
CD19 CD19 molecule 1.948
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.943
MCHR1 melanin-concentrating hormone receptor 1 1.939
HMOX1 heme oxygenase 1 1.937
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.937
IL31 interleukin 31 1.932
FLG filaggrin 1.925
NLRP3 NLR family, pyrin domain containing 3 1.914
HLA-C major histocompatibility complex, class I, C 1.914
NLRC4 NLR family, CARD domain containing 4 1.914
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.913
CCL22 chemokine (C-C motif) ligand 22 1.912
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.908
CD40 CD40 molecule, TNF receptor superfamily member 5 1.908
TP53 tumor protein p53 1.907
IFNB1 interferon, beta 1, fibroblast 1.906
ICAM1 intercellular adhesion molecule 1 1.902
LRR1 leucine rich repeat protein 1 1.898
FLG2 filaggrin family member 2 1.891
IL7R interleukin 7 receptor 1.883
HSPA4 heat shock 70kDa protein 4 1.883
TOR1A torsin family 1, member A (torsin A) 1.882
STAT4 signal transducer and activator of transcription 4 1.876
ASIP agouti signaling protein 1.873
TBX21 T-box 21 1.87
SELL selectin L 1.869
CXCR6 chemokine (C-X-C motif) receptor 6 1.867
XBP1 X-box binding protein 1 1.866
IL33 interleukin 33 1.865
DST dystonin 1.862
MAGEA3 melanoma antigen family A3 1.857
EDN1 endothelin 1 1.855
NFE2L2 nuclear factor, erythroid 2-like 2 1.852
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 1.851
ICOS inducible T-cell co-stimulator 1.847
TLR7 toll-like receptor 7 1.842
IFNA17 interferon, alpha 17 1.841
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.84
TSHR thyroid stimulating hormone receptor 1.833
PTPRC protein tyrosine phosphatase, receptor type, C 1.831
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.829
CTAG1B cancer/testis antigen 1B 1.824
SMOC2 SPARC related modular calcium binding 2 1.823
NOD2 nucleotide-binding oligomerization domain containing 2 1.819
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.818
CD27 CD27 molecule 1.817
NLRP5 NLR family, pyrin domain containing 5 1.813
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.813
ALB albumin 1.807
HAVCR2 hepatitis A virus cellular receptor 2 1.806
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.802
AIM2 absent in melanoma 2 1.8
IL23R interleukin 23 receptor 1.798
CREB1 cAMP responsive element binding protein 1 1.796
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.794
IFNA4 interferon, alpha 4 1.787
CRP C-reactive protein, pentraxin-related 1.786
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.786
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.785
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 1.783
PXDNL peroxidasin-like 1.783
PXDN peroxidasin 1.783
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.78
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.779
IFNA13 interferon, alpha 13 1.779
IFNA21 interferon, alpha 21 1.778
IFNA6 interferon, alpha 6 1.777
AHR aryl hydrocarbon receptor 1.776
C1QTNF6 C1q and tumor necrosis factor related protein 6 1.775
IFNA8 interferon, alpha 8 1.775
SH2B3 SH2B adaptor protein 3 1.773
IFNA14 interferon, alpha 14 1.77
IFNA16 interferon, alpha 16 1.768
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 1.768
IFNA5 interferon, alpha 5 1.768
IFNA10 interferon, alpha 10 1.767
CCL20 chemokine (C-C motif) ligand 20 1.766
TSLP thymic stromal lymphopoietin 1.765
IFNW1 interferon, omega 1 1.764
IFNA7 interferon, alpha 7 1.764
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.759
SLC45A2 solute carrier family 45, member 2 1.757
BCL2 B-cell CLL/lymphoma 2 1.756
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.756
FASLG Fas ligand (TNF superfamily, member 6) 1.755
CD276 CD276 molecule 1.75
KRT14 keratin 14, type I 1.742
LPP LIM domain containing preferred translocation partner in lipoma 1.741
PTPRN protein tyrosine phosphatase, receptor type, N 1.737
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 1.725
CCL5 chemokine (C-C motif) ligand 5 1.725
IL9 interleukin 9 1.724
NCAM1 neural cell adhesion molecule 1 1.724
TLR4 toll-like receptor 4 1.719
TLR9 toll-like receptor 9 1.719
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.716
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 1.716
AQP3 aquaporin 3 (Gill blood group) 1.714
CAMP cathelicidin antimicrobial peptide 1.705
IL15RA interleukin 15 receptor, alpha 1.699
RAG1 recombination activating gene 1 1.696
DDR1 discoidin domain receptor tyrosine kinase 1 1.69
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.69
CD40LG CD40 ligand 1.689
TLR2 toll-like receptor 2 1.689
IDO1 indoleamine 2,3-dioxygenase 1 1.687
PAX3 paired box 3 1.686
ZMIZ1 zinc finger, MIZ-type containing 1 1.682
ACTB actin, beta 1.682
CD1C CD1c molecule 1.672
EOMES eomesodermin 1.672
RERE arginine-glutamic acid dipeptide (RE) repeats 1.671
CCL2 chemokine (C-C motif) ligand 2 1.667
S1PR1 sphingosine-1-phosphate receptor 1 1.661
RAB27A RAB27A, member RAS oncogene family 1.657
KCNRG potassium channel regulator 1.654
CD44 CD44 molecule (Indian blood group) 1.649
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.646
SLC30A10 solute carrier family 30, member 10 1.64
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.638
C1ORF141 chromosome 1 open reading frame 141 1.638
CALR calreticulin 1.637
TXN thioredoxin 1.633
TRPM1 transient receptor potential cation channel, subfamily M, member 1 1.632
SLC30A8 solute carrier family 30 (zinc transporter), member 8 1.631
TAC1 tachykinin, precursor 1 1.631
TLR3 toll-like receptor 3 1.63
TGM2 transglutaminase 2 1.626
ATP5PO ATP synthase peripheral stalk subunit OSCP 1.625
EDN3 endothelin 3 1.623
PYDC1 PYD (pyrin domain) containing 1 1.623
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.622
EGFR epidermal growth factor receptor 1.616
ZNF683 zinc finger protein 683 1.612
TICAM1 toll-like receptor adaptor molecule 1 1.609
ACE angiotensin I converting enzyme 1.606
CARD8 caspase recruitment domain family, member 8 1.606
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.604
GPR143 G protein-coupled receptor 143 1.604
FGF7 fibroblast growth factor 7 1.604
CCL17 chemokine (C-C motif) ligand 17 1.603
KEAP1 kelch-like ECH-associated protein 1 1.601
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.601
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.6
HMGB1 high mobility group box 1 1.599
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.598
STAT5B signal transducer and activator of transcription 5B 1.594
IL19 interleukin 19 1.591
KLRG1 killer cell lectin-like receptor subfamily G, member 1 1.59
MMP9 matrix metallopeptidase 9 1.589
JUN jun proto-oncogene 1.589
IL17RA interleukin 17 receptor A 1.589
STX17 syntaxin 17 1.586
PDILT protein disulfide isomerase-like, testis expressed 1.584
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 1.582
COMT catechol-O-methyltransferase 1.582
ADAMTSL5 ADAMTS-like 5 1.579
NQO1 NAD(P)H dehydrogenase, quinone 1 1.576
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.569
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.564
IVL involucrin 1.564
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.563
SEPTIN4 septin 4 1.56
FN1 fibronectin 1 1.559
NLRP12 NLR family, pyrin domain containing 12 1.559
TBP TATA box binding protein 1.557
MYO5A myosin VA (heavy chain 12, myoxin) 1.555
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.554
CD1D CD1d molecule 1.547
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.546
IL1R1 interleukin 1 receptor, type I 1.545
UVRAG UV radiation resistance associated 1.545
CD1B CD1b molecule 1.543
CD1E CD1e molecule 1.543
TRIM21 tripartite motif containing 21 1.541
CIITA class II, major histocompatibility complex, transactivator 1.54
IL26 interleukin 26 1.539
WDR11 WD repeat domain 11 1.533
GAGE10 G antigen 10 1.527
CD1A CD1a molecule 1.527
TGM4 transglutaminase 4 1.526
GATA3 GATA binding protein 3 1.525
TRPM2 transient receptor potential cation channel, subfamily M, member 2 1.523
NLRP6 NLR family, pyrin domain containing 6 1.519
DSG1 desmoglein 1 1.517
IGF1 insulin-like growth factor 1 (somatomedin C) 1.516
TH tyrosine hydroxylase 1.516
ELN elastin 1.515
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.515
MEFV Mediterranean fever 1.513
FBXO11 F-box protein 11 1.512
IRF4 interferon regulatory factor 4 1.511
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.511
PDE4A phosphodiesterase 4A, cAMP-specific 1.505
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.503
IFNGR1 interferon gamma receptor 1 1.5
IDO2 indoleamine 2,3-dioxygenase 2 1.499
IL3 interleukin 3 1.499
CLNK cytokine-dependent hematopoietic cell linker 1.499
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.498
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.497
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.497
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.496
CCL27 chemokine (C-C motif) ligand 27 1.495
CCL19 chemokine (C-C motif) ligand 19 1.494
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.494
IRF1 interferon regulatory factor 1 1.493
EDNRB endothelin receptor type B 1.493
NELFCD negative elongation factor complex member C/D 1.493
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.491
CXCL12 chemokine (C-X-C motif) ligand 12 1.489
NLRP7 NLR family, pyrin domain containing 7 1.488
CSK c-src tyrosine kinase 1.481
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.481
PTH parathyroid hormone 1.479
CD247 CD247 molecule 1.479
TIGIT T cell immunoreceptor with Ig and ITIM domains 1.477
CSF3 colony stimulating factor 3 (granulocyte) 1.477
STAT5A signal transducer and activator of transcription 5A 1.476
IL4R interleukin 4 receptor 1.475
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 1.473
ERBB2 erb-b2 receptor tyrosine kinase 2 1.471
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.47
NPY neuropeptide Y 1.469
CD52 CD52 molecule 1.467
STAT2 signal transducer and activator of transcription 2, 113kDa 1.466
SIRT1 sirtuin 1 1.463
SYK spleen tyrosine kinase 1.461
GPNMB glycoprotein (transmembrane) nmb 1.46
MYD88 myeloid differentiation primary response 88 1.46
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.456
NOD1 nucleotide-binding oligomerization domain containing 1 1.456
EGF epidermal growth factor 1.455
CXCR5 chemokine (C-X-C motif) receptor 5 1.455
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.448
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 1.446
CD207 CD207 molecule, langerin 1.443
NGF nerve growth factor (beta polypeptide) 1.443
CRH corticotropin releasing hormone 1.443
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.443
DSG3 desmoglein 3 1.441
IL24 interleukin 24 1.441
GSK3B glycogen synthase kinase 3 beta 1.438
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.432
EGLN2 egl-9 family hypoxia-inducible factor 2 1.431
SOX9 SRY (sex determining region Y)-box 9 1.431
LTA lymphotoxin alpha 1.43
IL2RG interleukin 2 receptor, gamma 1.429
NAIP NLR family, apoptosis inhibitory protein 1.427
GNLY granulysin 1.426
ACKR2 atypical chemokine receptor 2 1.425
ECM1 extracellular matrix protein 1 1.424
CCR8 chemokine (C-C motif) receptor 8 1.42
KRT10 keratin 10, type I 1.419
CDKN2A cyclin-dependent kinase inhibitor 2A 1.419
ACKR4 atypical chemokine receptor 4 1.418
MAGEB2 melanoma antigen family B2 1.417
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.416
CYCS cytochrome c, somatic 1.416
LEF1 lymphoid enhancer-binding factor 1 1.413
HLA-DRA major histocompatibility complex, class II, DR alpha 1.412
TOX thymocyte selection-associated high mobility group box 1.411
PRDM1 PR domain containing 1, with ZNF domain 1.41
BPIFB1 BPI fold containing family B, member 1 1.409
PRL prolactin 1.409
MLPH melanophilin 1.408
CD68 CD68 molecule 1.404
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.403
CARD9 caspase recruitment domain family, member 9 1.403
PTEN phosphatase and tensin homolog 1.403
SOCS1 suppressor of cytokine signaling 1 1.401
BTLA B and T lymphocyte associated 1.401
CCR10 chemokine (C-C motif) receptor 10 1.401
CLEC11A C-type lectin domain family 11, member A 1.401
OPN3 opsin 3 1.399
IL20RB interleukin 20 receptor beta 1.396
IL1RN interleukin 1 receptor antagonist 1.389
ULBP3 UL16 binding protein 3 1.389
PAH phenylalanine hydroxylase 1.388
DEAF1 DEAF1 transcription factor 1.385
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.385
CDK4 cyclin-dependent kinase 4 1.383
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.381
CXCL13 chemokine (C-X-C motif) ligand 13 1.38
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 1.38
CCL4 chemokine (C-C motif) ligand 4 1.379
RAG2 recombination activating gene 2 1.379
CD34 CD34 molecule 1.377
KRT16 keratin 16, type I 1.374
NLRP10 NLR family, pyrin domain containing 10 1.373
GSDMD gasdermin D 1.369
MAGEA1 melanoma antigen family A1 1.366
PYCARD PYD and CARD domain containing 1.363
MIA melanoma inhibitory activity 1.363
ANXA5 annexin A5 1.363
PPARG peroxisome proliferator-activated receptor gamma 1.362
S100A7 S100 calcium binding protein A7 1.361
AMPH amphiphysin 1.358
IRF3 interferon regulatory factor 3 1.357
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.355
RAB38 RAB38, member RAS oncogene family 1.354
MAGEA12 melanoma antigen family A12 1.352
TPX2 TPX2, microtubule-associated 1.351
SOD2 superoxide dismutase 2, mitochondrial 1.35
IL21R interleukin 21 receptor 1.348
ARMC9 armadillo repeat containing 9 1.348
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.347
S100B S100 calcium binding protein B 1.347
CARD14 caspase recruitment domain family, member 14 1.344
KRT15 keratin 15, type I 1.344
CCL21 chemokine (C-C motif) ligand 21 1.344
CD83 CD83 molecule 1.341
KLRC1 killer cell lectin-like receptor subfamily C, member 1 1.34
DEFB103A defensin, beta 103A 1.336
IL20RA interleukin 20 receptor, alpha 1.336
IL12RB1 interleukin 12 receptor, beta 1 1.335
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.335
LAMP1 lysosomal-associated membrane protein 1 1.335
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.334
SPATA2L spermatogenesis associated 2-like 1.334
RPS26 ribosomal protein S26 1.333
GAST gastrin 1.332
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.332
MPO myeloperoxidase 1.328
MMP1 matrix metallopeptidase 1 1.323
LYST lysosomal trafficking regulator 1.318
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.317
CD2 CD2 molecule 1.316
PRTN3 proteinase 3 1.315
BAX BCL2-associated X protein 1.314
CXCR4 chemokine (C-X-C motif) receptor 4 1.313
LITAFD LITAF domain containing 1.312
MX1 MX dynamin-like GTPase 1 1.31
VCAM1 vascular cell adhesion molecule 1 1.31
LGI1 leucine-rich, glioma inactivated 1 1.309
TCHH trichohyalin 1.308
BATF3 basic leucine zipper transcription factor, ATF-like 3 1.307
CCL3 chemokine (C-C motif) ligand 3 1.305
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.304
ACHE acetylcholinesterase (Yt blood group) 1.301
MAPK3 mitogen-activated protein kinase 3 1.299
TSBP1 testis expressed basic protein 1 1.297
BTNL2 butyrophilin-like 2 1.295
IFI30 interferon, gamma-inducible protein 30 1.292
LCK LCK proto-oncogene, Src family tyrosine kinase 1.29
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.287
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.287
GCLM glutamate-cysteine ligase, modifier subunit 1.286
CD58 CD58 molecule 1.286
BTK Bruton agammaglobulinemia tyrosine kinase 1.285
CGAS cyclic GMP-AMP synthase 1.284
GSR glutathione reductase 1.284
CR2 complement component (3d/Epstein Barr virus) receptor 2 1.283
MICB MHC class I polypeptide-related sequence B 1.282
MC5R melanocortin 5 receptor 1.281
ERAP2 endoplasmic reticulum aminopeptidase 2 1.28
IFNE interferon, epsilon 1.28
IL6R interleukin 6 receptor 1.279
ESR1 estrogen receptor 1 1.278
KLRD1 killer cell lectin-like receptor subfamily D, member 1 1.278
GCLC glutamate-cysteine ligase, catalytic subunit 1.276
CLEC16A C-type lectin domain family 16, member A 1.275
CD38 CD38 molecule 1.273
IL22RA1 interleukin 22 receptor, alpha 1 1.271
NLRP4 NLR family, pyrin domain containing 4 1.271
CD163 CD163 molecule 1.27
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.27
MAPK8 mitogen-activated protein kinase 8 1.27
HLA-E major histocompatibility complex, class I, E 1.27
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.268
C4A complement component 4A (Rodgers blood group) 1.266
CD5 CD5 molecule 1.264
CD70 CD70 molecule 1.262
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.258
RUNX3 runt-related transcription factor 3 1.258
CLTA clathrin, light chain A 1.257
RORC RAR-related orphan receptor C 1.255
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.252
IL10RB interleukin 10 receptor, beta 1.252
TLR5 toll-like receptor 5 1.251
IL23A interleukin 23, alpha subunit p19 1.251
TRAF3IP2 TRAF3 interacting protein 2 1.25
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.248
NF1 neurofibromin 1 1.247
IFNK interferon, kappa 1.246
KLRB1 killer cell lectin-like receptor subfamily B, member 1 1.246
ATXN2 ataxin 2 1.243
FOXO3 forkhead box O3 1.242
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.238
KLF2 Kruppel-like factor 2 1.236
BCL2L1 BCL2-like 1 1.235
IL18R1 interleukin 18 receptor 1 1.234
TCF7 transcription factor 7 (T-cell specific, HMG-box) 1.234
IL12RB2 interleukin 12 receptor, beta 2 1.232
HLA-G major histocompatibility complex, class I, G 1.232
MFSD12 major facilitator superfamily domain containing 12 1.231
B2M beta-2-microglobulin 1.23
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.228
BIN1 bridging integrator 1 1.227
FOXP1 forkhead box P1 1.227
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.226
IRF8 interferon regulatory factor 8 1.225
MMP2 matrix metallopeptidase 2 1.225
CLEC4C C-type lectin domain family 4, member C 1.222
LOC102723996 ICOS ligand 1.221
ALK anaplastic lymphoma receptor tyrosine kinase 1.22
GSTM1 glutathione S-transferase mu 1 1.218
NRROS negative regulator of reactive oxygen species 1.217
DOCK8 dedicator of cytokinesis 8 1.217
SIRT3 sirtuin 3 1.214
FAS Fas cell surface death receptor 1.214
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.214
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.213
NT5E 5'-nucleotidase, ecto (CD73) 1.21
ATG5 autophagy related 5 1.209
SELE selectin E 1.209
CD226 CD226 molecule 1.207
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.206
F2 coagulation factor II (thrombin) 1.2
IRF5 interferon regulatory factor 5 1.199
FCRL3 Fc receptor-like 3 1.199
MMP3 matrix metallopeptidase 3 1.199
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.197
IL36R interleukin 36 receptor 1.197
MOG myelin oligodendrocyte glycoprotein 1.195
ATM ATM serine/threonine kinase 1.194
TLR1 toll-like receptor 1 1.194
CDSN corneodesmosin 1.193
NLRC5 NLR family, CARD domain containing 5 1.192
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.192
TBL1X transducin (beta)-like 1X-linked 1.192
ISG15 ISG15 ubiquitin-like modifier 1.191
MAOA monoamine oxidase A 1.19
DNAL1 dynein, axonemal, light chain 1 1.189
CBLIF cobalamin binding intrinsic factor 1.189
IFNL1 interferon, lambda 1 1.188
HP haptoglobin 1.186
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.185
NKTR natural killer cell triggering receptor 1.184
IFNLR1 interferon, lambda receptor 1 1.182
ERAP1 endoplasmic reticulum aminopeptidase 1 1.181
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.177
SSB Sjogren syndrome antigen B (autoantigen La) 1.176
TLR8 toll-like receptor 8 1.175
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.174
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.172
CKMT1B creatine kinase, mitochondrial 1B 1.171
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.169
DEFB4A defensin, beta 4A 1.169
FOS FBJ murine osteosarcoma viral oncogene homolog 1.169
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 1.169
FGF10 fibroblast growth factor 10 1.169
IL1F10 interleukin 1 family, member 10 (theta) 1.169
CKB creatine kinase, brain 1.168
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.167
CKM creatine kinase, muscle 1.167
MAVS mitochondrial antiviral signaling protein 1.167
PNPT1 polyribonucleotide nucleotidyltransferase 1 1.165
REN renin 1.165
CD200 CD200 molecule 1.165
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.165
CSNK1G3 casein kinase 1, gamma 3 1.164
CD3D CD3d molecule, delta (CD3-TCR complex) 1.163
DCLRE1C DNA cross-link repair 1C 1.162
FGF5 fibroblast growth factor 5 1.161
SP100 SP100 nuclear antigen 1.16
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.159
RBP3 retinol binding protein 3, interstitial 1.159
CD7 CD7 molecule 1.157
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.157
CXCL2 chemokine (C-X-C motif) ligand 2 1.156
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1.154
TNIP1 TNFAIP3 interacting protein 1 1.154
IL31RA interleukin 31 receptor A 1.153
TBK1 TANK-binding kinase 1 1.153
GABPB2 GA binding protein transcription factor, beta subunit 2 1.152
ENO1 enolase 1, (alpha) 1.152
EDAR ectodysplasin A receptor 1.152
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.151
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.15
MAGED4 melanoma antigen family D4 1.149
CLEC2B C-type lectin domain family 2, member B 1.149
RALY RALY heterogeneous nuclear ribonucleoprotein 1.148
LGI3 leucine-rich repeat LGI family, member 3 1.148
CCK cholecystokinin 1.147
FGF9 fibroblast growth factor 9 1.145
KRTAP10-11 keratin associated protein 10-11 1.144
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.143
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.143
BCR breakpoint cluster region 1.143
KRT5 keratin 5, type II 1.142
IRF7 interferon regulatory factor 7 1.141
CCR2 chemokine (C-C motif) receptor 2 1.14
DPP9 dipeptidyl-peptidase 9 1.138
IL32 interleukin 32 1.138
KLRC4 killer cell lectin-like receptor subfamily C, member 4 1.136
KRT1 keratin 1, type II 1.135
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.134
IL17C interleukin 17C 1.134
CNTNAP2 contactin associated protein-like 2 1.133
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.133
ATG12 autophagy related 12 1.133
MAGED4B melanoma antigen family D4B 1.131
CD3G CD3g molecule, gamma (CD3-TCR complex) 1.131
ERN1 endoplasmic reticulum to nucleus signaling 1 1.13
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.13
CCN3 cellular communication network factor 3 1.129
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.127
CDK5RAP1 CDK5 regulatory subunit associated protein 1 1.127
FLT3LG fms-related tyrosine kinase 3 ligand 1.127
CD101 CD101 molecule 1.126
IL10RA interleukin 10 receptor, alpha 1.126
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.124
C3 complement component 3 1.123
SUOX sulfite oxidase 1.121
FGF3 fibroblast growth factor 3 1.121
IL17RC interleukin 17 receptor C 1.12
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.119
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.117
DPP8 dipeptidyl-peptidase 8 1.116
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.115
PECAM1 platelet/endothelial cell adhesion molecule 1 1.115
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.115
IL36RN interleukin 36 receptor antagonist 1.115
LGALS9 lectin, galactoside-binding, soluble, 9 1.114
FGF22 fibroblast growth factor 22 1.113
TERT telomerase reverse transcriptase 1.113
FGF6 fibroblast growth factor 6 1.111
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.111
IFI27 interferon, alpha-inducible protein 27 1.111
FGF8 fibroblast growth factor 8 (androgen-induced) 1.111
DEFB1 defensin, beta 1 1.11
FGF20 fibroblast growth factor 20 1.109
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.109
ITK IL2-inducible T-cell kinase 1.109
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.107
XCL1 chemokine (C motif) ligand 1 1.106
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.106
ATG7 autophagy related 7 1.105
NCR1 natural cytotoxicity triggering receptor 1 1.105
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.105
FGF16 fibroblast growth factor 16 1.104
FGF18 fibroblast growth factor 18 1.103
FGF4 fibroblast growth factor 4 1.103
IGFBP7 insulin-like growth factor binding protein 7 1.103
IGLON5 IgLON family member 5 1.102
ICOSLG inducible T-cell co-stimulator ligand 1.101
MUSK muscle, skeletal, receptor tyrosine kinase 1.101
TTN titin 1.101
FGF17 fibroblast growth factor 17 1.099
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.098
SLC44A4 solute carrier family 44, member 4 1.098
AOC3 amine oxidase, copper containing 3 1.097
LGALS9B lectin, galactoside-binding, soluble, 9B 1.096
BATF basic leucine zipper transcription factor, ATF-like 1.095
CXCL5 chemokine (C-X-C motif) ligand 5 1.095
IL36G interleukin 36, gamma 1.094
CXCR2 chemokine (C-X-C motif) receptor 2 1.094
RIPK2 receptor-interacting serine-threonine kinase 2 1.094
LGALS9C lectin, galactoside-binding, soluble, 9C 1.093
GAGE12H G antigen 12H 1.092
COL6A5 collagen, type VI, alpha 5 1.092
H2BC21 H2B clustered histone 21 1.091
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.09
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.089
MISP3 MISP family member 3 1.089
GSTP1 glutathione S-transferase pi 1 1.088
BCHE butyrylcholinesterase 1.086
USP18 ubiquitin specific peptidase 18 1.085
CLEC7A C-type lectin domain family 7, member A 1.085
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 1.085
TOB2 transducer of ERBB2, 2 1.084
IL3RA interleukin 3 receptor, alpha (low affinity) 1.083
RO60 Ro60, Y RNA binding protein 1.083
IL11 interleukin 11 1.082
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 1.081
MBP myelin basic protein 1.078
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.077
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.077
IFITM1 interferon induced transmembrane protein 1 1.076
PCNA proliferating cell nuclear antigen 1.075
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.075
CARD18 caspase recruitment domain family, member 18 1.072
F3 coagulation factor III (thromboplastin, tissue factor) 1.072
B3GAT1 beta-1,3-glucuronyltransferase 1 1.071
DNAH8 dynein, axonemal, heavy chain 8 1.07
GPX4 glutathione peroxidase 4 1.069
XDH xanthine dehydrogenase 1.069
CCND1 cyclin D1 1.069
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.069
FOXO1 forkhead box O1 1.069
TRAF1 TNF receptor-associated factor 1 1.067
GSDMB gasdermin B 1.067
TGFB2 transforming growth factor, beta 2 1.067
CD8B CD8b molecule 1.067
GLB1 galactosidase, beta 1 1.067
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.067
SH2D1A SH2 domain containing 1A 1.066
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.065
SOX1 SRY (sex determining region Y)-box 1 1.064
NGFR nerve growth factor receptor 1.063
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.062
MPPE1 metallophosphoesterase 1 1.061
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 1.058
PMCH pro-melanin-concentrating hormone 1.056
APAF1 apoptotic peptidase activating factor 1 1.056
CD160 CD160 molecule 1.054
ASMT acetylserotonin O-methyltransferase 1.054
NFE2 nuclear factor, erythroid 2 1.054
ATF6 activating transcription factor 6 1.053
TGFA transforming growth factor, alpha 1.052
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.051
ZNHIT2 zinc finger, HIT-type containing 2 1.051
ADA adenosine deaminase 1.05
S100A12 S100 calcium binding protein A12 1.048
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 1.048
SAMHD1 SAM domain and HD domain 1 1.046
KRAS Kirsten rat sarcoma viral oncogene homolog 1.046
ADRB2 adrenoceptor beta 2, surface 1.045
ADAR adenosine deaminase, RNA-specific 1.043
CUL3 cullin 3 1.043
CCL11 chemokine (C-C motif) ligand 11 1.042
CD244 CD244 molecule, natural killer cell receptor 2B4 1.041
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.04
HPGDS hematopoietic prostaglandin D synthase 1.04
MISP mitotic spindle positioning 1.038
THPO thrombopoietin 1.037
STING1 stimulator of interferon response cGAMP interactor 1 1.037
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.036
TFRC transferrin receptor 1.035
IRAK1 interleukin-1 receptor-associated kinase 1 1.035
IRF9 interferon regulatory factor 9 1.034
PTK2 protein tyrosine kinase 2 1.034
GC group-specific component (vitamin D binding protein) 1.034
CARD11 caspase recruitment domain family, member 11 1.033
RORA RAR-related orphan receptor A 1.033
AQP12A aquaporin 12A 1.032
KRT17 keratin 17, type I 1.032
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.029
BECN1 beclin 1, autophagy related 1.029
VIP vasoactive intestinal peptide 1.028
IL16 interleukin 16 1.028
EPO erythropoietin 1.027
FOXN1 forkhead box N1 1.027
TPH1 tryptophan hydroxylase 1 1.027
LEP leptin 1.025
HNF4A hepatocyte nuclear factor 4, alpha 1.022
GSDMA gasdermin A 1.02
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.02
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.015
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 1.015
KRT2 keratin 2, type II 1.014
ZC2HC1A zinc finger, C2HC-type containing 1A 1.014
PARP1 poly (ADP-ribose) polymerase 1 1.013
CTCF CCCTC-binding factor (zinc finger protein) 1.013
NEK7 NIMA-related kinase 7 1.013
ERVW-1 endogenous retrovirus group W, member 1 1.013
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 1.011
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.01
CASR calcium-sensing receptor 1.009
TMX4 thioredoxin-related transmembrane protein 4 1.008
SPP1 secreted phosphoprotein 1 1.007
SOX5 SRY (sex determining region Y)-box 5 1.007
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 1.007
SQSTM1 sequestosome 1 1.005
POSTN periostin, osteoblast specific factor 1.004
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 1.003
IL18RAP interleukin 18 receptor accessory protein 1.002
G6PD glucose-6-phosphate dehydrogenase 1.001