Vitiligo Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached. (Experimental Factor Ontology, EFO_0004208)
External Link https://www.disgenet.org/browser/0/1/0/C0858681
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Genes

369 genes associated with the disease Vitiligo in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ABR active BCR-related
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ACP5 acid phosphatase 5, tartrate resistant
ADRB2 adrenoceptor beta 2, surface
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AHR aryl hydrocarbon receptor
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AIRE autoimmune regulator
ALB albumin
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASIP agouti signaling protein
ATAT1 alpha tubulin acetyltransferase 1
ATN1 atrophin 1
ATXN2 ataxin 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCL2L12 BCL2-like 12 (proline rich)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTNL2 butyrophilin-like 2
C1GALT1C1 C1GALT1-specific chaperone 1
C1QTNF6 C1q and tumor necrosis factor related protein 6
C4BPA complement component 4 binding protein, alpha
C6ORF10 chromosome 6 open reading frame 10
C7ORF72 chromosome 7 open reading frame 72
CALR calreticulin
CALR3 calreticulin 3
CANX calnexin
CARD14 caspase recruitment domain family, member 14
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAT catalase
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBR1 carbonyl reductase 1
CCDC88A coiled-coil domain containing 88A
CCHCR1 coiled-coil alpha-helical rod protein 1
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD274 CD274 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CD80 CD80 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5RAP1 CDK5 regulatory subunit associated protein 1
CDX2 caudal type homeobox 2
CEP43 centrosomal protein 43
CIITA class II, major histocompatibility complex, transactivator
CLEC11A C-type lectin domain family 11, member A
CLNK cytokine-dependent hematopoietic cell linker
COMT catechol-O-methyltransferase
COX2
CP ceruloplasmin (ferroxidase)
CPVL carboxypeptidase, vitellogenic-like
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CXCR6 chemokine (C-X-C motif) receptor 6
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DCLRE1C DNA cross-link repair 1C
DCT dopachrome tautomerase
DDR1 discoidin domain receptor tyrosine kinase 1
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEF8 differentially expressed in FDCP 8 homolog (mouse)
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPCR1 diffuse panbronchiolitis critical region 1
DSTYK dual serine/threonine and tyrosine protein kinase
EDN1 endothelin 1
EGFL8 EGF-like-domain, multiple 8
ELN elastin
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FANCA Fanconi anemia, complementation group A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO11 F-box protein 11
FGF2 fibroblast growth factor 2 (basic)
FGFR2 fibroblast growth factor receptor 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLNB filamin B, beta
FOXD3 forkhead box D3
FOXO3 forkhead box O3
FOXP1 forkhead box P1
FOXP3 forkhead box P3
G6PD glucose-6-phosphate dehydrogenase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GLI1 GLI family zinc finger 1
GPX1 glutathione peroxidase 1
GRAP2 GRB2-related adaptor protein 2
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAVCR2 hepatitis A virus cellular receptor 2
HCG22 HLA complex group 22
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HPGDS hematopoietic prostaglandin D synthase
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IFNLR1 interferon, lambda receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IKZF4 IKAROS family zinc finger 4 (Eos)
IL10 interleukin 10
IL15 interleukin 15
IL17A interleukin 17A
IL17B interleukin 17B
IL17F interleukin 17F
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL20RA interleukin 20 receptor, alpha
IL20RB interleukin 20 receptor beta
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL23A interleukin 23, alpha subunit p19
IL24 interleukin 24
IL26 interleukin 26
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL6 interleukin 6
IRF3 interferon regulatory factor 3
IRF4 interferon regulatory factor 4
ISYNA1 inositol-3-phosphate synthase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JAK1 Janus kinase 1
KIDINS220 kinase D-interacting substrate, 220kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLK3 kallikrein-related peptidase 3
KLRC1 killer cell lectin-like receptor subfamily C, member 1
LGI3 leucine-rich repeat LGI family, member 3
LMNA lamin A/C
LPP LIM domain containing preferred translocation partner in lipoma
LRR1 leucine rich repeat protein 1
LTA lymphotoxin alpha
MAOB monoamine oxidase B
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MBD1 methyl-CpG binding domain protein 1
MBD3 methyl-CpG binding domain protein 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCHR1 melanin-concentrating hormone receptor 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGC57346-CRHR1 MGC57346-CRHR1 readthrough
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MITF microphthalmia-associated transcription factor
MLANA melan-A
MMRN1 multimerin 1
MPO myeloperoxidase
MSRA methionine sulfoxide reductase A
MSRB2 methionine sulfoxide reductase B2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYG1 MYG1 exonuclease
NAIP NLR family, apoptosis inhibitory protein
NEK6 NIMA-related kinase 6
NEU1 sialidase 1 (lysosomal sialidase)
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NLE1 notchless homolog 1 (Drosophila)
NLN neurolysin (metallopeptidase M3 family)
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOS2 nitric oxide synthase 2, inducible
NOTCH4 notch 4
NOV nephroblastoma overexpressed
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRG1 neuregulin 1
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10
NXF1 nuclear RNA export factor 1
OPN4 opsin 4
OPRM1 opioid receptor, mu 1
PAH phenylalanine hydroxylase
PARP1 poly (ADP-ribose) polymerase 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PDCD1 programmed cell death 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PGD phosphogluconate dehydrogenase
PGP phosphoglycolate phosphatase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PMEL premelanosome protein
POGZ pogo transposable element with ZNF domain
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POMC proopiomelanocortin
POU5F1 POU class 5 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP4R3B protein phosphatase 4 regulatory subunit 3B
PPT2 palmitoyl-protein thioesterase 2
PRDX2 peroxiredoxin 2
PRDX5 peroxiredoxin 5
PRDX6 peroxiredoxin 6
PRL prolactin
PRNP prion protein
PRSS1 protease, serine, 1 (trypsin 1)
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PYDC1 PYD (pyrin domain) containing 1
QDPR quinoid dihydropteridine reductase
QPCT glutaminyl-peptide cyclotransferase
RAB5C RAB5C, member RAS oncogene family
RALY RALY heterogeneous nuclear ribonucleoprotein
RANBP2 RAN binding protein 2
RBM45 RNA binding motif protein 45
RERE arginine-glutamic acid dipeptide (RE) repeats
RMDN1 regulator of microtubule dynamics 1
RMDN2 regulator of microtubule dynamics 2
RMDN3 regulator of microtubule dynamics 3
RNASET2 ribonuclease T2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPGRIP1L RPGRIP1-like
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RTL1 retrotransposon-like 1
S100A1 S100 calcium binding protein A1
S100B S100 calcium binding protein B
SAFB scaffold attachment factor B
SEC14L2 SEC14-like 2 (S. cerevisiae)
SFTA2 surfactant associated 2
SH2B2 SH2B adaptor protein 2
SH2B3 SH2B adaptor protein 3
SH2D1A SH2 domain containing 1A
SIRT3 sirtuin 3
SLA Src-like-adaptor
SLC16A12 solute carrier family 16, member 12
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC44A4 solute carrier family 44, member 4
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMOC2 SPARC related modular calcium binding 2
SOAT1 sterol O-acyltransferase 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SOX10 SRY (sex determining region Y)-box 10
SP1 Sp1 transcription factor
STAT4 signal transducer and activator of transcription 4
STRN3 striatin, calmodulin binding protein 3
SUMO1 small ubiquitin-like modifier 1
SYBU syntabulin (syntaxin-interacting)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBP TATA box binding protein
TEF thyrotrophic embryonic factor
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TH tyrosine hydroxylase
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNC tenascin C
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNXB tenascin XB
TOB2 transducer of ERBB2, 2
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRIM15 tripartite motif containing 15
TRIM26 tripartite motif containing 26
TRIM31 tripartite motif containing 31
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSLP thymic stromal lymphopoietin
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
TYR tyrosinase
TYRP1 tyrosinase-related protein 1
UBASH3A ubiquitin associated and SH3 domain containing A
UBE2E2 ubiquitin-conjugating enzyme E2E 2
USO1 USO1 vesicle transport factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIT vitrin
XBP1 X-box binding protein 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF410 zinc finger protein 410