Volasertib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Volasertib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Volasertib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.103765
MMP12 matrix metallopeptidase 12 0.0740015
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0589462
DST dystonin 0.0534037
ERRFI1 ERBB receptor feedback inhibitor 1 0.0485129
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0469242
XPO1 exportin 1 0.0454555
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0443792
USP34 ubiquitin specific peptidase 34 0.0440691
SMYD3 SET and MYND domain containing 3 0.0413906
WWOX WW domain containing oxidoreductase 0.0388136
YAP1 Yes-associated protein 1 0.0385463
PUM2 pumilio RNA-binding family member 2 0.0385265
EPHA6 EPH receptor A6 0.0385011
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0384813
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0380979
TMEM41B transmembrane protein 41B 0.036547
TXNRD1 thioredoxin reductase 1 0.036366
TENM3 teneurin transmembrane protein 3 0.0358388
KDM3A lysine (K)-specific demethylase 3A 0.0351149
TAS2R14 taste receptor, type 2, member 14 0.0347018
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0335868
RRM2 ribonucleotide reductase M2 0.0335779
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0323125
ZNF292 zinc finger protein 292 0.0322592
NLGN1 neuroligin 1 0.0318345
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0316845
TRIO trio Rho guanine nucleotide exchange factor 0.0316729
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0315148
FUS FUS RNA binding protein 0.0312745
ZSWIM6 zinc finger, SWIM-type containing 6 0.0311898
CLTC clathrin, heavy chain (Hc) 0.030689
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0305576
RAD51B RAD51 paralog B 0.0299232
NIPBL Nipped-B homolog (Drosophila) 0.0297199
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0296452
ASPH aspartate beta-hydroxylase 0.029633
ARL15 ADP-ribosylation factor-like 15 0.0295122
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0293541
RAB1A RAB1A, member RAS oncogene family 0.0286166
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0283518
FNIP1 folliculin interacting protein 1 0.0283419
ATP11A ATPase, class VI, type 11A 0.0283108
ZBTB20 zinc finger and BTB domain containing 20 0.0277719
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0276376
VMP1 vacuole membrane protein 1 0.0270161
NRXN3 neurexin 3 0.0270112
PCDH7 protocadherin 7 0.0269281
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0266249
IPO7 importin 7 0.0262678
AFF4 AF4/FMR2 family, member 4 0.0260541
BIRC6 baculoviral IAP repeat containing 6 0.0260194
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257973
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0254393
ZNF638 zinc finger protein 638 0.0250364
FHIT fragile histidine triad 0.0246105
ECT2 epithelial cell transforming 2 0.024504
USP9X ubiquitin specific peptidase 9, X-linked 0.0244812
PHC3 polyhomeotic homolog 3 (Drosophila) 0.024438
NF1 neurofibromin 1 0.024121
CAMKMT calmodulin-lysine N-methyltransferase 0.0240975
EIF4B eukaryotic translation initiation factor 4B 0.0240818
TBC1D5 TBC1 domain family, member 5 0.024013
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0238132
ADIPOR2 adiponectin receptor 2 0.0238031
EXOC6B exocyst complex component 6B 0.0237123
RBM39 RNA binding motif protein 39 0.0235666
CEP192 centrosomal protein 192kDa 0.0234378
TBK1 TANK-binding kinase 1 0.0234372
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0234224
CANX calnexin 0.0233796
NAP1L1 nucleosome assembly protein 1-like 1 0.0233465
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0230742
TNPO1 transportin 1 0.0229772
YEATS2 YEATS domain containing 2 0.0224471
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0223223
SPAG9 sperm associated antigen 9 0.0222677
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0222417
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0222033
MARCHF6 membrane associated ring-CH-type finger 6 0.0219927
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0219196
RAB7A RAB7A, member RAS oncogene family 0.0218787
FNDC3B fibronectin type III domain containing 3B 0.0218445
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0217993
GSK3B glycogen synthase kinase 3 beta 0.0217288
HDLBP high density lipoprotein binding protein 0.0216747
ARB2A ARB2 cotranscriptional regulator A 0.0216566
EIF4A2 eukaryotic translation initiation factor 4A2 0.0216362
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0214642
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0213421
HDAC9 histone deacetylase 9 0.0213376
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0213075
RABGAP1L RAB GTPase activating protein 1-like 0.0212441
JMJD1C jumonji domain containing 1C 0.0210139
SPIDR scaffolding protein involved in DNA repair 0.0209826
FER fer (fps/fes related) tyrosine kinase 0.0208966
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0207258
MATR3 matrin 3 0.0207105
LRMDA leucine rich melanocyte differentiation associated 0.0206288
RSRC1 arginine/serine-rich coiled-coil 1 0.0203835

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.220692
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.166982
VIM vimentin -0.141022
TMSB10 thymosin beta 10 -0.0916274
FTL ferritin, light polypeptide -0.0844698
PTMA prothymosin, alpha -0.058054
RPS12 ribosomal protein S12 -0.0518674
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.05031
EGR1 early growth response 1 -0.0487493
RPL35A ribosomal protein L35a -0.0438252
RPL37A ribosomal protein L37a -0.0432496
RPS8 ribosomal protein S8 -0.042121
RPS3 ribosomal protein S3 -0.0415082
RPS29 ribosomal protein S29 -0.0400942
ACTG1 actin gamma 1 -0.0398565
RPS13 ribosomal protein S13 -0.0378571
RPL23 ribosomal protein L23 -0.0372019
RPL31 ribosomal protein L31 -0.0346778
CCN2 cellular communication network factor 2 -0.03428
GCG glucagon -0.0338364
RPS6 ribosomal protein S6 -0.0336469
RPLP2 ribosomal protein, large, P2 -0.0334714
RASAL2 RAS protein activator like 2 -0.0327157
RPS27A ribosomal protein S27a -0.0326947
TPT1 tumor protein, translationally-controlled 1 -0.0325344
TUBA1B tubulin, alpha 1b -0.0297636
RPL26 ribosomal protein L26 -0.0293632
RPL36 ribosomal protein L36 -0.0287122
RPL19 ribosomal protein L19 -0.0285396
PFN1 profilin 1 -0.0285204
POTEF POTE ankyrin domain family, member F -0.0277874
ATP5F1B ATP synthase F1 subunit beta -0.0271537
RPL12 ribosomal protein L12 -0.0271455
RPS19 ribosomal protein S19 -0.0268871
HMGA1 high mobility group AT-hook 1 -0.0256653
RPL9 ribosomal protein L9 -0.0256484
RPS23 ribosomal protein S23 -0.0253428
INTS6 integrator complex subunit 6 -0.0237578
CNRIP1 cannabinoid receptor interacting protein 1 -0.0223284
RPL15 ribosomal protein L15 -0.0216107
MYL12B myosin, light chain 12B, regulatory -0.0212477
RPS14 ribosomal protein S14 -0.0211163
RPL37 ribosomal protein L37 -0.020996
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0209929
HMGA2 high mobility group AT-hook 2 -0.0209197
RPS16 ribosomal protein S16 -0.0203081
VDAC1 voltage-dependent anion channel 1 -0.0201996
RPS25 ribosomal protein S25 -0.0200809
TPI1 triosephosphate isomerase 1 -0.0198772
RPS27 ribosomal protein S27 -0.0195925
HLA-A major histocompatibility complex, class I, A -0.0194582
S100A11 S100 calcium binding protein A11 -0.0193562
S100A10 S100 calcium binding protein A10 -0.0191308
RPS11 ribosomal protein S11 -0.0190606
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0188821
PRDX1 peroxiredoxin 1 -0.0186825
EIF1 eukaryotic translation initiation factor 1 -0.018655
RPL13A ribosomal protein L13a -0.0185835
RPL11 ribosomal protein L11 -0.0185445
RPS17 ribosomal protein S17 -0.0177468
RPL5 ribosomal protein L5 -0.0175614
RPS15 ribosomal protein S15 -0.0175242
RACK1 receptor for activated C kinase 1 -0.0174639
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0173789
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0173628
RPS10 ribosomal protein S10 -0.0173564
GATAD2B GATA zinc finger domain containing 2B -0.0168916
RSU1 Ras suppressor protein 1 -0.016883
TM4SF1 transmembrane 4 L six family member 1 -0.0168368
RPL28 ribosomal protein L28 -0.0167381
RPS21 ribosomal protein S21 -0.0165433
RPL34 ribosomal protein L34 -0.0162806
RPL8 ribosomal protein L8 -0.0161522
EIF5B eukaryotic translation initiation factor 5B -0.0159081
RPLP1 ribosomal protein, large, P1 -0.0158682
LOC112694756 uncharaterized LOC112694756 -0.0154399
RCC1 regulator of chromosome condensation 1 -0.0154108
NAV3 neuron navigator 3 -0.0153439
LRRC23 leucine rich repeat containing 23 -0.0152258
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0152078
RPS24 ribosomal protein S24 -0.0151894
RPL10A ribosomal protein L10a -0.0149499
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.014883
MARCHF4 membrane associated ring-CH-type finger 4 -0.0148719
RPL27 ribosomal protein L27 -0.0147754
S100A9 S100 calcium binding protein A9 -0.0141432
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0140817
HSPB1 heat shock 27kDa protein 1 -0.0137059
RPL7A ribosomal protein L7a -0.0136144
HDGF hepatoma-derived growth factor -0.0135415
GNAS GNAS complex locus -0.0134905
TBCA tubulin folding cofactor A -0.0133433
RPL36A ribosomal protein L36a -0.013312
PDCD5 programmed cell death 5 -0.0133097
S100A6 S100 calcium binding protein A6 -0.0132676
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0131498
RPL38 ribosomal protein L38 -0.0128821
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -0.0126712
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0125891
RPL18 ribosomal protein L18 -0.0124219