| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Volasertib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH13 | cadherin 13 | 0.186071 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.175038 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.152706 |
| EXT1 | exostosin glycosyltransferase 1 | 0.14803 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.12785 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.125188 |
| COL6A3 | collagen, type VI, alpha 3 | 0.122558 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.104658 |
| ASPH | aspartate beta-hydroxylase | 0.0849551 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0843147 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0828747 |
| GOLGB1 | golgin B1 | 0.0801467 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0728742 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0725024 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0680068 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0650112 |
| FBN1 | fibrillin 1 | 0.0643149 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0636036 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0600679 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0576605 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.056923 |
| CANX | calnexin | 0.0550789 |
| ENO1 | enolase 1, (alpha) | 0.0523934 |
| EFNA5 | ephrin-A5 | 0.0514988 |
| PDLIM5 | PDZ and LIM domain 5 | 0.050582 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0503104 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0502297 |
| FNIP1 | folliculin interacting protein 1 | 0.0491906 |
| VCL | vinculin | 0.0465033 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0462054 |
| CADM1 | cell adhesion molecule 1 | 0.0454012 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0448556 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0442955 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0433084 |
| CLIC4 | chloride intracellular channel 4 | 0.0428989 |
| PRELID2 | PRELI domain containing 2 | 0.0426727 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0426438 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0416858 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0416073 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0412398 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0408965 |
| GLIS3 | GLIS family zinc finger 3 | 0.0405583 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0404929 |
| B2M | beta-2-microglobulin | 0.0400721 |
| SP100 | SP100 nuclear antigen | 0.0398478 |
| CDK13 | cyclin-dependent kinase 13 | 0.0394942 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0387297 |
| CALR | calreticulin | 0.0386294 |
| CALU | calumenin | 0.0381341 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0379469 |
| SMYD3 | SET and MYND domain containing 3 | 0.0379198 |
| PTK2 | protein tyrosine kinase 2 | 0.0378965 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0376439 |
| HDAC9 | histone deacetylase 9 | 0.0373693 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0370243 |
| RND3 | Rho family GTPase 3 | 0.0365286 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0365212 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0363346 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0357621 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0355785 |
| MLF1 | myeloid leukemia factor 1 | 0.0353029 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0348651 |
| ZNF644 | zinc finger protein 644 | 0.0347896 |
| SQSTM1 | sequestosome 1 | 0.0345484 |
| TMSB4X | thymosin beta 4, X-linked | 0.0345197 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0332234 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0331869 |
| HDLBP | high density lipoprotein binding protein | 0.0331191 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0327193 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0325815 |
| ANO10 | anoctamin 10 | 0.0325607 |
| VMP1 | vacuole membrane protein 1 | 0.0322658 |
| SEC24D | SEC24 family member D | 0.0320017 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0316664 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0312891 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0305434 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0304389 |
| PGM3 | phosphoglucomutase 3 | 0.0302795 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0297745 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0297421 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0294935 |
| FMNL2 | formin-like 2 | 0.0294258 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0291564 |
| BRD2 | bromodomain containing 2 | 0.029132 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0289913 |
| APP | amyloid beta (A4) precursor protein | 0.0288562 |
| COG5 | component of oligomeric golgi complex 5 | 0.028709 |
| ANXA1 | annexin A1 | 0.0286891 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0286251 |
| INTS6 | integrator complex subunit 6 | 0.028438 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0275054 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0274716 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0274505 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0274501 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.027293 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0272689 |
| PMM2 | phosphomannomutase 2 | 0.0272544 |
| COPA | coatomer protein complex, subunit alpha | 0.0272445 |
| NEK10 | NIMA-related kinase 10 | 0.027223 |
| ATXN1 | ataxin 1 | 0.0271122 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.263469 |
| FN1 | fibronectin 1 | -0.150871 |
| MT2A | metallothionein 2A | -0.146658 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.137768 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.108954 |
| CD44 | CD44 molecule (Indian blood group) | -0.0667447 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0636134 |
| COL1A1 | collagen, type I, alpha 1 | -0.0604333 |
| PTMA | prothymosin, alpha | -0.0591563 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0511437 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.050516 |
| LOXL2 | lysyl oxidase-like 2 | -0.0425972 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0415958 |
| SMAD3 | SMAD family member 3 | -0.0407455 |
| MT1X | metallothionein 1X | -0.0398497 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0380274 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0369064 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0365693 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0364659 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0359422 |
| ATP13A3 | ATPase type 13A3 | -0.0353573 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0344972 |
| STC1 | stanniocalcin 1 | -0.0341879 |
| MTSS1 | metastasis suppressor 1 | -0.0315995 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0314737 |
| VEGFA | vascular endothelial growth factor A | -0.0313663 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0313262 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0311348 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0310165 |
| ARRDC3 | arrestin domain containing 3 | -0.0307192 |
| TMSB10 | thymosin beta 10 | -0.0300063 |
| ADM | adrenomedullin | -0.0283011 |
| COL1A2 | collagen, type I, alpha 2 | -0.026973 |
| FBXO32 | F-box protein 32 | -0.0268058 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0263964 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0253448 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0251705 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0247063 |
| MAP1B | microtubule-associated protein 1B | -0.0245757 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0243691 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.024234 |
| ECE1 | endothelin converting enzyme 1 | -0.0239713 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0233327 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233067 |
| HAS2 | hyaluronan synthase 2 | -0.0227064 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0227021 |
| ZNF292 | zinc finger protein 292 | -0.0226451 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0225892 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0223366 |
| AXL | AXL receptor tyrosine kinase | -0.0220554 |
| POTEF | POTE ankyrin domain family, member F | -0.0214604 |
| TAGLN2 | transgelin 2 | -0.0214527 |
| CENPF | centromere protein F, 350/400kDa | -0.0211949 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0208145 |
| S100A9 | S100 calcium binding protein A9 | -0.0207405 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0202789 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0202293 |
| PFN1 | profilin 1 | -0.0202041 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0195732 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0195493 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0194018 |
| FTL | ferritin, light polypeptide | -0.0192893 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | -0.0189297 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.018807 |
| DEPP1 | DEPP autophagy regulator 1 | -0.018583 |
| XPO1 | exportin 1 | -0.0183168 |
| USP3 | ubiquitin specific peptidase 3 | -0.0180401 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0179292 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0178852 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0175677 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0173641 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0172451 |
| S100A6 | S100 calcium binding protein A6 | -0.0172372 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0172236 |
| TPM1 | tropomyosin 1 (alpha) | -0.017116 |
| SQLE | squalene epoxidase | -0.0170527 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0169807 |
| RNF24 | ring finger protein 24 | -0.0168433 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0164717 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0163612 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.016169 |
| IL6 | interleukin 6 | -0.0160806 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0160485 |
| CD109 | CD109 molecule | -0.0160469 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0157443 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0156681 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0155551 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0155406 |
| SETD5 | SET domain containing 5 | -0.0155288 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0151126 |
| TRAM2 | translocation associated membrane protein 2 | -0.0147378 |
| EHD2 | EH-domain containing 2 | -0.0146757 |
| PXDN | peroxidasin | -0.0146498 |
| UBC | ubiquitin C | -0.0146037 |
| RTN4 | reticulon 4 | -0.0145634 |
| TMEM165 | transmembrane protein 165 | -0.014541 |
| KLF6 | Kruppel-like factor 6 | -0.0145044 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0144804 |
| H3-3B | H3.3 histone B | -0.0144154 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | -0.0143286 |
