| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Volasertib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.232559 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.141229 |
| SVIL | supervillin | 0.12387 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.118457 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.114655 |
| IGF2 | insulin-like growth factor 2 | 0.105708 |
| FAM107B | family with sequence similarity 107, member B | 0.101209 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0997753 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0970595 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0908365 |
| ASPH | aspartate beta-hydroxylase | 0.0893197 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.080521 |
| GPC6 | glypican 6 | 0.07668 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0737109 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0727012 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0712135 |
| DSPP | dentin sialophosphoprotein | 0.0689944 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0672274 |
| VCL | vinculin | 0.0659228 |
| ATXN1 | ataxin 1 | 0.0655217 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0651102 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0584197 |
| EHBP1 | EH domain binding protein 1 | 0.0572766 |
| KYNU | kynureninase | 0.0564563 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0554965 |
| FOXP1 | forkhead box P1 | 0.0540938 |
| DST | dystonin | 0.053861 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0532227 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0475502 |
| CRY1 | cryptochrome circadian clock 1 | 0.047383 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0471359 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0467202 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0465084 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.046501 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0463657 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0443523 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0424637 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0423027 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0405751 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0397741 |
| FRMD5 | FERM domain containing 5 | 0.039376 |
| RUNX1 | runt-related transcription factor 1 | 0.0392063 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0387478 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0382755 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0372983 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.037288 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0368501 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0366996 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0355547 |
| ITGAV | integrin, alpha V | 0.0351553 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0350397 |
| VMP1 | vacuole membrane protein 1 | 0.0350088 |
| MCL1 | myeloid cell leukemia 1 | 0.0345979 |
| TNS1 | tensin 1 | 0.0345649 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0340677 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0338872 |
| RASA2 | RAS p21 protein activator 2 | 0.0335599 |
| JMJD1C | jumonji domain containing 1C | 0.0331836 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0328466 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0324117 |
| RAI14 | retinoic acid induced 14 | 0.0322129 |
| SMAD3 | SMAD family member 3 | 0.0319416 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0317981 |
| BCL2L1 | BCL2-like 1 | 0.0316739 |
| MCU | mitochondrial calcium uniporter | 0.0313096 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0310922 |
| DIAPH1 | diaphanous-related formin 1 | 0.0309129 |
| FERMT2 | fermitin family member 2 | 0.0308187 |
| CADM1 | cell adhesion molecule 1 | 0.0307301 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.030612 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0303125 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0299099 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0298149 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0292767 |
| STK17A | serine/threonine kinase 17a | 0.0292599 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0288923 |
| CLIC4 | chloride intracellular channel 4 | 0.0288338 |
| USP34 | ubiquitin specific peptidase 34 | 0.0287706 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0287278 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0285268 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0284842 |
| ITGA6 | integrin, alpha 6 | 0.0282467 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.028177 |
| FKTN | fukutin | 0.0279534 |
| MYO6 | myosin VI | 0.0279138 |
| ANO6 | anoctamin 6 | 0.0275616 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.027439 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0273639 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0272074 |
| TXNRD1 | thioredoxin reductase 1 | 0.0271376 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0264617 |
| RPL14 | ribosomal protein L14 | 0.0262985 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0262088 |
| INTS6 | integrator complex subunit 6 | 0.0261333 |
| ZNF644 | zinc finger protein 644 | 0.0260794 |
| FAT1 | FAT atypical cadherin 1 | 0.0259984 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.025873 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0257431 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0257166 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0257033 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.238765 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.187771 |
| C3 | complement component 3 | -0.154869 |
| APOA2 | apolipoprotein A-II | -0.126921 |
| GPC3 | glypican 3 | -0.124937 |
| MT2A | metallothionein 2A | -0.119676 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0993481 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0954881 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0930037 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0829924 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0751019 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0726615 |
| FTL | ferritin, light polypeptide | -0.0632066 |
| RPS6 | ribosomal protein S6 | -0.0623159 |
| RPL35A | ribosomal protein L35a | -0.0620234 |
| RPL11 | ribosomal protein L11 | -0.0596996 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0571626 |
| AHSG | alpha-2-HS-glycoprotein | -0.0559971 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0556958 |
| RPS24 | ribosomal protein S24 | -0.0555702 |
| RPLP1 | ribosomal protein, large, P1 | -0.0537295 |
| RPL23 | ribosomal protein L23 | -0.0504533 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0496964 |
| A2M | alpha-2-macroglobulin | -0.0493596 |
| RPS19 | ribosomal protein S19 | -0.0492845 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.049084 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0477601 |
| APOE | apolipoprotein E | -0.0474108 |
| NDRG1 | N-myc downstream regulated 1 | -0.0468661 |
| RPL37A | ribosomal protein L37a | -0.0467607 |
| FN1 | fibronectin 1 | -0.0465739 |
| TMSB10 | thymosin beta 10 | -0.0457184 |
| RPS8 | ribosomal protein S8 | -0.0453953 |
| RPL31 | ribosomal protein L31 | -0.0448239 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0439494 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0432897 |
| TRIM26 | tripartite motif containing 26 | -0.0430016 |
| RPL34 | ribosomal protein L34 | -0.0406721 |
| PTMA | prothymosin, alpha | -0.0402747 |
| RRBP1 | ribosome binding protein 1 | -0.0402625 |
| CFB | complement factor B | -0.0395772 |
| RPL9 | ribosomal protein L9 | -0.0378465 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0366999 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0351022 |
| GNAS | GNAS complex locus | -0.0344069 |
| RPS27A | ribosomal protein S27a | -0.0340619 |
| RPS13 | ribosomal protein S13 | -0.0335754 |
| RPLP2 | ribosomal protein, large, P2 | -0.0333642 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0333127 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.032805 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0326985 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0322374 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0310745 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0308289 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0305427 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0302254 |
| RPLP0 | ribosomal protein, large, P0 | -0.0301013 |
| RPS21 | ribosomal protein S21 | -0.0300782 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0298052 |
| HMGA1 | high mobility group AT-hook 1 | -0.0286775 |
| NCOA7 | nuclear receptor coactivator 7 | -0.028479 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0281805 |
| RPS11 | ribosomal protein S11 | -0.0275515 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0274047 |
| APOA1 | apolipoprotein A-I | -0.0270799 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.026592 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0265123 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0263844 |
| GDF15 | growth differentiation factor 15 | -0.0263614 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0262729 |
| HLF | hepatic leukemia factor | -0.0262667 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0254209 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0253446 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0252751 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0251695 |
| RPS29 | ribosomal protein S29 | -0.0248722 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0248241 |
| RPL30 | ribosomal protein L30 | -0.0244618 |
| LYZ | lysozyme | -0.0240339 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0238023 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0237329 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0232054 |
| KRT18 | keratin 18, type I | -0.0231795 |
| H1-0 | H1.0 linker histone | -0.0231485 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0228104 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.0226088 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0225213 |
| RPL12 | ribosomal protein L12 | -0.0220133 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0216101 |
| RPL32 | ribosomal protein L32 | -0.0216029 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0215457 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.021535 |
| ZFHX3 | zinc finger homeobox 3 | -0.0215139 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0214998 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0214304 |
| IGF2R | insulin-like growth factor 2 receptor | -0.021211 |
| ANGPTL8 | angiopoietin like 8 | -0.0211684 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0210281 |
| CPE | carboxypeptidase E | -0.0207149 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0204451 |
