| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Volasertib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.150969 |
| INTS6 | integrator complex subunit 6 | 0.127387 |
| SLC35F3 | solute carrier family 35, member F3 | 0.127254 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.124527 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.119547 |
| B2M | beta-2-microglobulin | 0.097935 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.09348 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0901109 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0892979 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0864778 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0846469 |
| CD44 | CD44 molecule (Indian blood group) | 0.0784813 |
| PTK2 | protein tyrosine kinase 2 | 0.0730376 |
| SIK3 | SIK family kinase 3 | 0.0680813 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0653149 |
| RASAL2 | RAS protein activator like 2 | 0.0612528 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0607527 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0566348 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0562127 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0553499 |
| GRB10 | growth factor receptor-bound protein 10 | 0.053813 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0533162 |
| VCL | vinculin | 0.0523099 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0522169 |
| ASPH | aspartate beta-hydroxylase | 0.0519451 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0516898 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0512788 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0501136 |
| EFNA5 | ephrin-A5 | 0.0492869 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0491688 |
| FNIP1 | folliculin interacting protein 1 | 0.0482397 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0480996 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0465215 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.046418 |
| JMJD1C | jumonji domain containing 1C | 0.0451335 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0449654 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0439534 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0431895 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0425105 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0417811 |
| HDAC9 | histone deacetylase 9 | 0.0409801 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0409094 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0406683 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0391289 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0386957 |
| DIAPH1 | diaphanous-related formin 1 | 0.0384536 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.038367 |
| RPS3 | ribosomal protein S3 | 0.0383448 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0380459 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0366092 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0365575 |
| PRELID2 | PRELI domain containing 2 | 0.0364915 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0361564 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0359199 |
| RCOR1 | REST corepressor 1 | 0.0358658 |
| RPS8 | ribosomal protein S8 | 0.0349819 |
| GPR176 | G protein-coupled receptor 176 | 0.0344269 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0342563 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0339045 |
| RPS12 | ribosomal protein S12 | 0.0335914 |
| AMOTL1 | angiomotin like 1 | 0.0333449 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0332359 |
| CLIC4 | chloride intracellular channel 4 | 0.0330217 |
| CSMD2 | CUB and Sushi multiple domains 2 | 0.0327237 |
| RAD51B | RAD51 paralog B | 0.032664 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0325288 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0322929 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0319438 |
| CTBP2 | C-terminal binding protein 2 | 0.0314182 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.0313267 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0313131 |
| HMGA2 | high mobility group AT-hook 2 | 0.0310967 |
| RPS17 | ribosomal protein S17 | 0.0305844 |
| SQSTM1 | sequestosome 1 | 0.0303894 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0301333 |
| NAV2 | neuron navigator 2 | 0.0301258 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0299912 |
| RPL37 | ribosomal protein L37 | 0.0299628 |
| FAM107B | family with sequence similarity 107, member B | 0.0299264 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0296413 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0294906 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0294835 |
| PLXNA2 | plexin A2 | 0.0294459 |
| RNF217 | ring finger protein 217 | 0.0293983 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0288878 |
| AGO2 | argonaute RISC catalytic component 2 | 0.028844 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0287448 |
| DST | dystonin | 0.0283686 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0281897 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0279734 |
| PMM2 | phosphomannomutase 2 | 0.0279495 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0278118 |
| GOLGB1 | golgin B1 | 0.0273299 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0271723 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0270871 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0270444 |
| RAI14 | retinoic acid induced 14 | 0.0269201 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0267528 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0267232 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0265057 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.210848 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.184045 |
| FLNB | filamin B, beta | -0.13738 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.109435 |
| CLU | clusterin | -0.0926065 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0786679 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0728018 |
| CUL4B | cullin 4B | -0.068089 |
| PTMA | prothymosin, alpha | -0.0673241 |
| POTEF | POTE ankyrin domain family, member F | -0.0672484 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0609564 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0599578 |
| SULF1 | sulfatase 1 | -0.059305 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0569218 |
| IGF2 | insulin-like growth factor 2 | -0.0565631 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0535721 |
| PLAT | plasminogen activator, tissue | -0.052734 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0525502 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0514948 |
| AHNAK | AHNAK nucleoprotein | -0.0511251 |
| PODXL | podocalyxin-like | -0.0506633 |
| BCL2L1 | BCL2-like 1 | -0.0500981 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0483274 |
| ANLN | anillin, actin binding protein | -0.0482186 |
| H1-0 | H1.0 linker histone | -0.0471191 |
| GOLGA4 | golgin A4 | -0.0465366 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0459398 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0455234 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.045083 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0444229 |
| STC1 | stanniocalcin 1 | -0.0438486 |
| FN1 | fibronectin 1 | -0.0429143 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0428888 |
| RIN2 | Ras and Rab interactor 2 | -0.0427773 |
| RBM39 | RNA binding motif protein 39 | -0.0421218 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.041801 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0416292 |
| PGK1 | phosphoglycerate kinase 1 | -0.0408045 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0405558 |
| EFHD2 | EF-hand domain family, member D2 | -0.0402963 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0391305 |
| OGA | O-GlcNAcase | -0.0385125 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0384006 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0367958 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0366679 |
| RIOK3 | RIO kinase 3 | -0.036658 |
| XPO1 | exportin 1 | -0.0363986 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0358787 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0349212 |
| GNAS | GNAS complex locus | -0.0342415 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.034212 |
| PLAC8 | placenta-specific 8 | -0.0338835 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.03326 |
| CD99 | CD99 molecule | -0.0328993 |
| TPX2 | TPX2, microtubule-associated | -0.0319096 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0317092 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0316944 |
| SERINC3 | serine incorporator 3 | -0.0312924 |
| TAGLN2 | transgelin 2 | -0.0312035 |
| S100A2 | S100 calcium binding protein A2 | -0.0310413 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0307833 |
| C4BPB | complement component 4 binding protein, beta | -0.0307425 |
| PDLIM1 | PDZ and LIM domain 1 | -0.0304535 |
| LMNA | lamin A/C | -0.0304137 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0302113 |
| CANX | calnexin | -0.0299667 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0298774 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0295614 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0294362 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0292582 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0292254 |
| LMAN1 | lectin, mannose-binding, 1 | -0.028931 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0287028 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0285853 |
| MEF2A | myocyte enhancer factor 2A | -0.0283996 |
| PKM | pyruvate kinase, muscle | -0.0283788 |
| KRT17 | keratin 17, type I | -0.0283369 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0281087 |
| S100A4 | S100 calcium binding protein A4 | -0.0280048 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0277263 |
| FOSL1 | FOS-like antigen 1 | -0.027514 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0268994 |
| AFAP1 | actin filament associated protein 1 | -0.0266276 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0266145 |
| TPM4 | tropomyosin 4 | -0.0265475 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0264321 |
| YBX3 | Y box binding protein 3 | -0.0257568 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0252946 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0252457 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0251401 |
| ZNF292 | zinc finger protein 292 | -0.0251171 |
| ZFR | zinc finger RNA binding protein | -0.0249343 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0248274 |
| RPS2 | ribosomal protein S2 | -0.0248089 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0246809 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0246622 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0246144 |
| RPLP1 | ribosomal protein, large, P1 | -0.0246112 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0245752 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0245675 |
