| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Volasertib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.085739 |
| SMAD3 | SMAD family member 3 | 0.085149 |
| NAV2 | neuron navigator 2 | 0.0789677 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0744422 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0637492 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0546883 |
| PRELID2 | PRELI domain containing 2 | 0.0524974 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0515663 |
| EFNA5 | ephrin-A5 | 0.048734 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0484755 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0464836 |
| PCBP2 | poly(rC) binding protein 2 | 0.0455746 |
| RUNX1 | runt-related transcription factor 1 | 0.0432634 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0422073 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0415435 |
| FAM13A | family with sequence similarity 13, member A | 0.0382181 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0371468 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0370894 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0339679 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0335171 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0327544 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0323761 |
| GOLGA4 | golgin A4 | 0.0322768 |
| ZNF638 | zinc finger protein 638 | 0.0321766 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0318133 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0316696 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0307269 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0305474 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.030071 |
| FAM107B | family with sequence similarity 107, member B | 0.0299654 |
| EGFR | epidermal growth factor receptor | 0.0296752 |
| FNIP1 | folliculin interacting protein 1 | 0.0282374 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0276721 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0273809 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0273666 |
| ANO6 | anoctamin 6 | 0.0271406 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0269902 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0255351 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0253532 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0252162 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0250712 |
| HELZ | helicase with zinc finger | 0.0249115 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.024887 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0246034 |
| GPHN | gephyrin | 0.0240124 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0237494 |
| ZNF292 | zinc finger protein 292 | 0.0232694 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.023257 |
| HDAC9 | histone deacetylase 9 | 0.0230634 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0228425 |
| TAF4B | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | 0.0226688 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0226462 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0226007 |
| APP | amyloid beta (A4) precursor protein | 0.0225485 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0224785 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0219997 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0219749 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0219591 |
| RAD51B | RAD51 paralog B | 0.021696 |
| LRRC49 | leucine rich repeat containing 49 | 0.0214869 |
| CA12 | carbonic anhydrase XII | 0.0213839 |
| EZR | ezrin | 0.0208468 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0207803 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0206706 |
| MYOF | myoferlin | 0.020385 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0202705 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0202607 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0201875 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0201469 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0200443 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0199004 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0198753 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0197994 |
| USP34 | ubiquitin specific peptidase 34 | 0.0196729 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.019572 |
| METTL15 | methyltransferase like 15 | 0.019459 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0193758 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0193274 |
| ATP13A3 | ATPase type 13A3 | 0.0192299 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0191506 |
| NGLY1 | N-glycanase 1 | 0.0191261 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0189006 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0186429 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0183483 |
| NBAS | neuroblastoma amplified sequence | 0.0182411 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0182388 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0180076 |
| MYO1B | myosin IB | 0.0178926 |
| YEATS2 | YEATS domain containing 2 | 0.0177925 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0177261 |
| SPAG9 | sperm associated antigen 9 | 0.0177098 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0176928 |
| RAB1A | RAB1A, member RAS oncogene family | 0.017456 |
| ECE1 | endothelin converting enzyme 1 | 0.0174451 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0174109 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.017348 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0172894 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0172707 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0171956 |
| SMYD3 | SET and MYND domain containing 3 | 0.0170879 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.187274 |
| TMSB10 | thymosin beta 10 | -0.176133 |
| VIM | vimentin | -0.162474 |
| FN1 | fibronectin 1 | -0.143862 |
| GLCCI1 | glucocorticoid induced 1 | -0.11802 |
| STC1 | stanniocalcin 1 | -0.097764 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0823923 |
| FTL | ferritin, light polypeptide | -0.0823474 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0800019 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0789163 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0782158 |
| HMGA2 | high mobility group AT-hook 2 | -0.0773348 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0642822 |
| PTMA | prothymosin, alpha | -0.0637714 |
| S100A6 | S100 calcium binding protein A6 | -0.0577177 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0575183 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0561927 |
| NRP1 | neuropilin 1 | -0.0532166 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0525064 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0506959 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0492309 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0484052 |
| LOX | lysyl oxidase | -0.0480666 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0458768 |
| CLMP | CXADR-like membrane protein | -0.0448226 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0427125 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0417837 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0417211 |
| RPS19 | ribosomal protein S19 | -0.0411521 |
| MTSS1 | metastasis suppressor 1 | -0.0403638 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0402527 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0395503 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0395398 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0392241 |
| ANXA10 | annexin A10 | -0.0388501 |
| EGR1 | early growth response 1 | -0.0384547 |
| NRG1 | neuregulin 1 | -0.0384421 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0374425 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0373995 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0361965 |
| RPL35A | ribosomal protein L35a | -0.0359381 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0357952 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0357864 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0346845 |
| MT2A | metallothionein 2A | -0.0345679 |
| RPLP1 | ribosomal protein, large, P1 | -0.0340669 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.033879 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0337917 |
| NTN4 | netrin 4 | -0.0334931 |
| NUMB | numb homolog (Drosophila) | -0.0328658 |
| RPLP2 | ribosomal protein, large, P2 | -0.0326661 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0323276 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0313329 |
| RPL37A | ribosomal protein L37a | -0.031108 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0307194 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0302411 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0301067 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0298855 |
| RPS8 | ribosomal protein S8 | -0.0292545 |
| NDRG1 | N-myc downstream regulated 1 | -0.0290742 |
| IL1B | interleukin 1, beta | -0.0288455 |
| RPS29 | ribosomal protein S29 | -0.028745 |
| RPS21 | ribosomal protein S21 | -0.0280257 |
| PRRX1 | paired related homeobox 1 | -0.0277554 |
| RPL31 | ribosomal protein L31 | -0.027353 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0272353 |
| HMGA1 | high mobility group AT-hook 1 | -0.0271474 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0271285 |
| S100A10 | S100 calcium binding protein A10 | -0.0267942 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0266561 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0260832 |
| SNX9 | sorting nexin 9 | -0.0260262 |
| PRSS23 | protease, serine, 23 | -0.025708 |
| VRK2 | vaccinia related kinase 2 | -0.0255832 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0255332 |
| DNER | delta/notch-like EGF repeat containing | -0.0254862 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0254378 |
| OSMR | oncostatin M receptor | -0.025178 |
| RPS13 | ribosomal protein S13 | -0.0248414 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0246141 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0244037 |
| RPL36 | ribosomal protein L36 | -0.0243969 |
| RPS3 | ribosomal protein S3 | -0.0241768 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0240767 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0230669 |
| RPS12 | ribosomal protein S12 | -0.0229796 |
| HLA-B | major histocompatibility complex, class I, B | -0.0228394 |
| RPL34 | ribosomal protein L34 | -0.0226065 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0224405 |
| MECOM | MDS1 and EVI1 complex locus | -0.0224041 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0223604 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0223167 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.022306 |
| CP | ceruloplasmin (ferroxidase) | -0.0219006 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0218478 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.021842 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0218311 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0214435 |
| BMERB1 | bMERB domain containing 1 | -0.0210963 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.0207838 |
