| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Volasertib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.102874 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0765759 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.066013 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.060472 |
| B2M | beta-2-microglobulin | 0.0601354 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0515997 |
| RBM39 | RNA binding motif protein 39 | 0.0515632 |
| WDR43 | WD repeat domain 43 | 0.0488369 |
| SIK3 | SIK family kinase 3 | 0.0482464 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0475202 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0474531 |
| TPD52 | tumor protein D52 | 0.0460752 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0459877 |
| COPA | coatomer protein complex, subunit alpha | 0.0459355 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0443257 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.043986 |
| USP3 | ubiquitin specific peptidase 3 | 0.0436074 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.043211 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0426407 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0410407 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0409931 |
| NCKAP1 | NCK-associated protein 1 | 0.0389028 |
| RNF145 | ring finger protein 145 | 0.0383044 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0382677 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0373303 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0369182 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0363818 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0355778 |
| GOLGA4 | golgin A4 | 0.0346437 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0345682 |
| MATR3 | matrin 3 | 0.0338127 |
| TFG | TRK-fused gene | 0.0325041 |
| MCL1 | myeloid cell leukemia 1 | 0.0317194 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0314426 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.030892 |
| RLF | rearranged L-myc fusion | 0.0308372 |
| YME1L1 | YME1-like 1 ATPase | 0.0305782 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0305556 |
| APP | amyloid beta (A4) precursor protein | 0.0304868 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0303219 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0303119 |
| OLA1 | Obg-like ATPase 1 | 0.0299684 |
| COG5 | component of oligomeric golgi complex 5 | 0.0299394 |
| BRD2 | bromodomain containing 2 | 0.0297913 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0297636 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0295777 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0291035 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.028806 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0286599 |
| SPAG9 | sperm associated antigen 9 | 0.0286334 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.028349 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0282259 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0277652 |
| TXNRD1 | thioredoxin reductase 1 | 0.0275734 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0274532 |
| CCNL1 | cyclin L1 | 0.0273296 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0272313 |
| NEK7 | NIMA-related kinase 7 | 0.0272112 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0270388 |
| PTK2 | protein tyrosine kinase 2 | 0.0267749 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0267542 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0263789 |
| MLF1 | myeloid leukemia factor 1 | 0.0262139 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0259931 |
| NOP58 | NOP58 ribonucleoprotein | 0.0257826 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0257653 |
| QKI | QKI, KH domain containing, RNA binding | 0.0257021 |
| RAB18 | RAB18, member RAS oncogene family | 0.0256682 |
| USP36 | ubiquitin specific peptidase 36 | 0.0255341 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0250285 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0249707 |
| EZR | ezrin | 0.0247745 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0247445 |
| HELZ | helicase with zinc finger | 0.0245404 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.024162 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0240159 |
| CDC73 | cell division cycle 73 | 0.0237966 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0236719 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0235466 |
| RTN4 | reticulon 4 | 0.0235444 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0234503 |
| NUP58 | nucleoporin 58 | 0.0231208 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0231148 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0230279 |
| ZNF207 | zinc finger protein 207 | 0.0229164 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0229015 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0228245 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | 0.0224223 |
| RPL3 | ribosomal protein L3 | 0.0221509 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0221045 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0220942 |
| HLA-B | major histocompatibility complex, class I, B | 0.022065 |
| RUNX1 | runt-related transcription factor 1 | 0.0217676 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0217345 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0216596 |
| ZNF292 | zinc finger protein 292 | 0.0216034 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0213248 |
| GPHN | gephyrin | 0.0213083 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0210004 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0208704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.204417 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.189959 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.161611 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152645 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.147288 |
| ACTG1 | actin gamma 1 | -0.141107 |
| CMIP | c-Maf inducing protein | -0.139132 |
| POTEF | POTE ankyrin domain family, member F | -0.133777 |
| VIM | vimentin | -0.132384 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.110031 |
| DOCK4 | dedicator of cytokinesis 4 | -0.100038 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0978952 |
| TMSB10 | thymosin beta 10 | -0.0955752 |
| BICC1 | BicC family RNA binding protein 1 | -0.0893181 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0848399 |
| IGF2 | insulin-like growth factor 2 | -0.0839425 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0817653 |
| DST | dystonin | -0.0813443 |
| UTRN | utrophin | -0.076381 |
| EGFR | epidermal growth factor receptor | -0.0733246 |
| NEGR1 | neuronal growth regulator 1 | -0.07252 |
| AHNAK | AHNAK nucleoprotein | -0.0705627 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0692426 |
| PKM | pyruvate kinase, muscle | -0.0664993 |
| LDHA | lactate dehydrogenase A | -0.0654755 |
| RAD51B | RAD51 paralog B | -0.0654378 |
| FLNB | filamin B, beta | -0.0646464 |
| EFNA5 | ephrin-A5 | -0.0645303 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0636688 |
| ACTN1 | actinin, alpha 1 | -0.0621849 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.061371 |
| STC1 | stanniocalcin 1 | -0.0582489 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0575976 |
| SVIL | supervillin | -0.0564899 |
| GRAMD1B | GRAM domain containing 1B | -0.0558524 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0554194 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0532099 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0527478 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0523727 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0510147 |
| TPM4 | tropomyosin 4 | -0.0506926 |
| EGR1 | early growth response 1 | -0.0505879 |
| PYGL | phosphorylase, glycogen, liver | -0.0500392 |
| TPM1 | tropomyosin 1 (alpha) | -0.0473751 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0468025 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0458322 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0450324 |
| GLIS3 | GLIS family zinc finger 3 | -0.0449997 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0443844 |
| HMGA1 | high mobility group AT-hook 1 | -0.0439956 |
| NEBL | nebulette | -0.0418352 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0408403 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0404362 |
| AK1 | adenylate kinase 1 | -0.0401876 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0399481 |
| FLNA | filamin A, alpha | -0.0395874 |
| EHBP1 | EH domain binding protein 1 | -0.0394471 |
| PDE8A | phosphodiesterase 8A | -0.0392758 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0385298 |
| PFN1 | profilin 1 | -0.0383869 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0381011 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0379063 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0370454 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0366301 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0363147 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.036006 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0359048 |
| PFKP | phosphofructokinase, platelet | -0.0353497 |
| PTMA | prothymosin, alpha | -0.0352969 |
| CUX1 | cut-like homeobox 1 | -0.0351255 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0347336 |
| FOXP1 | forkhead box P1 | -0.0346803 |
| FMNL2 | formin-like 2 | -0.0346619 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0343003 |
| THBS1 | thrombospondin 1 | -0.0341742 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0337719 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0336376 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0329866 |
| VCL | vinculin | -0.0319034 |
| KYNU | kynureninase | -0.0317731 |
| ASPH | aspartate beta-hydroxylase | -0.0317516 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0316422 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0311411 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0310853 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0310772 |
| NAV3 | neuron navigator 3 | -0.0309353 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0308646 |
| TAGLN2 | transgelin 2 | -0.0308373 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0307823 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0307544 |
| PLS3 | plastin 3 | -0.0304154 |
| RNF213 | ring finger protein 213 | -0.0300999 |
| CAVIN1 | caveolae associated protein 1 | -0.0296969 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0290673 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.028885 |
| EXOC4 | exocyst complex component 4 | -0.0287234 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0284522 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.02842 |
| S100A6 | S100 calcium binding protein A6 | -0.0284097 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0284031 |
