| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Volasertib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.134688 |
| MYO1E | myosin IE | 0.122576 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.106305 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0913313 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0908969 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0907807 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0881046 |
| FN1 | fibronectin 1 | 0.0815781 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0782371 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0730835 |
| PLCB4 | phospholipase C, beta 4 | 0.0702507 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0667147 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0664024 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0621849 |
| B2M | beta-2-microglobulin | 0.0593316 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0586555 |
| JMJD1C | jumonji domain containing 1C | 0.058422 |
| HDAC9 | histone deacetylase 9 | 0.0556926 |
| STC1 | stanniocalcin 1 | 0.0546605 |
| GOLGB1 | golgin B1 | 0.0534763 |
| FOXP1 | forkhead box P1 | 0.0516591 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0511262 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0508662 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0507723 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0488303 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0487634 |
| SMYD3 | SET and MYND domain containing 3 | 0.0481815 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0479881 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0472671 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0463305 |
| EGFR | epidermal growth factor receptor | 0.0443579 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0440811 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0437801 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0433535 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0430219 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.041943 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0416905 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0392522 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0391867 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0390045 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0384111 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0378262 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0376728 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0376296 |
| ZNF644 | zinc finger protein 644 | 0.0374147 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0368043 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0361666 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0361484 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0360688 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0353018 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.035056 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0347144 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0341161 |
| ENO1 | enolase 1, (alpha) | 0.0340399 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0336088 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0333842 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0333254 |
| BBX | bobby sox homolog (Drosophila) | 0.0327905 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0327889 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0324639 |
| CEP350 | centrosomal protein 350kDa | 0.0323505 |
| RPS27A | ribosomal protein S27a | 0.0322963 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0321569 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0319245 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0319148 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0316275 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0315105 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0310742 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0309022 |
| ANXA2 | annexin A2 | 0.0304774 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0303395 |
| MYO5B | myosin VB | 0.0302573 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0301896 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.02998 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.0298153 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | 0.0295768 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0294837 |
| FAT1 | FAT atypical cadherin 1 | 0.0293619 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.029176 |
| AHNAK | AHNAK nucleoprotein | 0.0290307 |
| GPC6 | glypican 6 | 0.0289004 |
| VGF | VGF nerve growth factor inducible | 0.0285791 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0284888 |
| TBC1D5 | TBC1 domain family, member 5 | 0.028482 |
| COG5 | component of oligomeric golgi complex 5 | 0.028115 |
| SVIL | supervillin | 0.0280523 |
| SIK3 | SIK family kinase 3 | 0.0279343 |
| HDAC4 | histone deacetylase 4 | 0.027921 |
| RPL14 | ribosomal protein L14 | 0.027921 |
| LDHA | lactate dehydrogenase A | 0.0279106 |
| RUNX1 | runt-related transcription factor 1 | 0.0274104 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.027323 |
| CDCP1 | CUB domain containing protein 1 | 0.0273014 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0271964 |
| JAK1 | Janus kinase 1 | 0.0271693 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0269764 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0268196 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0268117 |
| RPL26 | ribosomal protein L26 | 0.0267919 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0267189 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC16 | mucin 16, cell surface associated | -0.127005 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.103725 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0851059 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0824683 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0774324 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0609612 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0590768 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0575745 |
| SLMAP | sarcolemma associated protein | -0.0557039 |
| KIF13B | kinesin family member 13B | -0.0532674 |
| POTEF | POTE ankyrin domain family, member F | -0.0532356 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0507805 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0499487 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0483657 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0482603 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0468528 |
| GRB10 | growth factor receptor-bound protein 10 | -0.046152 |
| TMEM165 | transmembrane protein 165 | -0.045556 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0453034 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0444125 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0442075 |
| NDRG1 | N-myc downstream regulated 1 | -0.0430763 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0429089 |
| SCEL | sciellin | -0.0422339 |
| SBF2 | SET binding factor 2 | -0.0419718 |
| FTL | ferritin, light polypeptide | -0.0413998 |
| FOSL2 | FOS-like antigen 2 | -0.041256 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.0412175 |
| NCOR2 | nuclear receptor corepressor 2 | -0.040804 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0406804 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0406189 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0404242 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0397131 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0395162 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0390871 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0387133 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0385532 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0374404 |
| IWS1 | IWS1 homolog (S. cerevisiae) | -0.0370034 |
| CCNL1 | cyclin L1 | -0.0367031 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0363267 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0360829 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0356923 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0355275 |
| LMO7 | LIM domain 7 | -0.0352779 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | -0.0351219 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0351216 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0346155 |
| TGFA | transforming growth factor, alpha | -0.0344057 |
| MYOF | myoferlin | -0.0343078 |
| TPCN1 | two pore segment channel 1 | -0.0341663 |
| ATP13A3 | ATPase type 13A3 | -0.0340121 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0337894 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0337774 |
| RORA | RAR-related orphan receptor A | -0.033534 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0334869 |
| PREPL | prolyl endopeptidase-like | -0.0332929 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0331792 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0326127 |
| PLSCR1 | phospholipid scramblase 1 | -0.0325476 |
| HDAC8 | histone deacetylase 8 | -0.0323736 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0323031 |
| WASF2 | WAS protein family, member 2 | -0.0321757 |
| HDLBP | high density lipoprotein binding protein | -0.0321552 |
| GOLGA3 | golgin A3 | -0.0318188 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0317933 |
| PGK1 | phosphoglycerate kinase 1 | -0.0317895 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -0.0317643 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0316332 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | -0.0316263 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0315005 |
| CLDN7 | claudin 7 | -0.0312089 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0312004 |
| MCU | mitochondrial calcium uniporter | -0.0310735 |
| MED13 | mediator complex subunit 13 | -0.0308165 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0307188 |
| PMM2 | phosphomannomutase 2 | -0.0302998 |
| CREBBP | CREB binding protein | -0.0302612 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.030207 |
| EXT1 | exostosin glycosyltransferase 1 | -0.029937 |
| ATOSA | atos homolog A | -0.0299197 |
| IL1RN | interleukin 1 receptor antagonist | -0.0293572 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0287895 |
| SRP54 | signal recognition particle 54kDa | -0.0287689 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0286531 |
| USP3 | ubiquitin specific peptidase 3 | -0.0284133 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0283613 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.02823 |
| SPAG9 | sperm associated antigen 9 | -0.0280808 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0279086 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0278957 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0276558 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0275729 |
| FAM107B | family with sequence similarity 107, member B | -0.0275512 |
| MLPH | melanophilin | -0.0274632 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0274217 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0268864 |
| PCNX1 | pecanex 1 | -0.0268776 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0268641 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0268453 |
