Volasertib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Volasertib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Volasertib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0869216
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0656108
RAD51B RAD51 paralog B 0.0635775
GPHN gephyrin 0.0607609
PDE4D phosphodiesterase 4D, cAMP-specific 0.0595092
THSD4 thrombospondin, type I, domain containing 4 0.0594968
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0566893
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0552684
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0539744
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0526383
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0524311
TAS2R14 taste receptor, type 2, member 14 0.0519169
ERRFI1 ERBB receptor feedback inhibitor 1 0.0515328
ZFAND3 zinc finger, AN1-type domain 3 0.0514492
GRAMD1B GRAM domain containing 1B 0.0512267
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0510986
LRPPRC leucine-rich pentatricopeptide repeat containing 0.050106
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0500395
DST dystonin 0.0482088
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0480295
INTS6 integrator complex subunit 6 0.0466981
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0460335
EXOC4 exocyst complex component 4 0.0448957
PRELID2 PRELI domain containing 2 0.0416251
MACF1 microtubule-actin crosslinking factor 1 0.0394511
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0393229
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0393154
RIMS2 regulating synaptic membrane exocytosis 2 0.0387799
PRKCE protein kinase C, epsilon 0.0381668
ZSWIM6 zinc finger, SWIM-type containing 6 0.0371794
SMYD3 SET and MYND domain containing 3 0.0371656
SAMD4A sterile alpha motif domain containing 4A 0.0365839
HOMER1 homer scaffolding protein 1 0.0363925
WWOX WW domain containing oxidoreductase 0.0358945
AEBP2 AE binding protein 2 0.0353833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0349145
MCL1 myeloid cell leukemia 1 0.0345976
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0343228
RABGAP1L RAB GTPase activating protein 1-like 0.0327961
SND1 staphylococcal nuclease and tudor domain containing 1 0.032752
ANO6 anoctamin 6 0.0319192
HSPA8 heat shock 70kDa protein 8 0.031632
TRIO trio Rho guanine nucleotide exchange factor 0.0314261
AFF3 AF4/FMR2 family, member 3 0.0306642
RAB7A RAB7A, member RAS oncogene family 0.0304
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.030395
TRIP12 thyroid hormone receptor interactor 12 0.0302643
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0296329
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0295171
FMNL2 formin-like 2 0.0294902
SPIDR scaffolding protein involved in DNA repair 0.0290814
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0287695
ELL2 elongation factor, RNA polymerase II, 2 0.0286778
CAMKMT calmodulin-lysine N-methyltransferase 0.0285777
FAF1 Fas (TNFRSF6) associated factor 1 0.0282504
OSMR oncostatin M receptor 0.0275225
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0272386
SFPQ splicing factor proline/glutamine-rich 0.0272317
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0270284
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.026497
ANK2 ankyrin 2, neuronal 0.0264318
FUS FUS RNA binding protein 0.0263959
IGF1R insulin-like growth factor 1 receptor 0.0259048
IPO7 importin 7 0.0252693
FNIP1 folliculin interacting protein 1 0.0252635
USP34 ubiquitin specific peptidase 34 0.0251245
KIAA1328 KIAA1328 0.02463
ATP11A ATPase, class VI, type 11A 0.0245702
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0243902
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0240023
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0236282
RRM2 ribonucleotide reductase M2 0.0232347
ZCCHC7 zinc finger, CCHC domain containing 7 0.0229423
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.022896
MIPOL1 mirror-image polydactyly 1 0.0225766
DENND1A DENN/MADD domain containing 1A 0.0224516
EXOC6B exocyst complex component 6B 0.0222579
PRH1 proline-rich protein HaeIII subfamily 1 0.0218904
GMDS GDP-mannose 4,6-dehydratase 0.0217385
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0216579
MBD5 methyl-CpG binding domain protein 5 0.0216316
DOCK1 dedicator of cytokinesis 1 0.0211249
TTC28 tetratricopeptide repeat domain 28 0.0210517
FBXL17 F-box and leucine-rich repeat protein 17 0.0210003
NF1 neurofibromin 1 0.0209179
DOCK5 dedicator of cytokinesis 5 0.0208851
RERE arginine-glutamic acid dipeptide (RE) repeats 0.020875
HDAC4 histone deacetylase 4 0.0206595
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0205582
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0201949
APP amyloid beta (A4) precursor protein 0.0201211
LARP4B La ribonucleoprotein domain family, member 4B 0.0199143
HMGA2 high mobility group AT-hook 2 0.0195949
WNT2B wingless-type MMTV integration site family, member 2B 0.0192878
SIK3 SIK family kinase 3 0.0191833
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0191502
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.01915
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0191489
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0191331
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0190827

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.297774
TMSB10 thymosin beta 10 -0.109718
VIM vimentin -0.0955696
PTMA prothymosin, alpha -0.0920187
EGR1 early growth response 1 -0.0753486
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0647856
PFN1 profilin 1 -0.0643111
POTEF POTE ankyrin domain family, member F -0.0627882
TPI1 triosephosphate isomerase 1 -0.0597463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0557774
YBX3 Y box binding protein 3 -0.0541115
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0493602
RPL35A ribosomal protein L35a -0.0449258
RPS27 ribosomal protein S27 -0.0420877
RPLP1 ribosomal protein, large, P1 -0.0414868
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0380494
RPL23 ribosomal protein L23 -0.0375093
RPS8 ribosomal protein S8 -0.0370758
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0365939
MT2A metallothionein 2A -0.0356028
RPS19 ribosomal protein S19 -0.0355474
FTL ferritin, light polypeptide -0.0353551
TPM2 tropomyosin 2 (beta) -0.0353023
RSF1 remodeling and spacing factor 1 -0.0351549
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0348842
RPS21 ribosomal protein S21 -0.0347137
HMGA1 high mobility group AT-hook 1 -0.0333869
RPS6 ribosomal protein S6 -0.0328435
WASF2 WAS protein family, member 2 -0.0321152
KMT2A lysine (K)-specific methyltransferase 2A -0.0319159
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0312099
RPL8 ribosomal protein L8 -0.0305409
IGF2 insulin-like growth factor 2 -0.0295812
GNAS GNAS complex locus -0.0295802
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0290404
LOC102724023 ES1 protein homolog, mitochondrial -0.0289288
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.028609
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0285846
WSB1 WD repeat and SOCS box containing 1 -0.0282567
KDM2A lysine (K)-specific demethylase 2A -0.0282464
PTMS parathymosin -0.0277317
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0272507
PDIA3 protein disulfide isomerase family A, member 3 -0.0271889
RPL11 ribosomal protein L11 -0.0265034
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0264135
LATS2 large tumor suppressor kinase 2 -0.0263616
MYL12B myosin, light chain 12B, regulatory -0.0260232
RPL12 ribosomal protein L12 -0.0258974
RPLP0 ribosomal protein, large, P0 -0.0253149
TAGLN2 transgelin 2 -0.0250948
BSG basigin (Ok blood group) -0.0247574
ATP5F1B ATP synthase F1 subunit beta -0.0246892
TMEM165 transmembrane protein 165 -0.0245233
BASP1 brain abundant, membrane attached signal protein 1 -0.0240914
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0234478
YBX1 Y box binding protein 1 -0.0234262
LOC112694756 uncharaterized LOC112694756 -0.0233835
GATAD2B GATA zinc finger domain containing 2B -0.023267
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0231861
RBM25 RNA binding motif protein 25 -0.023088
CBX3 chromobox homolog 3 -0.0229434
RPL34 ribosomal protein L34 -0.0224826
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0223511
RPL36 ribosomal protein L36 -0.0223413
TXNRD1 thioredoxin reductase 1 -0.0223221
RPS15 ribosomal protein S15 -0.0221056
HLA-B major histocompatibility complex, class I, B -0.0220822
ACTG1 actin gamma 1 -0.0218411
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0215531
HDGF hepatoma-derived growth factor -0.0206665
S100A6 S100 calcium binding protein A6 -0.0205289
RPS29 ribosomal protein S29 -0.0205182
RPS14 ribosomal protein S14 -0.0203266
SRRM2 serine/arginine repetitive matrix 2 -0.020109
SMC4 structural maintenance of chromosomes 4 -0.0200233
TPM4 tropomyosin 4 -0.0199143
EEF2 eukaryotic translation elongation factor 2 -0.0198855
SCAF11 SR-related CTD-associated factor 11 -0.0198057
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0197387
PHIP pleckstrin homology domain interacting protein -0.0195774
RPL28 ribosomal protein L28 -0.0195625
RPLP2 ribosomal protein, large, P2 -0.0195097
MIS18BP1 MIS18 binding protein 1 -0.0195036
PKM pyruvate kinase, muscle -0.0193441
BBX bobby sox homolog (Drosophila) -0.0192985
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0191623
EIF1 eukaryotic translation initiation factor 1 -0.0190461
LDHA lactate dehydrogenase A -0.0188794
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0187214
CCNL1 cyclin L1 -0.0184927
KLF6 Kruppel-like factor 6 -0.0184686
LDHB lactate dehydrogenase B -0.0183648
RPL35 ribosomal protein L35 -0.0183128
RNF38 ring finger protein 38 -0.0183082
ZMYND8 zinc finger, MYND-type containing 8 -0.0183071
SEPTIN7 septin 7 -0.0182791
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0182551
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0182006
DEK DEK proto-oncogene -0.0180909
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0180075