| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Volasertib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.133404 |
| FHIT | fragile histidine triad | 0.0928609 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0684196 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0661251 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0656492 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0600506 |
| EXT1 | exostosin glycosyltransferase 1 | 0.058116 |
| NAV2 | neuron navigator 2 | 0.0575295 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0571765 |
| PTK2 | protein tyrosine kinase 2 | 0.0556237 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0553186 |
| DTNA | dystrobrevin, alpha | 0.0551347 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0542027 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0500882 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0490717 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0487836 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0486769 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0476585 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0464294 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0455165 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0442599 |
| CANX | calnexin | 0.0428776 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0419767 |
| RYBP | RING1 and YY1 binding protein | 0.0401183 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0390209 |
| KIAA1217 | KIAA1217 | 0.0385781 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0374773 |
| INTS6 | integrator complex subunit 6 | 0.0374381 |
| SQSTM1 | sequestosome 1 | 0.0365173 |
| SGMS2 | sphingomyelin synthase 2 | 0.0364347 |
| BRD2 | bromodomain containing 2 | 0.0362066 |
| DST | dystonin | 0.035732 |
| DSPP | dentin sialophosphoprotein | 0.035686 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0353416 |
| RPL4 | ribosomal protein L4 | 0.0352569 |
| ENO1 | enolase 1, (alpha) | 0.0336478 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0333323 |
| SDC4 | syndecan 4 | 0.0330236 |
| TXNRD1 | thioredoxin reductase 1 | 0.0324679 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0314758 |
| GPHN | gephyrin | 0.0309955 |
| LAMC2 | laminin, gamma 2 | 0.0309403 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0306156 |
| RAD51B | RAD51 paralog B | 0.0305799 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0305251 |
| SMAD3 | SMAD family member 3 | 0.030279 |
| RPLP0 | ribosomal protein, large, P0 | 0.0294188 |
| RPL14 | ribosomal protein L14 | 0.028612 |
| STEAP4 | STEAP family member 4 | 0.0286094 |
| TPD52 | tumor protein D52 | 0.0285409 |
| PALLD | palladin, cytoskeletal associated protein | 0.028462 |
| PLEC | plectin | 0.0280818 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0279095 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0278012 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0277902 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.027643 |
| AHNAK | AHNAK nucleoprotein | 0.0276212 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0274292 |
| HDAC9 | histone deacetylase 9 | 0.0272696 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0271835 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0270243 |
| FNIP1 | folliculin interacting protein 1 | 0.0268792 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0267503 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0264009 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0261474 |
| RUNX1 | runt-related transcription factor 1 | 0.0257876 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0254396 |
| SMYD3 | SET and MYND domain containing 3 | 0.0254265 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0252055 |
| APP | amyloid beta (A4) precursor protein | 0.0251772 |
| RNF213 | ring finger protein 213 | 0.0251746 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0251703 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0250996 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0250191 |
| TFRC | transferrin receptor | 0.0250081 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0249005 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0248745 |
| TUFT1 | tuftelin 1 | 0.0248545 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0243273 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0241889 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0239891 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0238176 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0234954 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0232184 |
| VGLL3 | vestigial-like family member 3 | 0.0231538 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0230384 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0228919 |
| PLSCR1 | phospholipid scramblase 1 | 0.0228347 |
| YBX1 | Y box binding protein 1 | 0.0228295 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0224647 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0223113 |
| VCL | vinculin | 0.022203 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0221883 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0221128 |
| SCFD1 | sec1 family domain containing 1 | 0.0220524 |
| MYO5B | myosin VB | 0.0220121 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0219087 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0217535 |
| ANKRD17 | ankyrin repeat domain 17 | 0.021616 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0214492 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.198476 |
| POTEF | POTE ankyrin domain family, member F | -0.179419 |
| FTL | ferritin, light polypeptide | -0.141809 |
| FN1 | fibronectin 1 | -0.112342 |
| TMSB10 | thymosin beta 10 | -0.111386 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0951275 |
| ACTG1 | actin gamma 1 | -0.0907486 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0842223 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0837861 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0833188 |
| LMO7 | LIM domain 7 | -0.0820316 |
| FAM3C | family with sequence similarity 3, member C | -0.0664195 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.063145 |
| NDRG1 | N-myc downstream regulated 1 | -0.0630854 |
| MYO6 | myosin VI | -0.0624911 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0619089 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0601675 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0599381 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0586639 |
| CD2AP | CD2-associated protein | -0.0586175 |
| FBXO32 | F-box protein 32 | -0.0566716 |
| TPM4 | tropomyosin 4 | -0.0565164 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0557068 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0552257 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0531267 |
| ASPH | aspartate beta-hydroxylase | -0.0524539 |
| ERBIN | erbb2 interacting protein | -0.0520381 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0511468 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0510853 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0508143 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0507613 |
| TMEM165 | transmembrane protein 165 | -0.0505053 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0503597 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0491893 |
| TOP1 | topoisomerase (DNA) I | -0.0482204 |
| S100A6 | S100 calcium binding protein A6 | -0.0477754 |
| WASF2 | WAS protein family, member 2 | -0.0473546 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0466216 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0465563 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.04536 |
| MXD1 | MAX dimerization protein 1 | -0.0441848 |
| RNF145 | ring finger protein 145 | -0.0440887 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0439404 |
| CCND1 | cyclin D1 | -0.0435933 |
| COPA | coatomer protein complex, subunit alpha | -0.0435043 |
| HLA-A | major histocompatibility complex, class I, A | -0.0434296 |
| UBC | ubiquitin C | -0.0426851 |
| RBM25 | RNA binding motif protein 25 | -0.0426031 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0425567 |
| CSTB | cystatin B (stefin B) | -0.041445 |
| SLMAP | sarcolemma associated protein | -0.0398169 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.039641 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0393973 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0390346 |
| GNAS | GNAS complex locus | -0.0389331 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0386684 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0382562 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0379908 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0379872 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0376673 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0372488 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0365296 |
| RBM39 | RNA binding motif protein 39 | -0.0358967 |
| PGK1 | phosphoglycerate kinase 1 | -0.0357431 |
| TMF1 | TATA element modulatory factor 1 | -0.0354937 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0354819 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0353966 |
| VIM | vimentin | -0.0351906 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0346105 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0345504 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0340234 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0339836 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0339055 |
| TMEM263 | transmembrane protein 263 | -0.0336594 |
| HMGA1 | high mobility group AT-hook 1 | -0.0334558 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0324125 |
| SETD5 | SET domain containing 5 | -0.0321201 |
| JMJD1C | jumonji domain containing 1C | -0.0312552 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.031173 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0309789 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0306649 |
| TFG | TRK-fused gene | -0.0301438 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0300661 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0299405 |
| LAMB3 | laminin, beta 3 | -0.0293829 |
| CCNL1 | cyclin L1 | -0.0292823 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0290386 |
| AREG | amphiregulin | -0.0288227 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0283232 |
| JUP | junction plakoglobin | -0.0281302 |
| YY1 | YY1 transcription factor | -0.0279602 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0278114 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0275866 |
| S100A10 | S100 calcium binding protein A10 | -0.0274383 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0271898 |
| YTHDC1 | YTH domain containing 1 | -0.026973 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0267549 |
| HLA-B | major histocompatibility complex, class I, B | -0.0263682 |
| CTSD | cathepsin D | -0.0258565 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.025809 |
