| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Volasertib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.155407 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.140647 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.126411 |
| EFNA5 | ephrin-A5 | 0.119205 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.107305 |
| PDE10A | phosphodiesterase 10A | 0.106126 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.103755 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.103195 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.100352 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0999484 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0958634 |
| GRAMD1B | GRAM domain containing 1B | 0.0953301 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0889654 |
| GDA | guanine deaminase | 0.0848617 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0837407 |
| KYNU | kynureninase | 0.0824188 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0814725 |
| EZR | ezrin | 0.0803305 |
| MYOF | myoferlin | 0.0779735 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0775495 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0755927 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0682779 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0664407 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0648774 |
| CD44 | CD44 molecule (Indian blood group) | 0.0634486 |
| SMAD2 | SMAD family member 2 | 0.0633814 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.063302 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0620053 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.061093 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0610049 |
| FNIP1 | folliculin interacting protein 1 | 0.0595119 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0584782 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0580165 |
| FMNL2 | formin-like 2 | 0.0577535 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0561816 |
| MCL1 | myeloid cell leukemia 1 | 0.0553032 |
| CD109 | CD109 molecule | 0.0537331 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0529996 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0522436 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0521627 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0518673 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0516913 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0511402 |
| B2M | beta-2-microglobulin | 0.0489668 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0485853 |
| LDHA | lactate dehydrogenase A | 0.0480057 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0474493 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0468532 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0464983 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0464184 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0458425 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0445031 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.043634 |
| JMJD1C | jumonji domain containing 1C | 0.0434689 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0432476 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0427201 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0416694 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0412275 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0411616 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0410306 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0409989 |
| OSMR | oncostatin M receptor | 0.0409144 |
| CDH13 | cadherin 13 | 0.0408437 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0407498 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0400417 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0397261 |
| ABLIM1 | actin binding LIM protein 1 | 0.0397259 |
| ANXA2 | annexin A2 | 0.0395301 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0392407 |
| FAM107B | family with sequence similarity 107, member B | 0.0382829 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0377913 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0377735 |
| ENO1 | enolase 1, (alpha) | 0.0376049 |
| GPHN | gephyrin | 0.0372639 |
| PYGL | phosphorylase, glycogen, liver | 0.0371664 |
| SQSTM1 | sequestosome 1 | 0.0371216 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0369872 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0368225 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0363276 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0362316 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0362175 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0358896 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0358624 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0357732 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0353501 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0347027 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0346404 |
| CANX | calnexin | 0.0345101 |
| COL4A5 | collagen, type IV, alpha 5 | 0.034508 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.034496 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0342022 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0339459 |
| OXSR1 | oxidative stress responsive 1 | 0.0337378 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0335889 |
| USP34 | ubiquitin specific peptidase 34 | 0.0335427 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0334723 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0331397 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0329992 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0327236 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0326761 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.0649658 |
| FTL | ferritin, light polypeptide | -0.0624903 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0610069 |
| FN1 | fibronectin 1 | -0.0520894 |
| PTMA | prothymosin, alpha | -0.0452099 |
| RPL9 | ribosomal protein L9 | -0.0363847 |
| RPL37A | ribosomal protein L37a | -0.0300371 |
| TMSB10 | thymosin beta 10 | -0.0295197 |
| NEK7 | NIMA-related kinase 7 | -0.0290264 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0286323 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0277904 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.027456 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0268629 |
| LAMA5 | laminin, alpha 5 | -0.0264882 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0258793 |
| RPLP2 | ribosomal protein, large, P2 | -0.0254147 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0241695 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0234282 |
| RPS3 | ribosomal protein S3 | -0.0212555 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0211552 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0204526 |
| RPS29 | ribosomal protein S29 | -0.0196791 |
| RPS13 | ribosomal protein S13 | -0.0192699 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0186945 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0181079 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0180704 |
| OGA | O-GlcNAcase | -0.0176834 |
| CTSC | cathepsin C | -0.0171738 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0171563 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0170461 |
| GNAS | GNAS complex locus | -0.0167936 |
| RPL31 | ribosomal protein L31 | -0.0167705 |
| TBXT | T-box transcription factor T | -0.0152492 |
| NCKAP5 | NCK-associated protein 5 | -0.0150444 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0150225 |
| RPL35A | ribosomal protein L35a | -0.0148817 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0145007 |
| RPL13A | ribosomal protein L13a | -0.0144399 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.013969 |
| NEDD1 | neural precursor cell expressed, developmentally down-regulated 1 | -0.0138947 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.013797 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0132269 |
| PRDX1 | peroxiredoxin 1 | -0.0132211 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0131387 |
| LIN7A | lin-7 homolog A (C. elegans) | -0.012677 |
| NDRG1 | N-myc downstream regulated 1 | -0.0123035 |
| HBP1 | HMG-box transcription factor 1 | -0.0122757 |
| USP3 | ubiquitin specific peptidase 3 | -0.0121948 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0121518 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0118021 |
| SLCO1C1 | solute carrier organic anion transporter family, member 1C1 | -0.0116564 |
| RBM39 | RNA binding motif protein 39 | -0.0115845 |
| LYPLAL1 | lysophospholipase-like 1 | -0.0115591 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0113709 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0112659 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0107743 |
| PFN1 | profilin 1 | -0.0107627 |
| PHIP | pleckstrin homology domain interacting protein | -0.0106342 |
| RPS24 | ribosomal protein S24 | -0.0105323 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.0104569 |
| COX7B | cytochrome c oxidase subunit VIIb | -0.0104058 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0103688 |
| RPL28 | ribosomal protein L28 | -0.0102351 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0101445 |
| NOTCH3 | notch 3 | -0.0100324 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0100104 |
| RPS12 | ribosomal protein S12 | -0.00988936 |
| PERP | PERP, TP53 apoptosis effector | -0.00981329 |
| TMEM165 | transmembrane protein 165 | -0.00980345 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00979127 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.00974897 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.00971257 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0096055 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.00955467 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.00949589 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.00926831 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.00920237 |
| RBMX | RNA binding motif protein, X-linked | -0.00915022 |
| RPS11 | ribosomal protein S11 | -0.00914255 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00913563 |
| AGR2 | anterior gradient 2 | -0.00911044 |
| GSTP1 | glutathione S-transferase pi 1 | -0.00907476 |
| PDE8A | phosphodiesterase 8A | -0.00905099 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.00901461 |
| KLHL24 | kelch-like family member 24 | -0.00891353 |
| NRCAM | neuronal cell adhesion molecule | -0.00885866 |
| RTN1 | reticulon 1 | -0.00860352 |
| GLCCI1 | glucocorticoid induced 1 | -0.00859425 |
| RPS19 | ribosomal protein S19 | -0.00847268 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0084662 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00844076 |
| RPS23 | ribosomal protein S23 | -0.00841075 |
| RPS27A | ribosomal protein S27a | -0.0083057 |
| LASP1 | LIM and SH3 protein 1 | -0.0083008 |
| FSTL4 | follistatin-like 4 | -0.0082979 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00819791 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00812427 |
| PTGR1 | prostaglandin reductase 1 | -0.00791186 |
| RPS25 | ribosomal protein S25 | -0.00786892 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.007792 |
