| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Volasertib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Volasertib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.251109 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.178197 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.152677 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.145824 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.12372 |
| FNDC3B | fibronectin type III domain containing 3B | 0.119576 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.103422 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.089818 |
| ITGAV | integrin, alpha V | 0.0857128 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0818728 |
| NTM | neurotrimin | 0.0789533 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0729094 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0726837 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0724842 |
| PCDH9 | protocadherin 9 | 0.0645844 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0619565 |
| LRRC4C | leucine rich repeat containing 4C | 0.0618307 |
| TENM3 | teneurin transmembrane protein 3 | 0.0614457 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0604126 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0602789 |
| PHIP | pleckstrin homology domain interacting protein | 0.0587966 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0583727 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.058349 |
| ATXN2 | ataxin 2 | 0.0566922 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.054704 |
| PRTG | protogenin | 0.0541069 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 0.0534872 |
| DST | dystonin | 0.0530798 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0530506 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0522098 |
| RASAL2 | RAS protein activator like 2 | 0.0521543 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0514816 |
| PLPP1 | phospholipid phosphatase 1 | 0.0506254 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.050248 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0498831 |
| ANK2 | ankyrin 2, neuronal | 0.0489462 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0489014 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0482123 |
| PGK1 | phosphoglycerate kinase 1 | 0.0478067 |
| FOXP2 | forkhead box P2 | 0.04768 |
| SNX6 | sorting nexin 6 | 0.0475286 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0472269 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0470973 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0465848 |
| COL5A2 | collagen, type V, alpha 2 | 0.046123 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0456627 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0444734 |
| SRPK2 | SRSF protein kinase 2 | 0.0441118 |
| NHSL1 | NHS-like 1 | 0.0434146 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.042937 |
| RPS12 | ribosomal protein S12 | 0.0424677 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0422633 |
| WWC2 | WW and C2 domain containing 2 | 0.0416577 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0415329 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0413949 |
| CDC14A | cell division cycle 14A | 0.041123 |
| CADM2 | cell adhesion molecule 2 | 0.0409465 |
| UTRN | utrophin | 0.0407792 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0407088 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0404312 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0398877 |
| GPHN | gephyrin | 0.0396757 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0396597 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0391366 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0384945 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0381051 |
| USP25 | ubiquitin specific peptidase 25 | 0.0375349 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0374594 |
| B2M | beta-2-microglobulin | 0.0374079 |
| PCDH7 | protocadherin 7 | 0.0367952 |
| ZNF638 | zinc finger protein 638 | 0.0367272 |
| USP34 | ubiquitin specific peptidase 34 | 0.0365108 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0363869 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0362416 |
| RBM20 | RNA binding motif protein 20 | 0.0360393 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0356752 |
| SBF2 | SET binding factor 2 | 0.035606 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.035208 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0351408 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0351396 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0349651 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0347374 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0346532 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0343515 |
| NCKAP1 | NCK-associated protein 1 | 0.0343026 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0342931 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0340494 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0339511 |
| SMYD3 | SET and MYND domain containing 3 | 0.0336998 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0336113 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0331869 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.032178 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0321595 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0321242 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0319724 |
| PCDH18 | protocadherin 18 | 0.0318052 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0315211 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0314588 |
| NFIA | nuclear factor I/A | 0.0314457 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0313172 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0768741 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0687325 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0601376 |
| PEG10 | paternally expressed 10 | -0.0589135 |
| VIM | vimentin | -0.0572896 |
| ACTG1 | actin gamma 1 | -0.0548045 |
| THBS1 | thrombospondin 1 | -0.0498905 |
| CENPF | centromere protein F, 350/400kDa | -0.0438294 |
| HMGB2 | high mobility group box 2 | -0.037875 |
| ACTN4 | actinin, alpha 4 | -0.0369398 |
| POTEF | POTE ankyrin domain family, member F | -0.0335075 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0321575 |
| EMP1 | epithelial membrane protein 1 | -0.0317452 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0300539 |
| TMSB4X | thymosin beta 4, X-linked | -0.0291682 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0290167 |
| CBX3 | chromobox homolog 3 | -0.027562 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0274819 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0272382 |
| HMGA1 | high mobility group AT-hook 1 | -0.0264442 |
| RPLP1 | ribosomal protein, large, P1 | -0.0254627 |
| MKI67 | marker of proliferation Ki-67 | -0.0243105 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0240327 |
| PFN1 | profilin 1 | -0.0238762 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0236339 |
| RTN4 | reticulon 4 | -0.023461 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0231048 |
| HMGB1 | high mobility group box 1 | -0.022709 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.022614 |
| ANXA2 | annexin A2 | -0.0220858 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0215813 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -0.0215107 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0196777 |
| RPL12 | ribosomal protein L12 | -0.0195959 |
| DEK | DEK proto-oncogene | -0.019389 |
| RPL7 | ribosomal protein L7 | -0.0191464 |
| TPI1 | triosephosphate isomerase 1 | -0.0189836 |
| TFRC | transferrin receptor | -0.0189422 |
| POU3F2 | POU class 3 homeobox 2 | -0.0188889 |
| CAVIN1 | caveolae associated protein 1 | -0.0187991 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0187553 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0186908 |
| TMEM123 | transmembrane protein 123 | -0.0186279 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0185713 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0185081 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0184912 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.018447 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0182852 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0179029 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0177358 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0175743 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0175592 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0175187 |
| RBM25 | RNA binding motif protein 25 | -0.0173434 |
| RPL23 | ribosomal protein L23 | -0.0173007 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0171965 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0169974 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0169661 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0169007 |
| ZNF385D | zinc finger protein 385D | -0.0167136 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0166865 |
| AHNAK | AHNAK nucleoprotein | -0.0165346 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0165275 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0165028 |
| USP3 | ubiquitin specific peptidase 3 | -0.0164905 |
| CAPNS1 | calpain, small subunit 1 | -0.0161954 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0161601 |
| MTF2 | metal response element binding transcription factor 2 | -0.0159544 |
| FBL | fibrillarin | -0.0158728 |
| RPS4X | ribosomal protein S4, X-linked | -0.0158697 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0156641 |
| RPL35A | ribosomal protein L35a | -0.0156509 |
| MCM4 | minichromosome maintenance complex component 4 | -0.0156138 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0155921 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0155488 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0155394 |
| VBP1 | von Hippel-Lindau binding protein 1 | -0.015535 |
| CENPE | centromere protein E, 312kDa | -0.0154031 |
| RPS27A | ribosomal protein S27a | -0.0152933 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0152388 |
| POMP | proteasome maturation protein | -0.0151927 |
| GANAB | glucosidase, alpha; neutral AB | -0.014973 |
| GNAS | GNAS complex locus | -0.0147606 |
| USP15 | ubiquitin specific peptidase 15 | -0.0147192 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.014694 |
| YBX1 | Y box binding protein 1 | -0.0146738 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0145958 |
| SNU13 | small nuclear ribonucleoprotein 13 | -0.0145377 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.014462 |
| MYL9 | myosin, light chain 9, regulatory | -0.0144545 |
| TXNRD1 | thioredoxin reductase 1 | -0.0144229 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0143811 |
| CUL4B | cullin 4B | -0.0143676 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0143178 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0142464 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.0142447 |
| RPLP0 | ribosomal protein, large, P0 | -0.014235 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0142343 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | -0.0141605 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0141382 |
