Volasertib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Volasertib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Volasertib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.242263
COL6A3 collagen, type VI, alpha 3 0.167117
ERRFI1 ERBB receptor feedback inhibitor 1 0.105664
ELL2 elongation factor, RNA polymerase II, 2 0.0749762
NRXN3 neurexin 3 0.0682893
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0671056
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.06493
TENT5A terminal nucleotidyltransferase 5A 0.0637901
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0589715
HOOK2 hook microtubule-tethering protein 2 0.0586707
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.051185
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0491216
FNIP1 folliculin interacting protein 1 0.0482688
TRIO trio Rho guanine nucleotide exchange factor 0.0455405
BACE2 beta-site APP-cleaving enzyme 2 0.0436072
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0433014
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0420671
TRA2A transformer 2 alpha homolog (Drosophila) 0.0405985
FAM13A family with sequence similarity 13, member A 0.0399271
B2M beta-2-microglobulin 0.0395341
PRELID2 PRELI domain containing 2 0.038952
DLG1 discs, large homolog 1 (Drosophila) 0.0364567
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0359507
AFF4 AF4/FMR2 family, member 4 0.0338468
SND1 staphylococcal nuclease and tudor domain containing 1 0.0336766
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.033429
GOLGB1 golgin B1 0.0331643
VEGFA vascular endothelial growth factor A 0.0328175
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0326242
ATP13A3 ATPase type 13A3 0.0321601
ARRDC3 arrestin domain containing 3 0.0314358
ZBTB20 zinc finger and BTB domain containing 20 0.0313818
FER fer (fps/fes related) tyrosine kinase 0.0310808
KMT2C lysine (K)-specific methyltransferase 2C 0.0298995
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0296617
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0295378
EFNA5 ephrin-A5 0.0293999
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0291509
GARS1 glycyl-tRNA synthetase 1 0.0291141
NBAS neuroblastoma amplified sequence 0.0279712
ZCCHC7 zinc finger, CCHC domain containing 7 0.027766
ZSWIM6 zinc finger, SWIM-type containing 6 0.0277517
RYBP RING1 and YY1 binding protein 0.0276067
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0274011
NPTN neuroplastin 0.0268486
SOD2 superoxide dismutase 2, mitochondrial 0.0267786
MARCHF7 membrane associated ring-CH-type finger 7 0.0267367
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.026645
PDGFC platelet derived growth factor C 0.0263927
TTC3 tetratricopeptide repeat domain 3 0.02605
CADM1 cell adhesion molecule 1 0.0260379
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0259749
AKAP9 A kinase (PRKA) anchor protein 9 0.025824
SAMD4A sterile alpha motif domain containing 4A 0.0257497
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.025595
USP9X ubiquitin specific peptidase 9, X-linked 0.0248722
GLIS3 GLIS family zinc finger 3 0.0248341
RICTOR RPTOR independent companion of MTOR, complex 2 0.0244141
WDFY3 WD repeat and FYVE domain containing 3 0.0241499
IFRD1 interferon-related developmental regulator 1 0.0241404
WNT5A wingless-type MMTV integration site family, member 5A 0.0241189
MBD5 methyl-CpG binding domain protein 5 0.0241165
CXCL8 chemokine (C-X-C motif) ligand 8 0.0240982
FTH1 ferritin, heavy polypeptide 1 0.0238902
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0236986
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0235345
FXR1 fragile X mental retardation, autosomal homolog 1 0.0234874
SUCO SUN domain containing ossification factor 0.0232479
SFPQ splicing factor proline/glutamine-rich 0.0231181
RNF145 ring finger protein 145 0.0229294
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0228029
UBA6 ubiquitin-like modifier activating enzyme 6 0.0224728
OPTN optineurin 0.0221139
TMEM167A transmembrane protein 167A 0.0220418
HMGA2 high mobility group AT-hook 2 0.022026
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0219949
LPP LIM domain containing preferred translocation partner in lipoma 0.021967
TANK TRAF family member-associated NFKB activator 0.0219304
NDRG1 N-myc downstream regulated 1 0.0219097
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0217111
FAM13B family with sequence similarity 13, member B 0.0216185
MORF4L2 mortality factor 4 like 2 0.0216118
RLF rearranged L-myc fusion 0.0214712
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.021332
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0213028
TENT2 terminal nucleotidyltransferase 2 0.0211498
EXOC4 exocyst complex component 4 0.0211081
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0211063
MYH9 myosin, heavy chain 9, non-muscle 0.0210365
DMTF1 cyclin D binding myb-like transcription factor 1 0.0210313
ARHGAP22 Rho GTPase activating protein 22 0.0210163
COG5 component of oligomeric golgi complex 5 0.0209136
CYLD cylindromatosis (turban tumor syndrome) 0.0204563
COG6 component of oligomeric golgi complex 6 0.0203996
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0200765
PMM2 phosphomannomutase 2 0.0199909
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0197665
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0194648
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0193481
ZNF644 zinc finger protein 644 0.0193115

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.224028
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201975
VIM vimentin -0.18117
MT2A metallothionein 2A -0.154589
PTMA prothymosin, alpha -0.116643
FN1 fibronectin 1 -0.109258
COL1A1 collagen, type I, alpha 1 -0.0858226
COL1A2 collagen, type I, alpha 2 -0.0743065
ENO1 enolase 1, (alpha) -0.0733597
UBC ubiquitin C -0.0720795
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0695361
POTEF POTE ankyrin domain family, member F -0.0683228
TGFBI transforming growth factor, beta-induced, 68kDa -0.0645114
FTL ferritin, light polypeptide -0.0639847
HLA-B major histocompatibility complex, class I, B -0.0633764
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0617307
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0585285
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0561705
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0548349
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0547464
RPL23 ribosomal protein L23 -0.0512357
RPLP1 ribosomal protein, large, P1 -0.0496713
LDHA lactate dehydrogenase A -0.0464275
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0462758
TXNIP thioredoxin interacting protein -0.0459764
GRB10 growth factor receptor-bound protein 10 -0.0441727
F3 coagulation factor III (thromboplastin, tissue factor) -0.0441665
TPM4 tropomyosin 4 -0.0437951
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0434898
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0429534
TPT1 tumor protein, translationally-controlled 1 -0.0422258
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0413572
PDIA3 protein disulfide isomerase family A, member 3 -0.0373044
RRBP1 ribosome binding protein 1 -0.0372475
S100A6 S100 calcium binding protein A6 -0.0365487
S100A10 S100 calcium binding protein A10 -0.0356617
AHNAK AHNAK nucleoprotein -0.0354211
SEPTIN7 septin 7 -0.0345279
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0335885
RPL37A ribosomal protein L37a -0.0334636
SEC61G Sec61 gamma subunit -0.0328619
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0328544
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0327749
HLA-C major histocompatibility complex, class I, C -0.0318759
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0313974
H3-3B H3.3 histone B -0.0312826
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0311743
VDAC1 voltage-dependent anion channel 1 -0.031147
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0309884
LMNA lamin A/C -0.0305359
OAZ1 ornithine decarboxylase antizyme 1 -0.0298035
GNAS GNAS complex locus -0.0291074
RPS8 ribosomal protein S8 -0.0287654
SOS2 son of sevenless homolog 2 (Drosophila) -0.0280088
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.027924
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.027888
CD44 CD44 molecule (Indian blood group) -0.0278154
FKBP10 FK506 binding protein 10, 65 kDa -0.0268894
DDIT4 DNA-damage-inducible transcript 4 -0.0268247
HMGB2 high mobility group box 2 -0.0266828
ITM2B integral membrane protein 2B -0.0265077
FLNB filamin B, beta -0.0259624
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0258608
PKM pyruvate kinase, muscle -0.0258271
RPS23 ribosomal protein S23 -0.025788
WSB1 WD repeat and SOCS box containing 1 -0.0252952
LONP2 lon peptidase 2, peroxisomal -0.0250848
PSD3 pleckstrin and Sec7 domain containing 3 -0.0249291
CAV1 caveolin 1, caveolae protein, 22kDa -0.0249037
RPL37 ribosomal protein L37 -0.0246535
CDK6 cyclin-dependent kinase 6 -0.0245851
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0243886
CKAP4 cytoskeleton-associated protein 4 -0.0240594
DPYD dihydropyrimidine dehydrogenase -0.0240098
PGK1 phosphoglycerate kinase 1 -0.0237705
SRPK2 SRSF protein kinase 2 -0.0235374
ANXA5 annexin A5 -0.0233487
RPS11 ribosomal protein S11 -0.0230128
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0225183
JUN jun proto-oncogene -0.0224765
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0223015
WAC WW domain containing adaptor with coiled-coil -0.0221922
ATP5F1E ATP synthase F1 subunit epsilon -0.022141
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0221333
MT1X metallothionein 1X -0.0221118
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0220402
DEK DEK proto-oncogene -0.0219101
RPL27A ribosomal protein L27a -0.0217121
RPL34 ribosomal protein L34 -0.0215548
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0214705
RPS25 ribosomal protein S25 -0.0211816
PFN1 profilin 1 -0.0211106
NAP1L1 nucleosome assembly protein 1-like 1 -0.0210551
TMEM41B transmembrane protein 41B -0.0210377
GCC2 GRIP and coiled-coil domain containing 2 -0.0209464
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0208798
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0208776
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0207941
RPS13 ribosomal protein S13 -0.0207861
ACTG1 actin gamma 1 -0.0207705