Volasertib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Volasertib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Volasertib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.114547
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.106015
ZSWIM6 zinc finger, SWIM-type containing 6 0.105877
EXT1 exostosin glycosyltransferase 1 0.0867113
TRIO trio Rho guanine nucleotide exchange factor 0.0831225
FNDC3B fibronectin type III domain containing 3B 0.0698845
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0689051
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.068595
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0636842
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0591922
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0559409
FAT1 FAT atypical cadherin 1 0.0544039
ANKRD28 ankyrin repeat domain 28 0.0454007
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0428384
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0399734
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0366067
SAMD4A sterile alpha motif domain containing 4A 0.0361196
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0344723
CTBP2 C-terminal binding protein 2 0.033394
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0313954
FAM13A family with sequence similarity 13, member A 0.0312884
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0312751
DSCAM Down syndrome cell adhesion molecule 0.0306632
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0305588
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0304142
COPA coatomer protein complex, subunit alpha 0.0298189
SIK3 SIK family kinase 3 0.0296758
CD109 CD109 molecule 0.0290704
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0287655
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0285628
ELL2 elongation factor, RNA polymerase II, 2 0.0285142
SUCO SUN domain containing ossification factor 0.0284729
SOD2 superoxide dismutase 2, mitochondrial 0.0279312
INTS6 integrator complex subunit 6 0.0270723
FNIP1 folliculin interacting protein 1 0.0270001
PTK2 protein tyrosine kinase 2 0.0261916
RUNX1 runt-related transcription factor 1 0.0261436
DOCK5 dedicator of cytokinesis 5 0.0255632
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0253527
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0251557
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0246385
MBNL1 muscleblind-like splicing regulator 1 0.0245518
GPATCH2L G patch domain containing 2-like 0.0241601
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0241364
BIRC6 baculoviral IAP repeat containing 6 0.0241077
SND1 staphylococcal nuclease and tudor domain containing 1 0.023554
ATF6 activating transcription factor 6 0.0231192
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0230505
CRY1 cryptochrome circadian clock 1 0.0230057
GPHN gephyrin 0.0227532
TUFT1 tuftelin 1 0.022618
CADM1 cell adhesion molecule 1 0.0225616
ERRFI1 ERBB receptor feedback inhibitor 1 0.0223609
EZR ezrin 0.022253
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.021924
GOLGA4 golgin A4 0.0218947
SEC23A Sec23 homolog A (S. cerevisiae) 0.0217536
COG6 component of oligomeric golgi complex 6 0.0217424
PICALM phosphatidylinositol binding clathrin assembly protein 0.0216901
SMYD3 SET and MYND domain containing 3 0.0216736
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0216069
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0214298
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.021339
HELZ helicase with zinc finger 0.0212665
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0210689
RASAL2 RAS protein activator like 2 0.0209501
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0209432
RAB1A RAB1A, member RAS oncogene family 0.0207531
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0206913
ANO6 anoctamin 6 0.0204542
GLS2 glutaminase 2 (liver, mitochondrial) 0.020408
FRYL FRY-like 0.0202047
SIRT1 sirtuin 1 0.0199808
ZCCHC7 zinc finger, CCHC domain containing 7 0.0199777
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0199503
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0199277
NPTN neuroplastin 0.0198823
GPC6 glypican 6 0.0198245
USP15 ubiquitin specific peptidase 15 0.0198138
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.0197771
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0197088
TAS2R14 taste receptor, type 2, member 14 0.0196676
LIMCH1 LIM and calponin homology domains 1 0.0193103
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.018782
MYOF myoferlin 0.0186664
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.018646
ELOVL5 ELOVL fatty acid elongase 5 0.0186176
CDC73 cell division cycle 73 0.0185975
RASEF RAS and EF-hand domain containing 0.0183322
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0182358
DNM1L dynamin 1-like 0.0181551
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0181488
DST dystonin 0.0181468
KMT2C lysine (K)-specific methyltransferase 2C 0.0180666
TRA2A transformer 2 alpha homolog (Drosophila) 0.0180625
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0179929
UBAP2 ubiquitin associated protein 2 0.0179175
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0177
GMDS GDP-mannose 4,6-dehydratase 0.0175163
EMP1 epithelial membrane protein 1 0.0175065

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.306544
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.304885
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.181551
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.135069
NRG1 neuregulin 1 -0.112423
FTL ferritin, light polypeptide -0.10147
MT2A metallothionein 2A -0.0914158
ITGA1 integrin, alpha 1 -0.0854009
TMEM156 transmembrane protein 156 -0.0841738
HMGA2 high mobility group AT-hook 2 -0.0832177
PTMA prothymosin, alpha -0.0783097
TMSB10 thymosin beta 10 -0.0729115
SQSTM1 sequestosome 1 -0.0702943
IFI27 interferon, alpha-inducible protein 27 -0.0698747
GLIS3 GLIS family zinc finger 3 -0.0668252
VIM vimentin -0.0596036
HLA-B major histocompatibility complex, class I, B -0.0594151
NRP1 neuropilin 1 -0.0533344
ETV1 ets variant 1 -0.0523424
S100A6 S100 calcium binding protein A6 -0.0475881
FTH1 ferritin, heavy polypeptide 1 -0.0473865
PKM pyruvate kinase, muscle -0.0468351
TPT1 tumor protein, translationally-controlled 1 -0.0455891
SOX4 SRY (sex determining region Y)-box 4 -0.0448653
RPL37A ribosomal protein L37a -0.0440276
KLHL5 kelch-like family member 5 -0.0426832
NDRG1 N-myc downstream regulated 1 -0.0406349
RPL31 ribosomal protein L31 -0.0391022
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0376802
TMSB4X thymosin beta 4, X-linked -0.0370236
RPS12 ribosomal protein S12 -0.034387
LOC112694756 uncharaterized LOC112694756 -0.0342133
SYT1 synaptotagmin I -0.0335032
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0327224
RPL35A ribosomal protein L35a -0.032699
RPL26 ribosomal protein L26 -0.0325959
NTN4 netrin 4 -0.0321205
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0319843
RPS27 ribosomal protein S27 -0.030687
TPI1 triosephosphate isomerase 1 -0.0301649
OSMR oncostatin M receptor -0.029827
HLA-A major histocompatibility complex, class I, A -0.0298196
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0295411
SOS1 son of sevenless homolog 1 (Drosophila) -0.0292645
ENO1 enolase 1, (alpha) -0.0285006
RPS29 ribosomal protein S29 -0.0284486
NAMPT nicotinamide phosphoribosyltransferase -0.0281634
RPS6 ribosomal protein S6 -0.0280727
RACK1 receptor for activated C kinase 1 -0.0272292
RPL28 ribosomal protein L28 -0.0272219
TSC22D1 TSC22 domain family, member 1 -0.0266023
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0265163
ASPH aspartate beta-hydroxylase -0.0263434
RPS8 ribosomal protein S8 -0.0263367
RPL12 ribosomal protein L12 -0.0258262
ENO2 enolase 2 (gamma, neuronal) -0.0251961
STC2 stanniocalcin 2 -0.024941
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0249116
FOXP1 forkhead box P1 -0.0248785
RPS25 ribosomal protein S25 -0.0247014
WSB1 WD repeat and SOCS box containing 1 -0.023999
LOC102724023 ES1 protein homolog, mitochondrial -0.0239883
EIF1 eukaryotic translation initiation factor 1 -0.0238784
RPS3 ribosomal protein S3 -0.0235546
MKI67 marker of proliferation Ki-67 -0.0235169
ZMYND8 zinc finger, MYND-type containing 8 -0.0235092
PLIN2 perilipin 2 -0.0234254
RPS21 ribosomal protein S21 -0.0233624
RPS11 ribosomal protein S11 -0.0233262
IER3 immediate early response 3 -0.0233179
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0230856
HPCAL1 hippocalcin-like 1 -0.0230829
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0229547
HIPK2 homeodomain interacting protein kinase 2 -0.0216272
RPS19 ribosomal protein S19 -0.0215666
ITGB5 integrin, beta 5 -0.0215097
ETV6 ets variant 6 -0.0214929
RPS27A ribosomal protein S27a -0.0214841
IFI6 interferon, alpha-inducible protein 6 -0.0214113
RPL9 ribosomal protein L9 -0.0212557
IFI16 interferon, gamma-inducible protein 16 -0.0211139
PELO pelota homolog (Drosophila) -0.0210277
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0210202
HMGA1 high mobility group AT-hook 1 -0.0208686
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0207732
S100A9 S100 calcium binding protein A9 -0.0207133
RUNX2 runt-related transcription factor 2 -0.0206536
SMOX spermine oxidase -0.0200123
RPS16 ribosomal protein S16 -0.0200111
RPL37 ribosomal protein L37 -0.0199127
RPL19 ribosomal protein L19 -0.0198176
SMIM14 small integral membrane protein 14 -0.0198067
DNAH5 dynein, axonemal, heavy chain 5 -0.0198064
RPS23 ribosomal protein S23 -0.0197756
CDCP1 CUB domain containing protein 1 -0.0197342
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0196697
RAI14 retinoic acid induced 14 -0.0195822
RPL30 ribosomal protein L30 -0.0194129
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0192959
TGFA transforming growth factor, alpha -0.0191767