Voriconazole_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Voriconazole_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.118932
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0714959
INTS6 integrator complex subunit 6 0.06382
STS steroid sulfatase (microsomal), isozyme S 0.0635632
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.062019
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0572626
TMC5 transmembrane channel-like 5 0.0560468
IGFBP3 insulin-like growth factor binding protein 3 0.0551631
AREG amphiregulin 0.0548568
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0543753
SMAD3 SMAD family member 3 0.052257
VMP1 vacuole membrane protein 1 0.0516877
MYO1E myosin IE 0.0513582
EGR1 early growth response 1 0.0505375
MBNL2 muscleblind-like splicing regulator 2 0.0496044
TSC22D1 TSC22 domain family, member 1 0.0486815
DSCAM Down syndrome cell adhesion molecule 0.0466294
ZSWIM6 zinc finger, SWIM-type containing 6 0.0464376
MLPH melanophilin 0.044677
ERBIN erbb2 interacting protein 0.0437399
PHF3 PHD finger protein 3 0.0417581
PADI1 peptidyl arginine deiminase, type I 0.0398523
FTH1 ferritin, heavy polypeptide 1 0.0381463
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0373801
FAT1 FAT atypical cadherin 1 0.0371557
DIAPH1 diaphanous-related formin 1 0.0364475
CDHR2 cadherin-related family member 2 0.0360473
RAB7A RAB7A, member RAS oncogene family 0.0352483
N4BP2L2 NEDD4 binding protein 2-like 2 0.0351053
ARHGAP26 Rho GTPase activating protein 26 0.0342395
EPSTI1 epithelial stromal interaction 1 (breast) 0.0341098
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0340133
PKM pyruvate kinase, muscle 0.033594
ARGLU1 arginine and glutamate rich 1 0.0330648
ZMYND8 zinc finger, MYND-type containing 8 0.03163
ANXA2 annexin A2 0.030295
MX1 MX dynamin-like GTPase 1 0.0299795
RAD51B RAD51 paralog B 0.029645
KIF16B kinesin family member 16B 0.0292776
ITGA6 integrin, alpha 6 0.029088
PDZD8 PDZ domain containing 8 0.0287423
POU2F2 POU class 2 homeobox 2 0.0286
KDM4C lysine (K)-specific demethylase 4C 0.0283979
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0283709
SCARB1 scavenger receptor class B, member 1 0.0278414
PGK1 phosphoglycerate kinase 1 0.0276744
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.027414
SRRM2 serine/arginine repetitive matrix 2 0.0273651
MAP7 microtubule-associated protein 7 0.0273529
EFNB2 ephrin-B2 0.0269835
SQSTM1 sequestosome 1 0.0265669
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0256317
FNDC3B fibronectin type III domain containing 3B 0.024877
RBM47 RNA binding motif protein 47 0.0246056
AKAP13 A kinase (PRKA) anchor protein 13 0.0245089
MYH9 myosin, heavy chain 9, non-muscle 0.0243828
MYO5B myosin VB 0.024274
VEGFA vascular endothelial growth factor A 0.0237008
SH3PXD2A SH3 and PX domains 2A 0.0233119
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0232092
TMF1 TATA element modulatory factor 1 0.0231452
LAMA4 laminin, alpha 4 0.0228385
DSPP dentin sialophosphoprotein 0.0228377
MCL1 myeloid cell leukemia 1 0.0225968
GK glycerol kinase 0.0225897
C6ORF132 chromosome 6 open reading frame 132 0.0225804
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0225666
NCEH1 neutral cholesterol ester hydrolase 1 0.0223375
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0222401
SPATA6L spermatogenesis associated 6-like 0.0220384
MCU mitochondrial calcium uniporter 0.0219614
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0215565
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0214701
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0212565
HKDC1 hexokinase domain containing 1 0.0212551
APLP2 amyloid beta (A4) precursor-like protein 2 0.0211051
ERRFI1 ERBB receptor feedback inhibitor 1 0.020839
PSEN1 presenilin 1 0.020819
TM4SF19 transmembrane 4 L six family member 19 0.0206496
NPSR1 neuropeptide S receptor 1 0.0203969
BAIAP2L1 BAI1-associated protein 2-like 1 0.0203506
POTEF POTE ankyrin domain family, member F 0.0202631
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0198921
ZHX2 zinc fingers and homeoboxes 2 0.0196209
LURAP1L leucine rich adaptor protein 1-like 0.0195811
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0193367
SETX senataxin 0.0191774
EGLN3 egl-9 family hypoxia-inducible factor 3 0.019103
JUN jun proto-oncogene 0.0189748
BICRAL BICRA like chromatin remodeling complex associated protein 0.0189317
BRD2 bromodomain containing 2 0.0188272
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.01874
AEBP2 AE binding protein 2 0.0186661
SHB Src homology 2 domain containing adaptor protein B 0.0185278
ABHD2 abhydrolase domain containing 2 0.0185142
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0183606
ATXN1 ataxin 1 0.0181911
UBAP2 ubiquitin associated protein 2 0.0181223
PRSS22 protease, serine, 22 0.0178495
DUSP10 dual specificity phosphatase 10 0.0178144

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.129334
TPT1 tumor protein, translationally-controlled 1 -0.123772
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12166
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116573
H1-0 H1.0 linker histone -0.0913565
RHOBTB3 Rho-related BTB domain containing 3 -0.0635516
PTMA prothymosin, alpha -0.063353
HLA-B major histocompatibility complex, class I, B -0.0607945
RPL35A ribosomal protein L35a -0.0478514
RNF149 ring finger protein 149 -0.0449223
AHNAK AHNAK nucleoprotein -0.0447697
RPL23 ribosomal protein L23 -0.0444961
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0440207
RPS24 ribosomal protein S24 -0.0417071
PDIA3 protein disulfide isomerase family A, member 3 -0.0398986
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0398346
RBM39 RNA binding motif protein 39 -0.0395684
DLG1 discs, large homolog 1 (Drosophila) -0.0385925
RPL12 ribosomal protein L12 -0.0370878
RPL34 ribosomal protein L34 -0.0369917
PRELID2 PRELI domain containing 2 -0.0365596
NCKAP5 NCK-associated protein 5 -0.0359437
TMSB10 thymosin beta 10 -0.0354053
RPS6 ribosomal protein S6 -0.0352993
NRIP1 nuclear receptor interacting protein 1 -0.0352379
RPL19 ribosomal protein L19 -0.0352006
RNF43 ring finger protein 43 -0.0344423
SBF2 SET binding factor 2 -0.0339409
UBC ubiquitin C -0.0339087
HMGB1 high mobility group box 1 -0.0335947
NAMPT nicotinamide phosphoribosyltransferase -0.0328358
OGA O-GlcNAcase -0.0326985
PDE4D phosphodiesterase 4D, cAMP-specific -0.0325492
PDIA4 protein disulfide isomerase family A, member 4 -0.0324488
HLA-C major histocompatibility complex, class I, C -0.0322664
RAD21 RAD21 homolog (S. pombe) -0.0320694
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0320374
MEIS2 Meis homeobox 2 -0.0315714
GCC2 GRIP and coiled-coil domain containing 2 -0.0315102
RPS8 ribosomal protein S8 -0.0311179
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0306784
S100A10 S100 calcium binding protein A10 -0.0297664
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.02965
RPLP1 ribosomal protein, large, P1 -0.0295992
TMEM263 transmembrane protein 263 -0.0295218
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0288621
CANX calnexin -0.0288277
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0286406
PERP PERP, TP53 apoptosis effector -0.0283255
VCL vinculin -0.0280757
LOC112694756 uncharaterized LOC112694756 -0.0277639
UFM1 ubiquitin-fold modifier 1 -0.0275436
RUNX1 runt-related transcription factor 1 -0.0275407
XAF1 XIAP associated factor 1 -0.0271432
BRCA2 breast cancer 2, early onset -0.0267251
AGR2 anterior gradient 2 -0.026628
ACBD3 acyl-CoA binding domain containing 3 -0.0262513
MT2A metallothionein 2A -0.0261657
TOP2A topoisomerase (DNA) II alpha 170kDa -0.025713
DIAPH3 diaphanous-related formin 3 -0.0256602
EXT1 exostosin glycosyltransferase 1 -0.0250828
NIPBL Nipped-B homolog (Drosophila) -0.0250507
TMEM123 transmembrane protein 123 -0.0245485
MKI67 marker of proliferation Ki-67 -0.0243588
FOXP1 forkhead box P1 -0.0241529
RPL26 ribosomal protein L26 -0.0240961
TRA2A transformer 2 alpha homolog (Drosophila) -0.0240237
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0237872
BTBD9 BTB (POZ) domain containing 9 -0.0237717
IFT88 intraflagellar transport 88 -0.0233819
H3-3B H3.3 histone B -0.0230703
FTL ferritin, light polypeptide -0.0229404
PDE8A phosphodiesterase 8A -0.0229132
EPB41 erythrocyte membrane protein band 4.1 -0.0228014
MORF4L2 mortality factor 4 like 2 -0.0226905
CALU calumenin -0.0225899
LCN2 lipocalin 2 -0.0225292
RPS19 ribosomal protein S19 -0.0224418
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0223931
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0223839
GLO1 glyoxalase I -0.0222084
PTBP3 polypyrimidine tract binding protein 3 -0.0216891
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0216488
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0215883
RRBP1 ribosome binding protein 1 -0.0215875
NCOR1 nuclear receptor corepressor 1 -0.0214097
VIM vimentin -0.021401
GOLGA4 golgin A4 -0.0213166
NCOA7 nuclear receptor coactivator 7 -0.021288
ANAPC5 anaphase promoting complex subunit 5 -0.0212531
RSRC2 arginine/serine-rich coiled-coil 2 -0.021239
IFI27 interferon, alpha-inducible protein 27 -0.0211564
KLF6 Kruppel-like factor 6 -0.0211222
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0205982
SKAP1 src kinase associated phosphoprotein 1 -0.0205221
WSB1 WD repeat and SOCS box containing 1 -0.0204527
SPATA13 spermatogenesis associated 13 -0.0203439
GNAS GNAS complex locus -0.020323
RSF1 remodeling and spacing factor 1 -0.0201915
KDM3A lysine (K)-specific demethylase 3A -0.0201301