Voriconazole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Voriconazole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.201245
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.10229
FLNB filamin B, beta 0.085796
FTH1 ferritin, heavy polypeptide 1 0.074286
SLC35F3 solute carrier family 35, member F3 0.072378
IGF2 insulin-like growth factor 2 0.0711359
PODXL podocalyxin-like 0.0688791
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0536856
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0536585
ALCAM activated leukocyte cell adhesion molecule 0.0529689
PDLIM5 PDZ and LIM domain 5 0.0511548
LDHA lactate dehydrogenase A 0.0441403
SQLE squalene epoxidase 0.042769
NAV2 neuron navigator 2 0.0407443
HSPG2 heparan sulfate proteoglycan 2 0.0387916
ANO1 anoctamin 1, calcium activated chloride channel 0.0387054
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0383099
LMO7 LIM domain 7 0.038246
POTEF POTE ankyrin domain family, member F 0.0379025
GRB10 growth factor receptor-bound protein 10 0.0377682
INTS6 integrator complex subunit 6 0.0366986
LAMA5 laminin, alpha 5 0.0366487
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0352811
F3 coagulation factor III (thromboplastin, tissue factor) 0.035163
PTMA prothymosin, alpha 0.0348843
HLA-E major histocompatibility complex, class I, E 0.0346918
LAMC2 laminin, gamma 2 0.03312
KRT6A keratin 6A, type II 0.0330836
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0330599
MTSS1 metastasis suppressor 1 0.0322324
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0321451
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0307979
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0307458
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0297611
ABI3BP ABI family, member 3 (NESH) binding protein 0.0289042
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.028131
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0277931
TRIO trio Rho guanine nucleotide exchange factor 0.0276869
HLA-A major histocompatibility complex, class I, A 0.0276788
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0275417
SULF2 sulfatase 2 0.0269999
FTL ferritin, light polypeptide 0.0269194
AKAP13 A kinase (PRKA) anchor protein 13 0.025866
TMSB10 thymosin beta 10 0.0258588
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0255897
PLS3 plastin 3 0.0255432
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0248804
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0247569
B2M beta-2-microglobulin 0.024629
ZFP36L1 ZFP36 ring finger protein-like 1 0.0241958
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.0240628
PCDH1 protocadherin 1 0.0235435
ANKRD11 ankyrin repeat domain 11 0.0232048
RPL35A ribosomal protein L35a 0.0231546
CALB1 calbindin 1, 28kDa 0.023091
AMOTL1 angiomotin like 1 0.0229665
CALR calreticulin 0.022895
PALLD palladin, cytoskeletal associated protein 0.0226685
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0222784
NCOR2 nuclear receptor corepressor 2 0.0221671
CD59 CD59 molecule, complement regulatory protein 0.0216615
RCOR1 REST corepressor 1 0.0213579
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0212756
EGR1 early growth response 1 0.0212678
PSD3 pleckstrin and Sec7 domain containing 3 0.0211578
ZEB1 zinc finger E-box binding homeobox 1 0.021015
PGK1 phosphoglycerate kinase 1 0.0208126
THBD thrombomodulin 0.0203954
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0202595
KIAA1671 KIAA1671 0.019596
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0195756
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0194758
SQSTM1 sequestosome 1 0.0193982
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0193276
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0192136
HLA-B major histocompatibility complex, class I, B 0.0191051
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.018667
RAI14 retinoic acid induced 14 0.0184269
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.0182256
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0180809
RNF217 ring finger protein 217 0.018016
SULF1 sulfatase 1 0.0178304
ENO2 enolase 2 (gamma, neuronal) 0.0174475
HMGA1 high mobility group AT-hook 1 0.0174466
HDAC9 histone deacetylase 9 0.0174244
EEF2 eukaryotic translation elongation factor 2 0.017394
SOD2 superoxide dismutase 2, mitochondrial 0.0171524
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0170685
WDFY2 WD repeat and FYVE domain containing 2 0.016935
ITGB4 integrin, beta 4 0.0165256
CD9 CD9 molecule 0.0165053
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0163244
ZSWIM6 zinc finger, SWIM-type containing 6 0.0162831
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0160898
KRT14 keratin 14, type I 0.0160739
CAVIN1 caveolae associated protein 1 0.0158911
VCL vinculin 0.0156128
S100A11 S100 calcium binding protein A11 0.0156045
FBXO11 F-box protein 11 0.015599
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0155428

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.11417
NAMPT nicotinamide phosphoribosyltransferase -0.104559
MYOF myoferlin -0.0886905
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0864258
CLU clusterin -0.0765713
CUL4B cullin 4B -0.0700223
AHNAK AHNAK nucleoprotein -0.0608139
RPS2 ribosomal protein S2 -0.0606624
H1-0 H1.0 linker histone -0.0567209
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0553499
ASPH aspartate beta-hydroxylase -0.0524028
KMT2E lysine (K)-specific methyltransferase 2E -0.0509833
PRELID2 PRELI domain containing 2 -0.0475026
FOXP1 forkhead box P1 -0.0453248
RPS6 ribosomal protein S6 -0.0452742
MBNL1 muscleblind-like splicing regulator 1 -0.0444254
ANLN anillin, actin binding protein -0.044331
MEF2A myocyte enhancer factor 2A -0.0437587
ARHGAP29 Rho GTPase activating protein 29 -0.0429385
TMSB4X thymosin beta 4, X-linked -0.040236
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0401432
RIN2 Ras and Rab interactor 2 -0.0392371
CEMIP cell migration inducing protein, hyaluronan binding -0.0388406
BCL2L1 BCL2-like 1 -0.0373692
FOXO1 forkhead box O1 -0.0367894
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0351231
RBM39 RNA binding motif protein 39 -0.0350681
YBX3 Y box binding protein 3 -0.0342221
PLAT plasminogen activator, tissue -0.0338585
ANKRD12 ankyrin repeat domain 12 -0.0329286
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0324079
ADAR adenosine deaminase, RNA-specific -0.0319515
FNDC3B fibronectin type III domain containing 3B -0.0317406
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0314074
ZNF292 zinc finger protein 292 -0.0313928
NEK7 NIMA-related kinase 7 -0.031004
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.030519
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0298176
KIAA1217 KIAA1217 -0.0296005
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0290594
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0287681
MACF1 microtubule-actin crosslinking factor 1 -0.0285551
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0284789
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0280844
OSMR oncostatin M receptor -0.0278945
KTN1 kinectin 1 (kinesin receptor) -0.0276759
IFI16 interferon, gamma-inducible protein 16 -0.0274017
AOPEP aminopeptidase O (putative) -0.0271491
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0268829
BZW2 basic leucine zipper and W2 domains 2 -0.0262045
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0261433
IL6ST interleukin 6 signal transducer -0.0259849
METTL15 methyltransferase like 15 -0.0257751
MYH9 myosin, heavy chain 9, non-muscle -0.0256491
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0252514
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0250948
ARRDC3 arrestin domain containing 3 -0.0248874
STAU1 staufen double-stranded RNA binding protein 1 -0.0242151
CENPF centromere protein F, 350/400kDa -0.0234742
YAP1 Yes-associated protein 1 -0.0234617
CKAP5 cytoskeleton associated protein 5 -0.02303
TXNIP thioredoxin interacting protein -0.0230139
ANKRD33B ankyrin repeat domain 33B -0.022883
PDLIM1 PDZ and LIM domain 1 -0.0227191
ITGA6 integrin, alpha 6 -0.0226967
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0224761
DSTN destrin (actin depolymerizing factor) -0.0223851
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0218137
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0214244
NIPBL Nipped-B homolog (Drosophila) -0.0213374
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0212982
AKAP9 A kinase (PRKA) anchor protein 9 -0.0212654
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0211621
RPL26 ribosomal protein L26 -0.0209521
DENND4C DENN/MADD domain containing 4C -0.020668
RNF220 ring finger protein 220 -0.020638
MYO9A myosin IXA -0.0206337
PTK2 protein tyrosine kinase 2 -0.0205446
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0203658
IFI44 interferon-induced protein 44 -0.0202702
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0200369
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0199869
RPL7 ribosomal protein L7 -0.0199672
DOCK5 dedicator of cytokinesis 5 -0.0199311
WDR26 WD repeat domain 26 -0.0199259
SLC38A2 solute carrier family 38, member 2 -0.0198956
COG5 component of oligomeric golgi complex 5 -0.0198453
DST dystonin -0.0198143
ANO6 anoctamin 6 -0.0197183
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0190933
NF1 neurofibromin 1 -0.0188395
CSNK1A1 casein kinase 1, alpha 1 -0.0187941
EMP1 epithelial membrane protein 1 -0.0185099
RPL21 ribosomal protein L21 -0.0184566
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0184248
FER fer (fps/fes related) tyrosine kinase -0.0183218
RPL11 ribosomal protein L11 -0.0183208
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0182048
AGTPBP1 ATP/GTP binding protein 1 -0.0182036
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0180692