Voriconazole_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Voriconazole_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0416687
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0364597
ERRFI1 ERBB receptor feedback inhibitor 1 0.0341887
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0238806
CAPRIN2 caprin family member 2 0.0229395
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0209467
FNIP1 folliculin interacting protein 1 0.0209105
PLK2 polo-like kinase 2 0.0204324
MKI67 marker of proliferation Ki-67 0.0194949
CENPF centromere protein F, 350/400kDa 0.0185631
POTEF POTE ankyrin domain family, member F 0.0174961
PODXL podocalyxin-like 0.0167087
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0167023
MACF1 microtubule-actin crosslinking factor 1 0.0164953
SLK STE20-like kinase 0.0163859
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0159175
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0154991
ESYT2 extended synaptotagmin-like protein 2 0.0153795
TSC22D1 TSC22 domain family, member 1 0.0152547
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0149242
MBNL2 muscleblind-like splicing regulator 2 0.0146898
EEF2 eukaryotic translation elongation factor 2 0.0142917
KTN1 kinectin 1 (kinesin receptor) 0.0136691
RUNX1 runt-related transcription factor 1 0.0136514
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0134459
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0125674
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0121375
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0116714
FTH1 ferritin, heavy polypeptide 1 0.011636
NAV2 neuron navigator 2 0.011617
PRELID2 PRELI domain containing 2 0.0115384
DOCK11 dedicator of cytokinesis 11 0.0114903
YEATS2 YEATS domain containing 2 0.0112981
EFNA5 ephrin-A5 0.0110746
CADM2 cell adhesion molecule 2 0.0110732
MSN moesin 0.0109088
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0107408
ENO2 enolase 2 (gamma, neuronal) 0.010737
BCAR3 breast cancer anti-estrogen resistance 3 0.0105588
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0102692
CSMD3 CUB and Sushi multiple domains 3 0.0102311
ANKRD36 ankyrin repeat domain 36 0.0101532
F2R coagulation factor II (thrombin) receptor 0.00972204
RAB27B RAB27B, member RAS oncogene family 0.00970712
CLTC clathrin, heavy chain (Hc) 0.00969957
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.00938004
NCEH1 neutral cholesterol ester hydrolase 1 0.00933665
APOLD1 apolipoprotein L domain containing 1 0.00927861
SDK1 sidekick cell adhesion molecule 1 0.00921175
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.00906185
PCDH1 protocadherin 1 0.00897867
BIRC2 baculoviral IAP repeat containing 2 0.00893589
HPCAL1 hippocalcin-like 1 0.00887628
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.00881075
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.00875322
HDAC9 histone deacetylase 9 0.008693
LOXL2 lysyl oxidase-like 2 0.00857281
EGFR epidermal growth factor receptor 0.00835346
PYGL phosphorylase, glycogen, liver 0.00831041
HLA-A major histocompatibility complex, class I, A 0.0082408
CDK19 cyclin-dependent kinase 19 0.00817175
RAD51B RAD51 paralog B 0.00814586
ADAM10 ADAM metallopeptidase domain 10 0.00796725
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.00794132
DENND1A DENN/MADD domain containing 1A 0.00792059
DNER delta/notch-like EGF repeat containing 0.00774353
WNK1 WNK lysine deficient protein kinase 1 0.00766084
CD109 CD109 molecule 0.00761491
TRIP12 thyroid hormone receptor interactor 12 0.0075443
NEBL nebulette 0.00735222
MYO10 myosin X 0.00732327
ARRDC3 arrestin domain containing 3 0.00723095
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.00713338
VCL vinculin 0.00705493
SMAD4 SMAD family member 4 0.00704705
NT5E 5'-nucleotidase, ecto (CD73) 0.00701124
EHBP1 EH domain binding protein 1 0.00699193
EXOC4 exocyst complex component 4 0.00698935
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00697439
PIAS2 protein inhibitor of activated STAT, 2 0.00691556
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00686105
ARF6 ADP-ribosylation factor 6 0.00681289
ZNF121 zinc finger protein 121 0.00678018
ZNF146 zinc finger protein 146 0.00675611
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.00673609
MBNL1 muscleblind-like splicing regulator 1 0.00671298
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00665082
SGK1 serum/glucocorticoid regulated kinase 1 0.00664755
NUP58 nucleoporin 58 0.00662659
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0065813
TGM2 transglutaminase 2 0.00655166
ZNF160 zinc finger protein 160 0.00654844
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.00647178
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00642919
TPRG1 tumor protein p63 regulated 1 0.00641973
LYST lysosomal trafficking regulator 0.00639824
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00632647
TTC28 tetratricopeptide repeat domain 28 0.00627506
ZNF91 zinc finger protein 91 0.00625802
TP63 tumor protein p63 0.00623947

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.213286
VIM vimentin -0.151027
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.095301
TMSB10 thymosin beta 10 -0.0901651
MT2A metallothionein 2A -0.0834157
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0598369
PTMA prothymosin, alpha -0.0457557
UBC ubiquitin C -0.0450716
AHNAK AHNAK nucleoprotein -0.0428821
TMSB4X thymosin beta 4, X-linked -0.0428416
TM4SF1 transmembrane 4 L six family member 1 -0.0378208
LOC112694756 uncharaterized LOC112694756 -0.0328752
MT1X metallothionein 1X -0.0301724
RPL23 ribosomal protein L23 -0.0285881
TPT1 tumor protein, translationally-controlled 1 -0.028312
EZR ezrin -0.0281557
ACTG1 actin gamma 1 -0.0261695
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0256386
RPS8 ribosomal protein S8 -0.0255794
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0244787
FUS FUS RNA binding protein -0.0239908
JMJD1C jumonji domain containing 1C -0.0232255
SEPTIN7 septin 7 -0.0225666
S100A10 S100 calcium binding protein A10 -0.022295
RPS6 ribosomal protein S6 -0.0220679
FTL ferritin, light polypeptide -0.0219568
JUN jun proto-oncogene -0.0218927
GARS1 glycyl-tRNA synthetase 1 -0.0211402
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0208503
EIF1 eukaryotic translation initiation factor 1 -0.0207089
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.020597
RPLP1 ribosomal protein, large, P1 -0.0205349
RPL19 ribosomal protein L19 -0.0202175
KLF6 Kruppel-like factor 6 -0.0202047
RPL8 ribosomal protein L8 -0.0189528
RPL35A ribosomal protein L35a -0.0188634
RPS27A ribosomal protein S27a -0.0185719
ANXA2 annexin A2 -0.018342
EMP1 epithelial membrane protein 1 -0.0179948
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0179905
GCLM glutamate-cysteine ligase, modifier subunit -0.0175499
RAB7A RAB7A, member RAS oncogene family -0.017502
S100A6 S100 calcium binding protein A6 -0.0170268
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0169213
MT1E metallothionein 1E -0.0166344
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0164609
H1-0 H1.0 linker histone -0.0164274
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0163345
RPL12 ribosomal protein L12 -0.0163062
WSB1 WD repeat and SOCS box containing 1 -0.0162864
GNAS GNAS complex locus -0.0157885
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0147809
WDR45B WD repeat domain 45B -0.0146906
RPS24 ribosomal protein S24 -0.0146733
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0146657
ZMYND8 zinc finger, MYND-type containing 8 -0.0142691
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0142244
RPL5 ribosomal protein L5 -0.0141348
RPL26 ribosomal protein L26 -0.0141275
NAP1L1 nucleosome assembly protein 1-like 1 -0.0141271
NPR2 natriuretic peptide receptor 2 -0.0139923
RPLP2 ribosomal protein, large, P2 -0.0138248
PRDX1 peroxiredoxin 1 -0.0136397
RPL38 ribosomal protein L38 -0.0135873
RPL11 ribosomal protein L11 -0.0134925
SLC38A1 solute carrier family 38, member 1 -0.0134557
IARS1 isoleucyl-tRNA synthetase 1 -0.0133261
RPL35 ribosomal protein L35 -0.013134
IFRD1 interferon-related developmental regulator 1 -0.0130656
RPS19 ribosomal protein S19 -0.013054
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0128108
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0127117
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0125049
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0123506
NF1 neurofibromin 1 -0.012347
PRRC2C proline-rich coiled-coil 2C -0.0123455
YBX3 Y box binding protein 3 -0.0122343
YBX1 Y box binding protein 1 -0.0122295
RPS20 ribosomal protein S20 -0.0119305
RTN4 reticulon 4 -0.0118722
RPL36 ribosomal protein L36 -0.011757
TPI1 triosephosphate isomerase 1 -0.0115843
RPS16 ribosomal protein S16 -0.0115448
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0114393
SQSTM1 sequestosome 1 -0.0113875
PDIA3 protein disulfide isomerase family A, member 3 -0.0113855
RPS21 ribosomal protein S21 -0.0112133
MORF4L2 mortality factor 4 like 2 -0.0111703
OGA O-GlcNAcase -0.0111402
RPL34 ribosomal protein L34 -0.0111329
NAMPT nicotinamide phosphoribosyltransferase -0.0110426
RPL18 ribosomal protein L18 -0.0110199
RPL4 ribosomal protein L4 -0.0109325
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0109213
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0108974
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0108888
CELF1 CUGBP, Elav-like family member 1 -0.0108727
ANXA1 annexin A1 -0.0108236
TFRC transferrin receptor -0.0107743
RPS23 ribosomal protein S23 -0.0107543