Voriconazole_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Voriconazole_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.123473
AKAP12 A kinase (PRKA) anchor protein 12 0.116134
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0986163
GRB10 growth factor receptor-bound protein 10 0.0970454
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0948673
STC1 stanniocalcin 1 0.0917295
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.081798
SDK1 sidekick cell adhesion molecule 1 0.0792152
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0763567
AKAP13 A kinase (PRKA) anchor protein 13 0.0694059
IGFBP3 insulin-like growth factor binding protein 3 0.0690542
MTSS1 metastasis suppressor 1 0.0663771
LOX lysyl oxidase 0.0656901
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0615087
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0603902
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0592009
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0546181
SMAD3 SMAD family member 3 0.052226
TIMP1 TIMP metallopeptidase inhibitor 1 0.0509498
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0502774
PDE4D phosphodiesterase 4D, cAMP-specific 0.0500515
ARHGAP5 Rho GTPase activating protein 5 0.0494874
NRG1 neuregulin 1 0.0493183
FAM20C family with sequence similarity 20, member C 0.0489493
TRIO trio Rho guanine nucleotide exchange factor 0.0472272
CDH13 cadherin 13 0.0471654
TFPI2 tissue factor pathway inhibitor 2 0.0447936
DPYD dihydropyrimidine dehydrogenase 0.0439375
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0427388
CLMP CXADR-like membrane protein 0.0417596
ANTXR2 anthrax toxin receptor 2 0.0411059
DOCK5 dedicator of cytokinesis 5 0.0405827
WSB1 WD repeat and SOCS box containing 1 0.0405384
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0403926
TGM2 transglutaminase 2 0.0397134
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.039443
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0386458
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.03772
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0370481
VEGFA vascular endothelial growth factor A 0.0367442
COL7A1 collagen, type VII, alpha 1 0.0364814
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.03562
MSRB3 methionine sulfoxide reductase B3 0.0355884
JARID2 jumonji, AT rich interactive domain 2 0.0353241
USP34 ubiquitin specific peptidase 34 0.033822
OXR1 oxidation resistance 1 0.0335635
IGF1R insulin-like growth factor 1 receptor 0.0329215
PTK2 protein tyrosine kinase 2 0.0322915
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0321082
MEF2A myocyte enhancer factor 2A 0.0318962
MYO10 myosin X 0.0311453
PYGL phosphorylase, glycogen, liver 0.0310827
ITCH itchy E3 ubiquitin protein ligase 0.030795
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0301933
NAV2 neuron navigator 2 0.0301663
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0299926
ATP13A3 ATPase type 13A3 0.0299534
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0297938
MACF1 microtubule-actin crosslinking factor 1 0.029791
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0297874
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0296015
RAI14 retinoic acid induced 14 0.0295827
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.02937
TM4SF1 transmembrane 4 L six family member 1 0.0293043
ESYT2 extended synaptotagmin-like protein 2 0.0289393
TMSB10 thymosin beta 10 0.0289246
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0288226
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0284068
APP amyloid beta (A4) precursor protein 0.0282407
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0281965
ZEB2 zinc finger E-box binding homeobox 2 0.0280158
RAP1B RAP1B, member of RAS oncogene family 0.0278511
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0276985
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0276813
EFNA5 ephrin-A5 0.0274109
ANKRD11 ankyrin repeat domain 11 0.0271415
CEMIP cell migration inducing protein, hyaluronan binding 0.0266892
ENO2 enolase 2 (gamma, neuronal) 0.0265133
WWC2 WW and C2 domain containing 2 0.0262139
LOXL2 lysyl oxidase-like 2 0.0260458
GLCCI1 glucocorticoid induced 1 0.0256715
PSD3 pleckstrin and Sec7 domain containing 3 0.0256174
SEPTIN9 septin 9 0.0255558
PGK1 phosphoglycerate kinase 1 0.0254551
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0253699
EEF2 eukaryotic translation elongation factor 2 0.025322
PARD3 par-3 family cell polarity regulator 0.0251004
OXSR1 oxidative stress responsive 1 0.0249965
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0244264
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0243694
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0243619
TRPS1 trichorhinophalangeal syndrome I 0.0241472
OSBPL8 oxysterol binding protein-like 8 0.0240741
EXT1 exostosin glycosyltransferase 1 0.0239914
LTBP1 latent transforming growth factor beta binding protein 1 0.0238964
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0237646
NPAS2 neuronal PAS domain protein 2 0.0235897
HIPK2 homeodomain interacting protein kinase 2 0.0235632
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0235449
GREB1L growth regulation by estrogen in breast cancer-like 0.0235438

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.126301
NAMPT nicotinamide phosphoribosyltransferase -0.10358
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0958048
PDIA3 protein disulfide isomerase family A, member 3 -0.0496313
MT2A metallothionein 2A -0.0436998
MORF4L2 mortality factor 4 like 2 -0.0376276
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0374099
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0329088
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0328587
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0320574
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0311728
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0309715
DDIT3 DNA-damage-inducible transcript 3 -0.0308584
MON2 MON2 homolog (S. cerevisiae) -0.0306941
RBM39 RNA binding motif protein 39 -0.0304656
NCOA7 nuclear receptor coactivator 7 -0.0297056
GPC6 glypican 6 -0.0288208
BLZF1 basic leucine zipper nuclear factor 1 -0.0286368
C15ORF48 chromosome 15 open reading frame 48 -0.0282329
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0275163
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0273177
RPS6 ribosomal protein S6 -0.0251357
SEC31A SEC31 homolog A (S. cerevisiae) -0.0248244
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0242495
IER3 immediate early response 3 -0.0239463
FTL ferritin, light polypeptide -0.0239354
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0235798
DLG1 discs, large homolog 1 (Drosophila) -0.0233389
ARF4 ADP-ribosylation factor 4 -0.0230447
YBX1 Y box binding protein 1 -0.0226191
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0222687
RPL9 ribosomal protein L9 -0.0221614
TMEM263 transmembrane protein 263 -0.0220446
LRRC49 leucine rich repeat containing 49 -0.0219754
MAP1B microtubule-associated protein 1B -0.0208527
GOLGA4 golgin A4 -0.020574
RPL12 ribosomal protein L12 -0.0204511
SCFD1 sec1 family domain containing 1 -0.0194948
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0190406
RPLP1 ribosomal protein, large, P1 -0.0188757
RPLP0 ribosomal protein, large, P0 -0.0187991
SON SON DNA binding protein -0.0187268
RPS24 ribosomal protein S24 -0.0184532
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0180126
RPL35A ribosomal protein L35a -0.017853
RAD51B RAD51 paralog B -0.0177935
EIF1 eukaryotic translation initiation factor 1 -0.0174838
TMEM87A transmembrane protein 87A -0.0174728
PLIN2 perilipin 2 -0.017405
RPL19 ribosomal protein L19 -0.0167983
GCC2 GRIP and coiled-coil domain containing 2 -0.016766
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0167252
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0167167
RSRC2 arginine/serine-rich coiled-coil 2 -0.0165529
GLIPR1 GLI pathogenesis-related 1 -0.0165373
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0164981
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0164775
SEPTIN2 septin 2 -0.0164656
RPS25 ribosomal protein S25 -0.0164284
SEC24D SEC24 family member D -0.0163885
PFN1 profilin 1 -0.0163495
H1-0 H1.0 linker histone -0.0160621
RB1CC1 RB1-inducible coiled-coil 1 -0.0160508
RPS5 ribosomal protein S5 -0.0159933
ANXA1 annexin A1 -0.0159883
SRP54 signal recognition particle 54kDa -0.0158864
UBC ubiquitin C -0.0155039
GOLGB1 golgin B1 -0.0153053
IARS1 isoleucyl-tRNA synthetase 1 -0.0148785
BABAM2 BRISC and BRCA1 A complex member 2 -0.0148045
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0147567
SLC38A1 solute carrier family 38, member 1 -0.0146411
ANKRD17 ankyrin repeat domain 17 -0.0144869
RPL34 ribosomal protein L34 -0.0142974
SUCO SUN domain containing ossification factor -0.0142591
MBD5 methyl-CpG binding domain protein 5 -0.014156
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0141237
RTN4 reticulon 4 -0.0137633
TENT5A terminal nucleotidyltransferase 5A -0.0137564
PTPRR protein tyrosine phosphatase, receptor type, R -0.0135193
MRPS6 mitochondrial ribosomal protein S6 -0.013462
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0133438
PDIA4 protein disulfide isomerase family A, member 4 -0.013328
RHOBTB3 Rho-related BTB domain containing 3 -0.0133055
UGCG UDP-glucose ceramide glucosyltransferase -0.0132764
TBC1D5 TBC1 domain family, member 5 -0.013219
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0131645
GTF2B general transcription factor IIB -0.0130331
SLC38A2 solute carrier family 38, member 2 -0.0130183
ADAR adenosine deaminase, RNA-specific -0.012965
FKBP10 FK506 binding protein 10, 65 kDa -0.0127694
CLEC1B C-type lectin domain family 1, member B -0.0127566
SKAP2 src kinase associated phosphoprotein 2 -0.0126361
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0125686
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0125634
ZBTB43 zinc finger and BTB domain containing 43 -0.0124621
PRELID2 PRELI domain containing 2 -0.0124565
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -0.012452
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0122426
RPL23 ribosomal protein L23 -0.0121444