Voriconazole_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Voriconazole_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.184228
PM20D1 peptidase M20 domain containing 1 0.113119
IGF2 insulin-like growth factor 2 0.100283
FGB fibrinogen beta chain 0.0991285
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.096831
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0895042
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0802251
TXNRD1 thioredoxin reductase 1 0.0758212
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0730391
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0676399
EEF2 eukaryotic translation elongation factor 2 0.0658152
PDE4D phosphodiesterase 4D, cAMP-specific 0.0646566
FTH1 ferritin, heavy polypeptide 1 0.0614135
ZNF292 zinc finger protein 292 0.0603011
TPM3 tropomyosin 3 0.0600488
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0586865
ERRFI1 ERBB receptor feedback inhibitor 1 0.0579139
MCL1 myeloid cell leukemia 1 0.0571922
RTN4 reticulon 4 0.0559218
ASPH aspartate beta-hydroxylase 0.0519117
CALR calreticulin 0.045526
POTEF POTE ankyrin domain family, member F 0.045494
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0454756
NAMPT nicotinamide phosphoribosyltransferase 0.0451545
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0450564
FAM168A family with sequence similarity 168, member A 0.0447695
WDR43 WD repeat domain 43 0.0439573
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.042803
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0425052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0424758
FXR1 fragile X mental retardation, autosomal homolog 1 0.0416964
YBX3 Y box binding protein 3 0.041558
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0404236
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0399903
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0396553
CCNL1 cyclin L1 0.0391081
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0388962
RBM39 RNA binding motif protein 39 0.0387264
KMT2E lysine (K)-specific methyltransferase 2E 0.0385843
YME1L1 YME1-like 1 ATPase 0.0385226
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0369873
DOCK4 dedicator of cytokinesis 4 0.0366788
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0366687
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0364319
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0361279
APP amyloid beta (A4) precursor protein 0.0360673
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0358033
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0356583
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0356413
PAWR PRKC, apoptosis, WT1, regulator 0.0353661
PLS3 plastin 3 0.0353332
HYOU1 hypoxia up-regulated 1 0.0353272
DGKD diacylglycerol kinase, delta 130kDa 0.0352518
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0348157
PCBP2 poly(rC) binding protein 2 0.034745
YBX1 Y box binding protein 1 0.0346841
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0344389
THBS1 thrombospondin 1 0.0339864
MARCHF6 membrane associated ring-CH-type finger 6 0.033972
AHR aryl hydrocarbon receptor 0.0335535
CSDE1 cold shock domain containing E1, RNA-binding 0.0334041
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0332335
NUP58 nucleoporin 58 0.0332256
ZFAND3 zinc finger, AN1-type domain 3 0.0326097
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0325369
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0324257
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0323651
SPAG9 sperm associated antigen 9 0.032236
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0321051
MATR3 matrin 3 0.0320344
ANXA5 annexin A5 0.031681
QKI QKI, KH domain containing, RNA binding 0.0315459
FGD6 FYVE, RhoGEF and PH domain containing 6 0.031247
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0312467
DDIT4 DNA-damage-inducible transcript 4 0.0310805
ANXA1 annexin A1 0.0310456
NOP58 NOP58 ribonucleoprotein 0.0306392
BCLAF1 BCL2-associated transcription factor 1 0.0304329
ITGB5 integrin, beta 5 0.0304115
KIF5B kinesin family member 5B 0.0301821
BASP1 brain abundant, membrane attached signal protein 1 0.0300061
PKM pyruvate kinase, muscle 0.0299784
PDE10A phosphodiesterase 10A 0.0299347
CANX calnexin 0.0298088
FNDC3B fibronectin type III domain containing 3B 0.0297456
IL6 interleukin 6 0.0297447
JAK1 Janus kinase 1 0.0296718
IST1 increased sodium tolerance 1 homolog (yeast) 0.0295586
CYRIB CYFIP related Rac1 interactor B 0.0295529
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0293715
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0292661
FGG fibrinogen gamma chain 0.0292225
MORF4L1 mortality factor 4 like 1 0.028791
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0286849
ADAM9 ADAM metallopeptidase domain 9 0.0284395
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0281986
KTN1 kinectin 1 (kinesin receptor) 0.0281846
ADAM17 ADAM metallopeptidase domain 17 0.0281794
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.0280914
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0280162

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.339505
MT2A metallothionein 2A -0.102173
VIM vimentin -0.0964438
IER3 immediate early response 3 -0.0691385
RPL23 ribosomal protein L23 -0.0588947
ACTG1 actin gamma 1 -0.0578324
RPS8 ribosomal protein S8 -0.0572514
RPL19 ribosomal protein L19 -0.0541462
EIF1 eukaryotic translation initiation factor 1 -0.0485255
TPT1 tumor protein, translationally-controlled 1 -0.0478311
C15ORF48 chromosome 15 open reading frame 48 -0.0473447
S100A10 S100 calcium binding protein A10 -0.0461413
TMSB10 thymosin beta 10 -0.0423557
TM4SF1 transmembrane 4 L six family member 1 -0.039957
RPLP1 ribosomal protein, large, P1 -0.0389058
RPL31 ribosomal protein L31 -0.0373943
RPS15 ribosomal protein S15 -0.036319
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0361131
RPL11 ribosomal protein L11 -0.0356065
RPL35A ribosomal protein L35a -0.0347078
RPS6 ribosomal protein S6 -0.0322163
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0308219
RPL26 ribosomal protein L26 -0.0307135
AHNAK AHNAK nucleoprotein -0.0304782
ANKRD12 ankyrin repeat domain 12 -0.0300351
S100A9 S100 calcium binding protein A9 -0.0292425
ASTN2 astrotactin 2 -0.0288559
RPS17 ribosomal protein S17 -0.0279329
RPS25 ribosomal protein S25 -0.0272365
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0264129
RPS27A ribosomal protein S27a -0.0262422
RPL34 ribosomal protein L34 -0.026131
HLA-B major histocompatibility complex, class I, B -0.0260858
RPS16 ribosomal protein S16 -0.0259491
MAPK8 mitogen-activated protein kinase 8 -0.0259051
RPS19 ribosomal protein S19 -0.0252815
PCNX4 pecanex 4 -0.0246203
RPS11 ribosomal protein S11 -0.0244147
RPS29 ribosomal protein S29 -0.0242431
S100A6 S100 calcium binding protein A6 -0.0237706
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0235616
RPS24 ribosomal protein S24 -0.0234684
RPL38 ribosomal protein L38 -0.0233259
RPL9 ribosomal protein L9 -0.0232879
RPS23 ribosomal protein S23 -0.0231625
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0226422
RPS5 ribosomal protein S5 -0.0223194
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0222236
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0220106
USP34 ubiquitin specific peptidase 34 -0.0219456
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0217002
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0216395
RPS20 ribosomal protein S20 -0.0208567
UBB ubiquitin B -0.0203356
TMEM131 transmembrane protein 131 -0.020311
RPS13 ribosomal protein S13 -0.0202474
PRDX1 peroxiredoxin 1 -0.0199108
RPS27 ribosomal protein S27 -0.0197747
UBASH3B ubiquitin associated and SH3 domain containing B -0.0195849
LOC112694756 uncharaterized LOC112694756 -0.0194045
SAMD4A sterile alpha motif domain containing 4A -0.0193134
BPTF bromodomain PHD finger transcription factor -0.0193046
RPL12 ribosomal protein L12 -0.0187915
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0187456
RASAL2 RAS protein activator like 2 -0.0186123
RPL28 ribosomal protein L28 -0.0181584
RPL36A ribosomal protein L36a -0.01813
BIRC6 baculoviral IAP repeat containing 6 -0.0175018
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0174493
ZCCHC7 zinc finger, CCHC domain containing 7 -0.017039
RPLP2 ribosomal protein, large, P2 -0.0169514
UBC ubiquitin C -0.0166784
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0165215
KYNU kynureninase -0.0163675
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0163235
RPL36 ribosomal protein L36 -0.0162729
NF1 neurofibromin 1 -0.0162136
RPL8 ribosomal protein L8 -0.0161158
CDK13 cyclin-dependent kinase 13 -0.0160583
CUX1 cut-like homeobox 1 -0.0159693
INTS6 integrator complex subunit 6 -0.0159247
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0159143
HMGA1 high mobility group AT-hook 1 -0.0159027
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0157978
ZFY zinc finger protein, Y-linked -0.015758
RPL30 ribosomal protein L30 -0.0156953
DLG1 discs, large homolog 1 (Drosophila) -0.015691
RACK1 receptor for activated C kinase 1 -0.0156068
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0153808
GOLGB1 golgin B1 -0.0153565
TTC3 tetratricopeptide repeat domain 3 -0.0153086
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0151785
RPL35 ribosomal protein L35 -0.0151711
RPS14 ribosomal protein S14 -0.0150364
RPL37 ribosomal protein L37 -0.0150115
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.014865
VDAC1 voltage-dependent anion channel 1 -0.0145136
SH3KBP1 SH3-domain kinase binding protein 1 -0.0144921
RPS21 ribosomal protein S21 -0.0144091
GNAS GNAS complex locus -0.0143815