Voriconazole_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Voriconazole_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.109031
NAMPT nicotinamide phosphoribosyltransferase 0.0956431
NKD1 naked cuticle homolog 1 (Drosophila) 0.0938323
AKAP13 A kinase (PRKA) anchor protein 13 0.0929036
ZNF292 zinc finger protein 292 0.0833786
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0799916
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0752021
CKAP5 cytoskeleton associated protein 5 0.0743895
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0699818
OGA O-GlcNAcase 0.0621668
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0590118
CDC73 cell division cycle 73 0.0555395
FOXO1 forkhead box O1 0.0553698
CUL3 cullin 3 0.0548068
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0546716
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0542269
RAB8B RAB8B, member RAS oncogene family 0.0537889
CCNI cyclin I 0.053687
PDIA3 protein disulfide isomerase family A, member 3 0.0533656
DSCAM Down syndrome cell adhesion molecule 0.0523368
PDS5A PDS5 cohesin associated factor A 0.0514497
MYO5B myosin VB 0.0511426
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0494279
ANKRD12 ankyrin repeat domain 12 0.0479207
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0470156
ECT2 epithelial cell transforming 2 0.0468767
SMYD3 SET and MYND domain containing 3 0.0468426
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0468335
SRRM2 serine/arginine repetitive matrix 2 0.0463986
PCBP3 poly(rC) binding protein 3 0.0459527
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.045169
FTO fat mass and obesity associated 0.045162
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0446409
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0444417
EPS15 epidermal growth factor receptor pathway substrate 15 0.0444151
FXR1 fragile X mental retardation, autosomal homolog 1 0.0443535
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0442508
KDM6A lysine (K)-specific demethylase 6A 0.043877
IGF2R insulin-like growth factor 2 receptor 0.0428625
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.042711
PKN2 protein kinase N2 0.0426161
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0425266
TXNRD1 thioredoxin reductase 1 0.0425221
QKI QKI, KH domain containing, RNA binding 0.0423587
PEAK1 pseudopodium-enriched atypical kinase 1 0.0417488
NAP1L1 nucleosome assembly protein 1-like 1 0.0417139
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0415662
RORA RAR-related orphan receptor A 0.0415394
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0414831
FMNL2 formin-like 2 0.041304
FNBP1L formin binding protein 1-like 0.040988
EPS8 epidermal growth factor receptor pathway substrate 8 0.040948
ELL2 elongation factor, RNA polymerase II, 2 0.040872
ELOVL5 ELOVL fatty acid elongase 5 0.0405248
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0402874
FAM204A family with sequence similarity 204, member A 0.0396036
SKAP2 src kinase associated phosphoprotein 2 0.039505
TOP1 topoisomerase (DNA) I 0.0391633
SENP6 SUMO1/sentrin specific peptidase 6 0.0391062
LMAN1 lectin, mannose-binding, 1 0.0389445
PKM pyruvate kinase, muscle 0.0388987
RAD21 RAD21 homolog (S. pombe) 0.0388385
SET SET nuclear proto-oncogene 0.0387524
NRIP1 nuclear receptor interacting protein 1 0.0383261
MAST4 microtubule associated serine/threonine kinase family member 4 0.0382725
HSPH1 heat shock 105kDa/110kDa protein 1 0.038196
PDLIM5 PDZ and LIM domain 5 0.0379216
SLC35F5 solute carrier family 35, member F5 0.0375366
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0369908
IQGAP1 IQ motif containing GTPase activating protein 1 0.0363692
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0359491
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0358963
GLS2 glutaminase 2 (liver, mitochondrial) 0.0352216
RPL11 ribosomal protein L11 0.0350039
PDE8A phosphodiesterase 8A 0.0348483
PIAS1 protein inhibitor of activated STAT, 1 0.0348036
APP amyloid beta (A4) precursor protein 0.0345871
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0345367
CCNL1 cyclin L1 0.0344891
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0344041
SPRED2 sprouty-related, EVH1 domain containing 2 0.0338305
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0337036
GLG1 golgi glycoprotein 1 0.0334845
DMXL1 Dmx-like 1 0.0328423
PNISR PNN-interacting serine/arginine-rich protein 0.0322907
MATR3 matrin 3 0.0321933
TRA2A transformer 2 alpha homolog (Drosophila) 0.0318734
SEPTIN10 septin 10 0.0318568
PGK1 phosphoglycerate kinase 1 0.0318491
ZSWIM6 zinc finger, SWIM-type containing 6 0.0314787
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0311782
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0311209
MED13L mediator complex subunit 13-like 0.0299272
TPM3 tropomyosin 3 0.0297958
PTBP2 polypyrimidine tract binding protein 2 0.029175
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0287942
NALF1 NALCN channel auxiliary factor 1 0.0287504
NBAS neuroblastoma amplified sequence 0.0285327
TSC22D2 TSC22 domain family, member 2 0.0283168
TNPO1 transportin 1 0.0280413

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143564
TMSB10 thymosin beta 10 -0.114862
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0988397
AKAP12 A kinase (PRKA) anchor protein 12 -0.0890919
MUC16 mucin 16, cell surface associated -0.0847683
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0813994
KRT17 keratin 17, type I -0.080891
IGFBP3 insulin-like growth factor binding protein 3 -0.0769856
RPS25 ribosomal protein S25 -0.0731774
TPT1 tumor protein, translationally-controlled 1 -0.0666585
DLG1 discs, large homolog 1 (Drosophila) -0.0660616
RPS24 ribosomal protein S24 -0.0636687
RPL26 ribosomal protein L26 -0.0578826
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0567757
S100A9 S100 calcium binding protein A9 -0.0562059
RAB7A RAB7A, member RAS oncogene family -0.0554104
RPLP0 ribosomal protein, large, P0 -0.0553898
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0546827
RPL37A ribosomal protein L37a -0.0545854
HLA-A major histocompatibility complex, class I, A -0.0537476
PDE4D phosphodiesterase 4D, cAMP-specific -0.0530869
RPL15 ribosomal protein L15 -0.0530644
KATNBL1 katanin p80 subunit B-like 1 -0.0526915
LAMB3 laminin, beta 3 -0.0518403
MYO1E myosin IE -0.0508069
S100A6 S100 calcium binding protein A6 -0.0503995
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0482396
RPS12 ribosomal protein S12 -0.0468431
TPM4 tropomyosin 4 -0.0440266
CAPN2 calpain 2, (m/II) large subunit -0.0437731
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0421841
MT2A metallothionein 2A -0.0420445
RPL28 ribosomal protein L28 -0.0418033
BPTF bromodomain PHD finger transcription factor -0.0417147
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0416104
ENO1 enolase 1, (alpha) -0.0416077
EIF1 eukaryotic translation initiation factor 1 -0.0413691
RPL12 ribosomal protein L12 -0.0409578
RPS6 ribosomal protein S6 -0.0400399
ACTG1 actin gamma 1 -0.040038
SVIL supervillin -0.0396947
EXT1 exostosin glycosyltransferase 1 -0.0395079
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0393501
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0392693
CD44 CD44 molecule (Indian blood group) -0.0391683
ANXA1 annexin A1 -0.038998
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0386466
RPS27A ribosomal protein S27a -0.0382948
MACF1 microtubule-actin crosslinking factor 1 -0.0372113
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0367272
UGCG UDP-glucose ceramide glucosyltransferase -0.0362051
BCAR3 breast cancer anti-estrogen resistance 3 -0.0361693
UBC ubiquitin C -0.0358821
OSMR oncostatin M receptor -0.0355307
RPL35A ribosomal protein L35a -0.0354284
HLA-B major histocompatibility complex, class I, B -0.0353859
SLC38A1 solute carrier family 38, member 1 -0.034798
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0346483
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0345945
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0345502
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0343623
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0340371
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0335082
TMOD3 tropomodulin 3 (ubiquitous) -0.033285
RPS16 ribosomal protein S16 -0.0327911
ANXA2 annexin A2 -0.0327652
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0320705
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0313684
RPL31 ribosomal protein L31 -0.0310374
PDE10A phosphodiesterase 10A -0.0310232
FAM13A family with sequence similarity 13, member A -0.0307202
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0307199
RSF1 remodeling and spacing factor 1 -0.03066
SEPTIN9 septin 9 -0.0306097
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0305183
RPS20 ribosomal protein S20 -0.0302342
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.029733
FTH1 ferritin, heavy polypeptide 1 -0.0296968
POTEF POTE ankyrin domain family, member F -0.029211
CSNK1A1 casein kinase 1, alpha 1 -0.0289969
TJP1 tight junction protein 1 -0.0289109
RPS19 ribosomal protein S19 -0.0288419
PRKCA protein kinase C, alpha -0.0288334
BACE2 beta-site APP-cleaving enzyme 2 -0.0286872
FTL ferritin, light polypeptide -0.0281666
PTMA prothymosin, alpha -0.0276346
CCND1 cyclin D1 -0.0276127
SRPK2 SRSF protein kinase 2 -0.0269945
RPS8 ribosomal protein S8 -0.0266974
MBD5 methyl-CpG binding domain protein 5 -0.0262924
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0262847
DSTN destrin (actin depolymerizing factor) -0.02578
RAB6A RAB6A, member RAS oncogene family -0.0255977
TM4SF1 transmembrane 4 L six family member 1 -0.0254673
KLF7 Kruppel-like factor 7 (ubiquitous) -0.025084
N4BP2L2 NEDD4 binding protein 2-like 2 -0.025062
TES testin LIM domain protein -0.0250202
RBM39 RNA binding motif protein 39 -0.0246889
JMJD1C jumonji domain containing 1C -0.0246552
CEMIP cell migration inducing protein, hyaluronan binding -0.0245723