Voriconazole_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Voriconazole_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.222233
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0993885
TXNRD1 thioredoxin reductase 1 0.0919988
EEF2 eukaryotic translation elongation factor 2 0.0834657
ERRFI1 ERBB receptor feedback inhibitor 1 0.0807025
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0712345
CSDE1 cold shock domain containing E1, RNA-binding 0.063137
TPM3 tropomyosin 3 0.0607874
KDM2A lysine (K)-specific demethylase 2A 0.0584978
XPO1 exportin 1 0.0546779
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0518576
GRAMD1B GRAM domain containing 1B 0.0510026
KTN1 kinectin 1 (kinesin receptor) 0.0434068
ZFAND3 zinc finger, AN1-type domain 3 0.0422695
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0420764
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0416564
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0401722
TOP2A topoisomerase (DNA) II alpha 170kDa 0.039714
MMP12 matrix metallopeptidase 12 0.0393088
NUP58 nucleoporin 58 0.0374083
EML4 echinoderm microtubule associated protein like 4 0.0354579
MSN moesin 0.0344072
MKI67 marker of proliferation Ki-67 0.0339816
COPA coatomer protein complex, subunit alpha 0.0334967
PUM2 pumilio RNA-binding family member 2 0.0331901
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0331462
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0330717
KCMF1 potassium channel modulatory factor 1 0.0324129
KDM3A lysine (K)-specific demethylase 3A 0.0317327
SRP54 signal recognition particle 54kDa 0.0317128
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0316228
ACTN1 actinin, alpha 1 0.0312465
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0310858
IGF2 insulin-like growth factor 2 0.0308894
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0307315
POTEF POTE ankyrin domain family, member F 0.0304698
CDK17 cyclin-dependent kinase 17 0.0301378
OGA O-GlcNAcase 0.0300048
UBE2H ubiquitin-conjugating enzyme E2H 0.0299731
EIF4B eukaryotic translation initiation factor 4B 0.0297446
STC1 stanniocalcin 1 0.02966
TRIP12 thyroid hormone receptor interactor 12 0.0296438
SENP6 SUMO1/sentrin specific peptidase 6 0.0292394
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290547
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0289504
LRPPRC leucine-rich pentatricopeptide repeat containing 0.028931
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0288403
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0282688
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0281445
ENO1 enolase 1, (alpha) 0.0280856
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0279308
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.027874
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0276936
WASF2 WAS protein family, member 2 0.0270904
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0269425
VMP1 vacuole membrane protein 1 0.0265213
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.026109
SPAG9 sperm associated antigen 9 0.0261064
ANXA5 annexin A5 0.0257993
SMAD3 SMAD family member 3 0.0256993
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0256821
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0252327
MEMO1 mediator of cell motility 1 0.0251085
SRPK2 SRSF protein kinase 2 0.025096
CLTC clathrin, heavy chain (Hc) 0.0247162
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0246097
ANO6 anoctamin 6 0.0243216
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0242661
RTN4 reticulon 4 0.0238946
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0237243
KPNB1 karyopherin (importin) beta 1 0.0236885
TAOK1 TAO kinase 1 0.0236747
GOLGA4 golgin A4 0.0236485
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0234167
PPME1 protein phosphatase methylesterase 1 0.0233579
WRN Werner syndrome, RecQ helicase-like 0.0233415
RAB7A RAB7A, member RAS oncogene family 0.0231756
ADAM17 ADAM metallopeptidase domain 17 0.0230357
ZNF292 zinc finger protein 292 0.0229996
RICTOR RPTOR independent companion of MTOR, complex 2 0.022843
PGK1 phosphoglycerate kinase 1 0.0227959
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0227005
WDR43 WD repeat domain 43 0.0225937
LATS2 large tumor suppressor kinase 2 0.0225589
AVL9 AVL9 homolog (S. cerevisiase) 0.0224749
AKAP13 A kinase (PRKA) anchor protein 13 0.0219848
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0219615
ZBTB35 zinc finger and BTB domain containing 35 0.0217748
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0217647
XPO6 exportin 6 0.0217616
KMT5B lysine methyltransferase 5B 0.0217579
CSNK1A1 casein kinase 1, alpha 1 0.0217008
SRRM2 serine/arginine repetitive matrix 2 0.0216298
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.021576
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0215412
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0215354
USP9X ubiquitin specific peptidase 9, X-linked 0.0215354
KMT2E lysine (K)-specific methyltransferase 2E 0.021429
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0214239
ELL2 elongation factor, RNA polymerase II, 2 0.0213723

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148893
TMSB10 thymosin beta 10 -0.0811335
RPL26 ribosomal protein L26 -0.0622397
RPL35A ribosomal protein L35a -0.0556079
RPLP1 ribosomal protein, large, P1 -0.0549319
RPS29 ribosomal protein S29 -0.0537491
RPS21 ribosomal protein S21 -0.0515808
RPL23 ribosomal protein L23 -0.048542
TPT1 tumor protein, translationally-controlled 1 -0.0448852
RPS8 ribosomal protein S8 -0.0446776
RPL12 ribosomal protein L12 -0.0441377
RPLP2 ribosomal protein, large, P2 -0.0436521
RPL5 ribosomal protein L5 -0.0413724
TFPI2 tissue factor pathway inhibitor 2 -0.0411843
RPS15 ribosomal protein S15 -0.040422
NAP1L1 nucleosome assembly protein 1-like 1 -0.0384404
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0383918
RPL19 ribosomal protein L19 -0.0373313
MYL12B myosin, light chain 12B, regulatory -0.0371174
RPL11 ribosomal protein L11 -0.0370191
RPS27 ribosomal protein S27 -0.0369131
MT2A metallothionein 2A -0.0355032
RPL31 ribosomal protein L31 -0.0347572
RPL9 ribosomal protein L9 -0.0344124
RPS12 ribosomal protein S12 -0.0337808
RPL37A ribosomal protein L37a -0.03263
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0325406
RPS19 ribosomal protein S19 -0.0318297
RPS24 ribosomal protein S24 -0.0316275
RPL34 ribosomal protein L34 -0.0316076
RPS10 ribosomal protein S10 -0.0310096
RPS3 ribosomal protein S3 -0.0301296
RIMS2 regulating synaptic membrane exocytosis 2 -0.0295966
RPL38 ribosomal protein L38 -0.0291867
RPS6 ribosomal protein S6 -0.0284832
RPL37 ribosomal protein L37 -0.0282361
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.027511
ATP5F1E ATP synthase F1 subunit epsilon -0.0270475
RPL36 ribosomal protein L36 -0.0262469
PTMA prothymosin, alpha -0.0261318
RPLP0 ribosomal protein, large, P0 -0.0257815
FUS FUS RNA binding protein -0.0256151
AEBP2 AE binding protein 2 -0.0250082
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0246855
RPL8 ribosomal protein L8 -0.0245563
RPS27A ribosomal protein S27a -0.0244628
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0241068
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0236958
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0236812
RPS23 ribosomal protein S23 -0.0235568
RPS14 ribosomal protein S14 -0.0228231
RPS13 ribosomal protein S13 -0.0227681
RPL32 ribosomal protein L32 -0.0226227
RPL27 ribosomal protein L27 -0.0225591
RPS4X ribosomal protein S4, X-linked -0.0224585
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0222233
PRELID2 PRELI domain containing 2 -0.0220516
RPS25 ribosomal protein S25 -0.0218015
NACA nascent polypeptide-associated complex alpha subunit -0.0215722
EIF5B eukaryotic translation initiation factor 5B -0.0211856
INTS6 integrator complex subunit 6 -0.0210527
RPL36A ribosomal protein L36a -0.0210355
RPS20 ribosomal protein S20 -0.0210221
EIF1 eukaryotic translation initiation factor 1 -0.0209368
PRH1 proline-rich protein HaeIII subfamily 1 -0.0207596
RPL28 ribosomal protein L28 -0.0204191
ACTG1 actin gamma 1 -0.0201759
RPS17 ribosomal protein S17 -0.0200934
RPL13A ribosomal protein L13a -0.0198211
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0193825
RPL30 ribosomal protein L30 -0.0193355
RPS16 ribosomal protein S16 -0.019161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0190726
WNT2B wingless-type MMTV integration site family, member 2B -0.0189898
WWOX WW domain containing oxidoreductase -0.0188927
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0181458
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.017794
RPS11 ribosomal protein S11 -0.017477
RPL35 ribosomal protein L35 -0.0174628
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0173276
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0171297
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0170591
HMGB1 high mobility group box 1 -0.0166174
GSTP1 glutathione S-transferase pi 1 -0.0162827
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0158859
VIM vimentin -0.0158586
OAZ1 ornithine decarboxylase antizyme 1 -0.0157981
STYK1 serine/threonine/tyrosine kinase 1 -0.0156718
NDRG1 N-myc downstream regulated 1 -0.0155606
NEK10 NIMA-related kinase 10 -0.0155379
VDAC1 voltage-dependent anion channel 1 -0.0153604
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0150289
TBCA tubulin folding cofactor A -0.0145507
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0139221
S100A11 S100 calcium binding protein A11 -0.0139032
RFC3 replication factor C (activator 1) 3, 38kDa -0.0138162
RPL4 ribosomal protein L4 -0.0134876
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0133344
RPL18 ribosomal protein L18 -0.0133056
TPI1 triosephosphate isomerase 1 -0.0131778