Voriconazole_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Voriconazole_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.125333
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0959793
EGFR epidermal growth factor receptor 0.0732599
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0579235
EXT1 exostosin glycosyltransferase 1 0.0479795
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0478974
TXNRD1 thioredoxin reductase 1 0.0460874
ZBTB20 zinc finger and BTB domain containing 20 0.0440764
POTEF POTE ankyrin domain family, member F 0.0432477
VCL vinculin 0.0430289
PRELID2 PRELI domain containing 2 0.0426298
SLC38A2 solute carrier family 38, member 2 0.041195
ZFAND3 zinc finger, AN1-type domain 3 0.0411164
ANK2 ankyrin 2, neuronal 0.037312
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0367306
ADAM10 ADAM metallopeptidase domain 10 0.0360624
EVI5 ecotropic viral integration site 5 0.0359686
PDGFC platelet derived growth factor C 0.035914
ZNF608 zinc finger protein 608 0.0352498
FNIP1 folliculin interacting protein 1 0.0335299
TTC3 tetratricopeptide repeat domain 3 0.0331606
PYGB phosphorylase, glycogen; brain 0.0331195
SAMD4A sterile alpha motif domain containing 4A 0.0324602
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.031505
NCEH1 neutral cholesterol ester hydrolase 1 0.0312827
SOX6 SRY (sex determining region Y)-box 6 0.0312814
ADAM9 ADAM metallopeptidase domain 9 0.0312383
PKM pyruvate kinase, muscle 0.0311314
METTL15 methyltransferase like 15 0.0308787
ITCH itchy E3 ubiquitin protein ligase 0.030771
TJP1 tight junction protein 1 0.0305873
RBM26 RNA binding motif protein 26 0.0302998
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0298842
TMEM65 transmembrane protein 65 0.029741
SQSTM1 sequestosome 1 0.028919
GOLGA4 golgin A4 0.0286807
ZCCHC7 zinc finger, CCHC domain containing 7 0.0285699
SBF2 SET binding factor 2 0.0279562
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0271774
LPP LIM domain containing preferred translocation partner in lipoma 0.0263234
HM13 histocompatibility (minor) 13 0.025547
MBD5 methyl-CpG binding domain protein 5 0.0254991
SMYD3 SET and MYND domain containing 3 0.0254261
VIM vimentin 0.0251686
ASPH aspartate beta-hydroxylase 0.0250982
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0250557
ENO1 enolase 1, (alpha) 0.0247729
NUP58 nucleoporin 58 0.0247285
TMSB10 thymosin beta 10 0.0247174
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.024705
DENND4A DENN/MADD domain containing 4A 0.0244297
TAS2R14 taste receptor, type 2, member 14 0.0240138
SENP6 SUMO1/sentrin specific peptidase 6 0.0239788
N4BP2L2 NEDD4 binding protein 2-like 2 0.023798
JMJD1C jumonji domain containing 1C 0.0237129
VMP1 vacuole membrane protein 1 0.022936
COG6 component of oligomeric golgi complex 6 0.0227813
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0226898
USP34 ubiquitin specific peptidase 34 0.0225571
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0223202
LDHA lactate dehydrogenase A 0.0222655
MEF2A myocyte enhancer factor 2A 0.0222376
GLS2 glutaminase 2 (liver, mitochondrial) 0.0218772
DSCAM Down syndrome cell adhesion molecule 0.0212045
NPAS2 neuronal PAS domain protein 2 0.0211967
PLK2 polo-like kinase 2 0.0210267
PTEN phosphatase and tensin homolog 0.0209096
CLTC clathrin, heavy chain (Hc) 0.0206991
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0206504
CCNL1 cyclin L1 0.0205156
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0204539
PCBP2 poly(rC) binding protein 2 0.0204029
FHIT fragile histidine triad 0.0203049
APLP2 amyloid beta (A4) precursor-like protein 2 0.0201549
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.020058
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0200264
PMM2 phosphomannomutase 2 0.0199483
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0198774
TBC1D22A TBC1 domain family, member 22A 0.0197279
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0195154
PTPRG protein tyrosine phosphatase, receptor type, G 0.0194114
FER fer (fps/fes related) tyrosine kinase 0.0192177
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0191897
PRDX2 peroxiredoxin 2 0.0190914
PTK2 protein tyrosine kinase 2 0.0190453
RFX7 regulatory factor X, 7 0.019042
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.019019
EFNA5 ephrin-A5 0.0189668
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0189521
FXR1 fragile X mental retardation, autosomal homolog 1 0.0188892
RBM39 RNA binding motif protein 39 0.0188847
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0188593
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0184368
BRD2 bromodomain containing 2 0.0183794
CAMTA1 calmodulin binding transcription activator 1 0.0181065
GOSR2 golgi SNAP receptor complex member 2 0.0177226
PIAS2 protein inhibitor of activated STAT, 2 0.0176708
ZNF217 zinc finger protein 217 0.0174006
MED13 mediator complex subunit 13 0.0173934
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0171802

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.245424
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0883786
AHNAK AHNAK nucleoprotein -0.0636844
BMP10 bone morphogenetic protein 10 -0.0625554
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0510367
TMSB4X thymosin beta 4, X-linked -0.0474426
NAV2 neuron navigator 2 -0.0467714
MKI67 marker of proliferation Ki-67 -0.0439309
TPT1 tumor protein, translationally-controlled 1 -0.0416585
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0396133
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0391391
NAP1L1 nucleosome assembly protein 1-like 1 -0.0389058
DLG1 discs, large homolog 1 (Drosophila) -0.0369706
WSB1 WD repeat and SOCS box containing 1 -0.035916
KPNB1 karyopherin (importin) beta 1 -0.0333425
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0323832
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0321284
KDM3A lysine (K)-specific demethylase 3A -0.0320395
CENPF centromere protein F, 350/400kDa -0.0316201
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0308698
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303999
RPL26 ribosomal protein L26 -0.0288986
RPLP1 ribosomal protein, large, P1 -0.0283042
SSBP2 single-stranded DNA binding protein 2 -0.028286
RPL35A ribosomal protein L35a -0.0279678
ANXA1 annexin A1 -0.0274915
FOXP1 forkhead box P1 -0.0266317
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0263929
ZEB1 zinc finger E-box binding homeobox 1 -0.0258436
RPL34 ribosomal protein L34 -0.0258066
BCOR BCL6 corepressor -0.0257619
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0256039
HSPB1 heat shock 27kDa protein 1 -0.0243685
ARID4B AT rich interactive domain 4B (RBP1-like) -0.023813
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0237764
SMC4 structural maintenance of chromosomes 4 -0.0237052
RPS24 ribosomal protein S24 -0.0235412
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0235328
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0234234
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0233247
RSRC2 arginine/serine-rich coiled-coil 2 -0.0218746
NFIA nuclear factor I/A -0.0215286
TUBB4B tubulin, beta 4B class IVb -0.0213246
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0210789
USP3 ubiquitin specific peptidase 3 -0.0210111
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.020938
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0206165
SMC3 structural maintenance of chromosomes 3 -0.0201791
S100A4 S100 calcium binding protein A4 -0.0199724
EBNA1BP2 EBNA1 binding protein 2 -0.01992
RPS8 ribosomal protein S8 -0.0199142
MYOF myoferlin -0.0184713
HMGB1 high mobility group box 1 -0.0179833
MYL12B myosin, light chain 12B, regulatory -0.0177862
RPL38 ribosomal protein L38 -0.0175949
RRM2 ribonucleotide reductase M2 -0.0175626
KIF5B kinesin family member 5B -0.0173063
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0171954
BZW1 basic leucine zipper and W2 domains 1 -0.0170157
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0169472
RPLP0 ribosomal protein, large, P0 -0.0168811
GSE1 Gse1 coiled-coil protein -0.0168029
ANLN anillin, actin binding protein -0.0164567
UNC13A unc-13 homolog A (C. elegans) -0.0161505
S100A6 S100 calcium binding protein A6 -0.0161098
OGA O-GlcNAcase -0.016064
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0160354
FAM13A family with sequence similarity 13, member A -0.0159977
ZNF438 zinc finger protein 438 -0.0157628
PDE7B phosphodiesterase 7B -0.0154347
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0152704
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0149454
RPL23 ribosomal protein L23 -0.0147887
MYO5C myosin VC -0.0147527
RPL4 ribosomal protein L4 -0.0147178
RRBP1 ribosome binding protein 1 -0.0145425
RPL37A ribosomal protein L37a -0.0145151
RPL19 ribosomal protein L19 -0.01451
DENND1A DENN/MADD domain containing 1A -0.0144274
S100A10 S100 calcium binding protein A10 -0.0143981
GLI2 GLI family zinc finger 2 -0.0143553
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0143134
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0142228
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0141753
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0141119
FAM162A family with sequence similarity 162, member A -0.0141099
PUM2 pumilio RNA-binding family member 2 -0.014057
RPS6 ribosomal protein S6 -0.014042
RPL13A ribosomal protein L13a -0.0139555
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0139053
PRC1 protein regulator of cytokinesis 1 -0.0138112
XPO1 exportin 1 -0.0137826
RAD21 RAD21 homolog (S. pombe) -0.0137823
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0136105
YBX3 Y box binding protein 3 -0.0134796
GNAS GNAS complex locus -0.0134589
KIF18B kinesin family member 18B -0.0134452
CKAP2 cytoskeleton associated protein 2 -0.0134292
NOP56 NOP56 ribonucleoprotein -0.0134279
LMNA lamin A/C -0.013377