Voriconazole_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Voriconazole perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Voriconazole_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NUP58 nucleoporin 58 0.0748383
BIRC3 baculoviral IAP repeat containing 3 0.066654
ITCH itchy E3 ubiquitin protein ligase 0.0616692
PNISR PNN-interacting serine/arginine-rich protein 0.0589086
CHD1 chromodomain helicase DNA binding protein 1 0.054956
WAC WW domain containing adaptor with coiled-coil 0.0537289
NAP1L1 nucleosome assembly protein 1-like 1 0.053057
HILPDA hypoxia inducible lipid droplet-associated 0.0521734
KIF5B kinesin family member 5B 0.0483169
TNIP1 TNFAIP3 interacting protein 1 0.0472928
ISG15 ISG15 ubiquitin-like modifier 0.0458482
TNPO1 transportin 1 0.0444927
APLP2 amyloid beta (A4) precursor-like protein 2 0.0442146
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0439716
KMT2E lysine (K)-specific methyltransferase 2E 0.0435836
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0425711
FNDC3A fibronectin type III domain containing 3A 0.0419569
MIS18BP1 MIS18 binding protein 1 0.0418629
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0409728
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0400992
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0392919
HLA-A major histocompatibility complex, class I, A 0.0376872
TENT2 terminal nucleotidyltransferase 2 0.0375545
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0369278
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0362316
ERBIN erbb2 interacting protein 0.0361603
GLCCI1 glucocorticoid induced 1 0.0358358
SNX14 sorting nexin 14 0.0354683
DCAF7 DDB1 and CUL4 associated factor 7 0.0349813
CEP350 centrosomal protein 350kDa 0.0346145
SMC4 structural maintenance of chromosomes 4 0.0339551
TXNRD1 thioredoxin reductase 1 0.0337294
RB1 retinoblastoma 1 0.032952
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0326097
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0326003
SEPTIN2 septin 2 0.0324981
TOP1 topoisomerase (DNA) I 0.0321382
SEPTIN7 septin 7 0.0319575
MATR3 matrin 3 0.0318602
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0317605
CEP170 centrosomal protein 170kDa 0.0317459
MT2A metallothionein 2A 0.0315448
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0311985
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0310612
TNRC6A trinucleotide repeat containing 6A 0.0308165
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0307664
LARP4 La ribonucleoprotein domain family, member 4 0.0307394
GIGYF2 GRB10 interacting GYF protein 2 0.0306978
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0306715
SET SET nuclear proto-oncogene 0.0304985
WDR43 WD repeat domain 43 0.0303371
RSL24D1 ribosomal L24 domain containing 1 0.0299442
CENPF centromere protein F, 350/400kDa 0.0294714
NOP58 NOP58 ribonucleoprotein 0.0294244
NUP153 nucleoporin 153kDa 0.0292427
TM9SF2 transmembrane 9 superfamily member 2 0.029172
RAB6A RAB6A, member RAS oncogene family 0.0291706
RAD18 RAD18 E3 ubiquitin protein ligase 0.0289941
KTN1 kinectin 1 (kinesin receptor) 0.028699
B2M beta-2-microglobulin 0.0284913
CELF1 CUGBP, Elav-like family member 1 0.0284893
HSPH1 heat shock 105kDa/110kDa protein 1 0.0283847
USP37 ubiquitin specific peptidase 37 0.0283546
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0283055
WNK1 WNK lysine deficient protein kinase 1 0.0282633
GOLGA2 golgin A2 0.0281241
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0281175
S100A9 S100 calcium binding protein A9 0.0281144
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0280577
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0278724
TPST1 tyrosylprotein sulfotransferase 1 0.0278693
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0276169
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0275786
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0272949
CUL3 cullin 3 0.0272789
MCTP1 multiple C2 domains, transmembrane 1 0.0272524
ZNF148 zinc finger protein 148 0.0270925
NIPBL Nipped-B homolog (Drosophila) 0.0269268
ANLN anillin, actin binding protein 0.0268748
SRPK1 SRSF protein kinase 1 0.0264558
PHIP pleckstrin homology domain interacting protein 0.0263951
SLC35F5 solute carrier family 35, member F5 0.0262312
AHCTF1 AT hook containing transcription factor 1 0.0257741
ZBTB35 zinc finger and BTB domain containing 35 0.0257609
SPAG9 sperm associated antigen 9 0.0256673
LRRC49 leucine rich repeat containing 49 0.0256087
SEC24A SEC24 family member A 0.0255415
VMP1 vacuole membrane protein 1 0.0254988
ANXA5 annexin A5 0.025417
ZNF638 zinc finger protein 638 0.0253851
RNF149 ring finger protein 149 0.0251119
INSIG2 insulin induced gene 2 0.0250407
ARHGAP26 Rho GTPase activating protein 26 0.0250107
RPL35A ribosomal protein L35a 0.0250051
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0249556
NAMPT nicotinamide phosphoribosyltransferase 0.0248765
SGO2 shugoshin 2 0.0248548
RPL28 ribosomal protein L28 0.0247903
KIF18A kinesin family member 18A 0.0244565
TRA2A transformer 2 alpha homolog (Drosophila) 0.024418

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.259148
FNDC3B fibronectin type III domain containing 3B -0.0786155
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0775457
OSMR oncostatin M receptor -0.0764252
VCL vinculin -0.0698244
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0573946
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0557765
IGFBP3 insulin-like growth factor binding protein 3 -0.0551326
CD44 CD44 molecule (Indian blood group) -0.0532106
FMN1 formin 1 -0.0529455
ACTG1 actin gamma 1 -0.0478458
SAMD4A sterile alpha motif domain containing 4A -0.0477261
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0470536
DPYD dihydropyrimidine dehydrogenase -0.0461842
NALCN sodium leak channel, non selective -0.0453175
ANXA2 annexin A2 -0.045305
ZBTB20 zinc finger and BTB domain containing 20 -0.0446103
TMSB10 thymosin beta 10 -0.043935
ATM ATM serine/threonine kinase -0.0437623
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0436591
FLNB filamin B, beta -0.0427774
BASP1 brain abundant, membrane attached signal protein 1 -0.0426289
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0410903
SVIL supervillin -0.0410275
PBX3 pre-B-cell leukemia homeobox 3 -0.0408575
NDRG1 N-myc downstream regulated 1 -0.0402172
AHNAK AHNAK nucleoprotein -0.0400767
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0393871
SLC38A2 solute carrier family 38, member 2 -0.0386225
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0371796
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0355108
DST dystonin -0.0348592
MBNL1 muscleblind-like splicing regulator 1 -0.0343653
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0343433
DNER delta/notch-like EGF repeat containing -0.0341935
RAB7A RAB7A, member RAS oncogene family -0.0339213
LPP LIM domain containing preferred translocation partner in lipoma -0.0339093
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0329629
DLG1 discs, large homolog 1 (Drosophila) -0.0329366
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0328532
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0328271
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0326304
IL1RAP interleukin 1 receptor accessory protein -0.0324275
LATS2 large tumor suppressor kinase 2 -0.0319223
THSD4 thrombospondin, type I, domain containing 4 -0.0317212
TCF12 transcription factor 12 -0.0315914
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0312051
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0311274
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0310851
ELL2 elongation factor, RNA polymerase II, 2 -0.03039
MPRIP myosin phosphatase Rho interacting protein -0.0300914
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0300562
EIF5B eukaryotic translation initiation factor 5B -0.0296243
FERMT2 fermitin family member 2 -0.0290349
AKAP12 A kinase (PRKA) anchor protein 12 -0.0287492
RABGAP1L RAB GTPase activating protein 1-like -0.0285928
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.02853
EFNA5 ephrin-A5 -0.0284395
NKTR natural killer cell triggering receptor -0.0282721
PCNX4 pecanex 4 -0.0280246
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0279695
ZBTB38 zinc finger and BTB domain containing 38 -0.0275234
SLC35F3 solute carrier family 35, member F3 -0.0274672
HELZ helicase with zinc finger -0.0273654
SDCCAG8 serologically defined colon cancer antigen 8 -0.0273454
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0272829
CEP135 centrosomal protein 135kDa -0.0270652
RNF213 ring finger protein 213 -0.0267872
HMGA2 high mobility group AT-hook 2 -0.0266999
BCAR3 breast cancer anti-estrogen resistance 3 -0.0265339
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0263548
ANKRD28 ankyrin repeat domain 28 -0.0262221
ANKRD11 ankyrin repeat domain 11 -0.0261781
CAMKMT calmodulin-lysine N-methyltransferase -0.0260126
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -0.0257056
TPM4 tropomyosin 4 -0.0255502
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.025476
WWOX WW domain containing oxidoreductase -0.0251689
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0249495
CBX3 chromobox homolog 3 -0.0249172
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.024841
BTG1 B-cell translocation gene 1, anti-proliferative -0.0248097
EPAS1 endothelial PAS domain protein 1 -0.0248035
ATF7IP activating transcription factor 7 interacting protein -0.0240822
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.024038
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0239346
EXT1 exostosin glycosyltransferase 1 -0.0235747
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0235641
GPC6 glypican 6 -0.0235483
RAB31 RAB31, member RAS oncogene family -0.0234832
MSRB3 methionine sulfoxide reductase B3 -0.0234252
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0232141
CCDC91 coiled-coil domain containing 91 -0.0230753
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0226516
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0226502
EVI5 ecotropic viral integration site 5 -0.0222745
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0221139
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0219456
EGFR epidermal growth factor receptor -0.0218936
LOC112694756 uncharaterized LOC112694756 -0.0218477