| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5311 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Vorinostat relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 6.95 |
| VGF | VGF nerve growth factor inducible | 5.86 |
| PEG10 | paternally expressed 10 | 4.88 |
| IRF7 | interferon regulatory factor 7 | 4.54 |
| NCAM1 | neural cell adhesion molecule 1 | 4.08 |
| CCN2 | cellular communication network factor 2 | 4.07 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 3.95 |
| CCND3 | cyclin D3 | 3.75 |
| NGFR | nerve growth factor receptor | 3.64 |
| BAIAP3 | BAI1-associated protein 3 | 3.41 |
| ARG2 | arginase 2 | 3.38 |
| CLU | clusterin | 3.19 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 3.15 |
| SORBS1 | sorbin and SH3 domain containing 1 | 3.07 |
| EPPK1 | epiplakin 1 | 3.06 |
| MT1X | metallothionein 1X | 3.05 |
| CRYM | crystallin, mu | 3.01 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 2.97 |
| ABAT | 4-aminobutyrate aminotransferase | 2.97 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 2.84 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.73 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 2.7 |
| ANGPTL4 | angiopoietin-like 4 | 2.62 |
| TUFT1 | tuftelin 1 | 2.59 |
| CORO1A | coronin, actin binding protein, 1A | 2.54 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 2.48 |
| TPM1 | tropomyosin 1 (alpha) | 2.42 |
| TPPP | tubulin polymerization promoting protein | 2.4 |
| MAP2 | microtubule-associated protein 2 | 2.35 |
| MIDN | midnolin | 2.34 |
| CLIC3 | chloride intracellular channel 3 | 2.33 |
| MT2A | metallothionein 2A | 2.31 |
| KIAA0513 | KIAA0513 | 2.29 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 2.26 |
| DOCK4 | dedicator of cytokinesis 4 | 2.24 |
| CPA4 | carboxypeptidase A4 | 2.21 |
| SYN1 | synapsin I | 2.16 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 2.13 |
| FBXO3 | F-box protein 3 | 2.13 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 2.12 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 2.09 |
| GCH1 | GTP cyclohydrolase 1 | 2.08 |
| TDRKH | tudor and KH domain containing | 2.07 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 2.06 |
| LRRC46 | leucine rich repeat containing 46 | 2.05 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 2.05 |
| VWA5A | von Willebrand factor A domain containing 5A | 2.05 |
| HYKK | hydroxylysine kinase | 2.05 |
| H1-0 | H1.0 linker histone | 2.04 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 2.04 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 2.03 |
| GABRQ | gamma-aminobutyric acid (GABA) A receptor, theta | 2.01 |
| DERPC | DERPC proline and glycine rich nuclear protein | 2.0 |
| NOVA1 | neuro-oncological ventral antigen 1 | 2.0 |
| HPCAL4 | hippocalcin like 4 | 1.97 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 1.97 |
| CA8 | carbonic anhydrase VIII | 1.97 |
| ATF3 | activating transcription factor 3 | 1.97 |
| ODC1 | ornithine decarboxylase 1 | 1.96 |
| BTBD11 | BTB (POZ) domain containing 11 | 1.93 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 1.92 |
| CCDC170 | coiled-coil domain containing 170 | 1.91 |
| CALU | calumenin | 1.9 |
| GM2A | GM2 ganglioside activator | 1.87 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | 1.86 |
| DPYSL4 | dihydropyrimidinase-like 4 | 1.86 |
| NCKAP5L | NCK-associated protein 5-like | 1.85 |
| CAPN5 | calpain 5 | 1.85 |
| RAET1G | retinoic acid early transcript 1G | 1.83 |
| ALDOC | aldolase C, fructose-bisphosphate | 1.82 |
| IRF6 | interferon regulatory factor 6 | 1.82 |
| TPM3 | tropomyosin 3 | 1.82 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 1.81 |
| MAPK8IP3 | mitogen-activated protein kinase 8 interacting protein 3 | 1.81 |
| LMCD1 | LIM and cysteine-rich domains 1 | 1.79 |
| NARF | nuclear prelamin A recognition factor | 1.77 |
| CASZ1 | castor zinc finger 1 | 1.75 |
| RAB3A | RAB3A, member RAS oncogene family | 1.73 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 1.73 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 1.72 |
| KIF21B | kinesin family member 21B | 1.71 |
| OPTN | optineurin | 1.71 |
| GCDH | glutaryl-CoA dehydrogenase | 1.69 |
| SNAP29 | synaptosomal-associated protein, 29kDa | 1.69 |
| PLCD1 | phospholipase C, delta 1 | 1.68 |
| ZER1 | zyg-11 related, cell cycle regulator | 1.68 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.68 |
| CSRP2 | cysteine and glycine-rich protein 2 | 1.66 |
| PLA2G15 | phospholipase A2, group XV | 1.65 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 1.65 |
| ZFP36 | ZFP36 ring finger protein | 1.64 |
| BPGM | 2,3-bisphosphoglycerate mutase | 1.64 |
| ALAD | aminolevulinate dehydratase | 1.62 |
| GSKIP | GSK3B interacting protein | 1.62 |
| OSTF1 | osteoclast stimulating factor 1 | 1.6 |
| JPT1 | Jupiter microtubule associated homolog 1 | 1.58 |
| CYLD | cylindromatosis (turban tumor syndrome) | 1.57 |
| MAP1A | microtubule-associated protein 1A | 1.57 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | -3.74 |
| HOXB8 | homeobox B8 | -3.34 |
| EREG | epiregulin | -3.1 |
| TGIF1 | TGFB-induced factor homeobox 1 | -3.09 |
| E2F8 | E2F transcription factor 8 | -3.06 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -3.03 |
| JDP2 | Jun dimerization protein 2 | -2.78 |
| TRIB1 | tribbles pseudokinase 1 | -2.69 |
| PLAU | plasminogen activator, urokinase | -2.65 |
| HAS3 | hyaluronan synthase 3 | -2.62 |
| RARG | retinoic acid receptor, gamma | -2.59 |
| MLPH | melanophilin | -2.47 |
| ZBTB1 | zinc finger and BTB domain containing 1 | -2.42 |
| ADAM19 | ADAM metallopeptidase domain 19 | -2.41 |
| CCNA2 | cyclin A2 | -2.37 |
| PCLAF | PCNA clamp associated factor | -2.36 |
| HOXB7 | homeobox B7 | -2.35 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | -2.31 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -2.29 |
| ZBTB8A | zinc finger and BTB domain containing 8A | -2.28 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | -2.28 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -2.26 |
| WEE1 | WEE1 G2 checkpoint kinase | -2.25 |
| SCARA3 | scavenger receptor class A, member 3 | -2.17 |
| ZBED2 | zinc finger, BED-type containing 2 | -2.13 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -2.11 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -2.1 |
| RGS3 | regulator of G-protein signaling 3 | -2.07 |
| CFAP97 | cilia and flagella associated protein 97 | -2.07 |
| DUSP4 | dual specificity phosphatase 4 | -2.05 |
| UCK2 | uridine-cytidine kinase 2 | -2.05 |
| SMAD1 | SMAD family member 1 | -2.04 |
| ZNF367 | zinc finger protein 367 | -2.04 |
| SOCS6 | suppressor of cytokine signaling 6 | -2.02 |
| AEN | apoptosis enhancing nuclease | -2.01 |
| CUEDC1 | CUE domain containing 1 | -2.0 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | -2.0 |
| TYRO3 | TYRO3 protein tyrosine kinase | -1.98 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -1.98 |
| MROH6 | maestro heat-like repeat family member 6 | -1.97 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -1.95 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -1.93 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -1.93 |
| TCF12 | transcription factor 12 | -1.92 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -1.92 |
| E2F2 | E2F transcription factor 2 | -1.91 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -1.91 |
| FOXM1 | forkhead box M1 | -1.9 |
| HOXB4 | homeobox B4 | -1.89 |
| JADE2 | jade family PHD finger 2 | -1.88 |
| MID1IP1 | MID1 interacting protein 1 | -1.88 |
| CDC25B | cell division cycle 25B | -1.86 |
| CXXC5 | CXXC finger protein 5 | -1.86 |
| PATZ1 | POZ (BTB) and AT hook containing zinc finger 1 | -1.85 |
| OSMR | oncostatin M receptor | -1.85 |
| PRDM4 | PR domain containing 4 | -1.84 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -1.83 |
| SLC16A6 | solute carrier family 16, member 6 | -1.83 |
| KEAP1 | kelch-like ECH-associated protein 1 | -1.82 |
| TRIM8 | tripartite motif containing 8 | -1.81 |
| STC2 | stanniocalcin 2 | -1.8 |
| TP73 | tumor protein p73 | -1.8 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -1.79 |
| HOXB9 | homeobox B9 | -1.78 |
| TNS4 | tensin 4 | -1.77 |
| ZNF777 | zinc finger protein 777 | -1.77 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -1.76 |
| ARMC4 | armadillo repeat containing 4 | -1.76 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -1.76 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -1.75 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -1.74 |
| PLIN2 | perilipin 2 | -1.74 |
| TRIM7 | tripartite motif containing 7 | -1.74 |
| TRAF5 | TNF receptor-associated factor 5 | -1.74 |
| MYRF | myelin regulatory factor | -1.73 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -1.72 |
| HYLS1 | hydrolethalus syndrome 1 | -1.72 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -1.71 |
| VCAN | versican | -1.71 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | -1.71 |
| SACK1B | scaffolding CK1 anchoring protein B | -1.71 |
| NHSL1 | NHS-like 1 | -1.7 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -1.7 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -1.7 |
| CDX2 | caudal type homeobox 2 | -1.68 |
| TMEM51 | transmembrane protein 51 | -1.67 |
| SMAD3 | SMAD family member 3 | -1.67 |
| EHF | ets homologous factor | -1.67 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | -1.67 |
| PRNP | prion protein | -1.66 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -1.66 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | -1.66 |
| PHF19 | PHD finger protein 19 | -1.66 |
| SATB2 | SATB homeobox 2 | -1.65 |
| PHF20 | PHD finger protein 20 | -1.65 |
| TYMS | thymidylate synthetase | -1.64 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -1.64 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -1.64 |
| ZFX | zinc finger protein, X-linked | -1.64 |
| LZTS2 | leucine zipper, putative tumor suppressor 2 | -1.64 |
