| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SUCNR1 | succinate receptor 1 | 0.052134 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0449488 |
| POTEF | POTE ankyrin domain family, member F | 0.0308382 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0302148 |
| CDH13 | cadherin 13 | 0.0271458 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0257716 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0248462 |
| APP | amyloid beta (A4) precursor protein | 0.0242095 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0241143 |
| COL1A2 | collagen, type I, alpha 2 | 0.0232876 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0226909 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0223052 |
| COL3A1 | collagen, type III, alpha 1 | 0.0191822 |
| FADS2 | fatty acid desaturase 2 | 0.0184413 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0181907 |
| TPM4 | tropomyosin 4 | 0.0171509 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0169783 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0167478 |
| FRMD5 | FERM domain containing 5 | 0.0167231 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0163904 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0161751 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0159474 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0156754 |
| GOLGA2 | golgin A2 | 0.0150273 |
| CDC42SE1 | CDC42 small effector 1 | 0.0149517 |
| TPM1 | tropomyosin 1 (alpha) | 0.0148273 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0147785 |
| SON | SON DNA binding protein | 0.0146541 |
| FBN1 | fibrillin 1 | 0.0143955 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0136344 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0130378 |
| DENND2B | DENN domain containing 2B | 0.0130014 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0120274 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0119521 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0118767 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0115604 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0114797 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0112244 |
| PRPF6 | pre-mRNA processing factor 6 | 0.011016 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0109248 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0109007 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0108787 |
| COL6A2 | collagen, type VI, alpha 2 | 0.010836 |
| SET | SET nuclear proto-oncogene | 0.0108057 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0107894 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 0.0105924 |
| KRT18 | keratin 18, type I | 0.0102485 |
| ACTN1 | actinin, alpha 1 | 0.0102275 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.0101287 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0101055 |
| H1-4 | H1.4 linker histone, cluster member | 0.0100268 |
| TOX | thymocyte selection-associated high mobility group box | 0.00996123 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.00994669 |
| RASAL2 | RAS protein activator like 2 | 0.00990673 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.00982095 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.00975739 |
| INPPL1 | inositol polyphosphate phosphatase-like 1 | 0.00974014 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0093711 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0093698 |
| DOCK9 | dedicator of cytokinesis 9 | 0.00936292 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.00933982 |
| RPL3 | ribosomal protein L3 | 0.00931452 |
| NCOR2 | nuclear receptor corepressor 2 | 0.00928155 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00927255 |
| CDK14 | cyclin-dependent kinase 14 | 0.00919729 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.00916753 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00916292 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 | 0.00915393 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00911656 |
| TRAPPC10 | trafficking protein particle complex 10 | 0.00911127 |
| VMP1 | vacuole membrane protein 1 | 0.00905659 |
| MXRA5 | matrix-remodelling associated 5 | 0.00900816 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00897731 |
| GPR176 | G protein-coupled receptor 176 | 0.00895734 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.00895514 |
| DNM2 | dynamin 2 | 0.00894125 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.00883434 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.00881181 |
| RPL4 | ribosomal protein L4 | 0.00879943 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0087257 |
| ODAD2 | outer dynein arm docking complex subunit 2 | 0.00870284 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.00868999 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.00864548 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.0086329 |
| ADAM32 | ADAM metallopeptidase domain 32 | 0.00862719 |
| RNF169 | ring finger protein 169 | 0.00861917 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00844535 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00841566 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.0083943 |
| EP400 | E1A binding protein p400 | 0.00835801 |
| TMSB4X | thymosin beta 4, X-linked | 0.00835667 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.00830792 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.00830206 |
| GOLGA3 | golgin A3 | 0.00811478 |
| SIK2 | salt-inducible kinase 2 | 0.00810711 |
| SKIL | SKI-like proto-oncogene | 0.00810664 |
| LAMC2 | laminin, gamma 2 | 0.00808237 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.00807088 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.00806513 |
| TMEM154 | transmembrane protein 154 | 0.00800884 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.222001 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.16153 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.159272 |
| NDRG1 | N-myc downstream regulated 1 | -0.146675 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.14027 |
| TMSB10 | thymosin beta 10 | -0.118136 |
| MT2A | metallothionein 2A | -0.0923198 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0911524 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0769052 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0733874 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0695526 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0681551 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0664662 |
| B2M | beta-2-microglobulin | -0.0641975 |
| S100A10 | S100 calcium binding protein A10 | -0.0638426 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0619761 |
| FLNB | filamin B, beta | -0.0606257 |
| CANX | calnexin | -0.0595653 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0552092 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0535008 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0530321 |
| CD44 | CD44 molecule (Indian blood group) | -0.05221 |
| MYOF | myoferlin | -0.0494015 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.048108 |
| LOXL2 | lysyl oxidase-like 2 | -0.0479446 |
| OGA | O-GlcNAcase | -0.04718 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0454323 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0446966 |
| LOX | lysyl oxidase | -0.0440051 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0437512 |
| VIM | vimentin | -0.043153 |
| SPAG9 | sperm associated antigen 9 | -0.0430124 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0426015 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0410637 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0409371 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0397456 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0393061 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0385487 |
| CSTB | cystatin B (stefin B) | -0.0380791 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0379216 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0377704 |
| NAV2 | neuron navigator 2 | -0.0375971 |
| CALR | calreticulin | -0.0364684 |
| FAM107B | family with sequence similarity 107, member B | -0.0363331 |
| SBF2 | SET binding factor 2 | -0.0361819 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0354684 |
| RTN4 | reticulon 4 | -0.0352157 |
| HIP1 | huntingtin interacting protein 1 | -0.0350498 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0345216 |
| SQSTM1 | sequestosome 1 | -0.0339335 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0337859 |
| OPTN | optineurin | -0.0337546 |
| ZNF292 | zinc finger protein 292 | -0.0337423 |
| H2AC6 | H2A clustered histone 6 | -0.033539 |
| PLAT | plasminogen activator, tissue | -0.0332626 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.033225 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0320725 |
| XPO1 | exportin 1 | -0.0320059 |
| ADM | adrenomedullin | -0.0317805 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0315385 |
| MAP4 | microtubule-associated protein 4 | -0.0311649 |
| TAOK1 | TAO kinase 1 | -0.0311266 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0310403 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0305115 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0303827 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0303101 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0298302 |
| MB21D2 | Mab-21 domain containing 2 | -0.0297588 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0293728 |
| ANXA2 | annexin A2 | -0.0293055 |
| SEPTIN9 | septin 9 | -0.0292631 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0288804 |
| RPL28 | ribosomal protein L28 | -0.0288035 |
| SP100 | SP100 nuclear antigen | -0.0287921 |
| S100A6 | S100 calcium binding protein A6 | -0.0287494 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0285054 |
| UBC | ubiquitin C | -0.0282636 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | -0.0282342 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0281855 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0281202 |
| HELZ | helicase with zinc finger | -0.0280862 |
| RAI1 | retinoic acid induced 1 | -0.027733 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0276193 |
| STC1 | stanniocalcin 1 | -0.0274693 |
| CD99 | CD99 molecule | -0.027423 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0272155 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0271849 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | -0.0270823 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0270605 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0270561 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0270126 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0268004 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0266039 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0263379 |
| SLC22A23 | solute carrier family 22, member 23 | -0.0263301 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0261843 |
| PTMA | prothymosin, alpha | -0.0261661 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0259599 |
| LDHA | lactate dehydrogenase A | -0.0254682 |
| SEPTIN2 | septin 2 | -0.025429 |
