| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.108146 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0459817 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0416843 |
| SLC38A2 | solute carrier family 38, member 2 | 0.03937 |
| POTEF | POTE ankyrin domain family, member F | 0.0393011 |
| CCNL1 | cyclin L1 | 0.0335404 |
| PCBP2 | poly(rC) binding protein 2 | 0.033375 |
| CCN2 | cellular communication network factor 2 | 0.0328083 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0312209 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0301333 |
| RPL3 | ribosomal protein L3 | 0.0301297 |
| PTMS | parathymosin | 0.0266667 |
| EGR1 | early growth response 1 | 0.0255561 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0254578 |
| YBX1 | Y box binding protein 1 | 0.0248231 |
| HDGF | hepatoma-derived growth factor | 0.0243553 |
| BRD2 | bromodomain containing 2 | 0.02401 |
| PFN1 | profilin 1 | 0.0216202 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0193168 |
| PCM1 | pericentriolar material 1 | 0.0188965 |
| RPL4 | ribosomal protein L4 | 0.0187409 |
| SSRP1 | structure specific recognition protein 1 | 0.0183612 |
| PLK2 | polo-like kinase 2 | 0.0182233 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0171797 |
| HLA-A | major histocompatibility complex, class I, A | 0.0168055 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0161183 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0160366 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.015539 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0151972 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0148969 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0148903 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0147298 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0139343 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.013756 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0136893 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0131361 |
| TGM2 | transglutaminase 2 | 0.0129827 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0127465 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0127335 |
| COPA | coatomer protein complex, subunit alpha | 0.0124803 |
| CPOX | coproporphyrinogen oxidase | 0.0121356 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0120799 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0119613 |
| PTEN | phosphatase and tensin homolog | 0.0114512 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0112421 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.011208 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0111329 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0108946 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.010821 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.010644 |
| FOXM1 | forkhead box M1 | 0.010639 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0106276 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | 0.010408 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0103364 |
| TPM3 | tropomyosin 3 | 0.0103308 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | 0.0102047 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00993432 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.00977049 |
| NUP58 | nucleoporin 58 | 0.00955201 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.00938094 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00936408 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.00922234 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.00921213 |
| TCP1 | t-complex 1 | 0.0091784 |
| FNBP4 | formin binding protein 4 | 0.00915974 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00900439 |
| RPS12 | ribosomal protein S12 | 0.0089587 |
| ZNF146 | zinc finger protein 146 | 0.00886097 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.00882801 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00881425 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.00873453 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.0086462 |
| ATF7 | activating transcription factor 7 | 0.00850949 |
| SNX2 | sorting nexin 2 | 0.00844751 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.008419 |
| ERBIN | erbb2 interacting protein | 0.00833177 |
| CALD1 | caldesmon 1 | 0.00826007 |
| MBD6 | methyl-CpG binding domain protein 6 | 0.00820756 |
| PELP1 | proline, glutamate and leucine rich protein 1 | 0.00804418 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.00792898 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | 0.00791152 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.00790418 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.00786382 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.00783944 |
| RPL21 | ribosomal protein L21 | 0.00782138 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.00776473 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.00775382 |
| CASC3 | cancer susceptibility candidate 3 | 0.00767608 |
| SNX27 | sorting nexin family member 27 | 0.00764803 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.00758658 |
| RAB6A | RAB6A, member RAS oncogene family | 0.00758144 |
| MEF2D | myocyte enhancer factor 2D | 0.00755447 |
| NDUFAF2 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 | 0.00752988 |
| MSN | moesin | 0.00749255 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.00743921 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.00739538 |
| BRD4 | bromodomain containing 4 | 0.00735182 |
| YTHDC1 | YTH domain containing 1 | 0.00726777 |
| RBBP7 | retinoblastoma binding protein 7 | 0.00725624 |
| LDHB | lactate dehydrogenase B | 0.00725327 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.164524 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.108903 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.101438 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0890914 |
| PCDH7 | protocadherin 7 | -0.0610613 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0593935 |
| VIM | vimentin | -0.0533958 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0523532 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0521955 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.051845 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0489913 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0489544 |
| NHSL1 | NHS-like 1 | -0.0487633 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0476371 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0454788 |
| AHNAK | AHNAK nucleoprotein | -0.0448755 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0446727 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0433618 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0429538 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0419153 |
| ACTG1 | actin gamma 1 | -0.041715 |
| HMGA2 | high mobility group AT-hook 2 | -0.040764 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0401645 |
| TMSB10 | thymosin beta 10 | -0.0398954 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0391712 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0390688 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0386197 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0376417 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0367834 |
| MGAT4C | MGAT4 family, member C | -0.0356938 |
| FUS | FUS RNA binding protein | -0.0349147 |
| TBC1D5 | TBC1 domain family, member 5 | -0.034092 |
| MTAP | methylthioadenosine phosphorylase | -0.0339491 |
| CANX | calnexin | -0.0338293 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.033782 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0337774 |
| USP34 | ubiquitin specific peptidase 34 | -0.0336612 |
| TENM3 | teneurin transmembrane protein 3 | -0.033576 |
| WWOX | WW domain containing oxidoreductase | -0.0323736 |
| BCHE | butyrylcholinesterase | -0.0317234 |
| NEBL | nebulette | -0.0312667 |
| EHBP1 | EH domain binding protein 1 | -0.0311301 |
| RPS24 | ribosomal protein S24 | -0.0307224 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.030277 |
| RPLP1 | ribosomal protein, large, P1 | -0.0297361 |
| GNAS | GNAS complex locus | -0.02968 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0293044 |
| LMO7 | LIM domain 7 | -0.0291661 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0290629 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0289601 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0287628 |
| ZNF638 | zinc finger protein 638 | -0.0285192 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0284191 |
| ZNF217 | zinc finger protein 217 | -0.0283535 |
| SMYD3 | SET and MYND domain containing 3 | -0.0281162 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0278744 |
| RRM2 | ribonucleotide reductase M2 | -0.0274241 |
| EXOC4 | exocyst complex component 4 | -0.0271572 |
| YAP1 | Yes-associated protein 1 | -0.0270724 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0266466 |
| ASPH | aspartate beta-hydroxylase | -0.0264122 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.026064 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0257931 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.025599 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0252518 |
| PARD3 | par-3 family cell polarity regulator | -0.0251243 |
| RPL38 | ribosomal protein L38 | -0.0251151 |
| DST | dystonin | -0.0245205 |
| NF1 | neurofibromin 1 | -0.0243713 |
| RAD51B | RAD51 paralog B | -0.0239667 |
| PTK2 | protein tyrosine kinase 2 | -0.0231584 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0229678 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0229647 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0228347 |
| RPL35A | ribosomal protein L35a | -0.0228208 |
| PTMA | prothymosin, alpha | -0.022805 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0227547 |
| RPL34 | ribosomal protein L34 | -0.022451 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0221373 |
| PDGFC | platelet derived growth factor C | -0.0217519 |
| RASAL2 | RAS protein activator like 2 | -0.0217295 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0217118 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0215733 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0214963 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0213867 |
| KLF6 | Kruppel-like factor 6 | -0.0212297 |
| TMEM123 | transmembrane protein 123 | -0.0211537 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0209156 |
| R3HDM2 | R3H domain containing 2 | -0.0208473 |
| SYT1 | synaptotagmin I | -0.0206657 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0205886 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0205458 |
| RPS21 | ribosomal protein S21 | -0.0204998 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0203087 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0202589 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.020118 |
| RBM39 | RNA binding motif protein 39 | -0.0200251 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0199793 |
| PRELID2 | PRELI domain containing 2 | -0.0199757 |
| MAP4 | microtubule-associated protein 4 | -0.0199313 |
