Vortioxetine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.0752475
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0330572
RBM25 RNA binding motif protein 25 0.0284424
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.027673
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0272916
CLTC clathrin, heavy chain (Hc) 0.0265214
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0252774
MEIS2 Meis homeobox 2 0.0246998
RPL4 ribosomal protein L4 0.0246989
TPST1 tyrosylprotein sulfotransferase 1 0.0234292
PRRC2C proline-rich coiled-coil 2C 0.0223201
AMBRA1 autophagy/beclin-1 regulator 1 0.0220665
GPC5 glypican 5 0.0219795
VGF VGF nerve growth factor inducible 0.0217465
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0209633
ADGRG6 adhesion G protein-coupled receptor G6 0.0204024
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0192468
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.019121
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0185034
CNTN4 contactin 4 0.0178849
HSPA8 heat shock 70kDa protein 8 0.0178365
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0175681
TULP4 tubby like protein 4 0.0170579
PLPP1 phospholipid phosphatase 1 0.0169146
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0168885
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0168883
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0166466
AOPEP aminopeptidase O (putative) 0.0164752
RPL3 ribosomal protein L3 0.0162918
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0158909
PDZRN3 PDZ domain containing ring finger 3 0.0156264
EWSR1 EWS RNA-binding protein 1 0.0154893
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.0153444
ELP2 elongator acetyltransferase complex subunit 2 0.015209
CHN1 chimerin 1 0.0151887
SCARB2 scavenger receptor class B, member 2 0.0150998
ARHGAP5 Rho GTPase activating protein 5 0.0149055
NRIP1 nuclear receptor interacting protein 1 0.0148831
MYH9 myosin, heavy chain 9, non-muscle 0.0146753
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0145765
GLCCI1 glucocorticoid induced 1 0.0145095
ENAH enabled homolog (Drosophila) 0.0143508
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0142877
SETD2 SET domain containing 2 0.0140811
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0140021
TP53BP1 tumor protein p53 binding protein 1 0.0139594
TPM3 tropomyosin 3 0.0139097
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 0.0138606
ITPRID2 ITPR interacting domain containing 2 0.0138216
MMP2 matrix metallopeptidase 2 0.0137863
KDM5A lysine (K)-specific demethylase 5A 0.0137334
WDR36 WD repeat domain 36 0.0137248
ADGRB3 adhesion G protein-coupled receptor B3 0.0135996
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0134309
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0133483
WAPL WAPL cohesin release factor 0.0133094
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0132573
NCKAP1 NCK-associated protein 1 0.0131357
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0127295
MTAP methylthioadenosine phosphorylase 0.012683
PBX1 pre-B-cell leukemia homeobox 1 0.012636
TEX10 testis expressed 10 0.0125803
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0125481
LARP4B La ribonucleoprotein domain family, member 4B 0.0124673
MSMO1 methylsterol monooxygenase 1 0.0124198
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0123537
LDHB lactate dehydrogenase B 0.0123516
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.01234
CRY1 cryptochrome circadian clock 1 0.0121778
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0121498
AHR aryl hydrocarbon receptor 0.0121407
SKIC3 SKI3 subunit of superkiller complex 0.012089
IL6ST interleukin 6 signal transducer 0.0120368
MRPL3 mitochondrial ribosomal protein L3 0.011959
YY1AP1 YY1 associated protein 1 0.0119068
ACSL3 acyl-CoA synthetase long-chain family member 3 0.011857
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0117498
AQR aquarius intron-binding spliceosomal factor 0.0117136
ATAD1 ATPase family, AAA domain containing 1 0.0116805
ANKRD50 ankyrin repeat domain 50 0.0116202
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0115754
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0115298
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0115047
UCK2 uridine-cytidine kinase 2 0.0114345
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.011315
PCBP3 poly(rC) binding protein 3 0.0112597
SQLE squalene epoxidase 0.0112351
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0112287
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.011208
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0112069
MORF4L1 mortality factor 4 like 1 0.0112061
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0111891
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0111753
TMEM131 transmembrane protein 131 0.0111433
PCNX1 pecanex 1 0.0110752
UNC5C unc-5 homolog C (C. elegans) 0.0110685
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0110348
GAB2 GRB2-associated binding protein 2 0.0110049
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0109793
NES nestin 0.0109196

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190747
AKAP12 A kinase (PRKA) anchor protein 12 -0.158453
IGF2 insulin-like growth factor 2 -0.143471
NDRG1 N-myc downstream regulated 1 -0.0977733
ACTG1 actin gamma 1 -0.0969613
VIM vimentin -0.0853074
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0845847
RPS6 ribosomal protein S6 -0.0817237
VCL vinculin -0.0803379
EXT1 exostosin glycosyltransferase 1 -0.0682473
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0664173
NRG1 neuregulin 1 -0.0662844
TPT1 tumor protein, translationally-controlled 1 -0.0619647
PTPRD protein tyrosine phosphatase, receptor type, D -0.0609238
RPL23 ribosomal protein L23 -0.0592041
RPLP1 ribosomal protein, large, P1 -0.057983
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0523572
PTMA prothymosin, alpha -0.0519245
RPL19 ribosomal protein L19 -0.0514634
FTL ferritin, light polypeptide -0.0508614
DCAF7 DDB1 and CUL4 associated factor 7 -0.0499315
RPS3 ribosomal protein S3 -0.0493073
RPS8 ribosomal protein S8 -0.0488952
RPS24 ribosomal protein S24 -0.0476821
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0469961
TMSB10 thymosin beta 10 -0.0466063
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0464481
FAM13A family with sequence similarity 13, member A -0.0459322
LSAMP limbic system-associated membrane protein -0.0447353
RPL37A ribosomal protein L37a -0.0446121
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0440736
RPL31 ribosomal protein L31 -0.043666
HELZ helicase with zinc finger -0.0417582
RPL34 ribosomal protein L34 -0.0416638
FMN1 formin 1 -0.0415146
RPS12 ribosomal protein S12 -0.0414833
RPS19 ribosomal protein S19 -0.0412683
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0409748
RPL35A ribosomal protein L35a -0.0407372
RAB1A RAB1A, member RAS oncogene family -0.0400026
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0395695
B2M beta-2-microglobulin -0.0393338
RPL11 ribosomal protein L11 -0.0379118
CADM1 cell adhesion molecule 1 -0.0376993
MEF2A myocyte enhancer factor 2A -0.0366487
LIMCH1 LIM and calponin homology domains 1 -0.0363826
PDE4D phosphodiesterase 4D, cAMP-specific -0.0361532
ASPH aspartate beta-hydroxylase -0.0360988
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0357483
DPH6 diphthamine biosynthesis 6 -0.035457
IER3 immediate early response 3 -0.0350323
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0349801
RPL7A ribosomal protein L7a -0.0344699
RPS27 ribosomal protein S27 -0.0343282
NPAS2 neuronal PAS domain protein 2 -0.0341081
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0337672
RAB7A RAB7A, member RAS oncogene family -0.0337573
RPL12 ribosomal protein L12 -0.0335111
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0334799
RPL7 ribosomal protein L7 -0.0330226
RPS14 ribosomal protein S14 -0.0329277
RPS16 ribosomal protein S16 -0.0328036
ENO1 enolase 1, (alpha) -0.0327977
WDR45B WD repeat domain 45B -0.0327184
TPR translocated promoter region, nuclear basket protein -0.0324994
PGK1 phosphoglycerate kinase 1 -0.0321548
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0321392
EFNA5 ephrin-A5 -0.0320615
DTNA dystrobrevin, alpha -0.0320449
RPLP0 ribosomal protein, large, P0 -0.0317106
TRIO trio Rho guanine nucleotide exchange factor -0.0314236
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0307982
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0307862
RPS27A ribosomal protein S27a -0.0305372
IGFBP3 insulin-like growth factor binding protein 3 -0.0301333
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0300884
TLE4 transducin-like enhancer of split 4 -0.0300677
MACF1 microtubule-actin crosslinking factor 1 -0.0300315
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0294308
KTN1 kinectin 1 (kinesin receptor) -0.0291922
RPL37 ribosomal protein L37 -0.0287596
ACBD6 acyl-CoA binding domain containing 6 -0.028725
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0282851
FLNB filamin B, beta -0.0282603
CSNK1A1 casein kinase 1, alpha 1 -0.0282232
ANGPTL4 angiopoietin-like 4 -0.0282157
LPP LIM domain containing preferred translocation partner in lipoma -0.0281551
HILPDA hypoxia inducible lipid droplet-associated -0.0281314
TPM1 tropomyosin 1 (alpha) -0.0281313
PTPRM protein tyrosine phosphatase, receptor type, M -0.0280309
NALF1 NALCN channel auxiliary factor 1 -0.0279936
LOC102724023 ES1 protein homolog, mitochondrial -0.0276899
RPL28 ribosomal protein L28 -0.0275974
EIF1 eukaryotic translation initiation factor 1 -0.0275323
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0274781
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0271689
ATXN1 ataxin 1 -0.0271209
PHF21A PHD finger protein 21A -0.0270039
COL1A1 collagen, type I, alpha 1 -0.0270034
RPS29 ribosomal protein S29 -0.0269247