Vortioxetine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0792765
MYH9 myosin, heavy chain 9, non-muscle 0.0463887
DSCAM Down syndrome cell adhesion molecule 0.0391748
SRRM2 serine/arginine repetitive matrix 2 0.0368822
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0361985
SERINC5 serine incorporator 5 0.035856
STK24 serine/threonine kinase 24 0.0355053
APP amyloid beta (A4) precursor protein 0.0337275
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0331436
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0320642
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0314205
SMAD3 SMAD family member 3 0.0313715
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0304152
PHF3 PHD finger protein 3 0.0298274
TSC22D1 TSC22 domain family, member 1 0.029434
NKD1 naked cuticle homolog 1 (Drosophila) 0.0273264
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0272671
IFNGR1 interferon gamma receptor 1 0.0267351
PDZD8 PDZ domain containing 8 0.02539
MYO5B myosin VB 0.0252782
ACTN4 actinin, alpha 4 0.0246608
ARHGAP26 Rho GTPase activating protein 26 0.0241651
FAT1 FAT atypical cadherin 1 0.0240727
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0227891
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0225736
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0222912
MACC1 metastasis associated in colon cancer 1 0.0217309
PCED1B PC-esterase domain containing 1B 0.0215066
CENPF centromere protein F, 350/400kDa 0.0197799
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0197382
IL20RA interleukin 20 receptor, alpha 0.0197293
NRIP1 nuclear receptor interacting protein 1 0.0196337
EXOC4 exocyst complex component 4 0.0196194
ARGLU1 arginine and glutamate rich 1 0.0192673
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0188924
SYNE2 spectrin repeat containing, nuclear envelope 2 0.01881
TBPL1 TBP-like 1 0.0187296
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0186031
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0182045
SESTD1 SEC14 and spectrin domains 1 0.0180598
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.0177547
DSPP dentin sialophosphoprotein 0.0176844
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0175333
BCLAF1 BCL2-associated transcription factor 1 0.0173852
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0173438
SNX13 sorting nexin 13 0.0171576
NMU neuromedin U 0.0170883
YAP1 Yes-associated protein 1 0.0170493
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.01681
EHF ets homologous factor 0.0166574
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0166298
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0166038
GOLGA3 golgin A3 0.0165447
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0164955
PRPF8 pre-mRNA processing factor 8 0.0163039
MAP7 microtubule-associated protein 7 0.0162141
ATP10B ATPase, class V, type 10B 0.0160736
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0158453
GSK3B glycogen synthase kinase 3 beta 0.0158168
BICRAL BICRA like chromatin remodeling complex associated protein 0.0158061
RUNX1 runt-related transcription factor 1 0.0156973
USP9X ubiquitin specific peptidase 9, X-linked 0.0155461
ZC3H13 zinc finger CCCH-type containing 13 0.0153607
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0152776
STK39 serine threonine kinase 39 0.0151458
SPRED1 sprouty-related, EVH1 domain containing 1 0.0149754
SGK1 serum/glucocorticoid regulated kinase 1 0.0148568
FNIP2 folliculin interacting protein 2 0.014811
RAD51B RAD51 paralog B 0.0147418
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0146335
RABGAP1L RAB GTPase activating protein 1-like 0.0145582
AEBP2 AE binding protein 2 0.0144413
UBAC2 UBA domain containing 2 0.0144251
RPL4 ribosomal protein L4 0.0143924
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0143755
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.0142211
RPL3 ribosomal protein L3 0.0141435
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0140697
NUMA1 nuclear mitotic apparatus protein 1 0.0139084
LMTK2 lemur tyrosine kinase 2 0.0138944
USP12 ubiquitin specific peptidase 12 0.0138074
TMC5 transmembrane channel-like 5 0.0137497
EIF3D eukaryotic translation initiation factor 3, subunit D 0.0135631
TGFBR3 transforming growth factor, beta receptor III 0.0135459
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0135033
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0134655
MTMR3 myotubularin related protein 3 0.0133565
SREBF2 sterol regulatory element binding transcription factor 2 0.0133521
STK4 serine/threonine kinase 4 0.0133413
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0132583
ERCC5 excision repair cross-complementation group 5 0.013021
ATP9A ATPase, class II, type 9A 0.0129984
PNN pinin, desmosome associated protein 0.0128978
PRPF6 pre-mRNA processing factor 6 0.0128583
SET SET nuclear proto-oncogene 0.0128053
RPL21 ribosomal protein L21 0.0127154
RNF43 ring finger protein 43 0.0126819
SH3RF1 SH3 domain containing ring finger 1 0.0126174
SRSF4 serine/arginine-rich splicing factor 4 0.012483
CLYBL citrate lyase beta like 0.0124826

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.201533
B2M beta-2-microglobulin -0.179318
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.156674
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154731
PTMA prothymosin, alpha -0.0986105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0887315
HLA-B major histocompatibility complex, class I, B -0.0864926
MT2A metallothionein 2A -0.0792239
FTL ferritin, light polypeptide -0.0744706
RPL35A ribosomal protein L35a -0.0719632
PDIA3 protein disulfide isomerase family A, member 3 -0.0674818
FNDC3B fibronectin type III domain containing 3B -0.064441
IFI6 interferon, alpha-inducible protein 6 -0.063924
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0636539
TMSB10 thymosin beta 10 -0.0630626
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.061714
EGR1 early growth response 1 -0.0608011
RPL23 ribosomal protein L23 -0.0583882
SQSTM1 sequestosome 1 -0.0575146
RNF149 ring finger protein 149 -0.0568613
PERP PERP, TP53 apoptosis effector -0.0558031
NDRG1 N-myc downstream regulated 1 -0.0553228
RPLP1 ribosomal protein, large, P1 -0.0540511
IFI27 interferon, alpha-inducible protein 27 -0.053105
SEC31A SEC31 homolog A (S. cerevisiae) -0.0512673
GCLC glutamate-cysteine ligase, catalytic subunit -0.0506292
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0506014
CALR calreticulin -0.049931
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0486018
EZR ezrin -0.04804
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0477108
RPL34 ribosomal protein L34 -0.0468189
ACBD3 acyl-CoA binding domain containing 3 -0.0459358
C6ORF132 chromosome 6 open reading frame 132 -0.0447457
SLC38A1 solute carrier family 38, member 1 -0.0439595
XAF1 XIAP associated factor 1 -0.0431106
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0426219
WSB1 WD repeat and SOCS box containing 1 -0.0425901
RAB7A RAB7A, member RAS oncogene family -0.0417159
LOC102724023 ES1 protein homolog, mitochondrial -0.0414297
UFM1 ubiquitin-fold modifier 1 -0.0412288
ASPH aspartate beta-hydroxylase -0.0408157
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0405852
ABLIM1 actin binding LIM protein 1 -0.0404912
ESYT2 extended synaptotagmin-like protein 2 -0.040405
ANXA1 annexin A1 -0.0402536
GNAS GNAS complex locus -0.0400309
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0398571
RPS24 ribosomal protein S24 -0.0398363
GOLGA4 golgin A4 -0.0397897
AGR2 anterior gradient 2 -0.0396902
RNF213 ring finger protein 213 -0.0394053
DLG1 discs, large homolog 1 (Drosophila) -0.0393411
MBNL2 muscleblind-like splicing regulator 2 -0.0389022
S100A9 S100 calcium binding protein A9 -0.0388896
BPTF bromodomain PHD finger transcription factor -0.0385256
S100A10 S100 calcium binding protein A10 -0.038361
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0383357
MORF4L2 mortality factor 4 like 2 -0.0380602
HM13 histocompatibility (minor) 13 -0.0380561
TTC3 tetratricopeptide repeat domain 3 -0.0379783
AHNAK AHNAK nucleoprotein -0.0376618
MX2 MX dynamin-like GTPase 2 -0.0372442
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0369203
CSTB cystatin B (stefin B) -0.0367144
LYZ lysozyme -0.0362116
PGK1 phosphoglycerate kinase 1 -0.0362035
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0361803
H3-3B H3.3 histone B -0.0361239
KRT19 keratin 19, type I -0.0361005
LCN2 lipocalin 2 -0.0359112
UBC ubiquitin C -0.0358542
TMPRSS4 transmembrane protease, serine 4 -0.035519
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0352459
MT1X metallothionein 1X -0.035091
RRBP1 ribosome binding protein 1 -0.0349806
GMDS GDP-mannose 4,6-dehydratase -0.0343317
RAB1A RAB1A, member RAS oncogene family -0.0343254
FNDC3A fibronectin type III domain containing 3A -0.0341009
HLA-E major histocompatibility complex, class I, E -0.0340405
ZMYND8 zinc finger, MYND-type containing 8 -0.0338674
MUC20 mucin 20, cell surface associated -0.0338077
RPL26 ribosomal protein L26 -0.0337191
AHI1 Abelson helper integration site 1 -0.0336458
RPS19 ribosomal protein S19 -0.0335937
VIM vimentin -0.0333368
RPL37 ribosomal protein L37 -0.0331419
RPS8 ribosomal protein S8 -0.0329547
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0325466
NAMPT nicotinamide phosphoribosyltransferase -0.0321012
NCOA7 nuclear receptor coactivator 7 -0.0319831
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0318141
KDM5B lysine (K)-specific demethylase 5B -0.0316919
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0316655
S100A6 S100 calcium binding protein A6 -0.0315988
RPS6 ribosomal protein S6 -0.0315055
FTH1 ferritin, heavy polypeptide 1 -0.0312122
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.03079
TXNIP thioredoxin interacting protein -0.0304564
RPL37A ribosomal protein L37a -0.0304