| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.317142 |
| FN1 | fibronectin 1 | 0.18805 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.161281 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0907281 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0616082 |
| COL1A1 | collagen, type I, alpha 1 | 0.0509213 |
| STC1 | stanniocalcin 1 | 0.0495514 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.04857 |
| APP | amyloid beta (A4) precursor protein | 0.0424282 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0414333 |
| CALD1 | caldesmon 1 | 0.0399884 |
| PLEC | plectin | 0.0376607 |
| ATP13A3 | ATPase type 13A3 | 0.0339364 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0327048 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0295514 |
| FTL | ferritin, light polypeptide | 0.0284914 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0280705 |
| COL1A2 | collagen, type I, alpha 2 | 0.0274603 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0266554 |
| MYO10 | myosin X | 0.026439 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0254421 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0253676 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0245669 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0239972 |
| HMGA2 | high mobility group AT-hook 2 | 0.023791 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0228324 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0225852 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0223133 |
| TPM1 | tropomyosin 1 (alpha) | 0.02193 |
| SDC4 | syndecan 4 | 0.0218252 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0211627 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0198773 |
| PALLD | palladin, cytoskeletal associated protein | 0.0196387 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0187952 |
| COL3A1 | collagen, type III, alpha 1 | 0.0186672 |
| HAS2 | hyaluronan synthase 2 | 0.0183709 |
| RPL3 | ribosomal protein L3 | 0.0181397 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0176019 |
| MSN | moesin | 0.0173356 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0170996 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.016583 |
| RASA2 | RAS p21 protein activator 2 | 0.0165763 |
| SDC2 | syndecan 2 | 0.0165232 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0163949 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0162778 |
| COL12A1 | collagen, type XII, alpha 1 | 0.0162671 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0159457 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0159326 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0157211 |
| PLAU | plasminogen activator, urokinase | 0.0155158 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0154283 |
| CAVIN1 | caveolae associated protein 1 | 0.0151491 |
| HLA-B | major histocompatibility complex, class I, B | 0.015016 |
| TPM2 | tropomyosin 2 (beta) | 0.0150098 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0150089 |
| RPS23 | ribosomal protein S23 | 0.0149828 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0149386 |
| CD44 | CD44 molecule (Indian blood group) | 0.0145901 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.0145522 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0143745 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0141642 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0141399 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.014021 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0139773 |
| RIN2 | Ras and Rab interactor 2 | 0.0137952 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0136884 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0135486 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0135398 |
| RPL37A | ribosomal protein L37a | 0.0134913 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0132266 |
| MB21D2 | Mab-21 domain containing 2 | 0.0130276 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0130221 |
| COL4A1 | collagen, type IV, alpha 1 | 0.012998 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0126705 |
| ADM | adrenomedullin | 0.012661 |
| RPL35A | ribosomal protein L35a | 0.0126109 |
| SMAD3 | SMAD family member 3 | 0.0126027 |
| MYLK | myosin light chain kinase | 0.0124757 |
| DNM2 | dynamin 2 | 0.0123753 |
| ITGAV | integrin, alpha V | 0.0122612 |
| SPAG9 | sperm associated antigen 9 | 0.0122602 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0122554 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0122494 |
| GANAB | glucosidase, alpha; neutral AB | 0.0122323 |
| RNF216 | ring finger protein 216 | 0.012034 |
| TGM2 | transglutaminase 2 | 0.0119869 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.0119674 |
| RPL31 | ribosomal protein L31 | 0.0119374 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0118661 |
| ACTN4 | actinin, alpha 4 | 0.0117315 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | 0.011711 |
| DSTN | destrin (actin depolymerizing factor) | 0.0116914 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0116874 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.011657 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.011609 |
| CCNL1 | cyclin L1 | 0.011467 |
| LOXL2 | lysyl oxidase-like 2 | 0.0113896 |
| VCL | vinculin | 0.0113006 |
| KIF13A | kinesin family member 13A | 0.0112962 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0112953 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.280481 |
| NDRG1 | N-myc downstream regulated 1 | -0.203077 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.19693 |
| CDH13 | cadherin 13 | -0.116372 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.104418 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0951485 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0890286 |
| VIM | vimentin | -0.0777669 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0723132 |
| ENO1 | enolase 1, (alpha) | -0.0620071 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0578631 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0576391 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0538217 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0519642 |
| LDHA | lactate dehydrogenase A | -0.0466548 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0450776 |
| PTK2 | protein tyrosine kinase 2 | -0.0441986 |
| UBC | ubiquitin C | -0.0426259 |
| GOLGB1 | golgin B1 | -0.042114 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0408569 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0406366 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0401646 |
| RND3 | Rho family GTPase 3 | -0.0394912 |
| IL6ST | interleukin 6 signal transducer | -0.0391589 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0374537 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0365353 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0359948 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0358598 |
| HDAC9 | histone deacetylase 9 | -0.0340115 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0336917 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0336889 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0319167 |
| SQSTM1 | sequestosome 1 | -0.0317911 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0317034 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.031497 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0313067 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0312095 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0309306 |
| NAV2 | neuron navigator 2 | -0.0303823 |
| CANX | calnexin | -0.0302463 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0297493 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0296596 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0291767 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0290879 |
| ATXN1 | ataxin 1 | -0.0288156 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0278264 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0277706 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0273265 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0272084 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0262953 |
| TRAM1 | translocation associated membrane protein 1 | -0.026172 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0261633 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0259793 |
| RACK1 | receptor for activated C kinase 1 | -0.0258637 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0257673 |
| ANXA2 | annexin A2 | -0.0255782 |
| RAB1A | RAB1A, member RAS oncogene family | -0.025438 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0247493 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0247242 |
| SEC24D | SEC24 family member D | -0.0246942 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0242419 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0242157 |
| MTDH | metadherin | -0.0240076 |
| VEGFA | vascular endothelial growth factor A | -0.023972 |
| FOXP1 | forkhead box P1 | -0.0237364 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0235511 |
| RRBP1 | ribosome binding protein 1 | -0.0232495 |
| AHNAK | AHNAK nucleoprotein | -0.0231621 |
| BBX | bobby sox homolog (Drosophila) | -0.022824 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0227471 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0227024 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.022111 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0220729 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0219409 |
| PRELID2 | PRELI domain containing 2 | -0.0218978 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0212889 |
| LOX | lysyl oxidase | -0.0211595 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0211488 |
| FNDC3A | fibronectin type III domain containing 3A | -0.021128 |
| TFG | TRK-fused gene | -0.0211243 |
| GRB10 | growth factor receptor-bound protein 10 | -0.021093 |
| SNX9 | sorting nexin 9 | -0.0207577 |
| EFNA5 | ephrin-A5 | -0.0206311 |
| RTN4 | reticulon 4 | -0.0204877 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0201672 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0199857 |
| SMYD3 | SET and MYND domain containing 3 | -0.0197219 |
| ZNF292 | zinc finger protein 292 | -0.0196321 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0193614 |
| SEPTIN2 | septin 2 | -0.0191229 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0188087 |
| GPC6 | glypican 6 | -0.0187807 |
| FNIP1 | folliculin interacting protein 1 | -0.0186598 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0185722 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0185002 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0184096 |
| RPL12 | ribosomal protein L12 | -0.0182575 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0180056 |
| SDCBP | syndecan binding protein (syntenin) | -0.0178667 |
| SYNJ2 | synaptojanin 2 | -0.01786 |
