| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vortioxetine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.346194 |
| C3 | complement component 3 | 0.333018 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.212619 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.201509 |
| APOB | apolipoprotein B | 0.178274 |
| SDC4 | syndecan 4 | 0.0910343 |
| FN1 | fibronectin 1 | 0.0867697 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0731503 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.071848 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0670001 |
| CFB | complement factor B | 0.0658156 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.059962 |
| PEG3 | paternally expressed 3 | 0.0589405 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0582523 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.057279 |
| TF | transferrin | 0.0485051 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0481967 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0481383 |
| TRIM26 | tripartite motif containing 26 | 0.0480212 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0476194 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0449619 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0447564 |
| A2M | alpha-2-macroglobulin | 0.0419674 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0419306 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0392433 |
| FAT1 | FAT atypical cadherin 1 | 0.039129 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.039113 |
| KRT8 | keratin 8, type II | 0.0385058 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0381259 |
| CPE | carboxypeptidase E | 0.0373967 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0369556 |
| RPL4 | ribosomal protein L4 | 0.0361726 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0360665 |
| GPC3 | glypican 3 | 0.0356717 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0351342 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0336584 |
| HLF | hepatic leukemia factor | 0.033602 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0330101 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0329683 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0329112 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0322716 |
| DIAPH1 | diaphanous-related formin 1 | 0.0319877 |
| ACTN4 | actinin, alpha 4 | 0.0317389 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0313478 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0311407 |
| ITGAV | integrin, alpha V | 0.0294154 |
| SMAD3 | SMAD family member 3 | 0.0291709 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.027564 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0268133 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0264041 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0261131 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0260417 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0259377 |
| DENND4A | DENN/MADD domain containing 4A | 0.0259171 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0254444 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0253063 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0252211 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0248965 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0248543 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0247762 |
| BRD2 | bromodomain containing 2 | 0.0245397 |
| RND1 | Rho family GTPase 1 | 0.0245161 |
| MKI67 | marker of proliferation Ki-67 | 0.0242253 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0241042 |
| SIK3 | SIK family kinase 3 | 0.024092 |
| SVIL | supervillin | 0.024019 |
| TPM4 | tropomyosin 4 | 0.0239844 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0239565 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0237429 |
| RBM33 | RNA binding motif protein 33 | 0.0237055 |
| FILIP1L | filamin A interacting protein 1-like | 0.0236164 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0234703 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0234039 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0228818 |
| FOXO1 | forkhead box O1 | 0.0225972 |
| EGR1 | early growth response 1 | 0.0225123 |
| DSPP | dentin sialophosphoprotein | 0.0223019 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0222995 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0222776 |
| ENAH | enabled homolog (Drosophila) | 0.0221979 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0221028 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0217961 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.02175 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0213171 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | 0.0213094 |
| LUZP1 | leucine zipper protein 1 | 0.0212556 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 0.021191 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0209826 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0209579 |
| KRT18 | keratin 18, type I | 0.0208716 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0206883 |
| NUP54 | nucleoporin 54kDa | 0.0201621 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0200789 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0199521 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0199455 |
| ASGR1 | asialoglycoprotein receptor 1 | 0.0199246 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0198031 |
| CDK19 | cyclin-dependent kinase 19 | 0.019485 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0194218 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0193591 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EHBP1 | EH domain binding protein 1 | -0.0900983 |
| IGF2 | insulin-like growth factor 2 | -0.0839479 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0834438 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0730498 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0661285 |
| TMEM123 | transmembrane protein 123 | -0.0649714 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0602846 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0586186 |
| HMGA1 | high mobility group AT-hook 1 | -0.0571141 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0538957 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0532441 |
| ASPH | aspartate beta-hydroxylase | -0.050612 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0504816 |
| PLIN2 | perilipin 2 | -0.0493377 |
| RPLP1 | ribosomal protein, large, P1 | -0.0492726 |
| RPL12 | ribosomal protein L12 | -0.0492158 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0468979 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0467459 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.042882 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0426099 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0417478 |
| RPS6 | ribosomal protein S6 | -0.0414817 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0407632 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0403729 |
| NPR2 | natriuretic peptide receptor 2 | -0.0400522 |
| RPL23 | ribosomal protein L23 | -0.0387686 |
| CP | ceruloplasmin (ferroxidase) | -0.0387403 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0378261 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.036638 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0351731 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0337036 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0330257 |
| RPS12 | ribosomal protein S12 | -0.0328334 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0327546 |
| RRBP1 | ribosome binding protein 1 | -0.0317486 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.031562 |
| YME1L1 | YME1-like 1 ATPase | -0.0315116 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0311441 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.030596 |
| NHSL1 | NHS-like 1 | -0.030395 |
| LMAN1 | lectin, mannose-binding, 1 | -0.02952 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0295151 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0291434 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0290978 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0289603 |
| RACK1 | receptor for activated C kinase 1 | -0.0287593 |
| CNKSR3 | CNKSR family member 3 | -0.0285338 |
| FRMD5 | FERM domain containing 5 | -0.0278684 |
| ATXN1 | ataxin 1 | -0.0278094 |
| MAP1B | microtubule-associated protein 1B | -0.0277277 |
| ATP10A | ATPase, class V, type 10A | -0.0275367 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0271602 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0266947 |
| AAK1 | AP2 associated kinase 1 | -0.0265279 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0261241 |
| H1-0 | H1.0 linker histone | -0.0260197 |
| MT2A | metallothionein 2A | -0.0259197 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0258527 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0257338 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0252044 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0250227 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0248968 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0248131 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.024544 |
| RNASET2 | ribonuclease T2 | -0.0243086 |
| CD2AP | CD2-associated protein | -0.0242783 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0238395 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.023625 |
| RPL26 | ribosomal protein L26 | -0.0233997 |
| CANX | calnexin | -0.0232978 |
| CFDP1 | craniofacial development protein 1 | -0.0231626 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0226997 |
| SET | SET nuclear proto-oncogene | -0.0226171 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0224628 |
| PTCHD4 | patched domain containing 4 | -0.0224279 |
| AHSG | alpha-2-HS-glycoprotein | -0.0223178 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.022195 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0221892 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0221824 |
| STK17A | serine/threonine kinase 17a | -0.0221267 |
| RPS8 | ribosomal protein S8 | -0.0215705 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0213924 |
| GNAS | GNAS complex locus | -0.0213234 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.021129 |
| RPLP2 | ribosomal protein, large, P2 | -0.0211033 |
| RPS19 | ribosomal protein S19 | -0.0210781 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0209484 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0209425 |
| RPS17 | ribosomal protein S17 | -0.0207228 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0206402 |
| JMJD1C | jumonji domain containing 1C | -0.0206312 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0205248 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.0204236 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0203046 |
| TFRC | transferrin receptor | -0.0202724 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0202571 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0201784 |
| CRLS1 | cardiolipin synthase 1 | -0.0200656 |
| LAMA4 | laminin, alpha 4 | -0.0200571 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0200129 |
