| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vortioxetine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.116393 |
| POTEF | POTE ankyrin domain family, member F | 0.0886606 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0822738 |
| MSN | moesin | 0.0667841 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0664027 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0587076 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0572423 |
| PLEC | plectin | 0.0507338 |
| SLC35F3 | solute carrier family 35, member F3 | 0.049381 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0475742 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.046753 |
| RASAL2 | RAS protein activator like 2 | 0.0445795 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0437741 |
| SULF1 | sulfatase 1 | 0.0429844 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0429147 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0413393 |
| EGFR | epidermal growth factor receptor | 0.0402276 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0379105 |
| ACTN4 | actinin, alpha 4 | 0.0374716 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0359737 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0345605 |
| PCDH1 | protocadherin 1 | 0.0340071 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0338224 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0334707 |
| KRT14 | keratin 14, type I | 0.0333281 |
| CALB1 | calbindin 1, 28kDa | 0.0328261 |
| TPM3 | tropomyosin 3 | 0.0327002 |
| RAD51B | RAD51 paralog B | 0.0319491 |
| SMYD3 | SET and MYND domain containing 3 | 0.0317131 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0315946 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.030992 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.030984 |
| OSMR | oncostatin M receptor | 0.0308428 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0303415 |
| BLCAP | bladder cancer associated protein | 0.0299346 |
| MTSS1 | metastasis suppressor 1 | 0.0292402 |
| LUZP1 | leucine zipper protein 1 | 0.0291595 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0280441 |
| KIAA1217 | KIAA1217 | 0.0279303 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0271364 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0271209 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0270131 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0267995 |
| LAMC2 | laminin, gamma 2 | 0.0264682 |
| PTHLH | parathyroid hormone-like hormone | 0.0263416 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0263046 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0261313 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.0261095 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0254798 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0254761 |
| EXOC4 | exocyst complex component 4 | 0.0251367 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0250252 |
| AMOTL1 | angiomotin like 1 | 0.0249444 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0245234 |
| NAV2 | neuron navigator 2 | 0.0244822 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0244687 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.0240809 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0238337 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.023385 |
| DIAPH1 | diaphanous-related formin 1 | 0.0231934 |
| SULF2 | sulfatase 2 | 0.0228673 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0228554 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0227047 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0226981 |
| APP | amyloid beta (A4) precursor protein | 0.0222604 |
| CAPRIN2 | caprin family member 2 | 0.0221305 |
| JAK2 | Janus kinase 2 | 0.0220143 |
| IFI44L | interferon-induced protein 44-like | 0.0219292 |
| EXT1 | exostosin glycosyltransferase 1 | 0.021885 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0217696 |
| FOSL1 | FOS-like antigen 1 | 0.0209027 |
| DGKH | diacylglycerol kinase, eta | 0.0208313 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0207792 |
| SMAD3 | SMAD family member 3 | 0.0207304 |
| CDK6 | cyclin-dependent kinase 6 | 0.0205617 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0204237 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0204181 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.02012 |
| BCL2L1 | BCL2-like 1 | 0.019758 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0196503 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0196394 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.019543 |
| TENM4 | teneurin transmembrane protein 4 | 0.0192408 |
| RIGI | RNA sensor RIG-I | 0.0190718 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0187649 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0185708 |
| NCKAP5 | NCK-associated protein 5 | 0.0183332 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0181287 |
| PYGL | phosphorylase, glycogen, liver | 0.0180705 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0180217 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0180184 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0178665 |
| MXRA5 | matrix-remodelling associated 5 | 0.0177256 |
| PTK2 | protein tyrosine kinase 2 | 0.0176989 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0175884 |
| PODXL | podocalyxin-like | 0.0174175 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.017388 |
| CD9 | CD9 molecule | 0.0172088 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0170862 |
| INTS6 | integrator complex subunit 6 | 0.0170841 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.178261 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154208 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.128497 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0998812 |
| PTMA | prothymosin, alpha | -0.0822087 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0761595 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0717775 |
| ENO1 | enolase 1, (alpha) | -0.0667127 |
| MT2A | metallothionein 2A | -0.0603615 |
| ANXA1 | annexin A1 | -0.0600911 |
| TMSB10 | thymosin beta 10 | -0.0555227 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0543417 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0522887 |
| RPLP1 | ribosomal protein, large, P1 | -0.0517151 |
| GOLGA4 | golgin A4 | -0.0501699 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0501521 |
| S100A10 | S100 calcium binding protein A10 | -0.0493723 |
| MEF2A | myocyte enhancer factor 2A | -0.0486488 |
| H1-0 | H1.0 linker histone | -0.0479674 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0476237 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0474813 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0474709 |
| CANX | calnexin | -0.0466242 |
| AHNAK | AHNAK nucleoprotein | -0.0452074 |
| MYOF | myoferlin | -0.0449521 |
| GNAS | GNAS complex locus | -0.043716 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0426947 |
| RPL12 | ribosomal protein L12 | -0.0418871 |
| RPS8 | ribosomal protein S8 | -0.0398002 |
| MORF4L2 | mortality factor 4 like 2 | -0.0393606 |
| OGA | O-GlcNAcase | -0.0390258 |
| EMP1 | epithelial membrane protein 1 | -0.0389853 |
| DUSP6 | dual specificity phosphatase 6 | -0.0365968 |
| RPS6 | ribosomal protein S6 | -0.0356233 |
| CALR | calreticulin | -0.0355421 |
| RPL34 | ribosomal protein L34 | -0.0350835 |
| CLU | clusterin | -0.0350098 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0348757 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0338057 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0333668 |
| RRBP1 | ribosome binding protein 1 | -0.0331063 |
| YBX3 | Y box binding protein 3 | -0.0330197 |
| SRP54 | signal recognition particle 54kDa | -0.0330013 |
| PGK1 | phosphoglycerate kinase 1 | -0.0324264 |
| ANLN | anillin, actin binding protein | -0.0322932 |
| STC1 | stanniocalcin 1 | -0.0321583 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0321147 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0315859 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0314427 |
| RPS19 | ribosomal protein S19 | -0.0311895 |
| RPL26 | ribosomal protein L26 | -0.0311092 |
| LIMA1 | LIM domain and actin binding 1 | -0.0310604 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0310497 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.030735 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0305477 |
| SUCO | SUN domain containing ossification factor | -0.0305379 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0303168 |
| RPS3 | ribosomal protein S3 | -0.0302723 |
| RACK1 | receptor for activated C kinase 1 | -0.0299436 |
| RPS24 | ribosomal protein S24 | -0.0297271 |
| RPS25 | ribosomal protein S25 | -0.0296485 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0295968 |
| CAVIN1 | caveolae associated protein 1 | -0.0295647 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0293993 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0293715 |
| FTL | ferritin, light polypeptide | -0.0291993 |
| S100A6 | S100 calcium binding protein A6 | -0.0291552 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0290376 |
| RBM39 | RNA binding motif protein 39 | -0.0288413 |
| LDHA | lactate dehydrogenase A | -0.0285879 |
| SQLE | squalene epoxidase | -0.0285827 |
| RPL23 | ribosomal protein L23 | -0.0282654 |
| RPL35A | ribosomal protein L35a | -0.0282636 |
| TMSB4X | thymosin beta 4, X-linked | -0.0281591 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0281009 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0280706 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0275826 |
| S100A2 | S100 calcium binding protein A2 | -0.0274948 |
| RPL13A | ribosomal protein L13a | -0.0274571 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0273026 |
| HDLBP | high density lipoprotein binding protein | -0.0271802 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0269141 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0263549 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.02632 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.025994 |
| RPL27A | ribosomal protein L27a | -0.025953 |
| RPL19 | ribosomal protein L19 | -0.0259121 |
| RPL11 | ribosomal protein L11 | -0.025804 |
| RPLP0 | ribosomal protein, large, P0 | -0.0256499 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0255786 |
| IER3 | immediate early response 3 | -0.0255567 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0252349 |
| ANXA2 | annexin A2 | -0.0252265 |
| RPL30 | ribosomal protein L30 | -0.0250014 |
| GLYAT | glycine-N-acyltransferase | -0.0249876 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.024932 |
| LMNA | lamin A/C | -0.0249082 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0245937 |
| FAM13A | family with sequence similarity 13, member A | -0.0245317 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0244559 |
