| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.126433 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0710461 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0415283 |
| RPL3 | ribosomal protein L3 | 0.0389211 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0371323 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0342821 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0327273 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0325394 |
| VEGFA | vascular endothelial growth factor A | 0.029021 |
| ABHD2 | abhydrolase domain containing 2 | 0.0261071 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0230528 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0225697 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0219197 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0218632 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0195628 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0188234 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0183752 |
| VCL | vinculin | 0.0183732 |
| KRT19 | keratin 19, type I | 0.0165376 |
| RCOR1 | REST corepressor 1 | 0.0164069 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0163119 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0162716 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.0162022 |
| DNM2 | dynamin 2 | 0.0159644 |
| HYOU1 | hypoxia up-regulated 1 | 0.0157714 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | 0.0142239 |
| JUP | junction plakoglobin | 0.014025 |
| COPA | coatomer protein complex, subunit alpha | 0.0135608 |
| LIPH | lipase, member H | 0.0129283 |
| MYO1E | myosin IE | 0.0124117 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0123011 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0122281 |
| POTEF | POTE ankyrin domain family, member F | 0.0119885 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0119779 |
| SLK | STE20-like kinase | 0.0119682 |
| LAMA4 | laminin, alpha 4 | 0.0118894 |
| DIAPH1 | diaphanous-related formin 1 | 0.0115122 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0114896 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.011384 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0113402 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0112447 |
| EGR1 | early growth response 1 | 0.0112088 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0111793 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0111666 |
| BRD2 | bromodomain containing 2 | 0.0107715 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0106017 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.010572 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0105277 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0104955 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0101819 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0101338 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0101303 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0100084 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.00998753 |
| CALR | calreticulin | 0.0098951 |
| CD47 | CD47 molecule | 0.00978597 |
| SEPTIN9 | septin 9 | 0.00977619 |
| CLDN7 | claudin 7 | 0.00976239 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.00964644 |
| RPL4 | ribosomal protein L4 | 0.00944095 |
| NOSTRIN | nitric oxide synthase trafficking | 0.00943288 |
| MBD6 | methyl-CpG binding domain protein 6 | 0.00942336 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.00928659 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.00926625 |
| UBA5 | ubiquitin-like modifier activating enzyme 5 | 0.0092561 |
| AGRN | agrin | 0.00912931 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.00911875 |
| TMF1 | TATA element modulatory factor 1 | 0.00911835 |
| WDR59 | WD repeat domain 59 | 0.00907623 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.00906183 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.00902869 |
| AP1AR | adaptor-related protein complex 1 associated regulatory protein | 0.0090054 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.00894753 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.00885861 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.00885117 |
| FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | 0.00881467 |
| SETD5 | SET domain containing 5 | 0.00881118 |
| FLNB | filamin B, beta | 0.00880647 |
| NCOR2 | nuclear receptor corepressor 2 | 0.00878264 |
| PMM2 | phosphomannomutase 2 | 0.00875837 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00873647 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.00862482 |
| KSR1 | kinase suppressor of ras 1 | 0.00861488 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.00856787 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00851942 |
| STX18 | syntaxin 18 | 0.00841074 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00836143 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.00835017 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.00829569 |
| MLEC | malectin | 0.00828588 |
| SNX9 | sorting nexin 9 | 0.0082803 |
| VMP1 | vacuole membrane protein 1 | 0.00827164 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.00825956 |
| TJP3 | tight junction protein 3 | 0.00820051 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.00819268 |
| GPR39 | G protein-coupled receptor 39 | 0.00809775 |
| PKP2 | plakophilin 2 | 0.00808706 |
| CALB1 | calbindin 1, 28kDa | 0.00807214 |
| ANXA3 | annexin A3 | 0.0079933 |
| YTHDC1 | YTH domain containing 1 | 0.00798144 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204765 |
| PTMA | prothymosin, alpha | -0.172539 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.131545 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.127697 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.11564 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.101836 |
| NPSR1 | neuropeptide S receptor 1 | -0.0802527 |
| RPS6 | ribosomal protein S6 | -0.0705197 |
| AHNAK | AHNAK nucleoprotein | -0.070101 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0694447 |
| RPLP1 | ribosomal protein, large, P1 | -0.0632874 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0611947 |
| RPL34 | ribosomal protein L34 | -0.0601839 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0599242 |
| TMSB10 | thymosin beta 10 | -0.0595274 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0575339 |
| RPS8 | ribosomal protein S8 | -0.0568273 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0556522 |
| RPS24 | ribosomal protein S24 | -0.0537462 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0532384 |
| RPLP0 | ribosomal protein, large, P0 | -0.0527507 |
| LDHA | lactate dehydrogenase A | -0.0517451 |
| RPL35A | ribosomal protein L35a | -0.049949 |
| RPL26 | ribosomal protein L26 | -0.0490701 |
| PRELID2 | PRELI domain containing 2 | -0.0485824 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0483758 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0464323 |
| RPS19 | ribosomal protein S19 | -0.045964 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0457675 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0456083 |
| NDRG1 | N-myc downstream regulated 1 | -0.0450474 |
| ANXA2 | annexin A2 | -0.0447938 |
| FAT1 | FAT atypical cadherin 1 | -0.044646 |
| RPL12 | ribosomal protein L12 | -0.0443517 |
| PGK1 | phosphoglycerate kinase 1 | -0.0433988 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0431245 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0428861 |
| B2M | beta-2-microglobulin | -0.041994 |
| EPCAM | epithelial cell adhesion molecule | -0.0418293 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0402251 |
| CD44 | CD44 molecule (Indian blood group) | -0.040059 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0399319 |
| RPL9 | ribosomal protein L9 | -0.039628 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0391762 |
| FTL | ferritin, light polypeptide | -0.039145 |
| RPL30 | ribosomal protein L30 | -0.0388344 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0383688 |
| S100A10 | S100 calcium binding protein A10 | -0.0374299 |
| ENO1 | enolase 1, (alpha) | -0.0364398 |
| FHIT | fragile histidine triad | -0.0362164 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0356759 |
| GPHN | gephyrin | -0.0348805 |
| S100A6 | S100 calcium binding protein A6 | -0.0348356 |
| RPLP2 | ribosomal protein, large, P2 | -0.0348297 |
| SMYD3 | SET and MYND domain containing 3 | -0.0346721 |
| KIF5B | kinesin family member 5B | -0.0344629 |
| RPL32 | ribosomal protein L32 | -0.0342799 |
| AGR2 | anterior gradient 2 | -0.0341733 |
| ONECUT3 | one cut homeobox 3 | -0.0341172 |
| RPL11 | ribosomal protein L11 | -0.0338243 |
| RPS21 | ribosomal protein S21 | -0.0336517 |
| RPL37A | ribosomal protein L37a | -0.0329436 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0326215 |
| EREG | epiregulin | -0.0324624 |
| TXNRD1 | thioredoxin reductase 1 | -0.0318291 |
| RPL19 | ribosomal protein L19 | -0.0316244 |
| RPS23 | ribosomal protein S23 | -0.0315837 |
| RPS3 | ribosomal protein S3 | -0.0315006 |
| RPL36 | ribosomal protein L36 | -0.0312181 |
| NFIA | nuclear factor I/A | -0.0307888 |
| CADPS | Ca++-dependent secretion activator | -0.0307569 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0303623 |
| RPL23 | ribosomal protein L23 | -0.0303429 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.029977 |
| ACTG1 | actin gamma 1 | -0.0297904 |
| SERINC5 | serine incorporator 5 | -0.0297747 |
| RPS27A | ribosomal protein S27a | -0.029718 |
| EZR | ezrin | -0.0296004 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0295986 |
| INSIG1 | insulin induced gene 1 | -0.0295639 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0294158 |
| FOXP1 | forkhead box P1 | -0.0293522 |
| TFRC | transferrin receptor | -0.0292566 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0291062 |
| RPL27A | ribosomal protein L27a | -0.029098 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0290796 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0290631 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0289717 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0289522 |
| PCDHB16 | protocadherin beta 16 | -0.0288845 |
| MYO1D | myosin ID | -0.0282909 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0282191 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0281666 |
| HMGB1 | high mobility group box 1 | -0.0281472 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0280382 |
| JMJD1C | jumonji domain containing 1C | -0.0278228 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0277031 |
| RPL31 | ribosomal protein L31 | -0.0274034 |
| TRIM2 | tripartite motif containing 2 | -0.0273388 |
| LMNA | lamin A/C | -0.02733 |
