Vortioxetine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 0.0907188
TMSB4X thymosin beta 4, X-linked 0.0616689
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0609973
VIM vimentin 0.0548977
RPL4 ribosomal protein L4 0.0469277
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0458259
FTH1 ferritin, heavy polypeptide 1 0.0428964
TP63 tumor protein p63 0.0418077
SLC38A2 solute carrier family 38, member 2 0.0364703
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.033857
EEF2 eukaryotic translation elongation factor 2 0.0306822
TMSB10 thymosin beta 10 0.0293029
YBX1 Y box binding protein 1 0.0278984
EGR1 early growth response 1 0.027087
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.023604
ANXA1 annexin A1 0.0196306
RPL3 ribosomal protein L3 0.0195101
PDE10A phosphodiesterase 10A 0.0186216
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0175188
RPL18 ribosomal protein L18 0.0170451
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0165473
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.015651
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0153279
EFNA5 ephrin-A5 0.0139094
SOD2 superoxide dismutase 2, mitochondrial 0.0137104
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0136864
TSC22D1 TSC22 domain family, member 1 0.0135826
ZDHHC14 zinc finger, DHHC-type containing 14 0.0135435
LPIN1 lipin 1 0.0126597
DKC1 dyskeratosis congenita 1, dyskerin 0.0122864
WARS1 tryptophanyl-tRNA synthetase 1 0.0121274
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0118888
RGS4 regulator of G-protein signaling 4 0.0116354
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0112584
FDPS farnesyl diphosphate synthase 0.0112099
MSMO1 methylsterol monooxygenase 1 0.0111183
HSPA8 heat shock 70kDa protein 8 0.0110962
RPL13A ribosomal protein L13a 0.0110352
LRRC49 leucine rich repeat containing 49 0.0108287
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0107295
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.010428
DUSP12 dual specificity phosphatase 12 0.0102281
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.0100478
HDLBP high density lipoprotein binding protein 0.0100287
INSIG1 insulin induced gene 1 0.00976319
DPH6 diphthamine biosynthesis 6 0.00966318
SSRP1 structure specific recognition protein 1 0.00965653
JUN jun proto-oncogene 0.00955678
GARS1 glycyl-tRNA synthetase 1 0.00948079
CTSC cathepsin C 0.00936588
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00925692
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.00923285
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.009209
FLNA filamin A, alpha 0.00919164
AHNAK2 AHNAK nucleoprotein 2 0.00918924
RPN1 ribophorin I 0.00916187
EEF1G eukaryotic translation elongation factor 1 gamma 0.00912406
LOC102724023 ES1 protein homolog, mitochondrial 0.00912235
PLK2 polo-like kinase 2 0.00903913
EIF3D eukaryotic translation initiation factor 3, subunit D 0.00896867
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00896591
RPL35A ribosomal protein L35a 0.0089146
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.00883896
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.00882299
EIF4A1 eukaryotic translation initiation factor 4A1 0.00869804
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00869242
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 0.0085633
PTMS parathymosin 0.0085207
GPX4 glutathione peroxidase 4 0.00830332
SLC38A1 solute carrier family 38, member 1 0.00826603
IDI1 isopentenyl-diphosphate delta isomerase 1 0.00826156
TSC22D2 TSC22 domain family, member 2 0.00825824
RGS5 regulator of G-protein signaling 5 0.00819661
ZNF121 zinc finger protein 121 0.00815342
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00814438
GDI2 GDP dissociation inhibitor 2 0.00813557
RPS9 ribosomal protein S9 0.00808493
JUND jun D proto-oncogene 0.00803233
KRT18 keratin 18, type I 0.00802374
PRRC2A proline-rich coiled-coil 2A 0.00799837
HDGF hepatoma-derived growth factor 0.0079694
CRY1 cryptochrome circadian clock 1 0.00795029
FASN fatty acid synthase 0.00786811
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.00782204
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00778762
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 0.00774591
XBP1 X-box binding protein 1 0.00773638
RPS3 ribosomal protein S3 0.00763467
TUBB tubulin, beta class I 0.00756936
HMGB2 high mobility group box 2 0.00752264
ACSS2 acyl-CoA synthetase short-chain family member 2 0.00749374
CSMD3 CUB and Sushi multiple domains 3 0.00741798
LBR lamin B receptor 0.00741201
CADM2 cell adhesion molecule 2 0.00736413
NRDC nardilysin convertase 0.00735509
AARS1 alanyl-tRNA synthetase 1 0.00728521
NACA nascent polypeptide-associated complex alpha subunit 0.00726992
DHCR7 7-dehydrocholesterol reductase 0.00720758
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00708537
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.00699857

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22715
MT2A metallothionein 2A -0.148814
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117746
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0833622
FMNL2 formin-like 2 -0.0775917
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0728469
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0604059
KMT2E lysine (K)-specific methyltransferase 2E -0.0602585
TXNIP thioredoxin interacting protein -0.0596214
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0596091
MT1E metallothionein 1E -0.0574779
WSB1 WD repeat and SOCS box containing 1 -0.0545007
ZMYND8 zinc finger, MYND-type containing 8 -0.0541202
CAPRIN2 caprin family member 2 -0.051875
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0500316
SPAG9 sperm associated antigen 9 -0.0494371
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0488221
USP34 ubiquitin specific peptidase 34 -0.048045
DST dystonin -0.0477888
LOXL2 lysyl oxidase-like 2 -0.0455508
SRPK2 SRSF protein kinase 2 -0.0446409
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0422684
SNX14 sorting nexin 14 -0.0421461
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0418035
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0412767
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.041232
XPO1 exportin 1 -0.0409348
BIRC6 baculoviral IAP repeat containing 6 -0.0404576
BCAR3 breast cancer anti-estrogen resistance 3 -0.0399381
PSD3 pleckstrin and Sec7 domain containing 3 -0.0393022
MACF1 microtubule-actin crosslinking factor 1 -0.0385635
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0378915
BRWD1 bromodomain and WD repeat domain containing 1 -0.0378669
KMT2C lysine (K)-specific methyltransferase 2C -0.0376551
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0373727
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0373068
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0372461
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0370746
ARID4B AT rich interactive domain 4B (RBP1-like) -0.03689
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0368189
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0361522
ZNF292 zinc finger protein 292 -0.0361245
GCLM glutamate-cysteine ligase, modifier subunit -0.0354584
PTK2 protein tyrosine kinase 2 -0.0353904
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0352473
ERBIN erbb2 interacting protein -0.035156
GLG1 golgi glycoprotein 1 -0.0349752
AKAP9 A kinase (PRKA) anchor protein 9 -0.0349676
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0347522
SMYD3 SET and MYND domain containing 3 -0.0346369
ARHGAP5 Rho GTPase activating protein 5 -0.0345681
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0343796
TM4SF1 transmembrane 4 L six family member 1 -0.0343142
GOLGA4 golgin A4 -0.0340577
NCOR1 nuclear receptor corepressor 1 -0.03395
RPS2 ribosomal protein S2 -0.033745
EZR ezrin -0.0335592
NF1 neurofibromin 1 -0.0330173
ESYT2 extended synaptotagmin-like protein 2 -0.0329215
RCOR1 REST corepressor 1 -0.0328975
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0328014
RAD51B RAD51 paralog B -0.0326547
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0326437
KTN1 kinectin 1 (kinesin receptor) -0.0325878
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.032457
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0324506
KDM2A lysine (K)-specific demethylase 2A -0.0324387
ANKRD12 ankyrin repeat domain 12 -0.032401
RBM39 RNA binding motif protein 39 -0.0316744
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0315887
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.031374
CCDC88A coiled-coil domain containing 88A -0.0313657
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0312176
JMJD1C jumonji domain containing 1C -0.0308637
AFF4 AF4/FMR2 family, member 4 -0.0308138
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0307561
FBXO11 F-box protein 11 -0.0306791
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0304893
COG5 component of oligomeric golgi complex 5 -0.0304289
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0303674
WNK1 WNK lysine deficient protein kinase 1 -0.0302732
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.029989
OGA O-GlcNAcase -0.0299107
TTC3 tetratricopeptide repeat domain 3 -0.0298705
SSH2 slingshot protein phosphatase 2 -0.0298081
MED13 mediator complex subunit 13 -0.0296651
ATXN2 ataxin 2 -0.0291837
DPYD dihydropyrimidine dehydrogenase -0.0289366
CANX calnexin -0.0288861
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0285635
TRIO trio Rho guanine nucleotide exchange factor -0.0284634
KIF1B kinesin family member 1B -0.0284533
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0277201
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0276475
CSNK1A1 casein kinase 1, alpha 1 -0.0276468
PCM1 pericentriolar material 1 -0.0275154
PHIP pleckstrin homology domain interacting protein -0.02729
THOC2 THO complex 2 -0.0270582
NIPBL Nipped-B homolog (Drosophila) -0.0268472
ANGPTL4 angiopoietin-like 4 -0.0268281