| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vortioxetine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LOC112694756 | uncharaterized LOC112694756 | 0.0850233 |
| H1-0 | H1.0 linker histone | 0.0389793 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0225013 |
| PLEC | plectin | 0.0199216 |
| RPL4 | ribosomal protein L4 | 0.0187686 |
| RPL3 | ribosomal protein L3 | 0.013752 |
| SPAG9 | sperm associated antigen 9 | 0.0137397 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0136861 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0131575 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0131273 |
| BRD2 | bromodomain containing 2 | 0.0119433 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0118501 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0116707 |
| RNF24 | ring finger protein 24 | 0.0116207 |
| CASC3 | cancer susceptibility candidate 3 | 0.0112357 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0112127 |
| ARL8B | ADP-ribosylation factor-like 8B | 0.0110039 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0108667 |
| ANO6 | anoctamin 6 | 0.0106922 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0106616 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.010661 |
| UVRAG | UV radiation resistance associated | 0.0102502 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0102359 |
| TPD52 | tumor protein D52 | 0.00996537 |
| LAMB3 | laminin, beta 3 | 0.00971028 |
| RAB21 | RAB21, member RAS oncogene family | 0.00959323 |
| SEC61G | Sec61 gamma subunit | 0.00923395 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.00896348 |
| YEATS2 | YEATS domain containing 2 | 0.00890299 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.00866757 |
| PER1 | period circadian clock 1 | 0.00808603 |
| FOXO3 | forkhead box O3 | 0.00797695 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00797579 |
| ANKRD37 | ankyrin repeat domain 37 | 0.00785916 |
| HDLBP | high density lipoprotein binding protein | 0.00784309 |
| RAB6A | RAB6A, member RAS oncogene family | 0.00758169 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.00756804 |
| JPT2 | Jupiter microtubule associated homolog 2 | 0.00756411 |
| HYOU1 | hypoxia up-regulated 1 | 0.00753949 |
| CLK3 | CDC-like kinase 3 | 0.00746445 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.00732355 |
| STK40 | serine/threonine kinase 40 | 0.00729258 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 0.00714414 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00710464 |
| DHFR | dihydrofolate reductase | 0.00691068 |
| MANBA | mannosidase, beta A, lysosomal | 0.0068388 |
| ACVR1 | activin A receptor, type I | 0.00683068 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0068007 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.00678838 |
| SART3 | squamous cell carcinoma antigen recognized by T cells 3 | 0.00669731 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.00648539 |
| UBXN7 | UBX domain protein 7 | 0.00644098 |
| CES1 | carboxylesterase 1 | 0.00643505 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0064134 |
| GON4L | gon-4-like (C. elegans) | 0.00636922 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.00634905 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.00628056 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00622146 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.00621407 |
| PLXNB2 | plexin B2 | 0.00620602 |
| VWDE | von Willebrand factor D and EGF domains | 0.0061665 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.00614367 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.00613852 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.00605911 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.00604025 |
| IRF6 | interferon regulatory factor 6 | 0.00595639 |
| CNNM4 | cyclin and CBS domain divalent metal cation transport mediator 4 | 0.00591173 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.00586426 |
| WDR45B | WD repeat domain 45B | 0.00582894 |
| HDAC3 | histone deacetylase 3 | 0.00575994 |
| LRIG2 | leucine-rich repeats and immunoglobulin-like domains 2 | 0.00561528 |
| PGK1 | phosphoglycerate kinase 1 | 0.00550316 |
| KIF1A | kinesin family member 1A | 0.00549086 |
| CLDN12 | claudin 12 | 0.00547516 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.005475 |
| LIF | leukemia inhibitory factor | 0.00547156 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.00544816 |
| HBS1L | HBS1-like translational GTPase | 0.00536589 |
| ZSWIM4 | zinc finger, SWIM-type containing 4 | 0.00535788 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.00535497 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.00528504 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.00525496 |
| USP36 | ubiquitin specific peptidase 36 | 0.00522937 |
| CRKL | v-crk avian sarcoma virus CT10 oncogene homolog-like | 0.00521247 |
| ATF3 | activating transcription factor 3 | 0.00520431 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.00519624 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0051693 |
| HDGF | hepatoma-derived growth factor | 0.00507874 |
| ZNF598 | zinc finger protein 598 | 0.00506823 |
| YY1AP1 | YY1 associated protein 1 | 0.00506795 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.00505291 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.00503733 |
| ELMO2 | engulfment and cell motility 2 | 0.00501373 |
| PCNT | pericentrin | 0.00500431 |
| CFAP96 | cilia and flagella associated protein 96 | 0.00498723 |
| DSCAM | Down syndrome cell adhesion molecule | 0.00498609 |
| ELOVL7 | ELOVL fatty acid elongase 7 | 0.00497773 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 | 0.00495941 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.00491217 |
| SETD3 | SET domain containing 3 | 0.00489206 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.292804 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.211305 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.129939 |
| TXNRD1 | thioredoxin reductase 1 | -0.122562 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0957882 |
| NDRG1 | N-myc downstream regulated 1 | -0.0935009 |
| ASPH | aspartate beta-hydroxylase | -0.0842483 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0828707 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0719989 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0713525 |
| MT2A | metallothionein 2A | -0.0693258 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0638372 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0634959 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0632775 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0627336 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0617831 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0599984 |
| STC1 | stanniocalcin 1 | -0.0525866 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0525701 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0524586 |
| EFNA5 | ephrin-A5 | -0.0494994 |
| CDCP1 | CUB domain containing protein 1 | -0.0477163 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0476209 |
| TES | testin LIM domain protein | -0.0475519 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0465289 |
| LDHA | lactate dehydrogenase A | -0.0446166 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0445214 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0443289 |
| SLTM | SAFB-like, transcription modulator | -0.0430391 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0425991 |
| MCL1 | myeloid cell leukemia 1 | -0.0418768 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0417351 |
| S100A10 | S100 calcium binding protein A10 | -0.0413715 |
| RPS6 | ribosomal protein S6 | -0.0407501 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0405912 |
| CCNL1 | cyclin L1 | -0.0395243 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0368371 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0368356 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0368007 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.036659 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0366175 |
| RNF213 | ring finger protein 213 | -0.0365713 |
| CPE | carboxypeptidase E | -0.0352144 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0350705 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0343487 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0342184 |
| SUMF1 | sulfatase modifying factor 1 | -0.0342059 |
| ACTG1 | actin gamma 1 | -0.0341629 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0338554 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0335133 |
| RAD51B | RAD51 paralog B | -0.0334231 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0330748 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0329396 |
| MYOF | myoferlin | -0.0325783 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0324983 |
| SMAD3 | SMAD family member 3 | -0.0323829 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0323396 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0321987 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.031936 |
| ANXA2 | annexin A2 | -0.0317646 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0315763 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.031273 |
| FTL | ferritin, light polypeptide | -0.0310845 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0308118 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0304882 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.030366 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0299619 |
| RPS25 | ribosomal protein S25 | -0.0298425 |
| USP34 | ubiquitin specific peptidase 34 | -0.0296912 |
| RTN4 | reticulon 4 | -0.0296906 |
| VCL | vinculin | -0.0291058 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0291033 |
| RAB1A | RAB1A, member RAS oncogene family | -0.028789 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0287145 |
| RPS3 | ribosomal protein S3 | -0.0283178 |
| SCEL | sciellin | -0.0281266 |
| RPS24 | ribosomal protein S24 | -0.0280973 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0278317 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0276652 |
| PTK2 | protein tyrosine kinase 2 | -0.0275741 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0275309 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0273394 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0268443 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0261871 |
| B2M | beta-2-microglobulin | -0.026158 |
| ENSA | endosulfine alpha | -0.0261257 |
| ADAR | adenosine deaminase, RNA-specific | -0.026101 |
| RPLP0 | ribosomal protein, large, P0 | -0.0257856 |
| EGR1 | early growth response 1 | -0.0257214 |
| IER3 | immediate early response 3 | -0.0253069 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.025288 |
| RPL35A | ribosomal protein L35a | -0.0252762 |
| OSMR | oncostatin M receptor | -0.0251944 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0251856 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0250503 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.02493 |
| CCNI | cyclin I | -0.0248676 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0247243 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.024669 |
| ZNF292 | zinc finger protein 292 | -0.0245167 |
