| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vortioxetine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0994347 |
| FN1 | fibronectin 1 | 0.0917495 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0592916 |
| CDH13 | cadherin 13 | 0.0546857 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0507339 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0465266 |
| FAM20C | family with sequence similarity 20, member C | 0.0393532 |
| HMGA2 | high mobility group AT-hook 2 | 0.0365535 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0332784 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0292479 |
| MTSS1 | metastasis suppressor 1 | 0.0278651 |
| MEF2A | myocyte enhancer factor 2A | 0.0276291 |
| FBN1 | fibrillin 1 | 0.0267846 |
| NRG1 | neuregulin 1 | 0.0261185 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0234307 |
| CDK14 | cyclin-dependent kinase 14 | 0.0232578 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0224978 |
| DNER | delta/notch-like EGF repeat containing | 0.0217787 |
| CLMP | CXADR-like membrane protein | 0.0217728 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0217089 |
| IL1B | interleukin 1, beta | 0.0215334 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0209826 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.0209394 |
| RPL4 | ribosomal protein L4 | 0.0202913 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.019612 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0195807 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0187119 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0186131 |
| PRRX1 | paired related homeobox 1 | 0.0180889 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0180035 |
| DPYD | dihydropyrimidine dehydrogenase | 0.017922 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | 0.0172291 |
| PYGL | phosphorylase, glycogen, liver | 0.0159974 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0157728 |
| OXR1 | oxidation resistance 1 | 0.0157559 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0156325 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0155246 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0153107 |
| AADAC | arylacetamide deacetylase | 0.0152689 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0150781 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0141755 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0139174 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0137673 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0135999 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0132998 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0129505 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0127034 |
| NHSL1 | NHS-like 1 | 0.0126368 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | 0.0124438 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0123377 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0122209 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0121706 |
| GLIS3 | GLIS family zinc finger 3 | 0.0119872 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0118774 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0116004 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.011458 |
| RAI14 | retinoic acid induced 14 | 0.0114074 |
| WLS | wntless Wnt ligand secretion mediator | 0.0113871 |
| ADAM28 | ADAM metallopeptidase domain 28 | 0.011115 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.0110938 |
| NAV1 | neuron navigator 1 | 0.0108144 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.010792 |
| TNS3 | tensin 3 | 0.0107739 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0107224 |
| EFCAB13 | EF-hand calcium binding domain 13 | 0.0107146 |
| DCN | decorin | 0.0106886 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0105496 |
| DIAPH2 | diaphanous-related formin 2 | 0.0104993 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0104332 |
| VEGFA | vascular endothelial growth factor A | 0.0100456 |
| GLCCI1 | glucocorticoid induced 1 | 0.0100075 |
| PODXL | podocalyxin-like | 0.00998943 |
| TMEM165 | transmembrane protein 165 | 0.00993091 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.00992831 |
| DOCK5 | dedicator of cytokinesis 5 | 0.00979347 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00977759 |
| ANXA10 | annexin A10 | 0.00971383 |
| COL27A1 | collagen, type XXVII, alpha 1 | 0.00968597 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.00964702 |
| PDE7B | phosphodiesterase 7B | 0.00960121 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.00959964 |
| RPL3 | ribosomal protein L3 | 0.0095769 |
| NCOR2 | nuclear receptor corepressor 2 | 0.00945277 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.00925263 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.00898143 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0089402 |
| TMSB4X | thymosin beta 4, X-linked | 0.00892538 |
| SLC22A23 | solute carrier family 22, member 23 | 0.00891269 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0089116 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.00862363 |
| TNS1 | tensin 1 | 0.00859262 |
| CP | ceruloplasmin (ferroxidase) | 0.0085619 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.00851689 |
| GOLGA3 | golgin A3 | 0.00841127 |
| SUMF1 | sulfatase modifying factor 1 | 0.00833435 |
| SH3RF3 | SH3 domain containing ring finger 3 | 0.00831085 |
| SYT7 | synaptotagmin VII | 0.00824233 |
| PGM1 | phosphoglucomutase 1 | 0.00821752 |
| ZNF469 | zinc finger protein 469 | 0.0081704 |
| ZNF804A | zinc finger protein 804A | 0.00813383 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.248865 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.222998 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.113102 |
| VIM | vimentin | -0.110311 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0878661 |
| MT2A | metallothionein 2A | -0.0864707 |
| FTL | ferritin, light polypeptide | -0.0859931 |
| NDRG1 | N-myc downstream regulated 1 | -0.0847339 |
| RBM39 | RNA binding motif protein 39 | -0.0805904 |
| CD44 | CD44 molecule (Indian blood group) | -0.0804394 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0799303 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0755761 |
| GOLGA4 | golgin A4 | -0.0733041 |
| SMAD3 | SMAD family member 3 | -0.0680044 |
| RPLP1 | ribosomal protein, large, P1 | -0.0624143 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0601799 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0597469 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.059073 |
| PTMA | prothymosin, alpha | -0.0569284 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0533692 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0529695 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0528055 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.050711 |
| RPS6 | ribosomal protein S6 | -0.0488045 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0486579 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0484352 |
| USP34 | ubiquitin specific peptidase 34 | -0.0479418 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0467093 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0462834 |
| RPS19 | ribosomal protein S19 | -0.0443112 |
| FAM13A | family with sequence similarity 13, member A | -0.0432767 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0432052 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0404287 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0404091 |
| TMSB10 | thymosin beta 10 | -0.0400467 |
| PCBP2 | poly(rC) binding protein 2 | -0.0399132 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0398735 |
| B2M | beta-2-microglobulin | -0.0393808 |
| RPS8 | ribosomal protein S8 | -0.0386778 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0383226 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0382351 |
| RUNX1 | runt-related transcription factor 1 | -0.0382035 |
| OGA | O-GlcNAcase | -0.0380844 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0377243 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0376628 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0372302 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0371796 |
| ZNF292 | zinc finger protein 292 | -0.0370827 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0363477 |
| SRP54 | signal recognition particle 54kDa | -0.0363264 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.0354979 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0348308 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0346701 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0340256 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0335601 |
| RPS2 | ribosomal protein S2 | -0.0334732 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0334015 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.033315 |
| HELZ | helicase with zinc finger | -0.0330761 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0324918 |
| YBX3 | Y box binding protein 3 | -0.0323893 |
| CANX | calnexin | -0.0323693 |
| JMJD1C | jumonji domain containing 1C | -0.0319881 |
| EFNA5 | ephrin-A5 | -0.031772 |
| RPS12 | ribosomal protein S12 | -0.031675 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0313638 |
| RPL23 | ribosomal protein L23 | -0.0308088 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0307409 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0306649 |
| RPS21 | ribosomal protein S21 | -0.0304264 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0303882 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0301671 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0301192 |
| FLNB | filamin B, beta | -0.030114 |
| SPAG9 | sperm associated antigen 9 | -0.0298858 |
| RPL32 | ribosomal protein L32 | -0.0298101 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0297015 |
| RPLP0 | ribosomal protein, large, P0 | -0.0296986 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.029621 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0295969 |
| SBF2 | SET binding factor 2 | -0.0293479 |
| RAD51B | RAD51 paralog B | -0.0292881 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0292708 |
| RPL35A | ribosomal protein L35a | -0.0291791 |
| RPL12 | ribosomal protein L12 | -0.0289843 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.028767 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0287254 |
| RPS24 | ribosomal protein S24 | -0.0283788 |
| WDR45B | WD repeat domain 45B | -0.0283772 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.028115 |
| RPLP2 | ribosomal protein, large, P2 | -0.0281127 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0280084 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0279539 |
| ATXN1 | ataxin 1 | -0.0277356 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0276541 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.027644 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0274372 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0273733 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.027139 |
| COG5 | component of oligomeric golgi complex 5 | -0.0270436 |
