Vortioxetine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.100997
RPL4 ribosomal protein L4 0.0721097
PTMA prothymosin, alpha 0.0601984
MT2A metallothionein 2A 0.0507175
TMSB10 thymosin beta 10 0.0481989
IER3 immediate early response 3 0.0441923
LOC112694756 uncharaterized LOC112694756 0.041115
TPT1 tumor protein, translationally-controlled 1 0.0403172
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0374977
HLA-B major histocompatibility complex, class I, B 0.0353778
POTEF POTE ankyrin domain family, member F 0.0351687
ANGPTL4 angiopoietin-like 4 0.0334895
CXCL8 chemokine (C-X-C motif) ligand 8 0.0333327
CTSL cathepsin L 0.0315517
C15ORF48 chromosome 15 open reading frame 48 0.0315476
RPL35A ribosomal protein L35a 0.0298494
LOC102724023 ES1 protein homolog, mitochondrial 0.0294565
MYH9 myosin, heavy chain 9, non-muscle 0.0289256
EGR1 early growth response 1 0.0279259
RPS29 ribosomal protein S29 0.027755
PKM pyruvate kinase, muscle 0.0274995
RPL31 ribosomal protein L31 0.0274504
HLA-A major histocompatibility complex, class I, A 0.0268891
RPL13A ribosomal protein L13a 0.0258116
AKAP12 A kinase (PRKA) anchor protein 12 0.0248649
IGFBP3 insulin-like growth factor binding protein 3 0.0248478
EEF2 eukaryotic translation elongation factor 2 0.0246443
ACTG1 actin gamma 1 0.0245823
HDAC9 histone deacetylase 9 0.0244365
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0242128
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0237457
HMOX1 heme oxygenase 1 0.023527
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0234253
TPM4 tropomyosin 4 0.0223307
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0215856
LDHA lactate dehydrogenase A 0.0213573
RPL3 ribosomal protein L3 0.0212277
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0210108
IL6 interleukin 6 0.0209303
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0190594
NTN4 netrin 4 0.0184941
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0177525
CAVIN1 caveolae associated protein 1 0.0175233
IGFBP4 insulin-like growth factor binding protein 4 0.0174972
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0169515
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0164886
HLA-E major histocompatibility complex, class I, E 0.0164322
ENO1 enolase 1, (alpha) 0.0163065
SDC4 syndecan 4 0.0161231
RPL37A ribosomal protein L37a 0.015991
RPL7A ribosomal protein L7a 0.0156602
ACTN1 actinin, alpha 1 0.0156459
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0155761
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0155656
MCL1 myeloid cell leukemia 1 0.0153829
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0151922
RPS27A ribosomal protein S27a 0.0151243
RPS24 ribosomal protein S24 0.0150125
FBL fibrillarin 0.0148031
ISG15 ISG15 ubiquitin-like modifier 0.0145588
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0145366
PERP PERP, TP53 apoptosis effector 0.0143242
PYGL phosphorylase, glycogen, liver 0.014278
TUBB tubulin, beta class I 0.0142597
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.0141884
ETV3 ets variant 3 0.0141608
THBS1 thrombospondin 1 0.0141536
SOX4 SRY (sex determining region Y)-box 4 0.0139529
SRRM2 serine/arginine repetitive matrix 2 0.0136951
HDGF hepatoma-derived growth factor 0.0136103
FADS2 fatty acid desaturase 2 0.0134187
VDAC1 voltage-dependent anion channel 1 0.0133175
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0130375
IFITM3 interferon induced transmembrane protein 3 0.0129937
TCIM transcriptional and immune response regulator 0.0129838
ZNF804A zinc finger protein 804A 0.0129306
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0128911
LASP1 LIM and SH3 protein 1 0.0127882
CCL5 chemokine (C-C motif) ligand 5 0.0127541
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0126356
ENO2 enolase 2 (gamma, neuronal) 0.0125789
RPS27 ribosomal protein S27 0.0125729
AHI1 Abelson helper integration site 1 0.0125544
VAT1 vesicle amine transport 1 0.0125526
PGK1 phosphoglycerate kinase 1 0.0125037
OSMR oncostatin M receptor 0.0124824
CD9 CD9 molecule 0.0124752
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0124661
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0124048
S100A11 S100 calcium binding protein A11 0.012338
CHMP7 charged multivesicular body protein 7 0.0122482
HMGA2 high mobility group AT-hook 2 0.0119197
CDK12 cyclin-dependent kinase 12 0.0118944
IFIH1 interferon induced with helicase C domain 1 0.011821
POMP proteasome maturation protein 0.0118038
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0117872
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0117208
JUND jun D proto-oncogene 0.0114506
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0114241
NBR1 neighbor of BRCA1 gene 1 0.0113988

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.165556
PDE4D phosphodiesterase 4D, cAMP-specific -0.145507
ZFAND3 zinc finger, AN1-type domain 3 -0.102073
RBM39 RNA binding motif protein 39 -0.10121
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0939504
PM20D1 peptidase M20 domain containing 1 -0.089648
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0873782
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0848308
FNDC3B fibronectin type III domain containing 3B -0.0838358
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.081124
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0800222
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0785204
GRAMD1B GRAM domain containing 1B -0.0753724
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0741645
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0730406
TRIO trio Rho guanine nucleotide exchange factor -0.0724105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0711533
RPS2 ribosomal protein S2 -0.0709066
SAMD4A sterile alpha motif domain containing 4A -0.0693846
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0690365
DOCK4 dedicator of cytokinesis 4 -0.0650255
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0649241
RTN4 reticulon 4 -0.063394
PUM2 pumilio RNA-binding family member 2 -0.0628517
FTL ferritin, light polypeptide -0.0610593
LPP LIM domain containing preferred translocation partner in lipoma -0.0608815
ELL2 elongation factor, RNA polymerase II, 2 -0.0598578
FMNL2 formin-like 2 -0.0583795
PARD3 par-3 family cell polarity regulator -0.0573924
TFPI2 tissue factor pathway inhibitor 2 -0.0564244
WAC WW domain containing adaptor with coiled-coil -0.0552761
TPD52 tumor protein D52 -0.053247
WDR43 WD repeat domain 43 -0.0515572
AKAP13 A kinase (PRKA) anchor protein 13 -0.0511993
KIF5B kinesin family member 5B -0.0508316
SPAG9 sperm associated antigen 9 -0.0503087
KTN1 kinectin 1 (kinesin receptor) -0.0491083
TRA2A transformer 2 alpha homolog (Drosophila) -0.0486633
YBX3 Y box binding protein 3 -0.0483003
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.047844
ZNF292 zinc finger protein 292 -0.0476578
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0474938
RPL19 ribosomal protein L19 -0.0471054
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0468191
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0459123
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0454307
GLS2 glutaminase 2 (liver, mitochondrial) -0.045285
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0446197
EIF1 eukaryotic translation initiation factor 1 -0.0443298
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0438635
RAD21 RAD21 homolog (S. pombe) -0.0436731
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0432358
AHR aryl hydrocarbon receptor -0.0429502
JMJD1C jumonji domain containing 1C -0.0423902
YY1 YY1 transcription factor -0.0420977
TXNRD1 thioredoxin reductase 1 -0.0418714
PTK2 protein tyrosine kinase 2 -0.0417674
USP3 ubiquitin specific peptidase 3 -0.0413568
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0412064
NCOR1 nuclear receptor corepressor 1 -0.0410914
NIPBL Nipped-B homolog (Drosophila) -0.0410433
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0410333
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0409978
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0408744
MACF1 microtubule-actin crosslinking factor 1 -0.0405588
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0405163
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0402569
MIS18BP1 MIS18 binding protein 1 -0.0396979
DSCAM Down syndrome cell adhesion molecule -0.0396952
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0395889
ITCH itchy E3 ubiquitin protein ligase -0.0395848
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0389008
YAP1 Yes-associated protein 1 -0.0387682
DENND4A DENN/MADD domain containing 4A -0.0382542
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0379544
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0378772
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0377523
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0376248
BCLAF1 BCL2-associated transcription factor 1 -0.0376226
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0375222
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0373747
FNBP1L formin binding protein 1-like -0.0370229
MARCHF6 membrane associated ring-CH-type finger 6 -0.0368769
ZFR zinc finger RNA binding protein -0.0366735
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0365754
NCKAP1 NCK-associated protein 1 -0.0365638
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0362881
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0361419
PDLIM5 PDZ and LIM domain 5 -0.0357053
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.0356788
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0356064
PFDN2 prefoldin subunit 2 -0.0355754
NCEH1 neutral cholesterol ester hydrolase 1 -0.03528
ABI1 abl-interactor 1 -0.0351074
RHEB Ras homolog enriched in brain -0.0351047
NEK7 NIMA-related kinase 7 -0.0349961
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0349909
ERBIN erbb2 interacting protein -0.0349616
ZNF207 zinc finger protein 207 -0.0345696
GOLGA4 golgin A4 -0.0343642