| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vortioxetine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.094936 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0757048 |
| KRT17 | keratin 17, type I | 0.0729003 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0666015 |
| PTK2 | protein tyrosine kinase 2 | 0.0642264 |
| CD44 | CD44 molecule (Indian blood group) | 0.062517 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.060433 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0601505 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0553678 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.054151 |
| FAM13A | family with sequence similarity 13, member A | 0.0537453 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0530742 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0500969 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0485512 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0474279 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.046611 |
| CALD1 | caldesmon 1 | 0.0464496 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0447281 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0434632 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0429234 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0428171 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0423899 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0423579 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.042224 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0415247 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0411965 |
| OGA | O-GlcNAcase | 0.0408102 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0406845 |
| NDRG1 | N-myc downstream regulated 1 | 0.0393511 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0393202 |
| PTMA | prothymosin, alpha | 0.0377229 |
| ATXN1 | ataxin 1 | 0.037058 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0366517 |
| EGFR | epidermal growth factor receptor | 0.0360883 |
| MYO1E | myosin IE | 0.0342169 |
| MYO10 | myosin X | 0.0341972 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0337119 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0334041 |
| ANO6 | anoctamin 6 | 0.0332225 |
| SNX9 | sorting nexin 9 | 0.0321951 |
| STC1 | stanniocalcin 1 | 0.0315236 |
| RPS6 | ribosomal protein S6 | 0.0303389 |
| IGF2 | insulin-like growth factor 2 | 0.0298984 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0297498 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0292492 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0289076 |
| PDE8A | phosphodiesterase 8A | 0.0282997 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.027641 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.02712 |
| FLNB | filamin B, beta | 0.0263468 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0256356 |
| PGK1 | phosphoglycerate kinase 1 | 0.0253363 |
| GOLGA4 | golgin A4 | 0.0251071 |
| SPAG9 | sperm associated antigen 9 | 0.0245543 |
| GPC6 | glypican 6 | 0.0238919 |
| VIM | vimentin | 0.0234534 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.022973 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0226516 |
| MED13L | mediator complex subunit 13-like | 0.022595 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0222827 |
| RPL35A | ribosomal protein L35a | 0.022253 |
| KYNU | kynureninase | 0.0218463 |
| TMSB10 | thymosin beta 10 | 0.0216534 |
| TOP1 | topoisomerase (DNA) I | 0.0213124 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0212245 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0207319 |
| RPLP1 | ribosomal protein, large, P1 | 0.0203976 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0202924 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0200393 |
| USP34 | ubiquitin specific peptidase 34 | 0.0197686 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0196743 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0195242 |
| RUNX1 | runt-related transcription factor 1 | 0.01907 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0188866 |
| RPL19 | ribosomal protein L19 | 0.0173808 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0172951 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0171745 |
| ASPH | aspartate beta-hydroxylase | 0.0171139 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0168647 |
| RPL7A | ribosomal protein L7a | 0.0167057 |
| RPS8 | ribosomal protein S8 | 0.0166869 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0166087 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0164543 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0161773 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0151468 |
| MAP4 | microtubule-associated protein 4 | 0.0148875 |
| RNF145 | ring finger protein 145 | 0.0147779 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0146945 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0144367 |
| NAV2 | neuron navigator 2 | 0.013937 |
| RAD51B | RAD51 paralog B | 0.0137711 |
| SEPTIN7 | septin 7 | 0.0136491 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0134183 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0121189 |
| RLF | rearranged L-myc fusion | 0.0118349 |
| GPHN | gephyrin | 0.0118192 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0116069 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0113971 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0111276 |
| PKM | pyruvate kinase, muscle | 0.011047 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0943574 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0794399 |
| PDE10A | phosphodiesterase 10A | -0.0721694 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0631033 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0613324 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.060869 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0579167 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0545289 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0537528 |
| USP53 | ubiquitin specific peptidase 53 | -0.0523531 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0512186 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0493557 |
| ATOSA | atos homolog A | -0.0493015 |
| LMO7 | LIM domain 7 | -0.0489415 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0465377 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.044934 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0448378 |
| NBEA | neurobeachin | -0.0443613 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0420236 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0419303 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0411652 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0411283 |
| RIGI | RNA sensor RIG-I | -0.040761 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0394722 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0385162 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0383497 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0378353 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0366707 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0356757 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0356639 |
| RBM39 | RNA binding motif protein 39 | -0.0352504 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0349624 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0348672 |
| GOLGB1 | golgin B1 | -0.0345816 |
| TJP1 | tight junction protein 1 | -0.0336324 |
| CEP350 | centrosomal protein 350kDa | -0.0333019 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0328508 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.031946 |
| DSG2 | desmoglein 2 | -0.0312709 |
| DENND1A | DENN/MADD domain containing 1A | -0.0306345 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0295093 |
| USP33 | ubiquitin specific peptidase 33 | -0.0294142 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0293338 |
| MSI2 | musashi RNA-binding protein 2 | -0.028191 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0281141 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0270793 |
| AUTS2 | autism susceptibility candidate 2 | -0.0269038 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0268466 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0265828 |
| TC2N | tandem C2 domains, nuclear | -0.0256183 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.02543 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0252466 |
| MYOF | myoferlin | -0.0248871 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0242516 |
| SCFD1 | sec1 family domain containing 1 | -0.0239571 |
| RORA | RAR-related orphan receptor A | -0.0237174 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0235241 |
| LAMB3 | laminin, beta 3 | -0.0234976 |
| ENO1 | enolase 1, (alpha) | -0.0232177 |
| FN1 | fibronectin 1 | -0.0228754 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.022843 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0225489 |
| PHF21A | PHD finger protein 21A | -0.0223947 |
| SLC38A1 | solute carrier family 38, member 1 | -0.022283 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0218718 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0214233 |
| WASF2 | WAS protein family, member 2 | -0.0211753 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0211308 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0206378 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0205058 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0197001 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0191042 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0189936 |
| ANXA2 | annexin A2 | -0.0189106 |
| NEBL | nebulette | -0.0187116 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0180817 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0176441 |
| TXNIP | thioredoxin interacting protein | -0.0176144 |
| SEC24D | SEC24 family member D | -0.0175855 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0175597 |
| TUFT1 | tuftelin 1 | -0.0170564 |
| RTN4 | reticulon 4 | -0.0169992 |
| ZNF638 | zinc finger protein 638 | -0.0167071 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0165924 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0163512 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0160819 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0155414 |
| KIF5B | kinesin family member 5B | -0.0150202 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0149936 |
| SMYD3 | SET and MYND domain containing 3 | -0.0149248 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0148125 |
| PARD3 | par-3 family cell polarity regulator | -0.0147013 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0143944 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0141387 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0139456 |
| EZR | ezrin | -0.0136379 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0135906 |
| B2M | beta-2-microglobulin | -0.0135041 |
| NF1 | neurofibromin 1 | -0.0133224 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0132479 |
