| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vortioxetine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.289215 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.15542 |
| TXNRD1 | thioredoxin reductase 1 | 0.137426 |
| GRAMD1B | GRAM domain containing 1B | 0.119902 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.086483 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0749314 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0667883 |
| MKI67 | marker of proliferation Ki-67 | 0.0617787 |
| POTEF | POTE ankyrin domain family, member F | 0.0615742 |
| PTMA | prothymosin, alpha | 0.0603253 |
| KRT18 | keratin 18, type I | 0.0540778 |
| TPM3 | tropomyosin 3 | 0.0533152 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0510204 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0489626 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0485686 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0478277 |
| PCBP2 | poly(rC) binding protein 2 | 0.0475669 |
| RPL3 | ribosomal protein L3 | 0.04755 |
| BRD2 | bromodomain containing 2 | 0.0472078 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0445413 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0443479 |
| IPO7 | importin 7 | 0.0435049 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0433187 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0393386 |
| SET | SET nuclear proto-oncogene | 0.0385208 |
| RPL4 | ribosomal protein L4 | 0.038117 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0369804 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0365365 |
| CLTC | clathrin, heavy chain (Hc) | 0.0360518 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0356758 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0345739 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0343044 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0327955 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0326856 |
| PTMS | parathymosin | 0.0325016 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0315828 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0311071 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0308553 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0304234 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0299885 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0297923 |
| ACTN1 | actinin, alpha 1 | 0.0296483 |
| PKM | pyruvate kinase, muscle | 0.0295277 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0288538 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0274217 |
| TCIM | transcriptional and immune response regulator | 0.0266169 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0259257 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0258502 |
| CDK17 | cyclin-dependent kinase 17 | 0.0257598 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0255263 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0253258 |
| STMN1 | stathmin 1 | 0.0252733 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0248779 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0247199 |
| ENO1 | enolase 1, (alpha) | 0.024671 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0244926 |
| PLEC | plectin | 0.024152 |
| VIM | vimentin | 0.0237228 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0236096 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0235694 |
| HDGF | hepatoma-derived growth factor | 0.0235107 |
| RTN4 | reticulon 4 | 0.023476 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0234466 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0234037 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.02292 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0229039 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0228906 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0227943 |
| TPM2 | tropomyosin 2 (beta) | 0.0227279 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0224583 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0224045 |
| KIF4A | kinesin family member 4A | 0.0223448 |
| MSN | moesin | 0.0219566 |
| STC1 | stanniocalcin 1 | 0.021813 |
| LATS2 | large tumor suppressor kinase 2 | 0.0217453 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0217406 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0215109 |
| PGK1 | phosphoglycerate kinase 1 | 0.021443 |
| H1-4 | H1.4 linker histone, cluster member | 0.0213709 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0212718 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0212197 |
| MSH6 | mutS homolog 6 | 0.0207021 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.020594 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0205658 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0205252 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0204417 |
| CENPF | centromere protein F, 350/400kDa | 0.0204153 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0201341 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.019993 |
| CALD1 | caldesmon 1 | 0.0198188 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0198048 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0197976 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0196961 |
| EGR1 | early growth response 1 | 0.0196651 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0196085 |
| PDE10A | phosphodiesterase 10A | 0.0194472 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0193479 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0193342 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0193244 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0193135 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152886 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.126597 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0907237 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0685093 |
| PRELID2 | PRELI domain containing 2 | -0.051813 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0481624 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0453346 |
| BBX | bobby sox homolog (Drosophila) | -0.0433121 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0415766 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0407175 |
| COPA | coatomer protein complex, subunit alpha | -0.0345368 |
| YBX3 | Y box binding protein 3 | -0.0327739 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0327298 |
| RPLP1 | ribosomal protein, large, P1 | -0.0314866 |
| AEBP2 | AE binding protein 2 | -0.0314202 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0303942 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0286444 |
| RPL23 | ribosomal protein L23 | -0.0274451 |
| HELZ | helicase with zinc finger | -0.0274092 |
| RBM39 | RNA binding motif protein 39 | -0.0255976 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0255467 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0252366 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0248818 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0245658 |
| RPS8 | ribosomal protein S8 | -0.0244658 |
| HDAC8 | histone deacetylase 8 | -0.0244453 |
| GNAS | GNAS complex locus | -0.0242003 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0241758 |
| DTNB | dystrobrevin, beta | -0.0240279 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0240234 |
| NDRG1 | N-myc downstream regulated 1 | -0.0238345 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0237697 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0227587 |
| TMEM165 | transmembrane protein 165 | -0.0223062 |
| TUT4 | terminal uridylyl transferase 4 | -0.0222587 |
| PHF21A | PHD finger protein 21A | -0.0220897 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0220387 |
| TMEM263 | transmembrane protein 263 | -0.0219294 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0212975 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0210878 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0210749 |
| PARD3 | par-3 family cell polarity regulator | -0.0210674 |
| ATXN1 | ataxin 1 | -0.021067 |
| CALR | calreticulin | -0.0202712 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0201219 |
| RPL35A | ribosomal protein L35a | -0.0198936 |
| SCFD1 | sec1 family domain containing 1 | -0.0198742 |
| SETD5 | SET domain containing 5 | -0.0198601 |
| PREPL | prolyl endopeptidase-like | -0.0196092 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.019523 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0194795 |
| GOLGA4 | golgin A4 | -0.0193795 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0193199 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0188697 |
| ETNK1 | ethanolamine kinase 1 | -0.0188014 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0187448 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0186806 |
| TULP3 | tubby like protein 3 | -0.0186599 |
| NF1 | neurofibromin 1 | -0.0184414 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0183672 |
| INTS6 | integrator complex subunit 6 | -0.0183424 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0180691 |
| RPS24 | ribosomal protein S24 | -0.0179534 |
| RYK | receptor-like tyrosine kinase | -0.017879 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0176645 |
| PYGL | phosphorylase, glycogen, liver | -0.0175286 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.017517 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0174855 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0174118 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0173359 |
| SEC24D | SEC24 family member D | -0.0173295 |
| CANX | calnexin | -0.0173037 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0171674 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0169897 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0168464 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0165694 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0165176 |
| HBP1 | HMG-box transcription factor 1 | -0.0164911 |
| RRBP1 | ribosome binding protein 1 | -0.0164743 |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | -0.016394 |
| DIAPH2 | diaphanous-related formin 2 | -0.0162998 |
| ZNF207 | zinc finger protein 207 | -0.0162316 |
| METTL15 | methyltransferase like 15 | -0.0162288 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0162164 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0161979 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0161171 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0160969 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0160666 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0159443 |
| HM13 | histocompatibility (minor) 13 | -0.015933 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0158834 |
| RPL34 | ribosomal protein L34 | -0.0158828 |
| GPR75-ASB3 | GPR75-ASB3 readthrough | -0.0157666 |
| UVRAG | UV radiation resistance associated | -0.0156726 |
| HYOU1 | hypoxia up-regulated 1 | -0.0156538 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0156418 |
| RACK1 | receptor for activated C kinase 1 | -0.0155623 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0155476 |
| LRRC23 | leucine rich repeat containing 23 | -0.0155445 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0155416 |
