Vortioxetine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.24488
POTEF POTE ankyrin domain family, member F 0.160756
PABPC1 poly(A) binding protein, cytoplasmic 1 0.142667
PTMA prothymosin, alpha 0.103082
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.101507
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.100786
FTL ferritin, light polypeptide 0.095144
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0694959
BHLHE40 basic helix-loop-helix family, member e40 0.0675327
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0644605
MYH9 myosin, heavy chain 9, non-muscle 0.0615101
SLC38A1 solute carrier family 38, member 1 0.0612201
ASPH aspartate beta-hydroxylase 0.0589952
S100A6 S100 calcium binding protein A6 0.0587265
RPL4 ribosomal protein L4 0.0583983
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.051753
NAMPT nicotinamide phosphoribosyltransferase 0.0505122
EEF2 eukaryotic translation elongation factor 2 0.0486079
CCNL1 cyclin L1 0.0478513
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0474366
GARS1 glycyl-tRNA synthetase 1 0.0469457
TMSB4X thymosin beta 4, X-linked 0.0469205
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0462855
LOC112694756 uncharaterized LOC112694756 0.0457164
CALR calreticulin 0.0438692
RNF145 ring finger protein 145 0.0438146
TMSB10 thymosin beta 10 0.04364
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0421937
RBM25 RNA binding motif protein 25 0.0421746
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0417609
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0416826
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0412719
HMGB2 high mobility group box 2 0.0411544
HMGA1 high mobility group AT-hook 1 0.0398843
RPL35A ribosomal protein L35a 0.0391998
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0390885
PCBP2 poly(rC) binding protein 2 0.0382704
YBX1 Y box binding protein 1 0.0375847
RPL3 ribosomal protein L3 0.0372075
PEG10 paternally expressed 10 0.037157
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0366271
KMT2E lysine (K)-specific methyltransferase 2E 0.0363381
EIF1 eukaryotic translation initiation factor 1 0.0358849
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0358066
RACK1 receptor for activated C kinase 1 0.0356929
RPS12 ribosomal protein S12 0.0349904
ADAM9 ADAM metallopeptidase domain 9 0.0349892
PRRC2C proline-rich coiled-coil 2C 0.0349044
RPL8 ribosomal protein L8 0.034441
MATR3 matrin 3 0.034425
RPS8 ribosomal protein S8 0.0336744
RPS3 ribosomal protein S3 0.0335636
PAPOLA poly(A) polymerase alpha 0.0333073
APLP2 amyloid beta (A4) precursor-like protein 2 0.0331209
RPS6 ribosomal protein S6 0.032813
FTH1 ferritin, heavy polypeptide 1 0.032663
GOLGA4 golgin A4 0.0321887
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0316324
MSMO1 methylsterol monooxygenase 1 0.031401
RPL5 ribosomal protein L5 0.0312695
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0309568
CSDE1 cold shock domain containing E1, RNA-binding 0.030891
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0304917
HDGF hepatoma-derived growth factor 0.0302923
EEF1G eukaryotic translation elongation factor 1 gamma 0.0301733
RPS23 ribosomal protein S23 0.0293034
SETD5 SET domain containing 5 0.0291818
RPL12 ribosomal protein L12 0.0291083
USP3 ubiquitin specific peptidase 3 0.0290758
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0288007
MSN moesin 0.0286813
SET SET nuclear proto-oncogene 0.0286635
LDHB lactate dehydrogenase B 0.0285673
AREG amphiregulin 0.0284618
DSTN destrin (actin depolymerizing factor) 0.0283967
NAP1L1 nucleosome assembly protein 1-like 1 0.0283796
TPM3 tropomyosin 3 0.0283604
RPS19 ribosomal protein S19 0.0279406
RPL9 ribosomal protein L9 0.0278872
NUP58 nucleoporin 58 0.0278503
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0277753
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0277079
RPL7 ribosomal protein L7 0.0275156
RPLP2 ribosomal protein, large, P2 0.0273469
NACA nascent polypeptide-associated complex alpha subunit 0.0267944
RPL23 ribosomal protein L23 0.0267364
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0263661
HSPA8 heat shock 70kDa protein 8 0.0262331
RPLP0 ribosomal protein, large, P0 0.0259775
TFG TRK-fused gene 0.0259572
FXR1 fragile X mental retardation, autosomal homolog 1 0.0259245
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0256668
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0256604
PLAU plasminogen activator, urokinase 0.025485
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0254576
YTHDC1 YTH domain containing 1 0.0254259
RPL32 ribosomal protein L32 0.0253092
VIM vimentin 0.025179
KRT18 keratin 18, type I 0.0251353
TOP1 topoisomerase (DNA) I 0.0250307

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.160011
LPP LIM domain containing preferred translocation partner in lipoma -0.136434
SAMD4A sterile alpha motif domain containing 4A -0.124177
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.116555
NDRG1 N-myc downstream regulated 1 -0.0904263
EXT1 exostosin glycosyltransferase 1 -0.0772812
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0755772
AHNAK AHNAK nucleoprotein -0.0736128
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0711056
LIMCH1 LIM and calponin homology domains 1 -0.0707543
EFNA5 ephrin-A5 -0.0655856
GRB10 growth factor receptor-bound protein 10 -0.0627367
WSB1 WD repeat and SOCS box containing 1 -0.0599041
RNF213 ring finger protein 213 -0.0533778
IFI16 interferon, gamma-inducible protein 16 -0.0530348
NAV2 neuron navigator 2 -0.0520177
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0475782
IGFBP3 insulin-like growth factor binding protein 3 -0.047222
PDLIM5 PDZ and LIM domain 5 -0.0471905
FBXO32 F-box protein 32 -0.0463028
RIGI RNA sensor RIG-I -0.0434328
ZBTB20 zinc finger and BTB domain containing 20 -0.0429183
TRIO trio Rho guanine nucleotide exchange factor -0.0419586
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0401911
ACTG1 actin gamma 1 -0.0394656
RAI14 retinoic acid induced 14 -0.0392984
LAMC2 laminin, gamma 2 -0.0385755
LAMB3 laminin, beta 3 -0.0382003
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0376009
MX2 MX dynamin-like GTPase 2 -0.0375327
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0370909
SP100 SP100 nuclear antigen -0.0368748
MX1 MX dynamin-like GTPase 1 -0.0362806
FHIT fragile histidine triad -0.0360944
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0354636
GOLGB1 golgin B1 -0.0352254
AHNAK2 AHNAK nucleoprotein 2 -0.0348028
MAML2 mastermind-like 2 (Drosophila) -0.0345344
PLSCR1 phospholipid scramblase 1 -0.0342804
ATXN1 ataxin 1 -0.0342761
ATP11A ATPase, class VI, type 11A -0.0336264
RAD51B RAD51 paralog B -0.0333786
VCL vinculin -0.0331702
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0330779
LMO7 LIM domain 7 -0.0328802
MYO6 myosin VI -0.0326463
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0326362
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.032463
SMAD3 SMAD family member 3 -0.0323947
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.032222
MYO1E myosin IE -0.0321464
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0309998
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.030962
PLEC plectin -0.0298696
MACF1 microtubule-actin crosslinking factor 1 -0.0295596
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.029538
PATJ PATJ crumbs cell polarity complex component -0.0289952
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0287785
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0287687
IFIH1 interferon induced with helicase C domain 1 -0.0283588
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0280953
RRBP1 ribosome binding protein 1 -0.0280229
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0280019
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.027624
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0271429
ERRFI1 ERBB receptor feedback inhibitor 1 -0.026936
OGA O-GlcNAcase -0.0268001
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0266947
ARHGAP5 Rho GTPase activating protein 5 -0.0260831
IFI6 interferon, alpha-inducible protein 6 -0.0260598
FBXO34 F-box protein 34 -0.0257646
ARHGAP20 Rho GTPase activating protein 20 -0.0256996
ETV6 ets variant 6 -0.0256803
AKAP13 A kinase (PRKA) anchor protein 13 -0.0250077
RCOR1 REST corepressor 1 -0.0249166
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0241752
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0239112
AFF1 AF4/FMR2 family, member 1 -0.0237757
FNIP1 folliculin interacting protein 1 -0.0235577
EXOC4 exocyst complex component 4 -0.0234839
CCSER1 coiled-coil serine-rich protein 1 -0.0234279
FLNB filamin B, beta -0.0233067
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.022988
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0228708
TBC1D22A TBC1 domain family, member 22A -0.022853
BZW1 basic leucine zipper and W2 domains 1 -0.0227275
PRKCA protein kinase C, alpha -0.0226182
FRMD5 FERM domain containing 5 -0.0224889
ZNF217 zinc finger protein 217 -0.0224235
INTS6 integrator complex subunit 6 -0.0223761
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0223357
MCU mitochondrial calcium uniporter -0.0223339
PICALM phosphatidylinositol binding clathrin assembly protein -0.0221473
IFI44L interferon-induced protein 44-like -0.0220405
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0218438
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0213748
SAMD12 sterile alpha motif domain containing 12 -0.0212787
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0210998
PALLD palladin, cytoskeletal associated protein -0.0210663
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0209371