| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vortioxetine perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vortioxetine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.0264998 |
| RPL4 | ribosomal protein L4 | 0.0260942 |
| RPL3 | ribosomal protein L3 | 0.02508 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0201438 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0198657 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0197211 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0168754 |
| POTEF | POTE ankyrin domain family, member F | 0.0165958 |
| DST | dystonin | 0.016585 |
| MSN | moesin | 0.0139215 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0132739 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0127846 |
| MCL1 | myeloid cell leukemia 1 | 0.0125101 |
| TPM3 | tropomyosin 3 | 0.0119536 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0118565 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0117102 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0115794 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0111836 |
| CHL1 | cell adhesion molecule L1-like | 0.0106311 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0102739 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0100729 |
| INTS6 | integrator complex subunit 6 | 0.00988106 |
| BRD2 | bromodomain containing 2 | 0.00978825 |
| FLNA | filamin A, alpha | 0.00971453 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.00949075 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.00919813 |
| PRELID2 | PRELI domain containing 2 | 0.00882118 |
| PCDH9 | protocadherin 9 | 0.00869884 |
| LSAMP | limbic system-associated membrane protein | 0.00864716 |
| RAD51B | RAD51 paralog B | 0.00859523 |
| PKM | pyruvate kinase, muscle | 0.00858591 |
| BMP6 | bone morphogenetic protein 6 | 0.00855055 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00854528 |
| AUTS2 | autism susceptibility candidate 2 | 0.00851302 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0084057 |
| RPS18 | ribosomal protein S18 | 0.0082875 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00825446 |
| PLK2 | polo-like kinase 2 | 0.0081969 |
| HMG20B | high mobility group 20B | 0.00816424 |
| NRXN3 | neurexin 3 | 0.00795999 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.00784983 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.00775457 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00771639 |
| TENM2 | teneurin transmembrane protein 2 | 0.00769479 |
| LAMB4 | laminin, beta 4 | 0.00768132 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.00760721 |
| PCBP2 | poly(rC) binding protein 2 | 0.00758607 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.00755677 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00746783 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00740509 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.00736471 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0072954 |
| CRTC3 | CREB regulated transcription coactivator 3 | 0.00725808 |
| C9ORF153 | chromosome 9 open reading frame 153 | 0.00724764 |
| PLEC | plectin | 0.0072391 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.00718259 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00702556 |
| CTSL | cathepsin L | 0.00688223 |
| AADAC | arylacetamide deacetylase | 0.00684742 |
| HDGF | hepatoma-derived growth factor | 0.00679329 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.00677866 |
| NCOR2 | nuclear receptor corepressor 2 | 0.00670991 |
| NONO | non-POU domain containing, octamer-binding | 0.00666185 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 0.00652491 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.00641099 |
| PELP1 | proline, glutamate and leucine rich protein 1 | 0.00622806 |
| KRT19 | keratin 19, type I | 0.00616697 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.00613812 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.00606482 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.00599168 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00598282 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0059698 |
| PRDX3 | peroxiredoxin 3 | 0.0058879 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00579041 |
| EMC1 | ER membrane protein complex subunit 1 | 0.00578479 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00576044 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00574391 |
| MNT | MAX network transcriptional repressor | 0.00572555 |
| H1-4 | H1.4 linker histone, cluster member | 0.00570908 |
| GLRX | glutaredoxin (thioltransferase) | 0.00567835 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00563247 |
| HLA-A | major histocompatibility complex, class I, A | 0.0056188 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.00553684 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.00536576 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00534653 |
| PRPF8 | pre-mRNA processing factor 8 | 0.00533624 |
| SH3PXD2A | SH3 and PX domains 2A | 0.00532 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.00526107 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0052274 |
| FAT1 | FAT atypical cadherin 1 | 0.00521578 |
| GPATCH2 | G patch domain containing 2 | 0.00521096 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0051938 |
| PCDH7 | protocadherin 7 | 0.00518578 |
| WWOX | WW domain containing oxidoreductase | 0.0051349 |
| LAMA5 | laminin, alpha 5 | 0.00509048 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.00508704 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00502102 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0050038 |
| RPL21 | ribosomal protein L21 | 0.0049208 |
| HBS1L | HBS1-like translational GTPase | 0.00490827 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.166145 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.159492 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.134975 |
| EFNA5 | ephrin-A5 | -0.117611 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0893993 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0872493 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0824938 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0793453 |
| SMYD3 | SET and MYND domain containing 3 | -0.0783731 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0783105 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0728236 |
| VIM | vimentin | -0.0696853 |
| GDA | guanine deaminase | -0.067283 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0660217 |
| PDE10A | phosphodiesterase 10A | -0.0619916 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0607788 |
| CANX | calnexin | -0.0587478 |
| TMSB10 | thymosin beta 10 | -0.0582167 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0568036 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0560077 |
| FN1 | fibronectin 1 | -0.0556853 |
| TXNRD1 | thioredoxin reductase 1 | -0.0553502 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0552347 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0544641 |
| RPLP1 | ribosomal protein, large, P1 | -0.0511093 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0506298 |
| S100A6 | S100 calcium binding protein A6 | -0.0478201 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0476168 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.047613 |
| MYOF | myoferlin | -0.0469187 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0465523 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0461666 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0454763 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0448984 |
| COL5A2 | collagen, type V, alpha 2 | -0.0440221 |
| PTMA | prothymosin, alpha | -0.04373 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0436296 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0426788 |
| PTGR1 | prostaglandin reductase 1 | -0.0418475 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0418177 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0417343 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0414693 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0405993 |
| GNAS | GNAS complex locus | -0.0405569 |
| FTL | ferritin, light polypeptide | -0.040196 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0401345 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0398993 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0383869 |
| JMJD1C | jumonji domain containing 1C | -0.0381719 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0375395 |
| OGA | O-GlcNAcase | -0.036987 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.035128 |
| RPS6 | ribosomal protein S6 | -0.0349499 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0349457 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0339036 |
| ASPH | aspartate beta-hydroxylase | -0.0336606 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0335759 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0334534 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0331066 |
| RGS2 | regulator of G-protein signaling 2 | -0.033 |
| STC1 | stanniocalcin 1 | -0.0326503 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0326378 |
| NRCAM | neuronal cell adhesion molecule | -0.0321613 |
| B2M | beta-2-microglobulin | -0.032141 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0316164 |
| PCBP3 | poly(rC) binding protein 3 | -0.0311882 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0309808 |
| PHF20 | PHD finger protein 20 | -0.0304887 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0301489 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0297064 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0294571 |
| BMERB1 | bMERB domain containing 1 | -0.0290663 |
| OSMR | oncostatin M receptor | -0.0290461 |
| NF1 | neurofibromin 1 | -0.0287165 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0286458 |
| RPS24 | ribosomal protein S24 | -0.0283521 |
| MT2A | metallothionein 2A | -0.0281758 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0279478 |
| RPL12 | ribosomal protein L12 | -0.0275623 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.027387 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0269661 |
| TBXT | T-box transcription factor T | -0.0267939 |
| SRGN | serglycin | -0.0266638 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0263995 |
| COL4A5 | collagen, type IV, alpha 5 | -0.026379 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.026313 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0263121 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0263055 |
| KYNU | kynureninase | -0.0263009 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0262268 |
| SRPK2 | SRSF protein kinase 2 | -0.0258952 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0255589 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0255329 |
| RPL35A | ribosomal protein L35a | -0.0255224 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0254377 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0254163 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0253682 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0252333 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0251963 |
| S100A10 | S100 calcium binding protein A10 | -0.024906 |
