Vortioxetine_NCI-H596 Gene Set
Genes
39 genes differentially expressed following the Vortioxetine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
HSP90B1
|
heat shock protein 90kDa beta (Grp94), member 1
|
0.202201
|
|
PDE10A
|
phosphodiesterase 10A
|
0.195351
|
|
RORA
|
RAR-related orphan receptor A
|
0.190748
|
|
CD55
|
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
|
0.187924
|
|
PLCB1
|
phospholipase C, beta 1 (phosphoinositide-specific)
|
0.174715
|
|
NCOA3
|
nuclear receptor coactivator 3
|
0.166786
|
|
HSPA5
|
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
|
0.152232
|
|
TRIO
|
trio Rho guanine nucleotide exchange factor
|
0.128884
|
|
HSP90AB1
|
heat shock protein 90kDa alpha (cytosolic), class B member 1
|
0.0850876
|
|
ERO1A
|
endoplasmic reticulum oxidoreductase 1 alpha
|
0.0468776
|
|
LOC112694756
|
uncharaterized LOC112694756
|
0.0432566
|
|
DST
|
dystonin
|
0.0395767
|
|
PGK1
|
phosphoglycerate kinase 1
|
0.0367201
|
|
PABPC1
|
poly(A) binding protein, cytoplasmic 1
|
0.0310928
|
|
FN1
|
fibronectin 1
|
0.0187955
|
|
RPS6
|
ribosomal protein S6
|
0.0112961
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
-0.262424
|
|
NKD1
|
naked cuticle homolog 1 (Drosophila)
|
-0.179928
|
|
VIM
|
vimentin
|
-0.171981
|
|
HSP90AA1
|
heat shock protein 90kDa alpha (cytosolic), class A member 1
|
-0.120889
|
|
ZBTB20
|
zinc finger and BTB domain containing 20
|
-0.113006
|
|
AKAP12
|
A kinase (PRKA) anchor protein 12
|
-0.0986598
|
|
ROBO2
|
roundabout, axon guidance receptor, homolog 2 (Drosophila)
|
-0.0985853
|
|
UBC
|
ubiquitin C
|
-0.0897816
|
|
SERPINE1
|
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
|
-0.0865871
|
|
PTMA
|
prothymosin, alpha
|
-0.0852479
|
|
RPS16
|
ribosomal protein S16
|
-0.0818097
|
|
ATP2B1
|
ATPase, Ca++ transporting, plasma membrane 1
|
-0.0449567
|
|
ASPH
|
aspartate beta-hydroxylase
|
-0.0403582
|
|
NAV2
|
neuron navigator 2
|
-0.0345461
|
|
NAMPT
|
nicotinamide phosphoribosyltransferase
|
-0.0281312
|
|
LMO7
|
LIM domain 7
|
-0.0208803
|
|
MACF1
|
microtubule-actin crosslinking factor 1
|
-0.0203276
|
|
JMJD1C
|
jumonji domain containing 1C
|
-0.0195616
|
|
FNDC3B
|
fibronectin type III domain containing 3B
|
-0.0192258
|
|
ZNF292
|
zinc finger protein 292
|
-0.011826
|
|
SNX9
|
sorting nexin 9
|
-0.00929919
|
|
ANXA2
|
annexin A2
|
-0.00188041
|
|
LDHA
|
lactate dehydrogenase A
|
-0.00158288
|
