Vortioxetine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vortioxetine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vortioxetine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0519235
COL11A1 collagen, type XI, alpha 1 0.0431923
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0374639
GPC3 glypican 3 0.0361298
SIK3 SIK family kinase 3 0.0320364
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0312295
HSPA8 heat shock 70kDa protein 8 0.0300318
TMSB4X thymosin beta 4, X-linked 0.0294709
CLTC clathrin, heavy chain (Hc) 0.0289819
PCM1 pericentriolar material 1 0.0289192
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.025072
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.0240447
MYH9 myosin, heavy chain 9, non-muscle 0.0225972
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0219965
ZNF146 zinc finger protein 146 0.0216584
OPHN1 oligophrenin 1 0.0215507
STIP1 stress-induced phosphoprotein 1 0.0207829
NGFR nerve growth factor receptor 0.0206678
CHD4 chromodomain helicase DNA binding protein 4 0.0205664
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.020473
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0203162
DST dystonin 0.0202151
NUDC nudC nuclear distribution protein 0.0200958
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.0200864
NONO non-POU domain containing, octamer-binding 0.0200195
FIP1L1 factor interacting with PAPOLA and CPSF1 0.019986
LRRC4C leucine rich repeat containing 4C 0.0198688
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0198398
DMD dystrophin 0.019308
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0190561
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.018917
CAPRIN1 cell cycle associated protein 1 0.0189128
KANSL3 KAT8 regulatory NSL complex subunit 3 0.0188611
GAB2 GRB2-associated binding protein 2 0.0188337
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0187696
PUM1 pumilio RNA-binding family member 1 0.0187362
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.0186841
RPL18 ribosomal protein L18 0.0186095
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.0182695
FAM91A1 family with sequence similarity 91, member A1 0.018182
DOCK5 dedicator of cytokinesis 5 0.0181717
MLEC malectin 0.0181421
CKAP5 cytoskeleton associated protein 5 0.0181357
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0180983
PPT1 palmitoyl-protein thioesterase 1 0.0179204
XPO5 exportin 5 0.0178342
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.0175959
AKIRIN1 akirin 1 0.0175686
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0174646
RABL6 RAB, member RAS oncogene family-like 6 0.0172863
DACH1 dachshund family transcription factor 1 0.0172572
CTNNBL1 catenin, beta like 1 0.0169999
YLPM1 YLP motif containing 1 0.0167523
PLK2 polo-like kinase 2 0.0166619
GASK1B golgi associated kinase 1B 0.0163898
MYO5A myosin VA (heavy chain 12, myoxin) 0.0163697
NUBPL nucleotide binding protein-like 0.0163244
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0161951
SCAF4 SR-related CTD-associated factor 4 0.0160536
EEF1G eukaryotic translation elongation factor 1 gamma 0.0158898
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0157645
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0157443
SP3 Sp3 transcription factor 0.0157422
SLC38A2 solute carrier family 38, member 2 0.0157285
HEATR1 HEAT repeat containing 1 0.0156168
SYNE2 spectrin repeat containing, nuclear envelope 2 0.015575
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0155443
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0155216
ZNF711 zinc finger protein 711 0.0155172
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 0.0154554
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.0153779
SYTL2 synaptotagmin-like 2 0.0153397
FAM136A family with sequence similarity 136, member A 0.0153351
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0152875
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0152857
MSN moesin 0.015281
EWSR1 EWS RNA-binding protein 1 0.015273
H1-5 H1.5 linker histone, cluster member 0.0152251
ADGRL3 adhesion G protein-coupled receptor L3 0.015215
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0151553
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0151523
DSTYK dual serine/threonine and tyrosine protein kinase 0.0150997
MKRN2 makorin ring finger protein 2 0.0150771
CLCC1 chloride channel CLIC-like 1 0.015051
BRWD3 bromodomain and WD repeat domain containing 3 0.0149555
H1-10 H1.10 linker histone 0.014945
RANBP2 RAN binding protein 2 0.014943
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0148961
FANCC Fanconi anemia, complementation group C 0.0147608
CCDC14 coiled-coil domain containing 14 0.0145634
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.0145226
IPO5 importin 5 0.01451
MKI67 marker of proliferation Ki-67 0.0145073
BLTP2 bridge-like lipid transfer protein family member 2 0.0144794
RBM26 RNA binding motif protein 26 0.0144346
EEF2 eukaryotic translation elongation factor 2 0.0144238
PITPNB phosphatidylinositol transfer protein, beta 0.0143577
TMEM65 transmembrane protein 65 0.0143476
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0143055
RAB6A RAB6A, member RAS oncogene family 0.0142582

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.218278
PTMA prothymosin, alpha -0.114374
TMSB10 thymosin beta 10 -0.106041
PHIP pleckstrin homology domain interacting protein -0.105824
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0957209
RPS6 ribosomal protein S6 -0.0917218
GNAS GNAS complex locus -0.0913362
RPS16 ribosomal protein S16 -0.0900854
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0872274
HDAC9 histone deacetylase 9 -0.0866195
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0859617
RPLP1 ribosomal protein, large, P1 -0.0857549
TPT1 tumor protein, translationally-controlled 1 -0.0810983
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0810088
RPS8 ribosomal protein S8 -0.0785959
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0744332
PCDH9 protocadherin 9 -0.07149
ADGRL2 adhesion G protein-coupled receptor L2 -0.0694772
RPS12 ribosomal protein S12 -0.066826
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0646535
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0612607
COL5A2 collagen, type V, alpha 2 -0.0596989
CENPF centromere protein F, 350/400kDa -0.059403
GARS1 glycyl-tRNA synthetase 1 -0.057333
PLPP1 phospholipid phosphatase 1 -0.055662
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0553711
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0542186
PFN1 profilin 1 -0.0510782
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0508976
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0506363
PRTG protogenin -0.0496495
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0474992
MEIS2 Meis homeobox 2 -0.0473749
USP3 ubiquitin specific peptidase 3 -0.0464538
HMGB1 high mobility group box 1 -0.0464043
RPL11 ribosomal protein L11 -0.0458743
NAP1L1 nucleosome assembly protein 1-like 1 -0.0457443
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0451854
DEK DEK proto-oncogene -0.0442677
PGAP1 post-GPI attachment to proteins 1 -0.0440728
MYL12B myosin, light chain 12B, regulatory -0.0438524
ANKRD33B ankyrin repeat domain 33B -0.043499
RPL35A ribosomal protein L35a -0.0424465
MTF2 metal response element binding transcription factor 2 -0.0409788
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0405106
TSC22D2 TSC22 domain family, member 2 -0.040307
TRPS1 trichorhinophalangeal syndrome I -0.040116
RPS2 ribosomal protein S2 -0.040063
RPL19 ribosomal protein L19 -0.0398258
SHROOM3 shroom family member 3 -0.0387375
PNISR PNN-interacting serine/arginine-rich protein -0.0384694
ANXA1 annexin A1 -0.0384262
RBM25 RNA binding motif protein 25 -0.0383973
CNRIP1 cannabinoid receptor interacting protein 1 -0.0379368
ACTG1 actin gamma 1 -0.0378991
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0378663
RPLP0 ribosomal protein, large, P0 -0.0378367
BMPR1A bone morphogenetic protein receptor, type IA -0.0373985
MRPS30 mitochondrial ribosomal protein S30 -0.03722
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0365352
CDK6 cyclin-dependent kinase 6 -0.0360399
ENAH enabled homolog (Drosophila) -0.0356911
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0354437
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0351893
B2M beta-2-microglobulin -0.0347269
ATP5F1B ATP synthase F1 subunit beta -0.0343583
FOXP2 forkhead box P2 -0.0340861
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0340745
TRA2A transformer 2 alpha homolog (Drosophila) -0.0340462
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0338479
PDCD5 programmed cell death 5 -0.0336669
POU3F2 POU class 3 homeobox 2 -0.0335493
ZNF292 zinc finger protein 292 -0.0332881
RPL34 ribosomal protein L34 -0.033208
RPS21 ribosomal protein S21 -0.0330844
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0328329
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0324111
WSB1 WD repeat and SOCS box containing 1 -0.0319074
SRP54 signal recognition particle 54kDa -0.0316881
CXADR coxsackie virus and adenovirus receptor -0.0314581
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0312059
NALF1 NALCN channel auxiliary factor 1 -0.0311531
RTN4 reticulon 4 -0.0311491
RPL37 ribosomal protein L37 -0.0310831
RFPL4B ret finger protein-like 4B -0.0310731
NDFIP1 Nedd4 family interacting protein 1 -0.0310392
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.030968
SFRP4 secreted frizzled-related protein 4 -0.030865
NAMPT nicotinamide phosphoribosyltransferase -0.0306072
TNRC6B trinucleotide repeat containing 6B -0.0305071
NIPBL Nipped-B homolog (Drosophila) -0.0302052
RSL1D1 ribosomal L1 domain containing 1 -0.0300023
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0294916
RPL36 ribosomal protein L36 -0.0294223
URI1 URI1, prefoldin-like chaperone -0.0293436
SRRM1 serine/arginine repetitive matrix 1 -0.0291427
KDM3A lysine (K)-specific demethylase 3A -0.0291132
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0290081
RPS27A ribosomal protein S27a -0.0289169
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0286994